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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Pde6d (spascer ID:18582)

Gene summary for Pde6d

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Pde6d
	Gene ID	18582
	Gene name	phosphodiesterase 6D, cGMP-specific, rod, delta
	Synonyms	AI841218\|PrBP/delta
	Cytomap	1\|1 C5
	Type of gene	protein-coding
	Description	retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit deltaGMP-PDE delta
	Modification date	20220424
	UniProtAcc	O55057

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Pde6d	GO:0005737	cytoplasm	21873635	Component

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Spatial pattern events for Pde6d

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Pde6d	Mouse	Brain	S3	34413515	2.96e-15
Pde6d	Mouse	Brain	S4	34413515	1.37e-15
Pde6d	Mouse	Brain	S6	34413515	4.44e-07
Pde6d	Mouse	Brain	S7	34413515	3.15e-12
Pde6d	Mouse	Brain	rep_1	35141374	4.53e-06
Pde6d	Mouse	Brain	rep_2	35141374	8.28e-08
Pde6d	Mouse	Brain	rep_3	35141374	4.65e-09
Pde6d	Mouse	Brain	rep_4	35141374	1.57e-15
Pde6d	Mouse	Kidney	CLP	34003797	2.19e-15
Pde6d	Mouse	Kidney	Sham	34003797	2.58e-15
Pde6d	Mouse	Kidney	rep_1	34853151	1.59e-07
Pde6d	Mouse	Brain	rep_1	35027729	1.66e-15
Pde6d	Mouse	Brain	rep_2	35027729	2.83e-15
Pde6d	Mouse	Brain	rep_3	35027729	4.57e-15
Pde6d	Mouse	Brain	rep_5	35027729	2.62e-15
Pde6d	Mouse	Brain	rep_3	35210624	3.19e-06
Pde6d	Mouse	Brain	rep_5	35210624	4.88e-10
Pde6d	Mouse	Brain	rep_7	35210624	3.65e-08

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Kidney_CLP_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_5_H&E

