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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Pde4a (spascer ID:18577)

Gene summary for Pde4a

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Pde4a
	Gene ID	18577
	Gene name	phosphodiesterase 4A, cAMP specific
	Synonyms	D9Ertd60e\|Dpde2
	Cytomap	9 A3\|9 7.73 cM
	Type of gene	protein-coding
	Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4AcAMP-specific phosphodiesterase PDE4Acyclic AMP specific phosphodiesterase PDE4A5Adunce
	Modification date	20220515
	UniProtAcc	O89084

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Pde4a	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	21873635	Function
Pde4a	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	21873635	Function
Pde4a	GO:0005634	nucleus	21873635	Component
Pde4a	GO:0005829	cytosol	21873635	Component
Pde4a	GO:0007165	signal transduction	21873635	Process
Pde4a	GO:0048471	perinuclear region of cytoplasm	21873635	Component

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Spatial pattern events for Pde4a

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Pde4a	Mouse	Brain	S1	34413515	2.07e-15
Pde4a	Mouse	Brain	S2	34413515	1.56e-15
Pde4a	Mouse	Brain	S3	34413515	1.64e-15
Pde4a	Mouse	Brain	S4	34413515	1.37e-15
Pde4a	Mouse	Brain	S6	34413515	2.66e-15
Pde4a	Mouse	Brain	S7	34413515	1.55e-15
Pde4a	Mouse	Brain	27A	32637622	7.32e-08
Pde4a	Mouse	Brain	rep_1	35141374	5.90e-10
Pde4a	Mouse	Brain	rep_2	35141374	1.69e-15
Pde4a	Mouse	Brain	rep_3	35141374	1.64e-15
Pde4a	Mouse	Brain	rep_4	35141374	1.57e-15
Pde4a	Mouse	Brain	rep_5	35141374	1.47e-15
Pde4a	Mouse	Brain	rep_6	35141374	1.73e-15
Pde4a	Mouse	Kidney	IRI	34003797	3.92e-15
Pde4a	Mouse	Brain	rep_1	33469025	1.30e-15
Pde4a	Mouse	Brain	rep_1	35027729	1.66e-15
Pde4a	Mouse	Brain	rep_2	35027729	1.57e-15
Pde4a	Mouse	Brain	rep_3	35027729	1.32e-15
Pde4a	Mouse	Brain	rep_4	35027729	1.76e-15
Pde4a	Mouse	Brain	rep_5	35027729	1.46e-15
Pde4a	Mouse	Brain	B02_E1	32702314	1.98e-13
Pde4a	Mouse	Brain	N05_D2	32702314	3.35e-06
Pde4a	Mouse	Brain	rep_1	35210624	3.17e-15
Pde4a	Mouse	Brain	rep_2	35210624	3.17e-15
Pde4a	Mouse	Brain	rep_3	35210624	3.27e-15
Pde4a	Mouse	Brain	rep_5	35210624	8.76e-07
Pde4a	Mouse	Brain	rep_6	35210624	3.35e-08
Pde4a	Mouse	Brain	rep_7	35210624	7.21e-10

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_IRI_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_B02_E1_H&E
Brain_N05_D2_H&E

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Spatial pattern pathway has Pde4a envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Pde4a	GOBP_Regulation_Of_Protein_Kinase_A_Signaling	Mouse	Spinal cord	CN93_D2	4.3e-06
Pde4a	GOBP_Cyclic_Nucleotide_Catabolic_Process	Mouse	Spinal cord	L7bCN01_D2	5.8e-07
Pde4a	GOBP_Cyclic_Nucleotide_Metabolic_Process	Mouse	Spinal cord	L7bCN01_D2	9.2e-06
Pde4a	GOBP_Nervous_System_Process	Mouse	Spinal cord	L7bCN02_E1	2.5e-06
Pde4a	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Spinal cord	L7bCN02_E1	7.8e-06
