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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

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Related drugs with this gene

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Related diseases with this gene

Spatial pattern gene: Mgrn1 (spascer ID:17237)

Gene summary for Mgrn1

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Mgrn1

Gene ID

17237

Gene namemahogunin, ring finger 1
Synonyms2610042J20Rik|mKIAA0544|md|nc
Cytomap16 A1|16 2.48 cM
Type of geneprotein-coding
DescriptionE3 ubiquitin-protein ligase MGRN1RING-type E3 ubiquitin transferase MGRN1mahoganoidmahogunin RING finger protein 1probable E3 ubiquitin-protein ligase MGRN1
Modification date20220424
UniProtAcc

Q9D074


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Mgrn1

GO:0005634

nucleus

21873635

Component
Mgrn1

GO:0005737

cytoplasm

21873635

Component
Mgrn1

GO:0005769

early endosome

21873635

Component
Mgrn1

GO:0005886

plasma membrane

21873635

Component
Mgrn1

GO:0008333

endosome to lysosome transport

21873635

Process
Mgrn1

GO:0016567

protein ubiquitination

21873635

Process
Mgrn1

GO:0043951

negative regulation of cAMP-mediated signaling

21873635

Process
Mgrn1

GO:0045744

negative regulation of G protein-coupled receptor signaling pathway

21873635

Process
Mgrn1

GO:0061630

ubiquitin protein ligase activity

21873635

Function

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Spatial pattern events for Mgrn1

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Mgrn1MouseBrainS1 344135153.73e-15
Mgrn1MouseBrainS2 344135153.64e-08
Mgrn1MouseBrainS4 344135153.89e-12
Mgrn1MouseBrainS6 344135156.04e-08
Mgrn1MouseBrainS7 344135152.76e-09
Mgrn1MouseBrainrep_2 351413743.93e-14
Mgrn1MouseBrainrep_3 351413742.53e-10
Mgrn1MouseBrainrep_4 351413745.42e-15
Mgrn1MouseBrainrep_5 351413742.36e-12
Mgrn1MouseBrainrep_6 351413741.73e-15
Mgrn1MouseKidneyIRI 340037974.70e-08
Mgrn1MouseBrainrep_1 334690251.30e-15
Mgrn1MouseBrainrep_1 350277293.19e-06
Mgrn1MouseBrainrep_2 350277295.74e-06
Mgrn1MouseBrainrep_3 350277292.38e-15
Mgrn1MouseBrainrep_4 350277297.78e-11
Mgrn1MouseBrainrep_5 350277298.47e-10
Mgrn1MouseLymphPBS 06.88e-13

