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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Pcsk2 (spascer ID:18549)

Gene summary for Pcsk2

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Pcsk2
	Gene ID	18549
	Gene name	proprotein convertase subtilisin/kexin type 2
	Synonyms	6330411F23Rik\|AI839700\|Nec-2\|Nec2\|PC2\|Phpp-2\|SPC2
	Cytomap	2 G1\|2 70.89 cM
	Type of gene	protein-coding
	Description	neuroendocrine convertase 2KEX2-like endoprotease 2NEC 2prohormone convertase 2proprotein convertase 2
	Modification date	20220426
	UniProtAcc	P21661

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Pcsk2	GO:0004252	serine-type endopeptidase activity	21873635	Function
Pcsk2	GO:0005615	extracellular space	21873635	Component
Pcsk2	GO:0016020	membrane	21873635	Component
Pcsk2	GO:0016485	protein processing	21873635	Process
Pcsk2	GO:0016486	peptide hormone processing	21873635	Process
Pcsk2	GO:0043005	neuron projection	21873635	Component

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Spatial pattern events for Pcsk2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Pcsk2	Mouse	Brain	S1	34413515	2.07e-15
Pcsk2	Mouse	Brain	S2	34413515	1.56e-15
Pcsk2	Mouse	Brain	S3	34413515	1.64e-15
Pcsk2	Mouse	Brain	S4	34413515	1.37e-15
Pcsk2	Mouse	Brain	S6	34413515	1.46e-15
Pcsk2	Mouse	Brain	S7	34413515	1.55e-15
Pcsk2	Mouse	Brain	01A	32637622	3.13e-12
Pcsk2	Mouse	Brain	01B	32637622	9.29e-14
Pcsk2	Mouse	Brain	02A	32637622	1.97e-13
Pcsk2	Mouse	Brain	02B	32637622	4.36e-13
Pcsk2	Mouse	Brain	03A	32637622	1.68e-13
Pcsk2	Mouse	Brain	03B	32637622	1.50e-08
Pcsk2	Mouse	Brain	04A	32637622	8.85e-14
Pcsk2	Mouse	Brain	04B	32637622	1.59e-13
Pcsk2	Mouse	Brain	05A	32637622	4.78e-14
Pcsk2	Mouse	Brain	05B	32637622	4.48e-14
Pcsk2	Mouse	Brain	06A	32637622	2.52e-14
Pcsk2	Mouse	Brain	06B	32637622	1.68e-14
Pcsk2	Mouse	Brain	07A	32637622	1.93e-14
Pcsk2	Mouse	Brain	07B	32637622	1.82e-14
Pcsk2	Mouse	Brain	08A	32637622	2.39e-14
Pcsk2	Mouse	Brain	08B	32637622	5.71e-14
Pcsk2	Mouse	Brain	09A	32637622	2.68e-14
Pcsk2	Mouse	Brain	09B	32637622	1.89e-14
Pcsk2	Mouse	Brain	10A	32637622	3.84e-14
Pcsk2	Mouse	Brain	10B	32637622	9.69e-09
Pcsk2	Mouse	Brain	11A	32637622	1.61e-14
Pcsk2	Mouse	Brain	12A	32637622	5.87e-14
Pcsk2	Mouse	Brain	12B	32637622	1.20e-14
Pcsk2	Mouse	Brain	13A	32637622	5.04e-09
Pcsk2	Mouse	Brain	13B	32637622	1.72e-14
Pcsk2	Mouse	Brain	14A	32637622	1.38e-14
Pcsk2	Mouse	Brain	14B	32637622	1.35e-14
Pcsk2	Mouse	Brain	15A	32637622	6.87e-14
Pcsk2	Mouse	Brain	15B	32637622	3.40e-14
Pcsk2	Mouse	Brain	16A	32637622	5.29e-14
Pcsk2	Mouse	Brain	16B	32637622	6.12e-14
Pcsk2	Mouse	Brain	17A	32637622	1.19e-14
Pcsk2	Mouse	Brain	17B	32637622	1.32e-14
Pcsk2	Mouse	Brain	18A	32637622	1.20e-14
Pcsk2	Mouse	Brain	18B	32637622	1.38e-14
Pcsk2	Mouse	Brain	19A	32637622	1.35e-14
