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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Pdha1 (spascer ID:18597)

Gene summary for Pdha1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Pdha1
	Gene ID	18597
	Gene name	pyruvate dehydrogenase E1 alpha 1
	Synonyms	Pdha-1
	Cytomap	X F4\|X 73.95 cM
	Type of gene	protein-coding
	Description	pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialPDHE1-A type Ipyruvate dehydrogenase E1alpha subunit
	Modification date	20220424
	UniProtAcc	P35486

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Pdha1	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	21873635	Function
Pdha1	GO:0006086	acetyl-CoA biosynthetic process from pyruvate	21873635	Process

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Spatial pattern events for Pdha1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Pdha1	Mouse	Brain	S1	34413515	2.07e-15
Pdha1	Mouse	Brain	S2	34413515	1.56e-15
Pdha1	Mouse	Brain	S3	34413515	1.64e-15
Pdha1	Mouse	Brain	S4	34413515	4.65e-15
Pdha1	Mouse	Brain	S6	34413515	1.46e-15
Pdha1	Mouse	Brain	S7	34413515	1.55e-15
Pdha1	Mouse	Brain	rep_1	35141374	3.59e-10
Pdha1	Mouse	Brain	rep_2	35141374	3.05e-15
Pdha1	Mouse	Brain	rep_3	35141374	3.00e-15
Pdha1	Mouse	Brain	rep_4	35141374	1.57e-15
Pdha1	Mouse	Brain	rep_5	35141374	1.47e-15
Pdha1	Mouse	Brain	rep_6	35141374	1.73e-15
Pdha1	Mouse	Kidney	CLP	34003797	2.19e-15
Pdha1	Mouse	Kidney	IRI	34003797	2.29e-15
Pdha1	Mouse	Kidney	Sham	34003797	2.58e-15
Pdha1	Mouse	Kidney	rep_1	34853151	5.41e-11
Pdha1	Mouse	Kidney	rep_2	34853151	7.09e-10
Pdha1	Mouse	Kidney	rep_4	34853151	1.17e-10
Pdha1	Mouse	Kidney	rep_5	34853151	3.18e-15
Pdha1	Mouse	Brain	rep_1	33469025	1.30e-15
Pdha1	Mouse	Liver	rep_22	35021063	3.82e-07
Pdha1	Mouse	Brain	rep_1	35027729	2.98e-15
Pdha1	Mouse	Brain	rep_2	35027729	2.69e-11
Pdha1	Mouse	Brain	rep_3	35027729	1.37e-14
Pdha1	Mouse	Brain	rep_4	35027729	3.10e-15
Pdha1	Mouse	Brain	rep_5	35027729	2.62e-15
Pdha1	Mouse	Intestine	rep_1	35149721	6.08e-15
Pdha1	Mouse	Intestine	rep_2	35149721	3.44e-15
Pdha1	Mouse	Intestine	rep_3	35149721	3.25e-15
Pdha1	Mouse	Intestine	rep_4	35149721	2.30e-15
Pdha1	Mouse	Lung	rep_2	35290801	2.12e-10
Pdha1	Mouse	Lung	rep_3	35290801	8.40e-15
Pdha1	Mouse	Brain	rep_1	35210624	8.96e-13
Pdha1	Mouse	Brain	rep_2	35210624	6.05e-15
Pdha1	Mouse	Brain	rep_3	35210624	3.27e-15
Pdha1	Mouse	Brain	rep_5	35210624	3.62e-15
Pdha1	Mouse	Brain	rep_7	35210624	1.37e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_2_H&E
Kidney_rep_4_H&E
Kidney_rep_5_H&E
Brain_rep_1_H&E
Liver_rep_22_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E

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Spatial pattern pathway has Pdha1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Pdha1	GOBP_Acetyl_Coa_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	1.7e-07
Pdha1	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	5.6e-06
Pdha1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	7.1e-06
Pdha1	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7bCN02_E1	1.8e-07
Pdha1	GOBP_Thioester_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	1.4e-06
Pdha1	GOBP_Acetyl_Coa_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	1.1e-08
Pdha1	GOBP_Amide_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Pdha1	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	1.6e-07
Pdha1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.8e-07
