SPASCER Logo

Home

Download & Upload

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Spatial pattern gene: Mesp2 (spascer ID:17293)

Gene summary for Mesp2

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Mesp2

Gene ID

17293

Gene namemesoderm posterior 2
SynonymsbHLHc6
Cytomap7 D2|7 45.18 cM
Type of geneprotein-coding
Descriptionmesoderm posterior protein 2
Modification date20220424
UniProtAcc

O08574


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Mesp2

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

21873635

Function
Mesp2

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

21873635

Function
Mesp2

GO:0001707

mesoderm formation

21873635

Process
Mesp2

GO:0003007

heart morphogenesis

21873635

Process
Mesp2

GO:0005634

nucleus

21873635

Component
Mesp2

GO:0006357

regulation of transcription by RNA polymerase II

21873635

Process
Mesp2

GO:0032525

somite rostral/caudal axis specification

21873635

Process

Top

Spatial pattern events for Mesp2

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Mesp2MouseEmbryorep_1 344896003.74e-16
Mesp2MouseEmbryorep_2 344896004.14e-16
Mesp2MouseEmbryorep_4 344896003.67e-16
Mesp2MouseEmbryorep_5 344896004.08e-16

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map


Top

Spatial pattern pathway has Mesp2 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Mesp2GOBP_Animal_Organ_MorphogenesisMouseSpinal cordCN94_E1 6.6e-06
Mesp2GOBP_Formation_Of_Primary_Germ_LayerMouseSpinal cordCN94_E1 3.6e-06
Mesp2GOBP_Mesoderm_DevelopmentMouseSpinal cordCN94_E1 5.8e-06
Mesp2GOBP_Mesoderm_MorphogenesisMouseSpinal cordCN94_E1 1.8e-06
Mesp2GOBP_Notch_Signaling_PathwayMouseSpinal cordCN94_E1 1.5e-07
Mesp2GOBP_RegionalizationMouseSpinal cordCN94_E1 7.3e-06
Mesp2GOBP_Somite_DevelopmentMouseSpinal cordCN94_E1 5.8e-06
Mesp2GOBP_SomitogenesisMouseSpinal cordCN94_E1 3.8e-06
Mesp2GOBP_SegmentationMouseSpinal cordL7bCN02_E1 1.0e-05
Mesp2GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseSpinal cordL7CN45_C1 5.6e-06
Mesp2GOBP_Anterior_Posterior_Axis_SpecificationMouseSpinal cordL7CN45_C1 2.0e-09
Mesp2GOBP_Axis_SpecificationMouseSpinal cordL7CN45_C1 7.5e-06
Mesp2GOBP_Circulatory_System_DevelopmentMouseSpinal cordL7CN45_C1 5.7e-08
Mesp2GOBP_Embryo_DevelopmentMouseSpinal cordL7CN45_C1 3.4e-09
Mesp2GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_HatchingMouseSpinal cordL7CN45_C1 3.9e-07
Mesp2GOBP_Embryonic_Axis_SpecificationMouseSpinal cordL7CN45_C1 1.4e-06
Mesp2GOBP_Embryonic_MorphogenesisMouseSpinal cordL7CN45_C1 3.4e-09