Pde4a	GOBP_Nucleobase_Containing_Small_Molecule_Biosynthetic_Process	Mouse	Spinal cord	L7CN34_C1	7.9e-06
Pde4a	GOBP_Camp_Mediated_Signaling	Mouse	Spinal cord	L7CN45_C1	1.1e-07
Pde4a	GOBP_Carbohydrate_Derivative_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	2.7e-07
Pde4a	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.8e-07
Pde4a	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Spinal cord	L7CN45_C1	3.7e-06
Pde4a	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	8.8e-08
Pde4a	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.1e-07
Pde4a	GOBP_Nucleoside_Phosphate_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.3e-08
Pde4a	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Pde4a	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	5.1e-08
Pde4a	GOBP_Organophosphate_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.4e-07
Pde4a	GOBP_Organophosphate_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	2.0e-07
Pde4a	GOBP_Protein_Kinase_A_Signaling	Mouse	Spinal cord	L7CN45_C1	1.8e-06
Pde4a	GOBP_Purine_Containing_Compound_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-06
Pde4a	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.7e-07
Pde4a	GOBP_Regulation_Of_Camp_Mediated_Signaling	Mouse	Spinal cord	L7CN45_C1	2.6e-06
Pde4a	GOBP_Ribonucleotide_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	6.1e-07
Pde4a	GOBP_Sensory_Perception	Mouse	Spinal cord	L7CN45_C1	5.0e-07
Pde4a	GOBP_Sensory_Perception_Of_Chemical_Stimulus	Mouse	Spinal cord	L7CN45_C1	3.3e-08
Pde4a	GOBP_Sensory_Perception_Of_Smell	Mouse	Spinal cord	L7CN45_C1	9.5e-07
Pde4a	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	4.3e-07
Pde4a	GOBP_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Pde4a	GOBP_Camp_Metabolic_Process	Mouse	Spinal cord	L7CN45_E1	2.8e-06
Pde4a	GOBP_Camp_Catabolic_Process	Mouse	Spinal cord	L7CN97_E2	2.0e-07
Pde4a	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L8CN11_D1	5.6e-09
Pde4a	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_27	8.0e-06
Pde4a	GOBP_Protein_Kinase_A_Signaling	Mouse	Brain	rep_27	5.6e-07
Pde4a	GOBP_Sensory_Perception_Of_Smell	Mouse	Brain	rep_41	3.6e-11
Pde4a	GOBP_Camp_Mediated_Signaling	Mouse	Brain	rep_42	5.1e-05
Pde4a	GOBP_Camp_Catabolic_Process	Mouse	Brain	rep_75	5.0e-06
Pde4a	GOBP_Nucleobase_Containing_Small_Molecule_Biosynthetic_Process	Mouse	Brain	rep_75	8.0e-05
Pde4a	GOBP_Camp_Mediated_Signaling	Mouse	Brain	rep_1	1.1e-31
Pde4a	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_1	4.5e-16
Pde4a	GOBP_Nervous_System_Process	Mouse	Brain	rep_1	1.6e-36
Pde4a	GOBP_Purine_Containing_Compound_Catabolic_Process	Mouse	Brain	rep_1	7.9e-08
Pde4a	GOBP_Ribonucleotide_Catabolic_Process	Mouse	Brain	rep_1	1.1e-10
Pde4a	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Brain	rep_1	5.1e-20
Pde4a	GOBP_Sensory_Perception_Of_Chemical_Stimulus	Mouse	Brain	rep_1	1.5e-17
Pde4a	GOBP_Carbohydrate_Derivative_Catabolic_Process	Mouse	Brain	rep_3	3.4e-221