Pcsk2	Mouse	Brain	19B	32637622	4.09e-14
Pcsk2	Mouse	Brain	20A	32637622	4.43e-14
Pcsk2	Mouse	Brain	20B	32637622	2.93e-14
Pcsk2	Mouse	Brain	21A	32637622	4.17e-14
Pcsk2	Mouse	Brain	21B	32637622	4.11e-14
Pcsk2	Mouse	Brain	22A	32637622	8.87e-15
Pcsk2	Mouse	Brain	22B	32637622	8.81e-15
Pcsk2	Mouse	Brain	23A	32637622	1.92e-13
Pcsk2	Mouse	Brain	23B	32637622	3.33e-14
Pcsk2	Mouse	Brain	24A	32637622	4.29e-14
Pcsk2	Mouse	Brain	24B	32637622	1.40e-14
Pcsk2	Mouse	Brain	25A	32637622	8.62e-08
Pcsk2	Mouse	Brain	26A	32637622	1.34e-14
Pcsk2	Mouse	Brain	26B	32637622	5.28e-14
Pcsk2	Mouse	Brain	27A	32637622	1.03e-14
Pcsk2	Mouse	Brain	27B	32637622	1.06e-14
Pcsk2	Mouse	Brain	28A	32637622	1.06e-14
Pcsk2	Mouse	Brain	28B	32637622	1.24e-14
Pcsk2	Mouse	Brain	29A	32637622	1.08e-14
Pcsk2	Mouse	Brain	29B	32637622	1.08e-14
Pcsk2	Mouse	Brain	30A	32637622	2.66e-14
Pcsk2	Mouse	Brain	31A	32637622	1.59e-14
Pcsk2	Mouse	Brain	32A	32637622	1.52e-14
Pcsk2	Mouse	Brain	33A	32637622	1.50e-14
Pcsk2	Mouse	Brain	33B	32637622	1.94e-14
Pcsk2	Mouse	Brain	34A	32637622	1.42e-14
Pcsk2	Mouse	Brain	34B	32637622	1.67e-14
Pcsk2	Mouse	Brain	35A	32637622	1.48e-14
Pcsk2	Mouse	Brain	35B	32637622	1.78e-14
Pcsk2	Mouse	Brain	36A	32637622	3.57e-06
Pcsk2	Mouse	Brain	37A	32637622	1.06e-06
Pcsk2	Mouse	Brain	37B	32637622	3.39e-13
Pcsk2	Mouse	Brain	38A	32637622	1.02e-12
Pcsk2	Mouse	Brain	38B	32637622	6.59e-14
Pcsk2	Mouse	Brain	39A	32637622	2.64e-12
Pcsk2	Mouse	Brain	39B	32637622	7.33e-07
Pcsk2	Mouse	Brain	rep_1	35141374	2.02e-15
Pcsk2	Mouse	Brain	rep_2	35141374	1.69e-15
Pcsk2	Mouse	Brain	rep_3	35141374	1.64e-15
Pcsk2	Mouse	Brain	rep_4	35141374	1.57e-15
Pcsk2	Mouse	Brain	rep_5	35141374	1.47e-15
Pcsk2	Mouse	Brain	rep_6	35141374	1.73e-15
Pcsk2	Mouse	Embryo	1D	34210887	1.10e-09
Pcsk2	Mouse	Embryo	1G	34210887	1.50e-09
Pcsk2	Mouse	Embryo	2G	34210887	2.99e-13
Pcsk2	Mouse	Embryo	4E	34210887	4.53e-15
Pcsk2	Mouse	Embryo	rep_5	33188776	2.45e-10
Pcsk2	Mouse	Brain	rep_1	33469025	1.30e-15
Pcsk2	Mouse	Brain	rep_1	35027729	1.66e-15
Pcsk2	Mouse	Brain	rep_2	35027729	1.57e-15
Pcsk2	Mouse	Brain	rep_3	35027729	1.32e-15
Pcsk2	Mouse	Brain	rep_4	35027729	1.76e-15
Pcsk2	Mouse	Brain	rep_5	35027729	1.46e-15
Pcsk2	Mouse	Brain	B02_D1	32702314	1.50e-14
Pcsk2	Mouse	Brain	B02_E1	32702314	1.33e-14
Pcsk2	Mouse	Brain	B03_C2	32702314	3.45e-14
Pcsk2	Mouse	Brain	B03_D2	32702314	2.26e-11
Pcsk2	Mouse	Brain	B04_E1	32702314	1.27e-12
Pcsk2	Mouse	Brain	B05_D2	32702314	3.61e-08
Pcsk2	Mouse	Brain	B07_C2	32702314	2.81e-10
Pcsk2	Mouse	Brain	N02_D1	32702314	2.97e-10
Pcsk2	Mouse	Brain	N03_D2	32702314	3.32e-11
Pcsk2	Mouse	Brain	N04_D1	32702314	2.71e-09
Pcsk2	Mouse	Brain	N04_E1	32702314	6.35e-12
Pcsk2	Mouse	Brain	N05_D2	32702314	4.42e-09
Pcsk2	Mouse	Brain	N06_D2	32702314	5.53e-06
Pcsk2	Mouse	Brain	rep_1	35210624	1.74e-15
Pcsk2	Mouse	Brain	rep_2	35210624	1.74e-15
