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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Etv4 (spascer ID:18612)

Gene summary for Etv4

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Etv4
	Gene ID	18612
	Gene name	ets variant 4
	Synonyms	AW414408\|Pea-3\|Pea3
	Cytomap	11 D\|11 65.48 cM
	Type of gene	protein-coding
	Description	ETS translocation variant 4ETS variant protein 4POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3 PROTEIN) (ETS TRANSLOCATION VARIANT 4)ets variant gene 4 (E1A enhancer binding protein, E1AF)
	Modification date	20220424
	UniProtAcc	P28322

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Etv4	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	21873635	Function
Etv4	GO:0005634	nucleus	21873635	Component
Etv4	GO:0006357	regulation of transcription by RNA polymerase II	21873635	Process
Etv4	GO:0030154	cell differentiation	21873635	Process

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Spatial pattern events for Etv4

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Etv4	Mouse	Embryo	rep_1	34489600	3.74e-16
Etv4	Mouse	Embryo	rep_2	34489600	4.14e-16
Etv4	Mouse	Embryo	rep_3	34489600	4.04e-16
Etv4	Mouse	Embryo	rep_4	34489600	3.67e-16
Etv4	Mouse	Embryo	rep_5	34489600	4.08e-16
Etv4	Mouse	Embryo	rep_6	34489600	3.64e-16
Etv4	Mouse	Intestine	rep_2	35149721	2.12e-09
Etv4	Mouse	Intestine	rep_4	35149721	2.30e-15
Etv4	Mouse	Lymph	A1	0	3.29e-15
Etv4	Mouse	Lymph	B1	0	3.66e-15
Etv4	Mouse	Lung	rep_1	35290801	6.56e-15
Etv4	Mouse	Lung	rep_2	35290801	9.30e-11
Etv4	Mouse	Lung	rep_4	35290801	2.95e-07