Pdha1	GOBP_Carbohydrate_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	4.6e-08
Pdha1	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Pdha1	GOBP_Cellular_Respiration	Mouse	Spinal cord	L7CN45_C1	7.0e-07
Pdha1	GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds	Mouse	Spinal cord	L7CN45_C1	6.8e-07
Pdha1	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Mouse	Spinal cord	L7CN45_C1	2.2e-08
Pdha1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	6.2e-09
Pdha1	GOBP_Monosaccharide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	5.1e-06
Pdha1	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.1e-07
Pdha1	GOBP_Nucleoside_Bisphosphate_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	1.1e-08
Pdha1	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	1.4e-07
Pdha1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	5.6e-08
Pdha1	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Pdha1	GOBP_Organophosphate_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	2.0e-07
Pdha1	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-07
Pdha1	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.7e-07
Pdha1	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-07
Pdha1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Pdha1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	4.4e-07
Pdha1	GOBP_Thioester_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	3.7e-07
Pdha1	GOBP_Tricarboxylic_Acid_Cycle	Mouse	Brain	rep_11	2.1e-07
Pdha1	GOBP_Aerobic_Respiration	Mouse	Brain	rep_71	1.9e-06
Pdha1	GOBP_Cellular_Respiration	Mouse	Brain	rep_71	1.7e-06
Pdha1	GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds	Mouse	Brain	rep_71	3.4e-07
Pdha1	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Mouse	Brain	rep_71	2.1e-06
Pdha1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Brain	rep_71	8.1e-05
Pdha1	GOBP_Pyruvate_Metabolic_Process	Mouse	Brain	rep_71	1.3e-05
Pdha1	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Brain	rep_71	5.1e-05
Pdha1	GOBP_Aerobic_Respiration	Mouse	Brain	rep_1	5.5e-37
Pdha1	GOBP_Cellular_Respiration	Mouse	Brain	rep_1	9.5e-36
Pdha1	GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds	Mouse	Brain	rep_1	1.1e-29
Pdha1	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Mouse	Brain	rep_1	5.4e-15
Pdha1	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Brain	rep_1	3.5e-11
Pdha1	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Brain	rep_1	3.6e-14
Pdha1	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Brain	rep_1	1.2e-16
Pdha1	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Brain	rep_1	8.2e-08
Pdha1	GOBP_Acetyl_Coa_Biosynthetic_Process	Mouse	Brain	rep_3	5.8e-123
Pdha1	GOBP_Acetyl_Coa_Biosynthetic_Process_From_Pyruvate	Mouse	Brain	rep_3	6.9e-51
Pdha1	GOBP_Acetyl_Coa_Metabolic_Process	Mouse	Brain	rep_3	1.1e-123
Pdha1	GOBP_Amide_Biosynthetic_Process	Mouse	Brain	rep_3	2.5e-86
Pdha1	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Brain	rep_3	2.7e-27
Pdha1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Brain	rep_3	4.5e-61
Pdha1	GOBP_Carbohydrate_Metabolic_Process	Mouse	Brain	rep_3	1.4e-74
Pdha1	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	rep_3	2.1e-87
Pdha1	GOBP_Glucose_Metabolic_Process	Mouse	Brain	rep_3	6.3e-54
Pdha1	GOBP_Mitochondrial_Acetyl_Coa_Biosynthetic_Process_From_Pyruvate	Mouse	Brain	rep_3	1.8e-56