Pde4a	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Brain	rep_3	4.5e-61
Pde4a	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Brain	rep_3	2.3e-101
Pde4a	GOBP_Nucleobase_Containing_Small_Molecule_Biosynthetic_Process	Mouse	Brain	rep_3	1.9e-170
Pde4a	GOBP_Nucleoside_Phosphate_Catabolic_Process	Mouse	Brain	rep_3	4.1e-202
Pde4a	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Mouse	Brain	rep_3	1.2e-230
Pde4a	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Brain	rep_3	7.1e-166
Pde4a	GOBP_Organophosphate_Catabolic_Process	Mouse	Brain	rep_3	6.2e-102
Pde4a	GOBP_Organophosphate_Metabolic_Process	Mouse	Brain	rep_3	8.1e-43
Pde4a	GOBP_Protein_Kinase_A_Signaling	Mouse	Brain	rep_3	1.0e-134
Pde4a	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	1.3e-132
Pde4a	GOBP_Regulation_Of_Protein_Kinase_A_Signaling	Mouse	Brain	rep_3	1.6e-148
Pde4a	GOBP_Sensory_Perception	Mouse	Brain	rep_3	2.9e-57
Pde4a	GOBP_Sensory_Perception_Of_Smell	Mouse	Brain	rep_3	4.3e-10
Pde4a	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Brain	rep_3	1.1e-103
Pde4a	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	rep_3	2.7e-19
Pde4a	GOBP_Regulation_Of_Camp_Mediated_Signaling	Mouse	Brain	rep_5	1.3e-71
Pde4a	GOBP_Sensory_Perception_Of_Smell	Mouse	Embryo	rep_6	9.5e-11
Pde4a	GOBP_Camp_Catabolic_Process	Mouse	Embryo	rep_14	2.7e-65
Pde4a	GOBP_Camp_Mediated_Signaling	Mouse	Embryo	rep_14	1.0e-48
Pde4a	GOBP_Camp_Metabolic_Process	Mouse	Embryo	rep_14	7.0e-38
Pde4a	GOBP_Carbohydrate_Derivative_Catabolic_Process	Mouse	Embryo	rep_14	1.7e-43
Pde4a	GOBP_Cyclic_Nucleotide_Catabolic_Process	Mouse	Embryo	rep_14	3.7e-39
Pde4a	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Embryo	rep_14	1.3e-22
Pde4a	GOBP_Cyclic_Nucleotide_Metabolic_Process	Mouse	Embryo	rep_14	1.6e-64
Pde4a	GOBP_Nucleobase_Containing_Small_Molecule_Biosynthetic_Process	Mouse	Embryo	rep_14	1.4e-21
Pde4a	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_14	1.8e-12
Pde4a	GOBP_Nucleoside_Phosphate_Catabolic_Process	Mouse	Embryo	rep_14	1.8e-44
Pde4a	GOBP_Organophosphate_Catabolic_Process	Mouse	Embryo	rep_14	2.9e-51
Pde4a	GOBP_Organophosphate_Metabolic_Process	Mouse	Embryo	rep_14	2.0e-09
Pde4a	GOBP_Protein_Kinase_A_Signaling	Mouse	Embryo	rep_14	4.7e-18
Pde4a	GOBP_Purine_Containing_Compound_Catabolic_Process	Mouse	Embryo	rep_14	5.4e-32
Pde4a	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_14	6.5e-20
Pde4a	GOBP_Regulation_Of_Camp_Mediated_Signaling	Mouse	Embryo	rep_14	6.7e-18
Pde4a	GOBP_Regulation_Of_Protein_Kinase_A_Signaling	Mouse	Embryo	rep_14	3.6e-42
Pde4a	GOBP_Ribonucleotide_Catabolic_Process	Mouse	Embryo	rep_14	1.0e-59
Pde4a	GOBP_Sensory_Perception	Mouse	Embryo	rep_14	5.0e-07
Pde4a	GOBP_Sensory_Perception_Of_Chemical_Stimulus	Mouse	Embryo	rep_14	4.9e-23
Pde4a	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Embryo	rep_14	6.9e-13
Pde4a	GOBP_Nervous_System_Process	Mouse	Embryo	rep_1	1.4e-08