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Etv4 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Etv4	GOBP_Positive_Regulation_Of_Epidermal_Cell_Differentiation	Mouse	Spinal cord	CN90_C1	1.9e-07
Etv4	GOBP_Positive_Regulation_Of_Epidermis_Development	Mouse	Spinal cord	CN90_C1	1.6e-08
Etv4	GOBP_Epidermal_Cell_Differentiation	Mouse	Spinal cord	CN94_E1	2.9e-07
Etv4	GOBP_Epidermis_Development	Mouse	Spinal cord	CN94_E1	8.2e-07
Etv4	GOBP_Epithelial_Cell_Differentiation	Mouse	Spinal cord	CN94_E1	2.3e-07
Etv4	GOBP_Positive_Regulation_Of_Cell_Differentiation	Mouse	Spinal cord	CN94_E1	3.3e-06
Etv4	GOBP_Skin_Development	Mouse	Spinal cord	CN94_E1	1.6e-06
Etv4	GOBP_Epithelium_Development	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Etv4	GOBP_Keratinocyte_Differentiation	Mouse	Spinal cord	L7CN45_C1	1.5e-06
Etv4	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Mouse	Spinal cord	L7CN45_C1	6.3e-07
Etv4	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Etv4	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Etv4	GOBP_Regulation_Of_Epidermis_Development	Mouse	Spinal cord	L7CN45_C1	1.8e-07
Etv4	GOBP_Regulation_Of_Epithelial_Cell_Differentiation	Mouse	Spinal cord	L7CN45_C1	8.4e-06
Etv4	GOBP_Regulation_Of_Multicellular_Organismal_Development	Mouse	Spinal cord	L7CN45_C1	4.0e-08
Etv4	GOBP_Positive_Regulation_Of_Keratinocyte_Differentiation	Mouse	Spinal cord	L7CN45_E1	2.2e-06
Etv4	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Spinal cord	L8CN11_C1	7.5e-11
Etv4	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Mouse	Brain	rep_27	8.3e-05
Etv4	GOBP_Regulation_Of_Keratinocyte_Differentiation	Mouse	Brain	rep_36	2.0e-05
Etv4	GOBP_Positive_Regulation_Of_Keratinocyte_Differentiation	Mouse	Brain	rep_41	9.9e-05
Etv4	GOBP_Keratinocyte_Differentiation	Mouse	Brain	rep_1	7.8e-11
Etv4	GOBP_Positive_Regulation_Of_Cell_Differentiation	Mouse	Brain	rep_1	3.9e-15
Etv4	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_1	2.5e-12
Etv4	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_1	1.6e-17
Etv4	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Brain	rep_1	2.3e-15
Etv4	GOBP_Epidermal_Cell_Differentiation	Mouse	Brain	rep_3	9.0e-134
Etv4	GOBP_Epidermis_Development	Mouse	Brain	rep_3	3.2e-173
Etv4	GOBP_Epithelial_Cell_Differentiation	Mouse	Brain	rep_3	4.7e-108
Etv4	GOBP_Epithelium_Development	Mouse	Brain	rep_3	8.3e-102
Etv4	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Brain	rep_3	9.3e-50
Etv4	GOBP_Positive_Regulation_Of_Epidermal_Cell_Differentiation	Mouse	Brain	rep_3	6.3e-211
Etv4	GOBP_Positive_Regulation_Of_Epidermis_Development	Mouse	Brain	rep_3	1.3e-83
Etv4	GOBP_Positive_Regulation_Of_Keratinocyte_Differentiation	Mouse	Brain	rep_3	2.9e-89
Etv4	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Mouse	Brain	rep_3	3.5e-105
Etv4	GOBP_Regulation_Of_Epidermis_Development	Mouse	Brain	rep_3	5.6e-135
Etv4	GOBP_Regulation_Of_Epithelial_Cell_Differentiation	Mouse	Brain	rep_3	4.8e-162
Etv4	GOBP_Regulation_Of_Keratinocyte_Differentiation	Mouse	Brain	rep_3	7.6e-134
Etv4	GOBP_Regulation_Of_Multicellular_Organismal_Development	Mouse	Brain	rep_3	5.2e-95
Etv4	GOBP_Skin_Development	Mouse	Brain	rep_3	5.0e-187
Etv4	GOBP_Positive_Regulation_Of_Epithelial_Cell_Differentiation	Mouse	Brain	rep_7	4.4e-17
Etv4	GOBP_Regulation_Of_Keratinocyte_Differentiation	Mouse	Embryo	rep_6	2.3e-18
Etv4	GOBP_Epidermal_Cell_Differentiation	Mouse	Embryo	rep_14	2.9e-08
Etv4	GOBP_Keratinocyte_Differentiation	Mouse	Embryo	rep_14	1.4e-08
Etv4	GOBP_Positive_Regulation_Of_Epidermal_Cell_Differentiation	Mouse	Embryo	rep_14	1.9e-40
Etv4	GOBP_Positive_Regulation_Of_Epidermis_Development	Mouse	Embryo	rep_14	7.4e-34
Etv4	GOBP_Positive_Regulation_Of_Keratinocyte_Differentiation	Mouse	Embryo	rep_14	2.2e-14