Pdha1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Brain	rep_3	3.2e-119
Pdha1	GOBP_Monosaccharide_Metabolic_Process	Mouse	Brain	rep_3	9.2e-62
Pdha1	GOBP_Nucleoside_Bisphosphate_Biosynthetic_Process	Mouse	Brain	rep_3	2.2e-156
Pdha1	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Brain	rep_3	6.5e-148
Pdha1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	rep_3	1.5e-154
Pdha1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	rep_3	2.9e-144
Pdha1	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Brain	rep_3	2.9e-25
Pdha1	GOBP_Organophosphate_Metabolic_Process	Mouse	Brain	rep_3	8.1e-43
Pdha1	GOBP_Pyruvate_Metabolic_Process	Mouse	Brain	rep_3	4.4e-42
Pdha1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	rep_3	2.7e-19
Pdha1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Brain	rep_3	1.4e-160
Pdha1	GOBP_Thioester_Biosynthetic_Process	Mouse	Brain	rep_3	1.3e-128
Pdha1	GOBP_Thioester_Metabolic_Process	Mouse	Brain	rep_3	5.4e-146
Pdha1	GOBP_Tricarboxylic_Acid_Cycle	Mouse	Brain	rep_3	1.7e-102
Pdha1	GOBP_Acetyl_Coa_Biosynthetic_Process	Mouse	Embryo	rep_6	2.8e-12
Pdha1	GOBP_Acetyl_Coa_Biosynthetic_Process_From_Pyruvate	Mouse	Embryo	rep_6	1.3e-10
Pdha1	GOBP_Cellular_Respiration	Mouse	Embryo	rep_6	3.9e-08
Pdha1	GOBP_Mitochondrial_Acetyl_Coa_Biosynthetic_Process_From_Pyruvate	Mouse	Embryo	rep_6	2.5e-14
Pdha1	GOBP_Nucleoside_Bisphosphate_Biosynthetic_Process	Mouse	Embryo	rep_6	4.3e-08
Pdha1	GOBP_Acetyl_Coa_Metabolic_Process	Mouse	Embryo	rep_14	3.8e-74
Pdha1	GOBP_Aerobic_Respiration	Mouse	Embryo	rep_14	4.2e-31
Pdha1	GOBP_Amide_Biosynthetic_Process	Mouse	Embryo	rep_14	3.7e-18
Pdha1	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Embryo	rep_14	4.5e-09
Pdha1	GOBP_Carbohydrate_Metabolic_Process	Mouse	Embryo	rep_14	1.1e-08
Pdha1	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Pdha1	GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds	Mouse	Embryo	rep_14	2.3e-31
Pdha1	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Mouse	Embryo	rep_14	2.9e-37
Pdha1	GOBP_Glucose_Metabolic_Process	Mouse	Embryo	rep_14	1.4e-21
Pdha1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Embryo	rep_14	7.3e-13
Pdha1	GOBP_Monosaccharide_Metabolic_Process	Mouse	Embryo	rep_14	3.9e-21
Pdha1	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_14	1.8e-12
Pdha1	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Embryo	rep_14	9.1e-21
Pdha1	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Embryo	rep_14	4.8e-21
Pdha1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	2.4e-12
Pdha1	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Embryo	rep_14	1.8e-11
Pdha1	GOBP_Organophosphate_Metabolic_Process	Mouse	Embryo	rep_14	2.0e-09
Pdha1	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	4.8e-28
Pdha1	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_14	6.5e-20
Pdha1	GOBP_Pyruvate_Metabolic_Process	Mouse	Embryo	rep_14	3.2e-54
Pdha1	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Embryo	rep_14	9.6e-35
Pdha1	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	3.3e-48
Pdha1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Embryo	rep_14	5.8e-13
Pdha1	GOBP_Thioester_Biosynthetic_Process	Mouse	Embryo	rep_14	6.9e-47
Pdha1	GOBP_Thioester_Metabolic_Process	Mouse	Embryo	rep_14	1.1e-17
Pdha1	GOBP_Tricarboxylic_Acid_Cycle	Mouse	Embryo	rep_14	3.5e-21
Pdha1	GOBP_Carbohydrate_Metabolic_Process	Mouse	Embryo	rep_1	5.6e-24
