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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Nucb1 (spascer ID:18220)

Gene summary for Nucb1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Nucb1
	Gene ID	18220
	Gene name	nucleobindin 1
	Synonyms	B230337F23Rik\|C77483\|Calnuc\|MTEST82\|Nucb
	Cytomap	7\|7 B3
	Type of gene	protein-coding
	Description	nucleobindin-1
	Modification date	20220424
	UniProtAcc	Q02819

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Nucb1	GO:0005509	calcium ion binding	21873635	Function
Nucb1	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	21873635	Component

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Spatial pattern events for Nucb1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Nucb1	Mouse	Brain	S2	34413515	4.03e-10
Nucb1	Mouse	Brain	S3	34413515	1.64e-15
Nucb1	Mouse	Brain	S4	34413515	1.37e-15
Nucb1	Mouse	Brain	S6	34413515	1.03e-11
Nucb1	Mouse	Brain	S7	34413515	2.85e-15
Nucb1	Mouse	Brain	rep_1	35141374	3.58e-15
Nucb1	Mouse	Brain	rep_2	35141374	1.69e-15
Nucb1	Mouse	Brain	rep_3	35141374	1.64e-15
Nucb1	Mouse	Brain	rep_4	35141374	1.57e-15
Nucb1	Mouse	Brain	rep_5	35141374	1.47e-15
Nucb1	Mouse	Brain	rep_6	35141374	1.73e-15
Nucb1	Mouse	Kidney	CLP	34003797	1.03e-09
Nucb1	Mouse	Kidney	Sham	34003797	7.83e-15
Nucb1	Mouse	Kidney	rep_1	34853151	1.13e-06
Nucb1	Mouse	Kidney	rep_5	34853151	5.45e-15
Nucb1	Mouse	Brain	rep_1	33469025	7.41e-11
Nucb1	Mouse	Brain	rep_1	35027729	7.57e-13
Nucb1	Mouse	Brain	rep_3	35027729	1.32e-15
Nucb1	Mouse	Brain	rep_5	35027729	2.62e-15
Nucb1	Mouse	Lymph	A1	0	2.65e-12
Nucb1	Mouse	Lymph	B1	0	3.97e-08
Nucb1	Mouse	Lung	rep_1	35290801	2.39e-12
Nucb1	Mouse	Lung	rep_2	35290801	2.78e-06
Nucb1	Mouse	Lung	rep_3	35290801	7.73e-07
Nucb1	Mouse	Lung	rep_4	35290801	3.04e-08
Nucb1	Mouse	Brain	rep_1	35210624	1.79e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_CLP_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_5_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_3_H&E
Brain_rep_5_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Nucb1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Nucb1	GOBP_Regulation_Of_Cellular_Localization	Mouse	Spinal cord	CN94_E1	8.4e-06
Nucb1	GOBP_Regulation_Of_Intracellular_Protein_Transport	Mouse	Spinal cord	CN94_E1	4.4e-06
Nucb1	GOBP_Regulation_Of_Transport	Mouse	Spinal cord	CN94_E1	5.3e-07
Nucb1	GOBP_Regulation_Of_Peptide_Transport	Mouse	Spinal cord	L7bCN02_E1	1.5e-06
Nucb1	GOBP_Cellular_Macromolecule_Localization	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Nucb1	GOBP_Establishment_Of_Protein_Localization	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Nucb1	GOBP_Intracellular_Protein_Transport	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Nucb1	GOBP_Intracellular_Transport	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Nucb1	GOBP_Post_Translational_Protein_Modification	Mouse	Spinal cord	L7CN45_C1	5.2e-06
Nucb1	GOBP_Protein_Targeting	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Nucb1	GOBP_Regulation_Of_Ion_Transport	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Nucb1	GOBP_Regulation_Of_Protein_Targeting	Mouse	Spinal cord	L7CN45_C1	2.9e-06
Nucb1	GOBP_Response_To_Cisplatin	Mouse	Spinal cord	L7CN45_C1	2.0e-06
Nucb1	GOBP_Regulation_Of_Protein_Localization	Mouse	Spinal cord	L8CN14_E2	3.4e-12
Nucb1	GOBP_Response_To_Cisplatin	Mouse	Brain	rep_9	1.2e-17
