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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Mid1 (spascer ID:17318)

Gene summary for Mid1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Mid1
	Gene ID	17318
	Gene name	midline 1
	Synonyms	61B3-R\|DXHXS1141\|Fxy\|Trim18
	Cytomap	X F5\|X 79.19 cM
	Type of gene	protein-coding
	Description	E3 ubiquitin-protein ligase Midline-1RING finger protein Midline-1RING-type E3 ubiquitin transferase Midline-1midintripartite motif-containing protein 18
	Modification date	20220503
	UniProtAcc	O70583

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene

GO ID

GO term

PubMed ID

Category

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Spatial pattern events for Mid1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Mid1	Mouse	Embryo	1E	34210887	2.01e-07
Mid1	Mouse	Embryo	4E	34210887	1.04e-10
Mid1	Mouse	Testicle	rep_5	34731600	1.01e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)

Singel gene map

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Spatial pattern pathway has Mid1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Mid1	GOBP_Cytokine_Mediated_Signaling_Pathway	Mouse	Spinal cord	CN94_E1	3.0e-06
Mid1	GOBP_Microtubule_Based_Process	Mouse	Spinal cord	CN94_E1	2.4e-06
Mid1	GOBP_Cytoskeleton_Organization	Mouse	Spinal cord	L7bCN02_E1	8.3e-06
Mid1	GOBP_Cellular_Macromolecule_Localization	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Mid1	GOBP_Mapk_Cascade	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Mid1	GOBP_Pattern_Specification_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Mid1	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Mid1	GOBP_Positive_Regulation_Of_Signaling	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Mid1	GOBP_Positive_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Spinal cord	L7CN45_C1	2.1e-07
Mid1	GOBP_Protein_Localization_To_Cytoskeleton	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Mid1	GOBP_Protein_Localization_To_Microtubule	Mouse	Spinal cord	L7CN45_C1	1.9e-07
Mid1	GOBP_Protein_Localization_To_Organelle	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Mid1	GOBP_Regulation_Of_Cellular_Response_To_Stress	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Mid1	GOBP_Regulation_Of_Response_To_Stress	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Mid1	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Spinal cord	L7CN45_C1	5.5e-10
Mid1	GOBP_Response_To_Cytokine	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Mid1	GOBP_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Spinal cord	L7CN45_C1	8.8e-10
Mid1	GOBP_Defense_Response_To_Other_Organism	Mouse	Spinal cord	L7CN97_E2	7.9e-07
Mid1	GOBP_Innate_Immune_Response	Mouse	Spinal cord	L7CN97_E2	2.7e-06
Mid1	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Spinal cord	L7CN97_E2	4.9e-06
Mid1	GOBP_Defense_Response	Mouse	Spinal cord	L8CN11_C1	3.3e-17
Mid1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L8CN11_D1	5.6e-09
Mid1	GOBP_Pattern_Specification_Process	Mouse	Brain	rep_27	3.2e-09