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_2_H&E
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Brain_rep_3_H&E
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Brain_rep_4_H&E
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Brain_rep_5_H&E
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Brain_rep_6_H&E
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Kidney_IRI_H&E
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Brain_rep_1_H&E
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Brain_rep_1_H&E
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Brain_rep_2_H&E
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Brain_rep_3_H&E
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Brain_rep_4_H&E
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Brain_rep_5_H&E
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Spatial pattern pathway has Mgrn1 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Mgrn1GOBP_Lysosomal_TransportMouseSpinal cordCN94_E1 6.6e-06
Mgrn1GOBP_Protein_MonoubiquitinationMouseSpinal cordCN94_E1 1.3e-06
Mgrn1GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseSpinal cordCN94_E1 2.5e-06
Mgrn1GOBP_Regulation_Of_Smoothened_Signaling_PathwayMouseSpinal cordL7bCN02_E1 7.4e-06
Mgrn1GOBP_Second_Messenger_Mediated_SignalingMouseSpinal cordL7bCN02_E1 7.8e-06
Mgrn1GOBP_Camp_Mediated_SignalingMouseSpinal cordL7CN45_C1 1.1e-07
Mgrn1GOBP_Cyclic_Nucleotide_Mediated_SignalingMouseSpinal cordL7CN45_C1 3.7e-06
Mgrn1GOBP_G_Protein_Coupled_Receptor_Signaling_PathwayMouseSpinal cordL7CN45_C1 8.8e-08
Mgrn1GOBP_Intracellular_TransportMouseSpinal cordL7CN45_C1 4.4e-06
Mgrn1GOBP_Negative_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseSpinal cordL7CN45_C1 4.6e-08
Mgrn1GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseSpinal cordL7CN45_C1 2.2e-07
Mgrn1GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseSpinal cordL7CN45_C1 1.4e-06
Mgrn1GOBP_Regulation_Of_Camp_Mediated_SignalingMouseSpinal cordL7CN45_C1 2.6e-06
Mgrn1GOBP_Vacuolar_TransportMouseSpinal cordL7CN45_C1 5.1e-07
Mgrn1GOBP_Endosome_To_Lysosome_TransportMouseSpinal cordL7CN97_E2 3.3e-06
Mgrn1GOBP_Negative_Regulation_Of_Smoothened_Signaling_PathwayMouseSpinal cordL7CN97_E2 6.8e-07
Mgrn1GOBP_Regulation_Of_Intracellular_Signal_TransductionMouseSpinal cordL8CN11_D1 5.6e-09
Mgrn1GOBP_Negative_Regulation_Of_SignalingMouseSpinal cordL8CN17_E1 8.3e-06
Mgrn1GOBP_Endosome_To_Lysosome_TransportMouseBrainrep_27 4.7e-06
Mgrn1GOBP_G_Protein_Coupled_Receptor_Signaling_PathwayMouseBrainrep_27 8.0e-06
Mgrn1GOBP_Negative_Regulation_Of_Camp_Mediated_SignalingMouseBrainrep_27 2.4e-05
Mgrn1GOBP_Negative_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseBrainrep_27 8.2e-10
Mgrn1GOBP_Protein_MonoubiquitinationMouseBrainrep_27 1.7e-05
Mgrn1GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseBrainrep_27 4.5e-08
Mgrn1GOBP_Negative_Regulation_Of_Smoothened_Signaling_PathwayMouseBrainrep_41 3.4e-14
Mgrn1GOBP_Camp_Mediated_SignalingMouseBrainrep_42 5.1e-05
Mgrn1GOBP_Camp_Mediated_SignalingMouseBrainrep_1 1.1e-31
Mgrn1GOBP_Endosome_To_Lysosome_TransportMouseBrainrep_1 2.7e-29
Mgrn1GOBP_G_Protein_Coupled_Receptor_Signaling_PathwayMouseBrainrep_1 4.5e-16
Mgrn1GOBP_Negative_Regulation_Of_Camp_Mediated_SignalingMouseBrainrep_1 2.2e-31
Mgrn1GOBP_Negative_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseBrainrep_1 5.0e-42
Mgrn1GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseBrainrep_1 2.4e-43
Mgrn1GOBP_Second_Messenger_Mediated_SignalingMouseBrainrep_1 5.1e-20
Mgrn1GOBP_Cyclic_Nucleotide_Mediated_SignalingMouseBrainrep_32.3e-101
Mgrn1GOBP_Intracellular_TransportMouseBrainrep_31.0e-102
Mgrn1GOBP_Lysosomal_TransportMouseBrainrep_3 1.6e-81
Mgrn1GOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionMouseBrainrep_39.2e-120
Mgrn1GOBP_Negative_Regulation_Of_Response_To_StimulusMouseBrainrep_31.3e-138
Mgrn1GOBP_Negative_Regulation_Of_SignalingMouseBrainrep_37.8e-106
Mgrn1GOBP_Negative_Regulation_Of_Smoothened_Signaling_PathwayMouseBrainrep_32.0e-125
Mgrn1GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseBrainrep_31.4e-184