Etv4	GOBP_Regulation_Of_Epidermis_Development	Mouse	Embryo	rep_14	6.5e-12
Etv4	GOBP_Epithelium_Development	Mouse	Embryo	rep_1	1.7e-09
Etv4	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Embryo	rep_1	5.0e-13
Etv4	GOBP_Positive_Regulation_Of_Epidermal_Cell_Differentiation	Mouse	Embryo	rep_1	3.8e-24
Etv4	GOBP_Positive_Regulation_Of_Epidermis_Development	Mouse	Embryo	rep_1	3.8e-24
Etv4	GOBP_Positive_Regulation_Of_Keratinocyte_Differentiation	Mouse	Embryo	rep_1	2.8e-307
Etv4	GOBP_Regulation_Of_Multicellular_Organismal_Development	Mouse	Embryo	rep_1	2.8e-203
Etv4	GOBP_Epidermal_Cell_Differentiation	Mouse	Embryo	rep_2	3.6e-126
Etv4	GOBP_Keratinocyte_Differentiation	Mouse	Embryo	rep_2	3.7e-74
Etv4	GOBP_Positive_Regulation_Of_Epithelial_Cell_Differentiation	Mouse	Embryo	rep_2	3.0e-24
Etv4	GOBP_Regulation_Of_Epidermis_Development	Mouse	Embryo	rep_2	0.0e+00
Etv4	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	0.0e+00
Etv4	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
Etv4	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Embryo	rep_3	6.3e-72
Etv4	GOBP_Regulation_Of_Keratinocyte_Differentiation	Mouse	Embryo	rep_3	2.6e-16
Etv4	GOBP_Positive_Regulation_Of_Cell_Differentiation	Mouse	Embryo	rep_5	5.2e-15
Etv4	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Mouse	Embryo	rep_6	1.5e-08
Etv4	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Kidney	Nep	5.6e-37
Etv4	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Mouse	Kidney	Nep	1.8e-38
Etv4	GOBP_Regulation_Of_Multicellular_Organismal_Development	Mouse	Kidney	Nep	1.3e-32
Etv4	GOBP_Epidermal_Cell_Differentiation	Mouse	Kidney	rep_2	8.0e-54
Etv4	GOBP_Epidermis_Development	Mouse	Kidney	rep_2	3.0e-27
Etv4	GOBP_Epithelial_Cell_Differentiation	Mouse	Kidney	rep_2	4.2e-114
Etv4	GOBP_Epithelium_Development	Mouse	Kidney	rep_2	3.5e-92
Etv4	GOBP_Keratinocyte_Differentiation	Mouse	Kidney	rep_2	1.4e-48
Etv4	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Kidney	rep_2	3.1e-09
Etv4	GOBP_Positive_Regulation_Of_Epidermal_Cell_Differentiation	Mouse	Kidney	rep_2	2.8e-64
Etv4	GOBP_Positive_Regulation_Of_Epidermis_Development	Mouse	Kidney	rep_2	7.3e-38
Etv4	GOBP_Positive_Regulation_Of_Keratinocyte_Differentiation	Mouse	Kidney	rep_2	2.7e-78
Etv4	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Mouse	Kidney	rep_2	2.7e-43
Etv4	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	4.5e-10
Etv4	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	8.3e-40
Etv4	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Kidney	rep_2	2.6e-14
Etv4	GOBP_Regulation_Of_Epidermis_Development	Mouse	Kidney	rep_2	1.5e-35
Etv4	GOBP_Regulation_Of_Epithelial_Cell_Differentiation	Mouse	Kidney	rep_2	1.4e-21
Etv4	GOBP_Regulation_Of_Keratinocyte_Differentiation	Mouse	Kidney	rep_2	5.5e-56
Etv4	GOBP_Regulation_Of_Multicellular_Organismal_Development	Mouse	Kidney	rep_2	8.2e-110
Etv4	GOBP_Skin_Development	Mouse	Kidney	rep_2	3.4e-46
Etv4	GOBP_Epidermal_Cell_Differentiation	Mouse	Liver	CN16-D2	7.3e-10
Etv4	GOBP_Epidermis_Development	Mouse	Liver	CN16-D2	1.2e-09
Etv4	GOBP_Regulation_Of_Epithelial_Cell_Differentiation	Mouse	Liver	CN16-D2	4.9e-09
Etv4	GOBP_Skin_Development	Mouse	Liver	CN16-D2	5.4e-07
Etv4	GOBP_Keratinocyte_Differentiation	Mouse	Liver	rep_15	1.1e-15
Etv4	GOBP_Positive_Regulation_Of_Epidermal_Cell_Differentiation	Mouse	Liver	rep_15	6.9e-26
Etv4	GOBP_Positive_Regulation_Of_Epidermis_Development	Mouse	Liver	rep_15	2.1e-23
Etv4	GOBP_Positive_Regulation_Of_Keratinocyte_Differentiation	Mouse	Liver	rep_15	2.2e-15
Etv4	GOBP_Regulation_Of_Keratinocyte_Differentiation	Mouse	Liver	rep_15	2.9e-10
Etv4	GOBP_Epidermal_Cell_Differentiation	Mouse	Liver	rep_16	4.2e-10
Etv4	GOBP_Positive_Regulation_Of_Cell_Differentiation	Mouse	Liver	rep_16	4.7e-08