Mid1	GOBP_Protein_Localization_To_Cytoskeleton	Mouse	Brain	rep_27	4.6e-08
Mid1	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Brain	rep_27	4.7e-05
Mid1	GOBP_Protein_Localization_To_Microtubule	Mouse	Brain	rep_71	6.4e-05
Mid1	GOBP_Cytoskeleton_Organization	Mouse	Brain	rep_1	1.1e-11
Mid1	GOBP_Microtubule_Based_Process	Mouse	Brain	rep_1	1.6e-07
Mid1	GOBP_Positive_Regulation_Of_Signaling	Mouse	Brain	rep_1	3.1e-07
Mid1	GOBP_Positive_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Brain	rep_1	3.4e-19
Mid1	GOBP_Protein_Localization_To_Cytoskeleton	Mouse	Brain	rep_1	1.3e-43
Mid1	GOBP_Protein_Localization_To_Microtubule	Mouse	Brain	rep_1	2.7e-42
Mid1	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Brain	rep_1	5.0e-18
Mid1	GOBP_Response_To_Interferon_Gamma	Mouse	Brain	rep_1	1.9e-14
Mid1	GOBP_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Brain	rep_1	6.3e-16
Mid1	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	rep_3	1.6e-125
Mid1	GOBP_Cytokine_Mediated_Signaling_Pathway	Mouse	Brain	rep_3	4.9e-10
Mid1	GOBP_Defense_Response	Mouse	Brain	rep_3	8.7e-77
Mid1	GOBP_Defense_Response_To_Other_Organism	Mouse	Brain	rep_3	6.0e-105
Mid1	GOBP_Innate_Immune_Response	Mouse	Brain	rep_3	7.5e-97
Mid1	GOBP_Interferon_Gamma_Mediated_Signaling_Pathway	Mouse	Brain	rep_3	1.7e-145
Mid1	GOBP_Mapk_Cascade	Mouse	Brain	rep_3	4.8e-123
Mid1	GOBP_Microtubule_Cytoskeleton_Organization	Mouse	Brain	rep_3	8.5e-140
Mid1	GOBP_Pattern_Specification_Process	Mouse	Brain	rep_3	1.6e-118
Mid1	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	3.3e-214
Mid1	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Brain	rep_3	4.0e-152
Mid1	GOBP_Protein_Localization_To_Organelle	Mouse	Brain	rep_3	6.3e-172
Mid1	GOBP_Regulation_Of_Cellular_Response_To_Stress	Mouse	Brain	rep_3	5.1e-104
Mid1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	1.3e-132
Mid1	GOBP_Regulation_Of_Response_To_Stress	Mouse	Brain	rep_3	6.3e-95
Mid1	GOBP_Response_To_Cytokine	Mouse	Brain	rep_3	1.2e-08
Mid1	GOBP_Interferon_Gamma_Mediated_Signaling_Pathway	Mouse	Embryo	rep_14	2.5e-13
Mid1	GOBP_Protein_Localization_To_Cytoskeleton	Mouse	Embryo	rep_14	4.1e-10
Mid1	GOBP_Protein_Localization_To_Microtubule	Mouse	Embryo	rep_14	4.9e-32
Mid1	GOBP_Defense_Response	Mouse	Embryo	rep_1	5.2e-63
Mid1	GOBP_Response_To_Cytokine	Mouse	Embryo	rep_1	8.2e-211
Mid1	GOBP_Cellular_Macromolecule_Localization	Mouse	Embryo	rep_2	5.5e-15
Mid1	GOBP_Positive_Regulation_Of_Signaling	Mouse	Embryo	rep_2	1.4e-07
Mid1	GOBP_Defense_Response_To_Other_Organism	Mouse	Embryo	rep_3	2.6e-164
Mid1	GOBP_Innate_Immune_Response	Mouse	Embryo	rep_3	2.0e-259
Mid1	GOBP_Pattern_Specification_Process	Mouse	Embryo	rep_3	2.8e-168
Mid1	GOBP_Response_To_Interferon_Gamma	Mouse	Embryo	rep_3	2.5e-25
Mid1	GOBP_Regulation_Of_Cellular_Response_To_Stress	Mouse	Embryo	rep_5	1.1e-27
Mid1	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	Nep	5.3e-07
Mid1	GOBP_Positive_Regulation_Of_Signaling	Mouse	Kidney	Nep	1.1e-39
Mid1	GOBP_Regulation_Of_Response_To_Stress	Mouse	Kidney	Nep	1.1e-60
Mid1	GOBP_Cellular_Macromolecule_Localization	Mouse	Kidney	rep_2	3.5e-61
