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Spatial pattern gene: P4ha1 (spascer ID:18451) |
Gene summary for P4ha1 |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | P4ha1 | Gene ID | 18451 |
| Gene name | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide |
| Synonyms | AL022634|P4ha |
| Cytomap | 10|10 B4 |
| Type of gene | protein-coding |
| Description | prolyl 4-hydroxylase subunit alpha-14-PH alpha-1procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1 |
| Modification date | 20220424 |
| UniProtAcc | Q60715 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| P4ha1 | GO:0004656 | procollagen-proline 4-dioxygenase activity | 21873635 | Function |
| P4ha1 | GO:0005783 | endoplasmic reticulum | 21873635 | Component |
| P4ha1 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 21873635 | Process |
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Spatial pattern events for P4ha1 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| P4ha1 | Mouse | Brain | S4 | 34413515 | 9.23e-07 |
| P4ha1 | Mouse | Embryo | 4E | 34210887 | 4.59e-06 |
| P4ha1 | Mouse | Brain | rep_1 | 33469025 | 1.30e-15 |
| P4ha1 | Mouse | Brain | rep_2 | 35027729 | 4.39e-06 |
| P4ha1 | Mouse | Brain | rep_3 | 35027729 | 4.88e-06 |
| P4ha1 | Mouse | Brain | rep_4 | 35027729 | 2.13e-06 |
| P4ha1 | Mouse | Lymph | A1 | 0 | 3.29e-15 |
| P4ha1 | Mouse | Lymph | B1 | 0 | 3.66e-15 |
| P4ha1 | Mouse | Lung | rep_1 | 35290801 | 4.52e-15 |
| P4ha1 | Mouse | Lung | rep_2 | 35290801 | 1.42e-14 |
| P4ha1 | Mouse | Lung | rep_3 | 35290801 | 1.52e-14 |
| P4ha1 | Mouse | Lung | rep_4 | 35290801 | 3.04e-15 |
| P4ha1 | Mouse | Brain | rep_1 | 35210624 | 8.79e-06 |
| P4ha1 | Mouse | Brain | rep_7 | 35210624 | 2.40e-09 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_1_H&E  | |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Lung_rep_1_H&E  |  |
Lung_rep_2_H&E  |  |
Lung_rep_3_H&E  |  |
Lung_rep_4_H&E  |  |
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Spatial pattern pathway has P4ha1 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| P4ha1 | GOBP_Peptidyl_Proline_Hydroxylation | Mouse | Spinal cord | CN94_E1 | 7.5e-09 |
| P4ha1 | GOBP_Peptidyl_Proline_Hydroxylation_To_4_Hydroxy_L_Proline | Mouse | Spinal cord | L7CN44_D1 | 2.8e-06 |
| P4ha1 | GOBP_Peptidyl_Amino_Acid_Modification | Mouse | Spinal cord | L7CN45_C1 | 1.6e-07 |
| P4ha1 | GOBP_Peptidyl_Proline_Modification | Mouse | Spinal cord | L7CN45_C1 | 1.3e-07 |
| P4ha1 | GOBP_Protein_Hydroxylation | Mouse | Spinal cord | L7CN85_E1 | 1.9e-06 |
| P4ha1 | GOBP_Peptidyl_Amino_Acid_Modification | Mouse | Brain | rep_1 | 9.0e-07 |
| P4ha1 | GOBP_Peptidyl_Proline_Modification | Mouse | Brain | rep_1 | 1.4e-09 |
| P4ha1 | GOBP_Peptidyl_Proline_Hydroxylation | Mouse | Brain | rep_3 | 4.9e-174 |
| P4ha1 | GOBP_Peptidyl_Proline_Hydroxylation_To_4_Hydroxy_L_Proline | Mouse | Brain | rep_3 | 6.9e-201 |
| P4ha1 | GOBP_Protein_Hydroxylation | Mouse | Brain | rep_3 | 3.4e-188 |
| P4ha1 | GOBP_Peptidyl_Proline_Hydroxylation | Mouse | Embryo | rep_6 | 1.4e-12 |
| P4ha1 | GOBP_Peptidyl_Proline_Hydroxylation_To_4_Hydroxy_L_Proline | Mouse | Embryo | rep_6 | 6.4e-15 |
| P4ha1 | GOBP_Protein_Hydroxylation | Mouse | Embryo | rep_6 | 5.6e-38 |
| P4ha1 | GOBP_Peptidyl_Proline_Modification | Mouse | Embryo | rep_14 | 4.8e-45 |
| P4ha1 | GOBP_Peptidyl_Amino_Acid_Modification | Mouse | Embryo | rep_3 | 0.0e+00 |
| P4ha1 | GOBP_Peptidyl_Amino_Acid_Modification | Mouse | Kidney | rep_2 | 6.9e-23 |
| P4ha1 | GOBP_Peptidyl_Proline_Hydroxylation | Mouse | Kidney | rep_2 | 2.4e-11 |
| P4ha1 | GOBP_Peptidyl_Proline_Hydroxylation_To_4_Hydroxy_L_Proline | Mouse | Kidney | rep_2 | 6.1e-12 |
| P4ha1 | GOBP_Peptidyl_Proline_Modification | Mouse | Kidney | rep_2 | 1.2e-44 |
| P4ha1 | GOBP_Protein_Hydroxylation | Mouse | Kidney | rep_2 | 2.9e-35 |
| P4ha1 | GOBP_Peptidyl_Proline_Modification | Mouse | Liver | CN16-D1 | 6.1e-09 |
| P4ha1 | GOBP_Protein_Hydroxylation | Mouse | Liver | CN73-C1 | 5.1e-09 |
| P4ha1 | GOBP_Peptidyl_Amino_Acid_Modification | Mouse | Lymph | MS-1 | 1.2e-13 |
| P4ha1 | GOBP_Peptidyl_Proline_Modification | Mouse | Lymph | MS-1 | 2.7e-10 |
| P4ha1 | GOBP_Protein_Hydroxylation | Mouse | Lymph | MS-1 | 1.5e-09 |
| P4ha1 | GOBP_Peptidyl_Proline_Hydroxylation_To_4_Hydroxy_L_Proline | Mouse | Brain | HP_ad_rep3 | 9.4e-11 |
| P4ha1 | GOBP_Peptidyl_Amino_Acid_Modification | Mouse | Brain | HP_ad_rep7 | 3.2e-08 |
| P4ha1 | GOBP_Peptidyl_Proline_Hydroxylation | Mouse | Brain | HP_ad_rep7 | 2.9e-09 |
| P4ha1 | GOBP_Protein_Hydroxylation | Mouse | Brain | HP_ad_rep7 | 8.4e-15 |
| P4ha1 | GOBP_Peptidyl_Proline_Modification | Mouse | Brain | HP_polb_rep9 | 1.3e-15 |
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P4ha1 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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P4ha1 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for P4ha1 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for P4ha1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for P4ha1 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