Mesp2GOBP_Embryonic_Pattern_SpecificationMouseSpinal cordL7CN45_C1 1.0e-06
Mesp2GOBP_Epithelium_DevelopmentMouseSpinal cordL7CN45_C1 4.2e-06
Mesp2GOBP_GastrulationMouseSpinal cordL7CN45_C1 3.2e-07
Mesp2GOBP_Heart_DevelopmentMouseSpinal cordL7CN45_C1 2.7e-07
Mesp2GOBP_Heart_MorphogenesisMouseSpinal cordL7CN45_C1 5.1e-08
Mesp2GOBP_Pattern_Specification_ProcessMouseSpinal cordL7CN45_C1 2.2e-09
Mesp2GOBP_Somite_Rostral_Caudal_Axis_SpecificationMouseSpinal cordL7CN45_C1 8.1e-06
Mesp2GOBP_Tissue_MorphogenesisMouseSpinal cordL7CN45_C1 8.3e-08
Mesp2GOBP_Anterior_Posterior_Pattern_SpecificationMouseSpinal cordL8CN17_E1 2.7e-06
Mesp2GOBP_Somite_DevelopmentMouseBrainrep_19 1.6e-05
Mesp2GOBP_Axis_SpecificationMouseBrainrep_21 6.3e-05
Mesp2GOBP_Somite_Rostral_Caudal_Axis_SpecificationMouseBrainrep_23 1.2e-05
Mesp2GOBP_Animal_Organ_MorphogenesisMouseBrainrep_27 2.0e-06
Mesp2GOBP_Anterior_Posterior_Pattern_SpecificationMouseBrainrep_27 3.1e-05
Mesp2GOBP_Notch_Signaling_PathwayMouseBrainrep_27 2.9e-06
Mesp2GOBP_Pattern_Specification_ProcessMouseBrainrep_27 3.2e-09
Mesp2GOBP_RegionalizationMouseBrainrep_27 3.9e-08
Mesp2GOBP_Embryonic_Pattern_SpecificationMouseBrainrep_41 4.0e-05
Mesp2GOBP_SomitogenesisMouseBrainrep_41 9.2e-13
Mesp2GOBP_Anterior_Posterior_Axis_SpecificationMouseBrainrep_1 3.5e-27
Mesp2GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_HatchingMouseBrainrep_1 1.0e-08
Mesp2GOBP_Embryonic_Axis_SpecificationMouseBrainrep_1 3.4e-25
Mesp2GOBP_Embryonic_Pattern_SpecificationMouseBrainrep_1 1.0e-12
Mesp2GOBP_Heart_DevelopmentMouseBrainrep_1 9.3e-14
Mesp2GOBP_Heart_MorphogenesisMouseBrainrep_1 7.9e-49
Mesp2GOBP_Notch_Signaling_PathwayMouseBrainrep_1 3.8e-12
Mesp2GOBP_SegmentationMouseBrainrep_1 4.2e-62
Mesp2GOBP_Somite_DevelopmentMouseBrainrep_1 5.1e-35
Mesp2GOBP_SomitogenesisMouseBrainrep_1 1.8e-40
Mesp2GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseBrainrep_3 5.3e-58
Mesp2GOBP_Animal_Organ_MorphogenesisMouseBrainrep_3 5.4e-57
Mesp2GOBP_Anterior_Posterior_Pattern_SpecificationMouseBrainrep_31.2e-140
Mesp2GOBP_Axis_SpecificationMouseBrainrep_36.1e-125
Mesp2GOBP_Circulatory_System_DevelopmentMouseBrainrep_3 1.3e-81
Mesp2GOBP_Embryo_DevelopmentMouseBrainrep_31.3e-126
Mesp2GOBP_Embryonic_MorphogenesisMouseBrainrep_35.0e-165
Mesp2GOBP_Epithelium_DevelopmentMouseBrainrep_38.3e-102
Mesp2GOBP_Formation_Of_Primary_Germ_LayerMouseBrainrep_31.6e-137
Mesp2GOBP_GastrulationMouseBrainrep_3 2.3e-75
Mesp2GOBP_Mesoderm_DevelopmentMouseBrainrep_33.3e-168
