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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Melk (spascer ID:17279)

Gene summary for Melk

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Melk
	Gene ID	17279
	Gene name	maternal embryonic leucine zipper kinase
	Synonyms	AI327312\|MPK38\|mKIAA0175
	Cytomap	4 B1\|4 23.46 cM
	Type of gene	protein-coding
	Description	maternal embryonic leucine zipper kinaseprotein kinase PK38tyrosine-protein kinase MELK
	Modification date	20220424
	UniProtAcc	Q61846

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Melk	GO:0004674	protein serine/threonine kinase activity	21873635	Function
Melk	GO:0004715	non-membrane spanning protein tyrosine kinase activity	21873635	Function
Melk	GO:0006468	protein phosphorylation	21873635	Process
Melk	GO:0035556	intracellular signal transduction	21873635	Process

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Spatial pattern events for Melk

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Melk	Mouse	Kidney	rep_5	34853151	3.96e-13
Melk	Mouse	Intestine	rep_4	35149721	3.90e-15
Melk	Mouse	Lymph	A1	0	3.29e-15
Melk	Mouse	Lymph	B1	0	3.66e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_rep_5_H&E

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Spatial pattern pathway has Melk envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Oxidative_Stress	Mouse	Spinal cord	CN93_D2	8.7e-06
Melk	GOBP_Cell_Cycle	Mouse	Spinal cord	CN94_E1	1.1e-06
Melk	GOBP_Cell_Cycle_Process	Mouse	Spinal cord	CN94_E1	3.8e-06
Melk	GOBP_Peptidyl_Tyrosine_Modification	Mouse	Spinal cord	CN94_E1	3.6e-06
Melk	GOBP_Cell_Cycle_Phase_Transition	Mouse	Spinal cord	L7bCN02_E1	1.5e-06
Melk	GOBP_Apoptotic_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	2.0e-06
Melk	GOBP_Cell_Death_In_Response_To_Oxidative_Stress	Mouse	Spinal cord	L7CN45_C1	2.5e-06
Melk	GOBP_Cellular_Response_To_Chemical_Stress	Mouse	Spinal cord	L7CN45_C1	1.5e-07
Melk	GOBP_Immune_System_Development	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Melk	GOBP_Mitotic_Cell_Cycle	Mouse	Spinal cord	L7CN45_C1	2.4e-08
Melk	GOBP_Neural_Precursor_Cell_Proliferation	Mouse	Spinal cord	L7CN45_C1	5.8e-06
Melk	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Spinal cord	L7CN45_C1	1.6e-07
Melk	GOBP_Positive_Regulation_Of_Cell_Death	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Melk	GOBP_Protein_Autophosphorylation	Mouse	Spinal cord	L7CN45_C1	3.8e-08
Melk	GOBP_Response_To_Oxidative_Stress	Mouse	Spinal cord	L7CN45_C1	2.8e-06
Melk	GOBP_Cell_Cycle_G2_M_Phase_Transition	Mouse	Spinal cord	L7CN47_C1	3.3e-07
Melk	GOBP_Cell_Cycle	Mouse	Brain	rep_27	8.4e-07
Melk	GOBP_Mitotic_Cell_Cycle	Mouse	Brain	rep_27	1.1e-05
Melk	GOBP_Regulation_Of_Cell_Death	Mouse	Brain	rep_27	6.3e-05
Melk	GOBP_Cell_Cycle	Mouse	Brain	rep_1	7.0e-10
Melk	GOBP_Cell_Cycle_G2_M_Phase_Transition	Mouse	Brain	rep_1	8.5e-51
Melk	GOBP_Cell_Cycle_Phase_Transition	Mouse	Brain	rep_1	1.6e-31
Melk	GOBP_Cell_Cycle_Process	Mouse	Brain	rep_1	6.7e-14
Melk	GOBP_Mitotic_Cell_Cycle	Mouse	Brain	rep_1	1.5e-25
Melk	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Brain	rep_1	9.0e-07
Melk	GOBP_Positive_Regulation_Of_Cell_Death	Mouse	Brain	rep_1	3.1e-13
Melk	GOBP_Protein_Autophosphorylation	Mouse	Brain	rep_1	1.5e-46
Melk	GOBP_Apoptotic_Signaling_Pathway	Mouse	Brain	rep_3	3.7e-187
Melk	GOBP_Cell_Death_In_Response_To_Oxidative_Stress	Mouse	Brain	rep_3	3.2e-138
Melk	GOBP_Cellular_Response_To_Chemical_Stress	Mouse	Brain	rep_3	5.0e-121
Melk	GOBP_Immune_System_Development	Mouse	Brain	rep_3	1.3e-52
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Brain	rep_3	1.4e-174
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Oxidative_Stress	Mouse	Brain	rep_3	8.4e-128
Melk	GOBP_Neural_Precursor_Cell_Proliferation	Mouse	Brain	rep_3	6.8e-87
Melk	GOBP_Peptidyl_Tyrosine_Modification	Mouse	Brain	rep_3	9.6e-62
Melk	GOBP_Regulation_Of_Cell_Death	Mouse	Brain	rep_3	7.6e-107
Melk	GOBP_Response_To_Oxidative_Stress	Mouse	Brain	rep_3	5.9e-30
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Oxidative_Stress	Mouse	Embryo	rep_6	1.4e-08
Melk	GOBP_Cell_Death_In_Response_To_Oxidative_Stress	Mouse	Embryo	rep_14	4.3e-24
Melk	GOBP_Cellular_Response_To_Chemical_Stress	Mouse	Embryo	rep_14	6.0e-13
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Embryo	rep_14	6.3e-15
Melk	GOBP_Positive_Regulation_Of_Cell_Death	Mouse	Embryo	rep_14	1.2e-15
Melk	GOBP_Response_To_Oxidative_Stress	Mouse	Embryo	rep_14	6.9e-10
Melk	GOBP_Immune_System_Development	Mouse	Embryo	rep_1	0.0e+00
Melk	GOBP_Positive_Regulation_Of_Cell_Death	Mouse	Embryo	rep_1	3.3e-68
Melk	GOBP_Regulation_Of_Cell_Death	Mouse	Embryo	rep_1	8.4e-30
Melk	GOBP_Apoptotic_Signaling_Pathway	Mouse	Embryo	rep_3	2.2e-45
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Embryo	rep_3	0.0e+00
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Oxidative_Stress	Mouse	Embryo	rep_3	5.5e-13
Melk	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Embryo	rep_3	0.0e+00
Melk	GOBP_Peptidyl_Tyrosine_Modification	Mouse	Embryo	rep_3	7.3e-108
Melk	GOBP_Response_To_Oxidative_Stress	Mouse	Embryo	rep_3	2.3e-12
Melk	GOBP_Cell_Cycle_G2_M_Phase_Transition	Mouse	Embryo	rep_6	1.2e-274
Melk	GOBP_Protein_Autophosphorylation	Mouse	Embryo	rep_6	9.9e-40
Melk	GOBP_Apoptotic_Signaling_Pathway	Mouse	Kidney	rep_2	1.1e-44
Melk	GOBP_Cell_Cycle	Mouse	Kidney	rep_2	1.0e-24
Melk	GOBP_Cell_Cycle_G2_M_Phase_Transition	Mouse	Kidney	rep_2	8.2e-89
Melk	GOBP_Cell_Cycle_Phase_Transition	Mouse	Kidney	rep_2	6.8e-67
Melk	GOBP_Cell_Cycle_Process	Mouse	Kidney	rep_2	3.0e-21
Melk	GOBP_Cell_Death_In_Response_To_Oxidative_Stress	Mouse	Kidney	rep_2	1.1e-39
Melk	GOBP_Immune_System_Development	Mouse	Kidney	rep_2	4.6e-22
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Kidney	rep_2	3.8e-88
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Oxidative_Stress	Mouse	Kidney	rep_2	1.9e-45
Melk	GOBP_Mitotic_Cell_Cycle	Mouse	Kidney	rep_2	1.1e-15
Melk	GOBP_Neural_Precursor_Cell_Proliferation	Mouse	Kidney	rep_2	1.4e-29
Melk	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Kidney	rep_2	6.9e-23
Melk	GOBP_Peptidyl_Tyrosine_Modification	Mouse	Kidney	rep_2	5.7e-15
Melk	GOBP_Protein_Autophosphorylation	Mouse	Kidney	rep_2	7.6e-46
Melk	GOBP_Response_To_Oxidative_Stress	Mouse	Kidney	rep_2	2.2e-39
Melk	GOBP_Cell_Cycle_G2_M_Phase_Transition	Mouse	Liver	CN16-E1	4.3e-09
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Oxidative_Stress	Mouse	Liver	CN65-C1	3.3e-10
Melk	GOBP_Immune_System_Development	Mouse	Liver	CN73-C1	2.2e-07
Melk	GOBP_Immune_System_Development	Mouse	Liver	rep_16	5.3e-11
Melk	GOBP_Peptidyl_Tyrosine_Modification	Mouse	Liver	rep_16	1.3e-24
Melk	GOBP_Positive_Regulation_Of_Cell_Death	Mouse	Liver	rep_16	7.3e-07
Melk	GOBP_Regulation_Of_Cell_Death	Mouse	Liver	rep_16	2.0e-13
Melk	GOBP_Apoptotic_Signaling_Pathway	Mouse	Lymph	MS-1	1.2e-12
Melk	GOBP_Cell_Cycle	Mouse	Lymph	MS-1	1.3e-07
Melk	GOBP_Immune_System_Development	Mouse	Lymph	MS-1	1.2e-13
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Lymph	MS-1	2.5e-14
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway_In_Response_To_Oxidative_Stress	Mouse	Lymph	MS-1	9.5e-07
Melk	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Lymph	MS-1	1.2e-13
Melk	GOBP_Peptidyl_Tyrosine_Modification	Mouse	Lymph	MS-1	1.3e-15
Melk	GOBP_Positive_Regulation_Of_Cell_Death	Mouse	Lymph	MS-1	3.7e-07
Melk	GOBP_Protein_Autophosphorylation	Mouse	Lymph	MS-1	3.0e-10
Melk	GOBP_Regulation_Of_Cell_Death	Mouse	Lymph	MS-1	1.9e-12
Melk	GOBP_Cell_Cycle	Mouse	Brain	HP_ad_rep7	6.6e-08
Melk	GOBP_Cell_Cycle_G2_M_Phase_Transition	Mouse	Brain	HP_ad_rep7	3.1e-07
Melk	GOBP_Cell_Cycle_Phase_Transition	Mouse	Brain	HP_ad_rep7	4.9e-09
Melk	GOBP_Cell_Cycle_Process	Mouse	Brain	HP_ad_rep7	1.7e-09
Melk	GOBP_Immune_System_Development	Mouse	Brain	HP_ad_rep7	8.3e-09
Melk	GOBP_Neural_Precursor_Cell_Proliferation	Mouse	Brain	HP_ad_rep7	1.8e-08
Melk	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Brain	HP_ad_rep7	3.2e-08
Melk	GOBP_Positive_Regulation_Of_Cell_Death	Mouse	Brain	HP_ad_rep7	9.4e-07
Melk	GOBP_Protein_Autophosphorylation	Mouse	Brain	HP_ad_rep7	5.6e-08
Melk	GOBP_Regulation_Of_Cell_Death	Mouse	Brain	HP_ad_rep7	1.6e-07
Melk	GOBP_Apoptotic_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	3.2e-07
Melk	GOBP_Cell_Death_In_Response_To_Oxidative_Stress	Mouse	Brain	HP_polb_rep9	7.3e-07
Melk	GOBP_Cellular_Response_To_Chemical_Stress	Mouse	Brain	HP_polb_rep9	1.2e-09
Melk	GOBP_Intrinsic_Apoptotic_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	2.7e-09
Melk	GOBP_Mitotic_Cell_Cycle	Mouse	Brain	HP_polb_rep9	1.6e-10
Melk	GOBP_Response_To_Oxidative_Stress	Mouse	Brain	HP_polb_rep9	1.1e-09

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Melk function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Melk function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Melk envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Melk

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Melk

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Melk	C2239176	Liver carcinoma	1	CTD_human