Pde4a	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Embryo	rep_1	5.7e-21
Pde4a	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Embryo	rep_1	8.4e-169
Pde4a	GOBP_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_1	1.4e-55
Pde4a	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Mouse	Embryo	rep_2	3.3e-45
Pde4a	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Embryo	rep_3	0.0e+00
Pde4a	GOBP_Sensory_Perception	Mouse	Embryo	rep_3	0.0e+00
Pde4a	GOBP_Sensory_Perception_Of_Chemical_Stimulus	Mouse	Embryo	rep_3	0.0e+00
Pde4a	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Kidney	Nep	4.2e-26
Pde4a	GOBP_Camp_Catabolic_Process	Mouse	Kidney	rep_2	2.3e-09
Pde4a	GOBP_Camp_Metabolic_Process	Mouse	Kidney	rep_2	6.1e-12
Pde4a	GOBP_Carbohydrate_Derivative_Catabolic_Process	Mouse	Kidney	rep_2	5.9e-48
Pde4a	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-42
Pde4a	GOBP_Cyclic_Nucleotide_Catabolic_Process	Mouse	Kidney	rep_2	4.1e-29
Pde4a	GOBP_Cyclic_Nucleotide_Metabolic_Process	Mouse	Kidney	rep_2	2.6e-12
Pde4a	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Kidney	rep_2	3.0e-37
Pde4a	GOBP_Nervous_System_Process	Mouse	Kidney	rep_2	1.9e-90
Pde4a	GOBP_Nucleobase_Containing_Small_Molecule_Biosynthetic_Process	Mouse	Kidney	rep_2	2.0e-16
Pde4a	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	2.4e-27
Pde4a	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Kidney	rep_2	1.2e-14
Pde4a	GOBP_Organophosphate_Catabolic_Process	Mouse	Kidney	rep_2	3.9e-15
Pde4a	GOBP_Organophosphate_Metabolic_Process	Mouse	Kidney	rep_2	1.7e-41
Pde4a	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-17
Pde4a	GOBP_Regulation_Of_Camp_Mediated_Signaling	Mouse	Kidney	rep_2	1.1e-25
Pde4a	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	1.4e-17
Pde4a	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Kidney	rep_2	2.7e-12
Pde4a	GOBP_Sensory_Perception	Mouse	Kidney	rep_2	1.4e-94
Pde4a	GOBP_Sensory_Perception_Of_Chemical_Stimulus	Mouse	Kidney	rep_2	2.1e-70
Pde4a	GOBP_Sensory_Perception_Of_Smell	Mouse	Kidney	rep_2	4.4e-38
Pde4a	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Kidney	rep_2	1.8e-73
Pde4a	GOBP_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	1.8e-43
Pde4a	GOBP_Camp_Catabolic_Process	Mouse	Kidney	rep_3	1.5e-04
Pde4a	GOBP_Cyclic_Nucleotide_Catabolic_Process	Mouse	Liver	CN16-D1	1.1e-10
Pde4a	GOBP_Purine_Containing_Compound_Catabolic_Process	Mouse	Liver	CN16-D1	6.9e-14
Pde4a	GOBP_Camp_Metabolic_Process	Mouse	Liver	CN16-D2	6.1e-08
Pde4a	GOBP_Protein_Kinase_A_Signaling	Mouse	Liver	CN16-D2	3.2e-07
Pde4a	GOBP_Sensory_Perception_Of_Chemical_Stimulus	Mouse	Liver	CN16-D2	2.3e-07
Pde4a	GOBP_Sensory_Perception_Of_Smell	Mouse	Liver	CN16-D2	9.5e-07
Pde4a	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Liver	CN16-E1	4.0e-10
Pde4a	GOBP_Regulation_Of_Protein_Kinase_A_Signaling	Mouse	Liver	CN16-E1	3.3e-08
Pde4a	GOBP_Nucleobase_Containing_Small_Molecule_Biosynthetic_Process	Mouse	Liver	CN65-C1	5.9e-10