Mesp2GOBP_Mesoderm_MorphogenesisMouseBrainrep_34.5e-163
Mesp2GOBP_Pattern_Specification_ProcessMouseBrainrep_31.6e-118
Mesp2GOBP_RegionalizationMouseBrainrep_31.3e-180
Mesp2GOBP_Somite_Rostral_Caudal_Axis_SpecificationMouseBrainrep_31.6e-115
Mesp2GOBP_Tissue_MorphogenesisMouseBrainrep_34.8e-136
Mesp2GOBP_Anterior_Posterior_Axis_SpecificationMouseEmbryorep_4 8.0e-16
Mesp2GOBP_Axis_SpecificationMouseEmbryorep_4 3.8e-07
Mesp2GOBP_Heart_MorphogenesisMouseEmbryorep_4 8.9e-27
Mesp2GOBP_Anterior_Posterior_Pattern_SpecificationMouseEmbryorep_6 1.5e-09
Mesp2GOBP_Circulatory_System_DevelopmentMouseEmbryorep_6 1.6e-12
Mesp2GOBP_GastrulationMouseEmbryorep_6 5.8e-07
Mesp2GOBP_Mesoderm_MorphogenesisMouseEmbryorep_6 1.9e-10
Mesp2GOBP_Embryonic_Axis_SpecificationMouseEmbryorep_14 4.4e-32
Mesp2GOBP_Embryonic_Pattern_SpecificationMouseEmbryorep_14 4.8e-42
Mesp2GOBP_Formation_Of_Primary_Germ_LayerMouseEmbryorep_14 1.1e-10
Mesp2GOBP_Mesoderm_DevelopmentMouseEmbryorep_14 5.8e-16
Mesp2GOBP_SegmentationMouseEmbryorep_14 4.3e-11
Mesp2GOBP_Somite_Rostral_Caudal_Axis_SpecificationMouseEmbryorep_14 2.0e-19
Mesp2GOBP_Animal_Organ_MorphogenesisMouseEmbryorep_1 1.7e-10
Mesp2GOBP_Axis_SpecificationMouseEmbryorep_1 2.7e-23
Mesp2GOBP_Epithelium_DevelopmentMouseEmbryorep_1 1.7e-09
Mesp2GOBP_SegmentationMouseEmbryorep_1 0.0e+00
Mesp2GOBP_Somite_DevelopmentMouseEmbryorep_1 0.0e+00
Mesp2GOBP_SomitogenesisMouseEmbryorep_1 0.0e+00
Mesp2GOBP_Anterior_Posterior_Pattern_SpecificationMouseEmbryorep_28.6e-166
Mesp2GOBP_RegionalizationMouseEmbryorep_2 5.4e-84
Mesp2GOBP_Embryo_DevelopmentMouseEmbryorep_31.2e-173
Mesp2GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_HatchingMouseEmbryorep_3 0.0e+00
Mesp2GOBP_Embryonic_Pattern_SpecificationMouseEmbryorep_3 0.0e+00
Mesp2GOBP_Notch_Signaling_PathwayMouseEmbryorep_36.4e-228
Mesp2GOBP_Pattern_Specification_ProcessMouseEmbryorep_32.8e-168
Mesp2GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseEmbryorep_6 3.8e-28
Mesp2GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseKidneyNep 5.6e-37
Mesp2GOBP_Circulatory_System_DevelopmentMouseKidneyNep 5.6e-37
Mesp2GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseKidneyrep_25.6e-148
Mesp2GOBP_Animal_Organ_MorphogenesisMouseKidneyrep_2 4.2e-71
Mesp2GOBP_Anterior_Posterior_Axis_SpecificationMouseKidneyrep_2 3.3e-43
Mesp2GOBP_Anterior_Posterior_Pattern_SpecificationMouseKidneyrep_2 3.0e-23
Mesp2GOBP_Axis_SpecificationMouseKidneyrep_2 1.3e-23
Mesp2GOBP_Circulatory_System_DevelopmentMouseKidneyrep_26.7e-139
Mesp2GOBP_Embryo_DevelopmentMouseKidneyrep_2 7.4e-46
