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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Mknk2 (spascer ID:17347)

Gene summary for Mknk2

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Mknk2
	Gene ID	17347
	Gene name	MAP kinase-interacting serine/threonine kinase 2
	Synonyms	2010016G11Rik\|Gprk7\|Mnk2
	Cytomap	10\|10 C1
	Type of gene	protein-coding
	Description	MAP kinase-interacting serine/threonine-protein kinase 2G protein-coupled receptor kinase 7MAP kinase signal-integrating kinase 2
	Modification date	20220503
	UniProtAcc	Q8CDB0

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Mknk2	GO:0004683	calmodulin-dependent protein kinase activity	21873635	Function
Mknk2	GO:0005516	calmodulin binding	21873635	Function
Mknk2	GO:0005634	nucleus	21873635	Component
Mknk2	GO:0005737	cytoplasm	21873635	Component
Mknk2	GO:0009931	calcium-dependent protein serine/threonine kinase activity	21873635	Function
Mknk2	GO:0018105	peptidyl-serine phosphorylation	21873635	Process
Mknk2	GO:0035556	intracellular signal transduction	21873635	Process
Mknk2	GO:0046777	protein autophosphorylation	21873635	Process

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Spatial pattern events for Mknk2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Mknk2	Mouse	Brain	S4	34413515	5.30e-07
Mknk2	Mouse	Brain	S6	34413515	5.07e-15
Mknk2	Mouse	Kidney	CLP	34003797	2.19e-15
Mknk2	Mouse	Kidney	IRI	34003797	3.35e-10
Mknk2	Mouse	Kidney	rep_1	34853151	2.42e-15
Mknk2	Mouse	Kidney	rep_3	34853151	2.94e-15
Mknk2	Mouse	Kidney	rep_4	34853151	1.87e-06
Mknk2	Mouse	Kidney	rep_5	34853151	5.45e-15
Mknk2	Mouse	Brain	rep_1	33469025	1.30e-15
Mknk2	Mouse	Intestine	rep_2	35149721	4.25e-11
Mknk2	Mouse	Intestine	rep_3	35149721	1.33e-07
Mknk2	Mouse	Intestine	rep_4	35149721	2.56e-07

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_rep_1_H&E
Kidney_rep_3_H&E
Kidney_rep_4_H&E
Kidney_rep_5_H&E
Brain_rep_1_H&E