Pcsk2	Mouse	Brain	rep_3	35210624	1.82e-15
Pcsk2	Mouse	Brain	rep_4	35210624	2.34e-15
Pcsk2	Mouse	Brain	rep_5	35210624	2.07e-15
Pcsk2	Mouse	Brain	rep_6	35210624	2.05e-15
Pcsk2	Mouse	Brain	rep_7	35210624	1.87e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_B02_D1_H&E
Brain_B02_E1_H&E
Brain_B03_C2_H&E
Brain_B03_D2_H&E
Brain_B04_E1_H&E
Brain_B05_D2_H&E
Brain_B07_C2_H&E
Brain_N02_D1_H&E
Brain_N03_D2_H&E
Brain_N04_D1_H&E
Brain_N04_E1_H&E
Brain_N05_D2_H&E
Brain_N06_D2_H&E

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Spatial pattern pathway has Pcsk2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Pcsk2	GOBP_Protein_Autoprocessing	Mouse	Spinal cord	CN94_E1	1.9e-06
Pcsk2	GOBP_Protein_Maturation	Mouse	Spinal cord	CN94_E1	2.2e-06
Pcsk2	GOBP_Hormone_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	5.0e-06
Pcsk2	GOBP_Signaling_Receptor_Ligand_Precursor_Processing	Mouse	Spinal cord	L7bCN02_E1	8.0e-06
Pcsk2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Pcsk2	GOBP_Insulin_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.8e-06
Pcsk2	GOBP_Peptide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Pcsk2	GOBP_Protein_Processing	Mouse	Spinal cord	L7CN45_C1	7.1e-07
Pcsk2	GOBP_Proteolysis	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Pcsk2	GOBP_Regulation_Of_Hormone_Levels	Mouse	Spinal cord	L7CN45_C1	9.1e-07
Pcsk2	GOBP_Insulin_Metabolic_Process	Mouse	Brain	rep_74	1.5e-07
Pcsk2	GOBP_Protein_Autoprocessing	Mouse	Brain	rep_1	5.9e-07
Pcsk2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	rep_3	2.1e-87
Pcsk2	GOBP_Insulin_Metabolic_Process	Mouse	Brain	rep_3	3.7e-35
Pcsk2	GOBP_Peptide_Metabolic_Process	Mouse	Brain	rep_3	1.3e-86
Pcsk2	GOBP_Protein_Maturation	Mouse	Brain	rep_3	1.1e-160
Pcsk2	GOBP_Protein_Processing	Mouse	Brain	rep_3	2.3e-168
Pcsk2	GOBP_Proteolysis	Mouse	Brain	rep_3	1.8e-168
Pcsk2	GOBP_Signaling_Receptor_Ligand_Precursor_Processing	Mouse	Brain	rep_3	5.0e-111
Pcsk2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Pcsk2	GOBP_Hormone_Metabolic_Process	Mouse	Embryo	rep_14	1.6e-11
Pcsk2	GOBP_Insulin_Metabolic_Process	Mouse	Embryo	rep_14	3.1e-13
Pcsk2	GOBP_Peptide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Pcsk2	GOBP_Protein_Autoprocessing	Mouse	Embryo	rep_14	4.9e-15
Pcsk2	GOBP_Protein_Maturation	Mouse	Embryo	rep_14	6.3e-10
Pcsk2	GOBP_Protein_Processing	Mouse	Embryo	rep_14	4.6e-22
Pcsk2	GOBP_Signaling_Receptor_Ligand_Precursor_Processing	Mouse	Embryo	rep_14	2.3e-51
Pcsk2	GOBP_Hormone_Metabolic_Process	Mouse	Embryo	rep_1	0.0e+00
Pcsk2	GOBP_Regulation_Of_Hormone_Levels	Mouse	Embryo	rep_1	4.1e-102
Pcsk2	GOBP_Protein_Maturation	Mouse	Kidney	IRI	2.5e-33
Pcsk2	GOBP_Protein_Processing	Mouse	Kidney	IRI	4.8e-57
Pcsk2	GOBP_Proteolysis	Mouse	Kidney	Nep	6.8e-23
Pcsk2	GOBP_Protein_Processing	Mouse	Kidney	rep_1	8.0e-08