Mesp2GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_HatchingMouseKidneyrep_2 9.8e-28
Mesp2GOBP_Embryonic_Axis_SpecificationMouseKidneyrep_2 6.9e-19
Mesp2GOBP_Embryonic_MorphogenesisMouseKidneyrep_2 7.3e-66
Mesp2GOBP_Embryonic_Pattern_SpecificationMouseKidneyrep_2 1.2e-21
Mesp2GOBP_Epithelium_DevelopmentMouseKidneyrep_2 3.5e-92
Mesp2GOBP_Formation_Of_Primary_Germ_LayerMouseKidneyrep_2 2.0e-41
Mesp2GOBP_GastrulationMouseKidneyrep_2 2.6e-89
Mesp2GOBP_Heart_DevelopmentMouseKidneyrep_2 4.8e-38
Mesp2GOBP_Heart_MorphogenesisMouseKidneyrep_2 1.1e-48
Mesp2GOBP_Mesoderm_DevelopmentMouseKidneyrep_2 2.4e-61
Mesp2GOBP_Mesoderm_MorphogenesisMouseKidneyrep_2 3.1e-33
Mesp2GOBP_Notch_Signaling_PathwayMouseKidneyrep_24.9e-143
Mesp2GOBP_Pattern_Specification_ProcessMouseKidneyrep_2 2.3e-36
Mesp2GOBP_RegionalizationMouseKidneyrep_2 2.1e-25
Mesp2GOBP_SegmentationMouseKidneyrep_2 1.5e-33
Mesp2GOBP_Somite_DevelopmentMouseKidneyrep_2 7.0e-46
Mesp2GOBP_Somite_Rostral_Caudal_Axis_SpecificationMouseKidneyrep_2 2.4e-17
Mesp2GOBP_SomitogenesisMouseKidneyrep_2 5.9e-40
Mesp2GOBP_Tissue_MorphogenesisMouseKidneyrep_2 2.3e-21
Mesp2GOBP_Somite_Rostral_Caudal_Axis_SpecificationMouseLiverCN16-D2 2.5e-07
Mesp2GOBP_Embryonic_Axis_SpecificationMouseLiverCN16-E1 1.7e-14
Mesp2GOBP_Embryonic_Pattern_SpecificationMouseLiverCN16-E1 9.0e-09
Mesp2GOBP_Mesoderm_MorphogenesisMouseLiverCN16-E1 1.8e-09
Mesp2GOBP_SomitogenesisMouseLiverCN65-C1 7.4e-08
Mesp2GOBP_Somite_DevelopmentMouseLiverrep_15 3.5e-09
Mesp2GOBP_Pattern_Specification_ProcessMouseLiverrep_16 3.6e-20
Mesp2GOBP_RegionalizationMouseLiverrep_16 1.2e-11
Mesp2GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseLymphMS-1 6.4e-13
Mesp2GOBP_Animal_Organ_MorphogenesisMouseLymphMS-1 4.4e-09
Mesp2GOBP_Axis_SpecificationMouseLymphMS-1 5.4e-11
Mesp2GOBP_Circulatory_System_DevelopmentMouseLymphMS-1 1.6e-11
Mesp2GOBP_Embryo_DevelopmentMouseLymphMS-1 2.5e-08
Mesp2GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_HatchingMouseLymphMS-1 4.0e-11
Mesp2GOBP_Embryonic_Axis_SpecificationMouseLymphMS-1 9.8e-08
Mesp2GOBP_Embryonic_MorphogenesisMouseLymphMS-1 5.6e-07
Mesp2GOBP_Epithelium_DevelopmentMouseLymphMS-1 8.5e-09
Mesp2GOBP_Formation_Of_Primary_Germ_LayerMouseLymphMS-1 1.3e-08
Mesp2GOBP_Heart_DevelopmentMouseLymphMS-1 8.3e-10
Mesp2GOBP_Heart_MorphogenesisMouseLymphMS-1 1.8e-12
Mesp2GOBP_Mesoderm_DevelopmentMouseLymphMS-1 5.8e-10
Mesp2GOBP_Mesoderm_MorphogenesisMouseLymphMS-1 6.5e-08
Mesp2GOBP_Notch_Signaling_PathwayMouseLymphMS-1 3.0e-07