Pde4a	GOBP_Ribonucleotide_Catabolic_Process	Mouse	Liver	CN65-C1	4.9e-08
Pde4a	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Liver	CN73-C1	5.1e-08
Pde4a	GOBP_Nervous_System_Process	Mouse	Liver	CN73-C1	1.7e-08
Pde4a	GOBP_Camp_Metabolic_Process	Mouse	Liver	rep_15	8.0e-08
Pde4a	GOBP_Cyclic_Nucleotide_Catabolic_Process	Mouse	Liver	rep_15	9.6e-10
Pde4a	GOBP_Regulation_Of_Camp_Mediated_Signaling	Mouse	Liver	rep_15	2.4e-09
Pde4a	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Liver	rep_16	4.7e-11
Pde4a	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Liver	rep_16	5.2e-08
Pde4a	GOBP_Camp_Catabolic_Process	Mouse	Liver	rep_23	1.7e-25
Pde4a	GOBP_Cyclic_Nucleotide_Metabolic_Process	Mouse	Liver	rep_23	1.1e-07
Pde4a	GOBP_Protein_Kinase_A_Signaling	Mouse	Liver	rep_23	5.2e-11
Pde4a	GOBP_Regulation_Of_Protein_Kinase_A_Signaling	Mouse	Liver	rep_23	2.6e-27
Pde4a	GOBP_Camp_Mediated_Signaling	Mouse	Lymph	MS-1	3.2e-10
Pde4a	GOBP_Carbohydrate_Derivative_Catabolic_Process	Mouse	Lymph	MS-1	6.0e-17
Pde4a	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Lymph	MS-1	2.8e-10
Pde4a	GOBP_Cyclic_Nucleotide_Catabolic_Process	Mouse	Lymph	MS-1	2.0e-11
Pde4a	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Lymph	MS-1	1.8e-08
Pde4a	GOBP_Nervous_System_Process	Mouse	Lymph	MS-1	1.4e-08
Pde4a	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.7e-09
Pde4a	GOBP_Nucleoside_Phosphate_Catabolic_Process	Mouse	Lymph	MS-1	2.0e-12
Pde4a	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Mouse	Lymph	MS-1	1.2e-13
Pde4a	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Lymph	MS-1	1.2e-13
Pde4a	GOBP_Organophosphate_Catabolic_Process	Mouse	Lymph	MS-1	2.4e-09
Pde4a	GOBP_Organophosphate_Metabolic_Process	Mouse	Lymph	MS-1	7.3e-07
Pde4a	GOBP_Protein_Kinase_A_Signaling	Mouse	Lymph	MS-1	4.7e-11
Pde4a	GOBP_Purine_Containing_Compound_Catabolic_Process	Mouse	Lymph	MS-1	2.9e-12
Pde4a	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	8.0e-08
Pde4a	GOBP_Regulation_Of_Camp_Mediated_Signaling	Mouse	Lymph	MS-1	4.7e-11
Pde4a	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.0e-14
Pde4a	GOBP_Ribonucleotide_Catabolic_Process	Mouse	Lymph	MS-1	2.7e-14
Pde4a	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Lymph	MS-1	1.1e-10
Pde4a	GOBP_Sensory_Perception	Mouse	Lymph	MS-1	5.2e-11
Pde4a	GOBP_Sensory_Perception_Of_Chemical_Stimulus	Mouse	Lymph	MS-1	1.7e-09
Pde4a	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Lymph	MS-1	3.0e-17
Pde4a	GOBP_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.6e-11
Pde4a	GOBP_Camp_Catabolic_Process	Mouse	Lymph	MS-2	4.6e-08
Pde4a	GOBP_Regulation_Of_Protein_Kinase_A_Signaling	Mouse	Lymph	PBS	5.3e-08
Pde4a	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Lung	rep_1	1.7e-11
Pde4a	GOBP_Regulation_Of_Protein_Kinase_A_Signaling	Mouse	Lung	rep_1	6.0e-07
Pde4a	GOBP_Camp_Mediated_Signaling	Mouse	Brain	rep_4	2.0e-24
Pde4a	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_4	1.7e-17