Pcsk2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-85
Pcsk2	GOBP_Hormone_Metabolic_Process	Mouse	Kidney	rep_2	6.4e-55
Pcsk2	GOBP_Insulin_Metabolic_Process	Mouse	Kidney	rep_2	3.0e-15
Pcsk2	GOBP_Peptide_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-80
Pcsk2	GOBP_Protein_Autoprocessing	Mouse	Kidney	rep_2	7.5e-67
Pcsk2	GOBP_Protein_Maturation	Mouse	Kidney	rep_2	5.4e-103
Pcsk2	GOBP_Proteolysis	Mouse	Kidney	rep_2	6.0e-106
Pcsk2	GOBP_Regulation_Of_Hormone_Levels	Mouse	Kidney	rep_2	6.8e-73
Pcsk2	GOBP_Signaling_Receptor_Ligand_Precursor_Processing	Mouse	Kidney	rep_4	2.3e-09
Pcsk2	GOBP_Insulin_Metabolic_Process	Mouse	Liver	CN16-D2	2.8e-08
Pcsk2	GOBP_Protein_Autoprocessing	Mouse	Liver	CN16-D2	3.0e-07
Pcsk2	GOBP_Protein_Autoprocessing	Mouse	Liver	rep_16	5.5e-14
Pcsk2	GOBP_Protein_Maturation	Mouse	Liver	rep_16	4.5e-09
Pcsk2	GOBP_Protein_Processing	Mouse	Liver	rep_16	3.8e-09
Pcsk2	GOBP_Signaling_Receptor_Ligand_Precursor_Processing	Mouse	Liver	rep_16	3.5e-13
Pcsk2	GOBP_Hormone_Metabolic_Process	Mouse	Intestine	rep_2	1.8e-28
Pcsk2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Pcsk2	GOBP_Hormone_Metabolic_Process	Mouse	Lymph	MS-1	3.2e-08
Pcsk2	GOBP_Insulin_Metabolic_Process	Mouse	Lymph	MS-1	6.5e-07
Pcsk2	GOBP_Peptide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Pcsk2	GOBP_Protein_Autoprocessing	Mouse	Lymph	MS-1	8.1e-10
Pcsk2	GOBP_Protein_Processing	Mouse	Lymph	MS-1	8.5e-10
Pcsk2	GOBP_Proteolysis	Mouse	Lymph	MS-1	2.8e-10
Pcsk2	GOBP_Regulation_Of_Hormone_Levels	Mouse	Lymph	MS-1	1.6e-16
Pcsk2	GOBP_Signaling_Receptor_Ligand_Precursor_Processing	Mouse	Brain	rep_7	7.3e-13
Pcsk2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.6e-11
Pcsk2	GOBP_Peptide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-10
Pcsk2	GOBP_Proteolysis	Mouse	Brain	HP_ad_rep7	3.3e-07
Pcsk2	GOBP_Signaling_Receptor_Ligand_Precursor_Processing	Mouse	Brain	HP_adpolb_rep4	9.8e-07
Pcsk2	GOBP_Hormone_Metabolic_Process	Mouse	Brain	HP_polb_rep9	3.2e-09
Pcsk2	GOBP_Protein_Autoprocessing	Mouse	Brain	HP_polb_rep9	6.8e-11
Pcsk2	GOBP_Protein_Maturation	Mouse	Brain	HP_polb_rep9	9.1e-14
Pcsk2	GOBP_Protein_Processing	Mouse	Brain	HP_polb_rep9	1.6e-12
Pcsk2	GOBP_Regulation_Of_Hormone_Levels	Mouse	Brain	HP_polb_rep9	9.1e-09

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Pcsk2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Pcsk2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Pcsk2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Pcsk2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Pcsk2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Pcsk2	C0002152	Alloxan Diabetes	1	CTD_human
Pcsk2	C0011853	Diabetes Mellitus, Experimental	1	CTD_human
Pcsk2	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Pcsk2	C0038433	Streptozotocin Diabetes	1	CTD_human