Mesp2GOBP_Pattern_Specification_ProcessMouseLymphMS-1 3.9e-12
Mesp2GOBP_RegionalizationMouseLymphMS-1 2.7e-12
Mesp2GOBP_Tissue_MorphogenesisMouseLymphMS-1 1.4e-12
Mesp2GOBP_GastrulationMouseLymphMS-2 2.0e-07
Mesp2GOBP_Heart_MorphogenesisMouseLungrep_1 1.3e-07
Mesp2GOBP_Formation_Of_Primary_Germ_LayerMouseBrainrep_4 3.1e-21
Mesp2GOBP_Mesoderm_MorphogenesisMouseBrainrep_4 6.7e-13
Mesp2GOBP_RegionalizationMouseBrainrep_4 6.3e-07
Mesp2GOBP_Pattern_Specification_ProcessMouseBrainrep_7 1.0e-12
Mesp2GOBP_Somite_DevelopmentMouseBrainrep_7 1.3e-11
Mesp2GOBP_SomitogenesisMouseBrainrep_7 2.1e-07
Mesp2GOBP_Somite_Rostral_Caudal_Axis_SpecificationMouseBrainHP_ad_rep4 8.8e-09
Mesp2GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_HatchingMouseBrainHP_ad_rep7 7.5e-07
Mesp2GOBP_Embryonic_Axis_SpecificationMouseBrainHP_ad_rep7 9.5e-08
Mesp2GOBP_Embryonic_Pattern_SpecificationMouseBrainHP_ad_rep7 7.4e-11
Mesp2GOBP_Epithelium_DevelopmentMouseBrainHP_ad_rep7 2.8e-08
Mesp2GOBP_Heart_DevelopmentMouseBrainHP_ad_rep7 2.4e-08
Mesp2GOBP_Mesoderm_DevelopmentMouseBrainHP_ad_rep7 1.9e-08
Mesp2GOBP_Pattern_Specification_ProcessMouseBrainHP_ad_rep7 2.1e-10
Mesp2GOBP_RegionalizationMouseBrainHP_ad_rep7 2.8e-09
Mesp2GOBP_Anterior_Posterior_Pattern_SpecificationMouseBrainHP_adpolb_rep1 3.0e-08
Mesp2GOBP_Axis_SpecificationMouseBrainHP_adpolb_rep1 3.4e-10
Mesp2GOBP_Formation_Of_Primary_Germ_LayerMouseBrainHP_adpolb_rep1 1.4e-09
Mesp2GOBP_Somite_DevelopmentMouseBrainHP_adpolb_rep1 1.0e-07
Mesp2GOBP_SomitogenesisMouseBrainHP_adpolb_rep1 7.4e-10
Mesp2GOBP_Mesoderm_MorphogenesisMouseBrainHP_adpolb_rep5 7.9e-07
Mesp2GOBP_Anatomical_Structure_Formation_Involved_In_MorphogenesisMouseBrainHP_polb_rep9 6.3e-08
Mesp2GOBP_Circulatory_System_DevelopmentMouseBrainHP_polb_rep9 3.1e-09
Mesp2GOBP_Embryo_DevelopmentMouseBrainHP_polb_rep9 1.5e-10
Mesp2GOBP_Embryonic_MorphogenesisMouseBrainHP_polb_rep9 3.7e-09
Mesp2GOBP_Notch_Signaling_PathwayMouseBrainHP_polb_rep9 4.3e-09
Mesp2GOBP_SegmentationMouseBrainHP_polb_rep9 1.7e-08
Mesp2GOBP_Tissue_MorphogenesisMouseBrainHP_polb_rep9 1.2e-10

Top

Mesp2 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

Top

Mesp2 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

Top

Transcription factor for Mesp2 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

Top

Related Drugs for Mesp2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for Mesp2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
Mesp2C1837549SPONDYLOCOSTAL DYSOSTOSIS, AUTOSOMAL RECESSIVE 22CTD_human;GENOMICS_ENGLAND