Pdha1	GOBP_Glucose_Metabolic_Process	Mouse	Embryo	rep_1	9.4e-142
Pdha1	GOBP_Monosaccharide_Metabolic_Process	Mouse	Embryo	rep_1	6.0e-95
Pdha1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_1	1.4e-55
Pdha1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Embryo	rep_3	1.4e-07
Pdha1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Embryo	rep_4	0.0e+00
Pdha1	GOBP_Acetyl_Coa_Biosynthetic_Process	Mouse	Kidney	rep_2	2.0e-46
Pdha1	GOBP_Acetyl_Coa_Biosynthetic_Process_From_Pyruvate	Mouse	Kidney	rep_2	3.2e-45
Pdha1	GOBP_Amide_Biosynthetic_Process	Mouse	Kidney	rep_2	1.9e-84
Pdha1	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Kidney	rep_2	1.3e-08
Pdha1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-42
Pdha1	GOBP_Carbohydrate_Metabolic_Process	Mouse	Kidney	rep_2	5.2e-99
Pdha1	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-85
Pdha1	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Mouse	Kidney	rep_2	3.3e-14
Pdha1	GOBP_Glucose_Metabolic_Process	Mouse	Kidney	rep_2	2.6e-109
Pdha1	GOBP_Mitochondrial_Acetyl_Coa_Biosynthetic_Process_From_Pyruvate	Mouse	Kidney	rep_2	2.0e-14
Pdha1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Kidney	rep_2	4.4e-73
Pdha1	GOBP_Monosaccharide_Metabolic_Process	Mouse	Kidney	rep_2	4.3e-127
Pdha1	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	2.4e-27
Pdha1	GOBP_Nucleoside_Bisphosphate_Biosynthetic_Process	Mouse	Kidney	rep_2	2.1e-62
Pdha1	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Kidney	rep_2	1.5e-39
Pdha1	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Kidney	rep_2	4.6e-07
Pdha1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Kidney	rep_2	3.8e-62
Pdha1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Kidney	rep_2	8.9e-78
Pdha1	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Kidney	rep_2	1.2e-09
Pdha1	GOBP_Organophosphate_Metabolic_Process	Mouse	Kidney	rep_2	1.7e-41
Pdha1	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-17
Pdha1	GOBP_Pyruvate_Metabolic_Process	Mouse	Kidney	rep_2	3.6e-95
Pdha1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	1.8e-43
Pdha1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Kidney	rep_2	8.6e-17
Pdha1	GOBP_Thioester_Biosynthetic_Process	Mouse	Kidney	rep_2	1.4e-101
Pdha1	GOBP_Thioester_Metabolic_Process	Mouse	Kidney	rep_2	6.7e-64
Pdha1	GOBP_Tricarboxylic_Acid_Cycle	Mouse	Kidney	rep_2	2.4e-76
Pdha1	GOBP_Acetyl_Coa_Biosynthetic_Process	Mouse	Liver	CN16-D1	1.6e-24
Pdha1	GOBP_Acetyl_Coa_Metabolic_Process	Mouse	Liver	CN16-D1	5.5e-10
Pdha1	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Liver	CN16-D1	3.4e-08
Pdha1	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Liver	CN16-D1	9.2e-10
Pdha1	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Liver	CN73-C1	3.2e-07
Pdha1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Liver	CN73-C1	5.1e-08
Pdha1	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Liver	CN73-C1	2.1e-08
Pdha1	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Liver	CN73-C1	2.5e-07
Pdha1	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Liver	CN73-C1	3.0e-11
Pdha1	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Liver	CN73-C1	3.0e-08
Pdha1	GOBP_Thioester_Metabolic_Process	Mouse	Liver	CN73-C1	3.0e-07
Pdha1	GOBP_Aerobic_Respiration	Mouse	Liver	rep_16	2.7e-35
Pdha1	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Liver	rep_16	2.6e-08
Pdha1	GOBP_Cellular_Respiration	Mouse	Liver	rep_16	8.0e-25