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Spatial pattern pathway has Mknk2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Mknk2	GOBP_Signal_Transduction_In_Absence_Of_Ligand	Mouse	Spinal cord	CN94_E1	1.2e-07
Mknk2	GOBP_Amide_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Mknk2	GOBP_Apoptotic_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	2.0e-06
Mknk2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Mknk2	GOBP_Cellular_Response_To_Arsenic_Containing_Substance	Mouse	Spinal cord	L7CN45_C1	7.1e-09
Mknk2	GOBP_Extrinsic_Apoptotic_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	2.0e-07
Mknk2	GOBP_Immune_System_Development	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Mknk2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	5.6e-08
Mknk2	GOBP_Peptide_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	3.5e-08
Mknk2	GOBP_Peptide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Mknk2	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Spinal cord	L7CN45_C1	1.6e-07
Mknk2	GOBP_Peptidyl_Serine_Modification	Mouse	Spinal cord	L7CN45_C1	2.8e-08
Mknk2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Spinal cord	L7CN45_C1	7.4e-09
Mknk2	GOBP_Protein_Autophosphorylation	Mouse	Spinal cord	L7CN45_C1	3.8e-08
Mknk2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	2.4e-08
Mknk2	GOBP_Cellular_Response_To_Arsenic_Containing_Substance	Mouse	Brain	rep_41	9.8e-06
Mknk2	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Brain	rep_1	9.0e-07
Mknk2	GOBP_Peptidyl_Serine_Modification	Mouse	Brain	rep_1	5.2e-23
Mknk2	GOBP_Protein_Autophosphorylation	Mouse	Brain	rep_1	1.5e-46
Mknk2	GOBP_Response_To_Arsenic_Containing_Substance	Mouse	Brain	rep_1	2.1e-12
Mknk2	GOBP_Amide_Biosynthetic_Process	Mouse	Brain	rep_3	2.5e-86
Mknk2	GOBP_Apoptotic_Signaling_Pathway	Mouse	Brain	rep_3	3.7e-187
Mknk2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	rep_3	2.1e-87
Mknk2	GOBP_Cellular_Response_To_Arsenic_Containing_Substance	Mouse	Brain	rep_3	4.4e-65
Mknk2	GOBP_Extrinsic_Apoptotic_Signaling_Pathway	Mouse	Brain	rep_3	3.6e-176
Mknk2	GOBP_Immune_System_Development	Mouse	Brain	rep_3	1.3e-52
Mknk2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	rep_3	2.9e-144
Mknk2	GOBP_Peptide_Biosynthetic_Process	Mouse	Brain	rep_3	2.1e-69
Mknk2	GOBP_Peptide_Metabolic_Process	Mouse	Brain	rep_3	1.3e-86
Mknk2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Brain	rep_3	8.5e-206
Mknk2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Mouse	Brain	rep_3	5.2e-187
Mknk2	GOBP_Signal_Transduction_In_Absence_Of_Ligand	Mouse	Brain	rep_3	5.0e-22
Mknk2	GOBP_Amide_Biosynthetic_Process	Mouse	Embryo	rep_14	3.7e-18
Mknk2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Mknk2	GOBP_Cellular_Response_To_Arsenic_Containing_Substance	Mouse	Embryo	rep_14	6.1e-28
Mknk2	GOBP_Extrinsic_Apoptotic_Signaling_Pathway	Mouse	Embryo	rep_14	7.3e-07
Mknk2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	2.4e-12
Mknk2	GOBP_Peptide_Biosynthetic_Process	Mouse	Embryo	rep_14	2.8e-15
Mknk2	GOBP_Peptide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Mknk2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Embryo	rep_14	1.4e-11
Mknk2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Mouse	Embryo	rep_14	9.9e-25
Mknk2	GOBP_Response_To_Arsenic_Containing_Substance	Mouse	Embryo	rep_14	2.6e-38
Mknk2	GOBP_Signal_Transduction_In_Absence_Of_Ligand	Mouse	Embryo	rep_14	5.7e-57
Mknk2	GOBP_Immune_System_Development	Mouse	Embryo	rep_1	0.0e+00
Mknk2	GOBP_Peptidyl_Serine_Modification	Mouse	Embryo	rep_1	2.5e-276
Mknk2	GOBP_Apoptotic_Signaling_Pathway	Mouse	Embryo	rep_3	2.2e-45
Mknk2	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Embryo	rep_3	0.0e+00
Mknk2	GOBP_Response_To_Arsenic_Containing_Substance	Mouse	Embryo	rep_3	0.0e+00
Mknk2	GOBP_Signal_Transduction_In_Absence_Of_Ligand	Mouse	Embryo	rep_3	0.0e+00
Mknk2	GOBP_Extrinsic_Apoptotic_Signaling_Pathway	Mouse	Embryo	rep_4	2.0e-12