Mid1	GOBP_Cytoskeleton_Organization	Mouse	Kidney	rep_2	1.5e-44
Mid1	GOBP_Defense_Response	Mouse	Kidney	rep_2	6.8e-127
Mid1	GOBP_Defense_Response_To_Other_Organism	Mouse	Kidney	rep_2	2.3e-129
Mid1	GOBP_Innate_Immune_Response	Mouse	Kidney	rep_2	3.1e-117
Mid1	GOBP_Mapk_Cascade	Mouse	Kidney	rep_2	1.1e-19
Mid1	GOBP_Pattern_Specification_Process	Mouse	Kidney	rep_2	2.3e-36
Mid1	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Kidney	rep_2	1.8e-39
Mid1	GOBP_Positive_Regulation_Of_Signaling	Mouse	Kidney	rep_2	3.4e-17
Mid1	GOBP_Positive_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Kidney	rep_2	3.6e-44
Mid1	GOBP_Protein_Localization_To_Cytoskeleton	Mouse	Kidney	rep_2	2.2e-16
Mid1	GOBP_Protein_Localization_To_Microtubule	Mouse	Kidney	rep_2	2.4e-23
Mid1	GOBP_Protein_Localization_To_Organelle	Mouse	Kidney	rep_2	3.4e-44
Mid1	GOBP_Regulation_Of_Cellular_Response_To_Stress	Mouse	Kidney	rep_2	6.4e-80
Mid1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	1.4e-17
Mid1	GOBP_Regulation_Of_Response_To_Stress	Mouse	Kidney	rep_2	2.8e-119
Mid1	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Kidney	rep_2	2.5e-26
Mid1	GOBP_Response_To_Cytokine	Mouse	Kidney	rep_2	3.1e-14
Mid1	GOBP_Response_To_Interferon_Gamma	Mouse	Kidney	rep_2	1.3e-61
Mid1	GOBP_Microtubule_Based_Process	Mouse	Liver	CN16-D2	1.8e-11
Mid1	GOBP_Microtubule_Cytoskeleton_Organization	Mouse	Liver	CN16-D2	2.8e-10
Mid1	GOBP_Interferon_Gamma_Mediated_Signaling_Pathway	Mouse	Liver	CN16-E1	7.3e-11
Mid1	GOBP_Protein_Localization_To_Microtubule	Mouse	Liver	CN16-E1	1.6e-11
Mid1	GOBP_Interferon_Gamma_Mediated_Signaling_Pathway	Mouse	Liver	rep_15	3.7e-07
Mid1	GOBP_Defense_Response	Mouse	Liver	rep_16	8.0e-16
Mid1	GOBP_Defense_Response_To_Other_Organism	Mouse	Liver	rep_16	1.8e-13
Mid1	GOBP_Innate_Immune_Response	Mouse	Liver	rep_16	5.5e-09
Mid1	GOBP_Pattern_Specification_Process	Mouse	Liver	rep_16	3.6e-20
Mid1	GOBP_Positive_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Liver	rep_16	5.4e-08
Mid1	GOBP_Protein_Localization_To_Microtubule	Mouse	Liver	rep_16	7.7e-15
Mid1	GOBP_Response_To_Cytokine	Mouse	Liver	rep_16	1.4e-13
Mid1	GOBP_Response_To_Interferon_Gamma	Mouse	Liver	rep_16	3.2e-16
Mid1	GOBP_Cellular_Macromolecule_Localization	Mouse	Lymph	MS-1	1.1e-11
Mid1	GOBP_Cytokine_Mediated_Signaling_Pathway	Mouse	Lymph	MS-1	6.7e-17
Mid1	GOBP_Cytoskeleton_Organization	Mouse	Lymph	MS-1	1.8e-13
Mid1	GOBP_Defense_Response	Mouse	Lymph	MS-1	8.6e-18
Mid1	GOBP_Defense_Response_To_Other_Organism	Mouse	Lymph	MS-1	6.7e-20
Mid1	GOBP_Innate_Immune_Response	Mouse	Lymph	MS-1	6.7e-20
Mid1	GOBP_Mapk_Cascade	Mouse	Lymph	MS-1	8.8e-20
Mid1	GOBP_Microtubule_Based_Process	Mouse	Lymph	MS-1	1.5e-08
Mid1	GOBP_Microtubule_Cytoskeleton_Organization	Mouse	Lymph	MS-1	7.6e-07
Mid1	GOBP_Pattern_Specification_Process	Mouse	Lymph	MS-1	3.9e-12
Mid1	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	2.3e-12
Mid1	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Lymph	MS-1	2.7e-14
Mid1	GOBP_Positive_Regulation_Of_Signaling	Mouse	Lymph	MS-1	2.3e-12
Mid1	GOBP_Protein_Localization_To_Cytoskeleton	Mouse	Lymph	MS-1	3.4e-12