Etv4	GOBP_Positive_Regulation_Of_Epithelial_Cell_Differentiation	Mouse	Liver	rep_16	2.1e-15
Etv4	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Liver	rep_16	3.6e-08
Etv4	GOBP_Regulation_Of_Epidermis_Development	Mouse	Liver	rep_16	2.9e-34
Etv4	GOBP_Skin_Development	Mouse	Liver	rep_16	1.5e-13
Etv4	GOBP_Regulation_Of_Keratinocyte_Differentiation	Mouse	Intestine	rep_2	4.5e-29
Etv4	GOBP_Epidermal_Cell_Differentiation	Mouse	Lymph	MS-1	3.3e-13
Etv4	GOBP_Epidermis_Development	Mouse	Lymph	MS-1	4.0e-14
Etv4	GOBP_Epithelial_Cell_Differentiation	Mouse	Lymph	MS-1	1.2e-07
Etv4	GOBP_Epithelium_Development	Mouse	Lymph	MS-1	8.5e-09
Etv4	GOBP_Keratinocyte_Differentiation	Mouse	Lymph	MS-1	9.7e-12
Etv4	GOBP_Positive_Regulation_Of_Cell_Differentiation	Mouse	Lymph	MS-1	2.3e-12
Etv4	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Lymph	MS-1	8.9e-15
Etv4	GOBP_Positive_Regulation_Of_Epithelial_Cell_Differentiation	Mouse	Lymph	MS-1	1.6e-11
Etv4	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Mouse	Lymph	MS-1	1.4e-15
Etv4	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	4.4e-12
Etv4	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	1.7e-12
Etv4	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Lymph	MS-1	1.3e-14
Etv4	GOBP_Regulation_Of_Epithelial_Cell_Differentiation	Mouse	Lymph	MS-1	5.4e-12
Etv4	GOBP_Regulation_Of_Keratinocyte_Differentiation	Mouse	Lymph	MS-1	4.2e-10
Etv4	GOBP_Regulation_Of_Multicellular_Organismal_Development	Mouse	Lymph	MS-1	7.2e-15
Etv4	GOBP_Skin_Development	Mouse	Lymph	MS-1	8.0e-14
Etv4	GOBP_Epidermal_Cell_Differentiation	Mouse	Brain	HP_ad_rep7	2.9e-12
Etv4	GOBP_Epithelial_Cell_Differentiation	Mouse	Brain	HP_ad_rep7	1.7e-13
Etv4	GOBP_Epithelium_Development	Mouse	Brain	HP_ad_rep7	2.8e-08
Etv4	GOBP_Keratinocyte_Differentiation	Mouse	Brain	HP_ad_rep7	2.3e-08
Etv4	GOBP_Positive_Regulation_Of_Cell_Differentiation	Mouse	Brain	HP_ad_rep7	3.3e-07
Etv4	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Brain	HP_ad_rep7	4.0e-07
Etv4	GOBP_Positive_Regulation_Of_Epidermal_Cell_Differentiation	Mouse	Brain	HP_ad_rep7	3.8e-17
Etv4	GOBP_Positive_Regulation_Of_Epidermis_Development	Mouse	Brain	HP_ad_rep7	2.8e-23
Etv4	GOBP_Positive_Regulation_Of_Keratinocyte_Differentiation	Mouse	Brain	HP_ad_rep7	3.5e-08
Etv4	GOBP_Positive_Regulation_Of_Multicellular_Organismal_Process	Mouse	Brain	HP_ad_rep7	9.1e-08
Etv4	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-11
Etv4	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.3e-11
Etv4	GOBP_Regulation_Of_Epidermis_Development	Mouse	Brain	HP_ad_rep7	6.1e-17
Etv4	GOBP_Regulation_Of_Epithelial_Cell_Differentiation	Mouse	Brain	HP_ad_rep7	2.3e-12
Etv4	GOBP_Regulation_Of_Keratinocyte_Differentiation	Mouse	Brain	HP_ad_rep7	1.6e-09
Etv4	GOBP_Regulation_Of_Multicellular_Organismal_Development	Mouse	Brain	HP_ad_rep7	1.1e-08
Etv4	GOBP_Skin_Development	Mouse	Brain	HP_ad_rep7	5.7e-08
Etv4	GOBP_Positive_Regulation_Of_Epithelial_Cell_Differentiation	Mouse	Brain	HP_ad_rep8	8.1e-10
Etv4	GOBP_Epidermis_Development	Mouse	Brain	HP_polb_rep9	5.3e-12
Etv4	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Brain	HP_polb_rep9	6.5e-09

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Etv4 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Etv4 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Etv4 envolved

Transcription factor analysis using single cell data.

TF	Tissue	Group	Cell types	Target genes	Rss score
ETV4	Skin	tumor	T_cells	CD63,ZC3H13,ETV5, etc.	0.34
ETV4	Skin	tumor	Neurons	CD63,ZC3H13,ETV5, etc.	0.567
ETV4	Skin	tumor	Tissue_stem_cells	CD63,ZC3H13,ETV5, etc.	0.259

Motif information.

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Related Drugs for Etv4

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Etv4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source