Mknk2	GOBP_Protein_Autophosphorylation	Mouse	Embryo	rep_6	9.9e-40
Mknk2	GOBP_Amide_Biosynthetic_Process	Mouse	Kidney	rep_2	1.9e-84
Mknk2	GOBP_Apoptotic_Signaling_Pathway	Mouse	Kidney	rep_2	1.1e-44
Mknk2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-85
Mknk2	GOBP_Cellular_Response_To_Arsenic_Containing_Substance	Mouse	Kidney	rep_2	3.6e-12
Mknk2	GOBP_Extrinsic_Apoptotic_Signaling_Pathway	Mouse	Kidney	rep_2	1.4e-09
Mknk2	GOBP_Immune_System_Development	Mouse	Kidney	rep_2	4.6e-22
Mknk2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Kidney	rep_2	8.9e-78
Mknk2	GOBP_Peptide_Biosynthetic_Process	Mouse	Kidney	rep_2	2.9e-85
Mknk2	GOBP_Peptide_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-80
Mknk2	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Kidney	rep_2	6.9e-23
Mknk2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Kidney	rep_2	1.1e-92
Mknk2	GOBP_Protein_Autophosphorylation	Mouse	Kidney	rep_2	7.6e-46
Mknk2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Mouse	Kidney	rep_2	9.8e-137
Mknk2	GOBP_Peptidyl_Serine_Modification	Mouse	Liver	CN16-D2	2.3e-09
Mknk2	GOBP_Immune_System_Development	Mouse	Liver	CN73-C1	2.2e-07
Mknk2	GOBP_Extrinsic_Apoptotic_Signaling_Pathway	Mouse	Liver	rep_16	2.3e-08
Mknk2	GOBP_Immune_System_Development	Mouse	Liver	rep_16	5.3e-11
Mknk2	GOBP_Peptidyl_Serine_Modification	Mouse	Liver	rep_16	6.1e-20
Mknk2	GOBP_Amide_Biosynthetic_Process	Mouse	Lymph	MS-1	1.3e-09
Mknk2	GOBP_Apoptotic_Signaling_Pathway	Mouse	Lymph	MS-1	1.2e-12
Mknk2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Mknk2	GOBP_Extrinsic_Apoptotic_Signaling_Pathway	Mouse	Lymph	MS-1	3.8e-12
Mknk2	GOBP_Immune_System_Development	Mouse	Lymph	MS-1	1.2e-13
Mknk2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	1.4e-09
Mknk2	GOBP_Peptide_Biosynthetic_Process	Mouse	Lymph	MS-1	7.1e-07
Mknk2	GOBP_Peptide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Mknk2	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Lymph	MS-1	1.2e-13
Mknk2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Lymph	MS-1	7.1e-09
Mknk2	GOBP_Protein_Autophosphorylation	Mouse	Lymph	MS-1	3.0e-10
Mknk2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Mouse	Lymph	MS-1	2.1e-08
Mknk2	GOBP_Signal_Transduction_In_Absence_Of_Ligand	Mouse	Lymph	MS-1	1.6e-07
Mknk2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Lung	rep_1	1.6e-15
Mknk2	GOBP_Cellular_Response_To_Arsenic_Containing_Substance	Mouse	Brain	rep_7	1.0e-25
Mknk2	GOBP_Amide_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	8.0e-10
Mknk2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.6e-11
Mknk2	GOBP_Cellular_Response_To_Arsenic_Containing_Substance	Mouse	Brain	HP_ad_rep7	7.4e-08
Mknk2	GOBP_Immune_System_Development	Mouse	Brain	HP_ad_rep7	8.3e-09
Mknk2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	2.8e-08
Mknk2	GOBP_Peptide_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	4.4e-10
Mknk2	GOBP_Peptide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-10
Mknk2	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Brain	HP_ad_rep7	3.2e-08
Mknk2	GOBP_Peptidyl_Serine_Modification	Mouse	Brain	HP_ad_rep7	4.6e-07
Mknk2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Brain	HP_ad_rep7	1.9e-10
Mknk2	GOBP_Protein_Autophosphorylation	Mouse	Brain	HP_ad_rep7	5.6e-08
Mknk2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-07
Mknk2	GOBP_Response_To_Arsenic_Containing_Substance	Mouse	Brain	HP_ad_rep7	1.8e-08
Mknk2	GOBP_Apoptotic_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	3.2e-07
Mknk2	GOBP_Extrinsic_Apoptotic_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	7.7e-07

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Mknk2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Mknk2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Mknk2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Mknk2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Mknk2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source