Pdha1	GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds	Mouse	Liver	rep_16	2.0e-28
Pdha1	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Mouse	Liver	rep_16	7.4e-11
Pdha1	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Liver	rep_16	1.6e-18
Pdha1	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Liver	rep_16	7.0e-15
Pdha1	GOBP_Pyruvate_Metabolic_Process	Mouse	Liver	rep_16	8.6e-09
Pdha1	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Liver	rep_16	4.5e-22
Pdha1	GOBP_Acetyl_Coa_Biosynthetic_Process_From_Pyruvate	Mouse	Intestine	rep_2	7.0e-37
Pdha1	GOBP_Acetyl_Coa_Metabolic_Process	Mouse	Intestine	rep_2	1.4e-76
Pdha1	GOBP_Mitochondrial_Acetyl_Coa_Biosynthetic_Process_From_Pyruvate	Mouse	Intestine	rep_2	4.7e-104
Pdha1	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Intestine	rep_2	6.0e-29
Pdha1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Intestine	rep_2	7.1e-07
Pdha1	GOBP_Thioester_Metabolic_Process	Mouse	Intestine	rep_2	7.2e-29
Pdha1	GOBP_Amide_Biosynthetic_Process	Mouse	Lymph	MS-1	1.3e-09
Pdha1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Lymph	MS-1	2.8e-10
Pdha1	GOBP_Carbohydrate_Metabolic_Process	Mouse	Lymph	MS-1	5.9e-10
Pdha1	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Pdha1	GOBP_Glucose_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-09
Pdha1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-15
Pdha1	GOBP_Monosaccharide_Metabolic_Process	Mouse	Lymph	MS-1	9.5e-09
Pdha1	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.7e-09
Pdha1	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Lymph	MS-1	3.6e-07
Pdha1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-15
Pdha1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	1.4e-09
Pdha1	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Lymph	MS-1	6.7e-07
Pdha1	GOBP_Organophosphate_Metabolic_Process	Mouse	Lymph	MS-1	7.3e-07
Pdha1	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	3.6e-07
Pdha1	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	8.0e-08
Pdha1	GOBP_Pyruvate_Metabolic_Process	Mouse	Lymph	MS-1	7.1e-07
Pdha1	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Lymph	MS-1	3.6e-07
Pdha1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.6e-11
Pdha1	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	4.5e-10
Pdha1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Lymph	MS-1	7.8e-10
Pdha1	GOBP_Thioester_Biosynthetic_Process	Mouse	Lymph	MS-1	7.3e-10
Pdha1	GOBP_Tricarboxylic_Acid_Cycle	Mouse	Brain	rep_7	8.9e-09
Pdha1	GOBP_Acetyl_Coa_Biosynthetic_Process	Mouse	Brain	HP_ad_rep3	4.1e-07
Pdha1	GOBP_Acetyl_Coa_Metabolic_Process	Mouse	Brain	HP_ad_rep7	3.0e-08
Pdha1	GOBP_Amide_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	8.0e-10
Pdha1	GOBP_Carbohydrate_Derivative_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	9.8e-07
Pdha1	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.6e-11
Pdha1	GOBP_Nucleoside_Bisphosphate_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	1.7e-09
Pdha1	GOBP_Nucleoside_Bisphosphate_Metabolic_Process	Mouse	Brain	HP_ad_rep7	1.8e-08
Pdha1	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	2.4e-07
Pdha1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	HP_ad_rep7	4.1e-08
Pdha1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	2.8e-08
Pdha1	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.2e-11
Pdha1	GOBP_Thioester_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.1e-12
Pdha1	GOBP_Thioester_Metabolic_Process	Mouse	Brain	HP_ad_rep7	4.7e-10
Pdha1	GOBP_Aerobic_Respiration	Mouse	Brain	HP_polb_rep9	1.4e-09
Pdha1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Brain	HP_polb_rep9	5.2e-12
Pdha1	GOBP_Carbohydrate_Metabolic_Process	Mouse	Brain	HP_polb_rep9	1.6e-09
Pdha1	GOBP_Cellular_Respiration	Mouse	Brain	HP_polb_rep9	2.1e-07
Pdha1	GOBP_Energy_Derivation_By_Oxidation_Of_Organic_Compounds	Mouse	Brain	HP_polb_rep9	3.0e-10
Pdha1	GOBP_Generation_Of_Precursor_Metabolites_And_Energy	Mouse	Brain	HP_polb_rep9	5.4e-11
Pdha1	GOBP_Glucose_Metabolic_Process	Mouse	Brain	HP_polb_rep9	1.8e-10
Pdha1	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	1.7e-11
Pdha1	GOBP_Monosaccharide_Metabolic_Process	Mouse	Brain	HP_polb_rep9	1.7e-09
Pdha1	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	6.9e-09
Pdha1	GOBP_Organophosphate_Metabolic_Process	Mouse	Brain	HP_polb_rep9	7.1e-09
Pdha1	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	6.8e-08
Pdha1	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.4e-07
Pdha1	GOBP_Pyruvate_Metabolic_Process	Mouse	Brain	HP_polb_rep9	6.5e-09
Pdha1	GOBP_Ribose_Phosphate_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	1.4e-08
Pdha1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.0e-09
Pdha1	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	2.2e-10
Pdha1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.9e-08
Pdha1	GOBP_Tricarboxylic_Acid_Cycle	Mouse	Brain	HP_polb_rep9	9.1e-07

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Pdha1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Pdha1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Pdha1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Pdha1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Pdha1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Pdha1	C1839413	Pyruvate Dehydrogenase E1 Alpha Deficiency	24	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Pdha1	C0023264	Leigh Disease	8	CLINGEN
Pdha1	C1838951	LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY	8	CLINGEN
Pdha1	C1850597	Leigh Syndrome Due To Mitochondrial Complex II Deficiency	8	CLINGEN
Pdha1	C1850598	Leigh Syndrome due to Mitochondrial Complex III Deficiency	8	CLINGEN
Pdha1	C1850599	Leigh Syndrome due to Mitochondrial Complex IV Deficiency	8	CLINGEN
Pdha1	C1850600	Leigh Syndrome due to Mitochondrial Complex V Deficiency	8	CLINGEN
Pdha1	C2931891	Necrotizing encephalopathy, infantile subacute, of Leigh	8	CLINGEN
Pdha1	C0034345	Pyruvate Dehydrogenase Complex Deficiency Disease	4	CTD_human;ORPHANET
Pdha1	C0033578	Prostatic Neoplasms	2	CTD_human
Pdha1	C0376358	Malignant neoplasm of prostate	2	CTD_human
Pdha1	C0001125	Acidosis, Lactic	1	CTD_human
Pdha1	C0024623	Malignant neoplasm of stomach	1	CTD_human
Pdha1	C0029408	Degenerative polyarthritis	1	CTD_human
Pdha1	C0034350	Pyruvate Metabolism, Inborn Errors	1	CTD_human
Pdha1	C0038356	Stomach Neoplasms	1	CTD_human
Pdha1	C0086743	Osteoarthrosis Deformans	1	CTD_human
Pdha1	C0151744	Myocardial Ischemia	1	CTD_human
Pdha1	C0235874	Disease Exacerbation	1	CTD_human
Pdha1	C0751595	Juvenile Pyruvate Dehydrogenase Complex Deficiency Disease	1	CTD_human
Pdha1	C0751596	Pyruvate Dehydrogenase Complex Deficiency Disease, Neonatal	1	CTD_human
Pdha1	C0751597	Ataxia with Lactic Acidosis, Type I	1	CTD_human
Pdha1	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human