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Spatial pattern pathway has Pde6d envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Pde6d	GOBP_Nervous_System_Process	Mouse	Spinal cord	L7bCN02_E1	2.5e-06
Pde6d	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Pde6d	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Pde6d	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Pde6d	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Spinal cord	L7CN45_C1	2.3e-07
Pde6d	GOBP_Sensory_Perception	Mouse	Spinal cord	L7CN45_C1	5.0e-07
Pde6d	GOBP_Sensory_Perception_Of_Light_Stimulus	Mouse	Spinal cord	L7CN45_C1	2.3e-08
Pde6d	GOBP_Negative_Regulation_Of_Gtpase_Activity	Mouse	Spinal cord	L7CN47_D1	3.1e-06
Pde6d	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_27	8.1e-06
Pde6d	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_27	4.2e-05
Pde6d	GOBP_Sensory_Perception_Of_Light_Stimulus	Mouse	Brain	rep_71	5.8e-05
Pde6d	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Brain	rep_1	1.0e-08
Pde6d	GOBP_Nervous_System_Process	Mouse	Brain	rep_1	1.6e-36
Pde6d	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_1	5.6e-32
Pde6d	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_3	5.2e-181
Pde6d	GOBP_Negative_Regulation_Of_Gtpase_Activity	Mouse	Brain	rep_3	6.2e-33
Pde6d	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Brain	rep_3	3.5e-163
Pde6d	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Brain	rep_3	1.4e-120
Pde6d	GOBP_Sensory_Perception	Mouse	Brain	rep_3	2.9e-57
Pde6d	GOBP_Sensory_Perception_Of_Light_Stimulus	Mouse	Brain	rep_3	1.1e-51
Pde6d	GOBP_Negative_Regulation_Of_Gtpase_Activity	Mouse	Embryo	rep_6	3.6e-14
Pde6d	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_14	4.4e-26
Pde6d	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_14	8.5e-07
Pde6d	GOBP_Sensory_Perception	Mouse	Embryo	rep_14	5.0e-07
Pde6d	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Embryo	rep_1	2.5e-32
Pde6d	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_1	4.6e-17
Pde6d	GOBP_Nervous_System_Process	Mouse	Embryo	rep_1	1.4e-08
Pde6d	GOBP_Sensory_Perception	Mouse	Embryo	rep_3	0.0e+00
Pde6d	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Kidney	Nep	8.3e-23
Pde6d	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	Nep	1.3e-36
Pde6d	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Kidney	rep_2	5.2e-90
Pde6d	GOBP_Negative_Regulation_Of_Gtpase_Activity	Mouse	Kidney	rep_2	7.4e-61
Pde6d	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	rep_2	5.7e-63
Pde6d	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Kidney	rep_2	2.5e-99
Pde6d	GOBP_Nervous_System_Process	Mouse	Kidney	rep_2	1.9e-90
Pde6d	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Kidney	rep_2	1.2e-71
Pde6d	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	rep_2	1.4e-60
Pde6d	GOBP_Sensory_Perception	Mouse	Kidney	rep_2	1.4e-94
Pde6d	GOBP_Sensory_Perception_Of_Light_Stimulus	Mouse	Kidney	rep_2	1.2e-132
Pde6d	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Liver	CN16-D2	1.9e-10
Pde6d	GOBP_Negative_Regulation_Of_Gtpase_Activity	Mouse	Liver	CN65-C1	5.0e-07
Pde6d	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Liver	CN73-C1	9.9e-07
Pde6d	GOBP_Nervous_System_Process	Mouse	Liver	CN73-C1	1.7e-08
Pde6d	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Lymph	MS-1	2.2e-13
Pde6d	GOBP_Negative_Regulation_Of_Gtpase_Activity	Mouse	Lymph	MS-1	6.1e-12
Pde6d	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Lymph	MS-1	4.3e-09
Pde6d	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Lymph	MS-1	6.9e-11
Pde6d	GOBP_Nervous_System_Process	Mouse	Lymph	MS-1	1.4e-08
Pde6d	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Lymph	MS-1	1.9e-08
Pde6d	GOBP_Sensory_Perception	Mouse	Lymph	MS-1	5.2e-11
Pde6d	GOBP_Sensory_Perception_Of_Light_Stimulus	Mouse	Lymph	MS-1	3.2e-08
Pde6d	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Lung	rep_1	6.3e-10
Pde6d	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Lung	rep_1	9.4e-15
Pde6d	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Brain	HP_ad_rep7	4.0e-09
Pde6d	GOBP_Negative_Regulation_Of_Gtpase_Activity	Mouse	Brain	HP_ad_rep7	9.8e-13
Pde6d	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Brain	HP_ad_rep7	3.4e-10
Pde6d	GOBP_Nervous_System_Process	Mouse	Brain	HP_ad_rep7	7.0e-10
Pde6d	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Brain	HP_polb_rep9	7.1e-13
Pde6d	GOBP_Regulation_Of_Gtpase_Activity	Mouse	Brain	HP_polb_rep9	4.2e-09
Pde6d	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Brain	HP_polb_rep9	6.0e-09
Pde6d	GOBP_Sensory_Perception	Mouse	Brain	HP_polb_rep9	1.2e-09
Pde6d	GOBP_Sensory_Perception_Of_Light_Stimulus	Mouse	Brain	HP_polb_rep9	5.5e-10

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Pde6d function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Pde6d function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Pde6d envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Pde6d

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Pde6d

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Pde6d	C3810278	JOUBERT SYNDROME 22	2	GENOMICS_ENGLAND
Pde6d	C0152427	Polydactyly	1	GENOMICS_ENGLAND
Pde6d	C2745997	OROFACIODIGITAL SYNDROME VI	1	ORPHANET