Pde4a	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Brain	rep_4	9.1e-14
Pde4a	GOBP_Sensory_Perception_Of_Chemical_Stimulus	Mouse	Brain	rep_4	8.2e-10
Pde4a	GOBP_Regulation_Of_Protein_Kinase_A_Signaling	Mouse	Brain	rep_7	4.3e-14
Pde4a	GOBP_Sensory_Perception_Of_Smell	Mouse	Brain	HP_ad_rep3	4.7e-13
Pde4a	GOBP_Camp_Mediated_Signaling	Mouse	Brain	HP_ad_rep7	2.2e-12
Pde4a	GOBP_Nervous_System_Process	Mouse	Brain	HP_ad_rep7	7.0e-10
Pde4a	GOBP_Nucleobase_Containing_Small_Molecule_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	7.8e-13
Pde4a	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Brain	HP_ad_rep7	3.3e-07
Pde4a	GOBP_Purine_Containing_Compound_Catabolic_Process	Mouse	Brain	HP_ad_rep7	1.5e-07
Pde4a	GOBP_Regulation_Of_Camp_Mediated_Signaling	Mouse	Brain	HP_ad_rep7	1.4e-11
Pde4a	GOBP_Protein_Kinase_A_Signaling	Mouse	Brain	HP_ad_rep8	3.7e-07
Pde4a	GOBP_Sensory_Perception_Of_Chemical_Stimulus	Mouse	Brain	HP_adpolb_rep1	1.2e-09
Pde4a	GOBP_Camp_Catabolic_Process	Mouse	Brain	HP_polb_rep1	3.8e-19
Pde4a	GOBP_Carbohydrate_Derivative_Catabolic_Process	Mouse	Brain	HP_polb_rep9	4.0e-16
Pde4a	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Brain	HP_polb_rep9	5.2e-12
Pde4a	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Brain	HP_polb_rep9	6.5e-09
Pde4a	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	6.4e-16
Pde4a	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	6.9e-09
Pde4a	GOBP_Nucleoside_Phosphate_Catabolic_Process	Mouse	Brain	HP_polb_rep9	1.7e-19
Pde4a	GOBP_Organic_Cyclic_Compound_Catabolic_Process	Mouse	Brain	HP_polb_rep9	1.6e-08
Pde4a	GOBP_Organophosphate_Catabolic_Process	Mouse	Brain	HP_polb_rep9	1.2e-08
Pde4a	GOBP_Organophosphate_Metabolic_Process	Mouse	Brain	HP_polb_rep9	7.1e-09
Pde4a	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.4e-07
Pde4a	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	3.9e-11
Pde4a	GOBP_Regulation_Of_Protein_Kinase_A_Signaling	Mouse	Brain	HP_polb_rep9	6.0e-13
Pde4a	GOBP_Ribonucleotide_Catabolic_Process	Mouse	Brain	HP_polb_rep9	2.7e-21
Pde4a	GOBP_Sensory_Perception	Mouse	Brain	HP_polb_rep9	1.2e-09
Pde4a	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	2.8e-11
Pde4a	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.0e-09
Pde4a	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Brain	HP_wt_rep2	2.8e-08

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Pde4a function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Pde4a function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Pde4a envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Pde4a

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Pde4a

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Pde4a	C0011570	Mental Depression	5	PSYGENET
Pde4a	C0011581	Depressive disorder	5	PSYGENET
Pde4a	C0036341	Schizophrenia	2	PSYGENET
Pde4a	C0004352	Autistic Disorder	1	CTD_human
Pde4a	C0005586	Bipolar Disorder	1	PSYGENET
Pde4a	C0085159	Seasonal Affective Disorder	1	PSYGENET