Mid1	GOBP_Protein_Localization_To_Microtubule	Mouse	Lymph	MS-1	7.0e-11
Mid1	GOBP_Protein_Localization_To_Organelle	Mouse	Lymph	MS-1	1.4e-09
Mid1	GOBP_Regulation_Of_Cellular_Response_To_Stress	Mouse	Lymph	MS-1	1.6e-14
Mid1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.0e-14
Mid1	GOBP_Regulation_Of_Response_To_Stress	Mouse	Lymph	MS-1	1.1e-10
Mid1	GOBP_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Lymph	MS-1	1.4e-10
Mid1	GOBP_Response_To_Cytokine	Mouse	Lymph	MS-1	5.7e-15
Mid1	GOBP_Response_To_Interferon_Gamma	Mouse	Lymph	MS-1	1.3e-12
Mid1	GOBP_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Lymph	MS-1	1.0e-10
Mid1	GOBP_Positive_Regulation_Of_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Lung	rep_1	3.9e-12
Mid1	GOBP_Regulation_Of_Response_To_Stress	Mouse	Lung	rep_1	3.3e-20
Mid1	GOBP_Response_To_Cytokine	Mouse	Lung	rep_1	1.2e-17
Mid1	GOBP_Protein_Localization_To_Cytoskeleton	Mouse	Brain	rep_4	3.9e-21
Mid1	GOBP_Pattern_Specification_Process	Mouse	Brain	rep_7	1.0e-12
Mid1	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	HP_ad_rep7	6.6e-10
Mid1	GOBP_Cytoskeleton_Organization	Mouse	Brain	HP_ad_rep7	5.3e-08
Mid1	GOBP_Defense_Response	Mouse	Brain	HP_ad_rep7	5.6e-10
Mid1	GOBP_Microtubule_Based_Process	Mouse	Brain	HP_ad_rep7	2.8e-10
Mid1	GOBP_Microtubule_Cytoskeleton_Organization	Mouse	Brain	HP_ad_rep7	3.8e-13
Mid1	GOBP_Pattern_Specification_Process	Mouse	Brain	HP_ad_rep7	2.1e-10
Mid1	GOBP_Protein_Localization_To_Organelle	Mouse	Brain	HP_ad_rep7	4.8e-12
Mid1	GOBP_Regulation_Of_Response_To_Stress	Mouse	Brain	HP_ad_rep7	5.4e-09
Mid1	GOBP_Response_To_Cytokine	Mouse	Brain	HP_ad_rep7	2.1e-08
Mid1	GOBP_Response_To_Interferon_Gamma	Mouse	Brain	HP_ad_rep7	2.2e-09
Mid1	GOBP_Protein_Localization_To_Microtubule	Mouse	Brain	HP_adpolb_rep1	2.9e-11
Mid1	GOBP_Cytokine_Mediated_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	5.5e-07
Mid1	GOBP_Defense_Response_To_Other_Organism	Mouse	Brain	HP_polb_rep9	2.1e-11
Mid1	GOBP_Innate_Immune_Response	Mouse	Brain	HP_polb_rep9	3.9e-11
Mid1	GOBP_Interferon_Gamma_Mediated_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	4.9e-14
Mid1	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	1.7e-14
Mid1	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Brain	HP_polb_rep9	6.9e-10
Mid1	GOBP_Positive_Regulation_Of_Signaling	Mouse	Brain	HP_polb_rep9	1.3e-14
Mid1	GOBP_Protein_Localization_To_Cytoskeleton	Mouse	Brain	HP_polb_rep9	6.1e-11
Mid1	GOBP_Regulation_Of_Cellular_Response_To_Stress	Mouse	Brain	HP_polb_rep9	1.2e-11
Mid1	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	3.9e-11
Mid1	GOBP_Stress_Activated_Protein_Kinase_Signaling_Cascade	Mouse	Brain	HP_polb_rep9	4.4e-08

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Mid1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Mid1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Mid1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Mid1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Mid1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Mid1	C2936904	Opitz GBBB Syndrome, X-Linked	8	CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT