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Spatial pattern gene: Pcolce (spascer ID:18542) |
Gene summary for Pcolce |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Pcolce | Gene ID | 18542 |
| Gene name | procollagen C-endopeptidase enhancer protein |
| Synonyms | Astt-2|Astt2|P14|PCPE-1 |
| Cytomap | 5 G2|5 76.59 cM |
| Type of gene | protein-coding |
| Description | procollagen C-endopeptidase enhancer 1astroglial cell transcript 2procollagen C-proteinase enhancer 1procollagen C-proteinase enhancer proteinprocollagen COOH-terminal proteinase enhancer 1type 1 procollagen C-proteinase enhancer proteintype I proco |
| Modification date | 20220424 |
| UniProtAcc | Q61398 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Pcolce | GO:0005518 | collagen binding | 21873635 | Function |
| Pcolce | GO:0006508 | proteolysis | 21873635 | Process |
| Pcolce | GO:0016504 | peptidase activator activity | 21873635 | Function |
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Spatial pattern events for Pcolce |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Pcolce | Mouse | Brain | S2 | 34413515 | 2.86e-06 |
| Pcolce | Mouse | Brain | S3 | 34413515 | 1.64e-15 |
| Pcolce | Mouse | Brain | S4 | 34413515 | 1.37e-15 |
| Pcolce | Mouse | Brain | S6 | 34413515 | 1.46e-15 |
| Pcolce | Mouse | Brain | 12B | 32637622 | 3.62e-07 |
| Pcolce | Mouse | Brain | 24A | 32637622 | 4.29e-14 |
| Pcolce | Mouse | Brain | rep_1 | 35141374 | 2.02e-15 |
| Pcolce | Mouse | Brain | rep_2 | 35141374 | 1.69e-15 |
| Pcolce | Mouse | Brain | rep_3 | 35141374 | 1.64e-15 |
| Pcolce | Mouse | Brain | rep_4 | 35141374 | 1.57e-15 |
| Pcolce | Mouse | Brain | rep_5 | 35141374 | 1.47e-15 |
| Pcolce | Mouse | Brain | rep_6 | 35141374 | 1.73e-15 |
| Pcolce | Mouse | Embryo | 4E | 34210887 | 2.01e-09 |
| Pcolce | Mouse | Embryo | rep_1 | 33188776 | 2.09e-08 |
| Pcolce | Mouse | Embryo | rep_2 | 33188776 | 1.37e-14 |
| Pcolce | Mouse | Embryo | rep_3 | 33188776 | 2.75e-11 |
| Pcolce | Mouse | Embryo | rep_4 | 33188776 | 2.71e-09 |
| Pcolce | Mouse | Embryo | rep_5 | 33188776 | 1.40e-14 |
| Pcolce | Mouse | Embryo | rep_12 | 33188776 | 4.84e-15 |
| Pcolce | Mouse | Embryo | rep_13 | 33188776 | 4.49e-15 |
| Pcolce | Mouse | Kidney | CLP | 34003797 | 2.19e-15 |
| Pcolce | Mouse | Kidney | IRI | 34003797 | 2.29e-15 |
| Pcolce | Mouse | Kidney | Sham | 34003797 | 2.58e-15 |
| Pcolce | Mouse | Kidney | rep_1 | 34853151 | 2.42e-15 |
| Pcolce | Mouse | Kidney | rep_2 | 34853151 | 7.96e-08 |
| Pcolce | Mouse | Kidney | rep_3 | 34853151 | 2.94e-15 |
| Pcolce | Mouse | Kidney | rep_4 | 34853151 | 4.07e-15 |
| Pcolce | Mouse | Kidney | rep_5 | 34853151 | 3.18e-15 |
| Pcolce | Mouse | Liver | rep_18 | 35021063 | 1.49e-11 |
| Pcolce | Mouse | Brain | rep_3 | 35027729 | 1.32e-15 |
| Pcolce | Mouse | Brain | rep_5 | 35027729 | 1.46e-15 |
| Pcolce | Mouse | Intestine | rep_1 | 35149721 | 2.06e-07 |
| Pcolce | Mouse | Intestine | rep_2 | 35149721 | 3.44e-15 |
| Pcolce | Mouse | Intestine | rep_3 | 35149721 | 3.25e-15 |
| Pcolce | Mouse | Intestine | rep_4 | 35149721 | 1.34e-13 |
| Pcolce | Mouse | Lymph | A1 | 0 | 3.29e-15 |
| Pcolce | Mouse | Lymph | B1 | 0 | 6.08e-15 |
| Pcolce | Mouse | Lung | rep_1 | 35290801 | 4.52e-15 |
| Pcolce | Mouse | Lung | rep_2 | 35290801 | 7.23e-15 |
| Pcolce | Mouse | Lung | rep_3 | 35290801 | 5.26e-15 |
| Pcolce | Mouse | Lung | rep_4 | 35290801 | 5.40e-15 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Brain_rep_6_H&E  |  |
Kidney_CLP_H&E  |  |
Kidney_IRI_H&E  |  |
Kidney_Sham_H&E  |  |
Kidney_rep_1_H&E  |  |
Kidney_rep_2_H&E  |  |
Kidney_rep_3_H&E  |  |
Kidney_rep_4_H&E  |  |
Kidney_rep_5_H&E  |  |
Liver_rep_18_H&E  | |
Brain_rep_3_H&E  |  |
Brain_rep_5_H&E  |  |
Lung_rep_1_H&E  |  |
Lung_rep_2_H&E  |  |
Lung_rep_3_H&E  |  |
Lung_rep_4_H&E  |  |
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Spatial pattern pathway has Pcolce envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Pcolce | GOBP_Regulation_Of_Peptidase_Activity | Mouse | Spinal cord | CN94_E1 | 2.4e-06 |
| Pcolce | GOBP_Positive_Regulation_Of_Catalytic_Activity | Mouse | Spinal cord | L7CN45_C1 | 3.2e-07 |
| Pcolce | GOBP_Positive_Regulation_Of_Hydrolase_Activity | Mouse | Spinal cord | L7CN45_C1 | 1.8e-08 |
| Pcolce | GOBP_Positive_Regulation_Of_Molecular_Function | Mouse | Spinal cord | L7CN45_C1 | 3.2e-07 |
| Pcolce | GOBP_Positive_Regulation_Of_Peptidase_Activity | Mouse | Spinal cord | L7CN45_C1 | 1.5e-07 |
| Pcolce | GOBP_Positive_Regulation_Of_Protein_Metabolic_Process | Mouse | Spinal cord | L7CN45_C1 | 3.2e-07 |
| Pcolce | GOBP_Positive_Regulation_Of_Proteolysis | Mouse | Spinal cord | L7CN45_C1 | 4.7e-10 |
| Pcolce | GOBP_Proteolysis | Mouse | Spinal cord | L7CN45_C1 | 1.1e-06 |
| Pcolce | GOBP_Regulation_Of_Hydrolase_Activity | Mouse | Spinal cord | L7CN45_C1 | 2.3e-07 |
| Pcolce | GOBP_Regulation_Of_Proteolysis | Mouse | Spinal cord | L7CN45_C1 | 8.0e-07 |
| Pcolce | GOBP_Regulation_Of_Peptidase_Activity | Mouse | Brain | rep_61 | 2.0e-05 |
| Pcolce | GOBP_Positive_Regulation_Of_Hydrolase_Activity | Mouse | Brain | rep_1 | 1.0e-11 |
| Pcolce | GOBP_Positive_Regulation_Of_Catalytic_Activity | Mouse | Brain | rep_3 | 8.5e-79 |
| Pcolce | GOBP_Positive_Regulation_Of_Molecular_Function | Mouse | Brain | rep_3 | 2.6e-94 |
| Pcolce | GOBP_Positive_Regulation_Of_Peptidase_Activity | Mouse | Brain | rep_3 | 6.0e-162 |
| Pcolce | GOBP_Positive_Regulation_Of_Protein_Metabolic_Process | Mouse | Brain | rep_3 | 9.9e-174 |
| Pcolce | GOBP_Positive_Regulation_Of_Proteolysis | Mouse | Brain | rep_3 | 3.7e-138 |
| Pcolce | GOBP_Proteolysis | Mouse | Brain | rep_3 | 1.8e-168 |
| Pcolce | GOBP_Regulation_Of_Hydrolase_Activity | Mouse | Brain | rep_3 | 1.4e-120 |
| Pcolce | GOBP_Regulation_Of_Peptidase_Activity | Mouse | Brain | rep_3 | 9.5e-157 |
| Pcolce | GOBP_Regulation_Of_Proteolysis | Mouse | Brain | rep_3 | 6.6e-161 |
| Pcolce | GOBP_Positive_Regulation_Of_Peptidase_Activity | Mouse | Embryo | rep_14 | 7.0e-34 |
| Pcolce | GOBP_Positive_Regulation_Of_Proteolysis | Mouse | Embryo | rep_14 | 3.1e-16 |
| Pcolce | GOBP_Regulation_Of_Hydrolase_Activity | Mouse | Embryo | rep_14 | 8.5e-07 |
| Pcolce | GOBP_Regulation_Of_Peptidase_Activity | Mouse | Embryo | rep_14 | 6.4e-29 |
| Pcolce | GOBP_Regulation_Of_Proteolysis | Mouse | Embryo | rep_14 | 3.6e-20 |
| Pcolce | GOBP_Positive_Regulation_Of_Catalytic_Activity | Mouse | Embryo | rep_1 | 2.2e-98 |
| Pcolce | GOBP_Positive_Regulation_Of_Hydrolase_Activity | Mouse | Embryo | rep_1 | 1.6e-15 |
| Pcolce | GOBP_Positive_Regulation_Of_Peptidase_Activity | Mouse | Embryo | rep_1 | 5.0e-25 |
| Pcolce | GOBP_Positive_Regulation_Of_Catalytic_Activity | Mouse | Kidney | Nep | 1.8e-46 |
| Pcolce | GOBP_Positive_Regulation_Of_Hydrolase_Activity | Mouse | Kidney | Nep | 1.4e-48 |
| Pcolce | GOBP_Positive_Regulation_Of_Molecular_Function | Mouse | Kidney | Nep | 1.8e-46 |
| Pcolce | GOBP_Positive_Regulation_Of_Protein_Metabolic_Process | Mouse | Kidney | Nep | 4.3e-38 |
| Pcolce | GOBP_Positive_Regulation_Of_Proteolysis | Mouse | Kidney | Nep | 1.9e-36 |
| Pcolce | GOBP_Proteolysis | Mouse | Kidney | Nep | 6.8e-23 |
| Pcolce | GOBP_Regulation_Of_Hydrolase_Activity | Mouse | Kidney | Nep | 1.3e-36 |
| Pcolce | GOBP_Regulation_Of_Peptidase_Activity | Mouse | Kidney | Nep | 5.6e-37 |
| Pcolce | GOBP_Regulation_Of_Proteolysis | Mouse | Kidney | Nep | 4.3e-38 |
| Pcolce | GOBP_Positive_Regulation_Of_Catalytic_Activity | Mouse | Kidney | rep_2 | 2.1e-66 |
| Pcolce | GOBP_Positive_Regulation_Of_Hydrolase_Activity | Mouse | Kidney | rep_2 | 3.6e-50 |
| Pcolce | GOBP_Positive_Regulation_Of_Molecular_Function | Mouse | Kidney | rep_2 | 2.2e-45 |
| Pcolce | GOBP_Positive_Regulation_Of_Peptidase_Activity | Mouse | Kidney | rep_2 | 3.0e-111 |
| Pcolce | GOBP_Positive_Regulation_Of_Protein_Metabolic_Process | Mouse | Kidney | rep_2 | 1.7e-43 |
| Pcolce | GOBP_Positive_Regulation_Of_Proteolysis | Mouse | Kidney | rep_2 | 7.0e-61 |
| Pcolce | GOBP_Proteolysis | Mouse | Kidney | rep_2 | 6.0e-106 |
| Pcolce | GOBP_Regulation_Of_Hydrolase_Activity | Mouse | Kidney | rep_2 | 1.4e-60 |
| Pcolce | GOBP_Regulation_Of_Peptidase_Activity | Mouse | Kidney | rep_2 | 5.7e-75 |
| Pcolce | GOBP_Regulation_Of_Proteolysis | Mouse | Kidney | rep_2 | 4.3e-62 |
| Pcolce | GOBP_Positive_Regulation_Of_Catalytic_Activity | Mouse | Lymph | MS-1 | 2.2e-13 |
| Pcolce | GOBP_Positive_Regulation_Of_Molecular_Function | Mouse | Lymph | MS-1 | 1.9e-12 |
| Pcolce | GOBP_Positive_Regulation_Of_Protein_Metabolic_Process | Mouse | Lymph | MS-1 | 1.9e-12 |
| Pcolce | GOBP_Proteolysis | Mouse | Lymph | MS-1 | 2.8e-10 |
| Pcolce | GOBP_Regulation_Of_Hydrolase_Activity | Mouse | Lymph | MS-1 | 1.9e-08 |
| Pcolce | GOBP_Regulation_Of_Peptidase_Activity | Mouse | Lymph | MS-1 | 4.0e-08 |
| Pcolce | GOBP_Regulation_Of_Proteolysis | Mouse | Lymph | MS-1 | 7.3e-10 |
| Pcolce | GOBP_Positive_Regulation_Of_Catalytic_Activity | Mouse | Brain | HP_ad_rep7 | 2.8e-07 |
| Pcolce | GOBP_Positive_Regulation_Of_Hydrolase_Activity | Mouse | Brain | HP_ad_rep7 | 4.8e-07 |
| Pcolce | GOBP_Positive_Regulation_Of_Molecular_Function | Mouse | Brain | HP_ad_rep7 | 2.8e-07 |
| Pcolce | GOBP_Proteolysis | Mouse | Brain | HP_ad_rep7 | 3.3e-07 |
| Pcolce | GOBP_Positive_Regulation_Of_Protein_Metabolic_Process | Mouse | Brain | HP_polb_rep9 | 6.0e-11 |
| Pcolce | GOBP_Regulation_Of_Hydrolase_Activity | Mouse | Brain | HP_polb_rep9 | 6.0e-09 |
| Pcolce | GOBP_Regulation_Of_Peptidase_Activity | Mouse | Brain | HP_polb_rep9 | 5.2e-09 |
| Pcolce | GOBP_Regulation_Of_Proteolysis | Mouse | Brain | HP_polb_rep9 | 1.5e-07 |
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Pcolce function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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Pcolce function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for Pcolce envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for Pcolce |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for Pcolce |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| Pcolce | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
| Pcolce | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Pcolce | C0239946 | Fibrosis, Liver | 1 | CTD_human |
| Pcolce | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
| Pcolce | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
| Pcolce | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
| Pcolce | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Pcolce | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