Nucb1	GOBP_Regulation_Of_Cellular_Localization	Mouse	Brain	rep_27	5.0e-06
Nucb1	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	rep_1	6.6e-07
Nucb1	GOBP_Regulation_Of_Cellular_Localization	Mouse	Brain	rep_1	3.0e-15
Nucb1	GOBP_Regulation_Of_Ion_Transport	Mouse	Brain	rep_1	8.9e-34
Nucb1	GOBP_Regulation_Of_Peptide_Transport	Mouse	Brain	rep_1	1.1e-56
Nucb1	GOBP_Regulation_Of_Protein_Localization	Mouse	Brain	rep_1	2.2e-07
Nucb1	GOBP_Regulation_Of_Protein_Targeting	Mouse	Brain	rep_1	6.3e-11
Nucb1	GOBP_Regulation_Of_Transport	Mouse	Brain	rep_1	3.9e-15
Nucb1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	rep_1	5.1e-22
Nucb1	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	rep_3	1.6e-125
Nucb1	GOBP_Intracellular_Protein_Transport	Mouse	Brain	rep_3	2.7e-132
Nucb1	GOBP_Intracellular_Transport	Mouse	Brain	rep_3	1.0e-102
Nucb1	GOBP_Post_Translational_Protein_Modification	Mouse	Brain	rep_3	6.2e-128
Nucb1	GOBP_Protein_Targeting	Mouse	Brain	rep_3	2.9e-187
Nucb1	GOBP_Regulation_Of_Intracellular_Protein_Transport	Mouse	Brain	rep_3	6.4e-112
Nucb1	GOBP_Regulation_Of_Intracellular_Transport	Mouse	Brain	rep_3	2.8e-123
Nucb1	GOBP_Post_Translational_Protein_Modification	Mouse	Embryo	rep_14	1.7e-45
Nucb1	GOBP_Protein_Targeting	Mouse	Embryo	rep_14	6.3e-09
Nucb1	GOBP_Regulation_Of_Anion_Transport	Mouse	Embryo	rep_14	1.3e-71
Nucb1	GOBP_Regulation_Of_Protein_Targeting	Mouse	Embryo	rep_14	4.6e-14
Nucb1	GOBP_Response_To_Cisplatin	Mouse	Embryo	rep_14	5.6e-15
Nucb1	GOBP_Cellular_Macromolecule_Localization	Mouse	Embryo	rep_2	5.5e-15
Nucb1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Embryo	rep_3	5.2e-68
Nucb1	GOBP_Intracellular_Protein_Transport	Mouse	Embryo	rep_4	1.1e-39
Nucb1	GOBP_Regulation_Of_Protein_Localization	Mouse	Kidney	Nep	1.1e-16
Nucb1	GOBP_Regulation_Of_Transport	Mouse	Kidney	Nep	2.6e-47
Nucb1	GOBP_Cellular_Macromolecule_Localization	Mouse	Kidney	rep_2	3.5e-61
Nucb1	GOBP_Establishment_Of_Protein_Localization	Mouse	Kidney	rep_2	9.8e-86
Nucb1	GOBP_Intracellular_Protein_Transport	Mouse	Kidney	rep_2	7.5e-54
Nucb1	GOBP_Intracellular_Transport	Mouse	Kidney	rep_2	7.9e-80
Nucb1	GOBP_Post_Translational_Protein_Modification	Mouse	Kidney	rep_2	7.2e-84
Nucb1	GOBP_Protein_Targeting	Mouse	Kidney	rep_2	1.7e-40
Nucb1	GOBP_Regulation_Of_Anion_Transport	Mouse	Kidney	rep_2	5.2e-139
Nucb1	GOBP_Regulation_Of_Cellular_Localization	Mouse	Kidney	rep_2	2.8e-40
Nucb1	GOBP_Regulation_Of_Intracellular_Protein_Transport	Mouse	Kidney	rep_2	2.6e-24
Nucb1	GOBP_Regulation_Of_Ion_Transport	Mouse	Kidney	rep_2	5.5e-106
Nucb1	GOBP_Regulation_Of_Peptide_Transport	Mouse	Kidney	rep_2	1.1e-18
Nucb1	GOBP_Regulation_Of_Protein_Localization	Mouse	Kidney	rep_2	1.5e-38
Nucb1	GOBP_Regulation_Of_Protein_Targeting	Mouse	Kidney	rep_2	5.6e-08
Nucb1	GOBP_Regulation_Of_Transport	Mouse	Kidney	rep_2	2.4e-58
Nucb1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Kidney	rep_2	1.2e-75
Nucb1	GOBP_Regulation_Of_Anion_Transport	Mouse	Liver	CN16-D1	7.0e-08
Nucb1	GOBP_Response_To_Cisplatin	Mouse	Liver	CN16-D2	6.0e-11
Nucb1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Liver	CN16-D2	1.3e-07
Nucb1	GOBP_Post_Translational_Protein_Modification	Mouse	Liver	CN73-C1	9.0e-07
Nucb1	GOBP_Regulation_Of_Peptide_Transport	Mouse	Liver	CN73-C1	2.7e-07
Nucb1	GOBP_Regulation_Of_Transport	Mouse	Liver	CN73-C1	1.8e-07
Nucb1	GOBP_Response_To_Cisplatin	Mouse	Liver	rep_15	4.0e-36
Nucb1	GOBP_Regulation_Of_Anion_Transport	Mouse	Liver	rep_16	1.8e-07
Nucb1	GOBP_Response_To_Cisplatin	Mouse	Brain	rep_1	4.6e-32
Nucb1	GOBP_Response_To_Cisplatin	Mouse	Intestine	rep_3	8.2e-07
Nucb1	GOBP_Cellular_Macromolecule_Localization	Mouse	Lymph	MS-1	1.1e-11
Nucb1	GOBP_Establishment_Of_Protein_Localization	Mouse	Lymph	MS-1	2.5e-11
Nucb1	GOBP_Intracellular_Protein_Transport	Mouse	Lymph	MS-1	3.0e-17
Nucb1	GOBP_Intracellular_Transport	Mouse	Lymph	MS-1	3.3e-11
Nucb1	GOBP_Protein_Targeting	Mouse	Lymph	MS-1	2.1e-09
Nucb1	GOBP_Regulation_Of_Anion_Transport	Mouse	Lymph	MS-1	4.5e-13
Nucb1	GOBP_Regulation_Of_Cellular_Localization	Mouse	Lymph	MS-1	1.5e-07
Nucb1	GOBP_Regulation_Of_Intracellular_Protein_Transport	Mouse	Lymph	MS-1	2.5e-11
Nucb1	GOBP_Regulation_Of_Intracellular_Transport	Mouse	Lymph	MS-1	3.3e-11
Nucb1	GOBP_Regulation_Of_Ion_Transport	Mouse	Lymph	MS-1	1.5e-09
Nucb1	GOBP_Regulation_Of_Peptide_Transport	Mouse	Lymph	MS-1	2.3e-19
Nucb1	GOBP_Regulation_Of_Protein_Localization	Mouse	Lymph	MS-1	1.3e-07
Nucb1	GOBP_Regulation_Of_Protein_Targeting	Mouse	Lymph	MS-1	3.7e-10
Nucb1	GOBP_Regulation_Of_Transport	Mouse	Lymph	MS-1	1.4e-12
Nucb1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Lymph	MS-1	3.5e-10
Nucb1	GOBP_Post_Translational_Protein_Modification	Mouse	Lymph	PBS	6.0e-07
Nucb1	GOBP_Response_To_Cisplatin	Mouse	Lung	rep_1	7.7e-09
Nucb1	GOBP_Regulation_Of_Anion_Transport	Mouse	Brain	rep_4	2.4e-47
Nucb1	GOBP_Regulation_Of_Protein_Targeting	Mouse	Brain	rep_4	5.6e-07
Nucb1	GOBP_Response_To_Cisplatin	Mouse	Brain	rep_4	1.5e-12
Nucb1	GOBP_Response_To_Cisplatin	Mouse	Brain	HP_ad_rep3	1.8e-12
Nucb1	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	HP_ad_rep7	6.6e-10
Nucb1	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	HP_ad_rep7	8.7e-10
Nucb1	GOBP_Intracellular_Protein_Transport	Mouse	Brain	HP_ad_rep7	3.6e-08
Nucb1	GOBP_Intracellular_Transport	Mouse	Brain	HP_ad_rep7	3.1e-08
Nucb1	GOBP_Regulation_Of_Anion_Transport	Mouse	Brain	HP_ad_rep7	2.1e-07
Nucb1	GOBP_Regulation_Of_Cellular_Localization	Mouse	Brain	HP_ad_rep7	2.0e-07
Nucb1	GOBP_Regulation_Of_Protein_Localization	Mouse	Brain	HP_ad_rep7	1.1e-09
Nucb1	GOBP_Regulation_Of_Transport	Mouse	Brain	HP_ad_rep7	9.2e-09
Nucb1	GOBP_Small_Gtpase_Mediated_Signal_Transduction	Mouse	Brain	HP_ad_rep7	4.6e-08
Nucb1	GOBP_Post_Translational_Protein_Modification	Mouse	Brain	HP_polb_rep9	5.1e-14
Nucb1	GOBP_Protein_Targeting	Mouse	Brain	HP_polb_rep9	1.8e-11
Nucb1	GOBP_Regulation_Of_Intracellular_Protein_Transport	Mouse	Brain	HP_polb_rep9	6.3e-09
Nucb1	GOBP_Regulation_Of_Intracellular_Transport	Mouse	Brain	HP_polb_rep9	2.7e-09
Nucb1	GOBP_Regulation_Of_Peptide_Transport	Mouse	Brain	HP_polb_rep9	6.8e-12
Nucb1	GOBP_Regulation_Of_Protein_Targeting	Mouse	Brain	HP_polb_rep9	1.5e-08

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Nucb1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Nucb1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Nucb1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Nucb1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Nucb1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Nucb1	C0014518	Toxic Epidermal Necrolysis	1	CTD_human
Nucb1	C0038325	Stevens-Johnson Syndrome	1	CTD_human
Nucb1	C1274933	Drug-Induced Stevens Johnson Syndrome	1	CTD_human
Nucb1	C3658301	Mycoplasma-Induced Stevens-Johnson Syndrome	1	CTD_human
Nucb1	C3658302	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum	1	CTD_human