Mgrn1GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseBrainrep_36.3e-190
Mgrn1GOBP_Protein_MonoubiquitinationMouseBrainrep_35.2e-196
Mgrn1GOBP_Regulation_Of_Intracellular_Signal_TransductionMouseBrainrep_31.3e-132
Mgrn1GOBP_Regulation_Of_Smoothened_Signaling_PathwayMouseBrainrep_32.1e-100
Mgrn1GOBP_Smoothened_Signaling_PathwayMouseBrainrep_38.0e-137
Mgrn1GOBP_Vacuolar_TransportMouseBrainrep_33.9e-136
Mgrn1GOBP_Regulation_Of_Camp_Mediated_SignalingMouseBrainrep_5 1.3e-71
Mgrn1GOBP_Camp_Mediated_SignalingMouseEmbryorep_14 1.0e-48
Mgrn1GOBP_Cyclic_Nucleotide_Mediated_SignalingMouseEmbryorep_14 1.3e-22
Mgrn1GOBP_Endosome_To_Lysosome_TransportMouseEmbryorep_14 2.1e-30
Mgrn1GOBP_Negative_Regulation_Of_Camp_Mediated_SignalingMouseEmbryorep_14 9.8e-30
Mgrn1GOBP_Negative_Regulation_Of_Smoothened_Signaling_PathwayMouseEmbryorep_14 6.3e-42
Mgrn1GOBP_Regulation_Of_Camp_Mediated_SignalingMouseEmbryorep_14 6.7e-18
Mgrn1GOBP_Regulation_Of_Smoothened_Signaling_PathwayMouseEmbryorep_14 9.2e-37
Mgrn1GOBP_Smoothened_Signaling_PathwayMouseEmbryorep_14 7.6e-35
Mgrn1GOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionMouseEmbryorep_1 1.0e-64
Mgrn1GOBP_Negative_Regulation_Of_Response_To_StimulusMouseEmbryorep_1 1.1e-25
Mgrn1GOBP_Negative_Regulation_Of_SignalingMouseEmbryorep_1 5.6e-10
Mgrn1GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseEmbryorep_1 4.4e-16
Mgrn1GOBP_Protein_MonoubiquitinationMouseEmbryorep_2 6.1e-63
Mgrn1GOBP_G_Protein_Coupled_Receptor_Signaling_PathwayMouseEmbryorep_3 0.0e+00
Mgrn1GOBP_Negative_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseEmbryorep_3 1.3e-36
Mgrn1GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseEmbryorep_3 4.2e-21
Mgrn1GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseEmbryorep_3 4.4e-96
Mgrn1GOBP_G_Protein_Coupled_Receptor_Signaling_PathwayMouseKidneyNep 4.2e-26
Mgrn1GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseKidneyNep 4.2e-26
Mgrn1GOBP_Endosome_To_Lysosome_TransportMouseKidneyrep_2 3.2e-89
Mgrn1GOBP_G_Protein_Coupled_Receptor_Signaling_PathwayMouseKidneyrep_2 3.0e-37
Mgrn1GOBP_Intracellular_TransportMouseKidneyrep_2 7.9e-80
Mgrn1GOBP_Lysosomal_TransportMouseKidneyrep_2 6.1e-84
Mgrn1GOBP_Negative_Regulation_Of_Camp_Mediated_SignalingMouseKidneyrep_2 5.8e-82
Mgrn1GOBP_Negative_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseKidneyrep_2 5.2e-09
Mgrn1GOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionMouseKidneyrep_2 9.1e-83
Mgrn1GOBP_Negative_Regulation_Of_Response_To_StimulusMouseKidneyrep_2 1.7e-39
Mgrn1GOBP_Negative_Regulation_Of_SignalingMouseKidneyrep_2 4.0e-40
Mgrn1GOBP_Negative_Regulation_Of_Smoothened_Signaling_PathwayMouseKidneyrep_2 1.5e-67
Mgrn1GOBP_Protein_MonoubiquitinationMouseKidneyrep_2 5.7e-37
Mgrn1GOBP_Regulation_Of_Camp_Mediated_SignalingMouseKidneyrep_2 1.1e-25
Mgrn1GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseKidneyrep_2 3.4e-47
Mgrn1GOBP_Regulation_Of_Intracellular_Signal_TransductionMouseKidneyrep_2 1.4e-17
Mgrn1GOBP_Regulation_Of_Smoothened_Signaling_PathwayMouseKidneyrep_2 2.9e-90
Mgrn1GOBP_Second_Messenger_Mediated_SignalingMouseKidneyrep_2 2.7e-12
Mgrn1GOBP_Smoothened_Signaling_PathwayMouseKidneyrep_2 5.6e-72
Mgrn1GOBP_Vacuolar_TransportMouseKidneyrep_2 5.2e-99
Mgrn1GOBP_Endosome_To_Lysosome_TransportMouseLiverCN16-D1 2.7e-08
Mgrn1GOBP_Negative_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseLiverCN16-D2 2.9e-07
Mgrn1GOBP_Cyclic_Nucleotide_Mediated_SignalingMouseLiverCN16-E1 4.0e-10
Mgrn1GOBP_Negative_Regulation_Of_Camp_Mediated_SignalingMouseLiverrep_15 5.7e-09
Mgrn1GOBP_Regulation_Of_Camp_Mediated_SignalingMouseLiverrep_15 2.4e-09
Mgrn1GOBP_Cyclic_Nucleotide_Mediated_SignalingMouseLiverrep_16 4.7e-11
Mgrn1GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseLiverrep_16 7.2e-08
Mgrn1GOBP_Second_Messenger_Mediated_SignalingMouseLiverrep_16 5.2e-08
Mgrn1GOBP_Camp_Mediated_SignalingMouseLymphMS-1 3.2e-10
Mgrn1GOBP_Endosome_To_Lysosome_TransportMouseLymphMS-1 4.5e-15
Mgrn1GOBP_G_Protein_Coupled_Receptor_Signaling_PathwayMouseLymphMS-1 1.8e-08
Mgrn1GOBP_Intracellular_TransportMouseLymphMS-1 3.3e-11
Mgrn1GOBP_Lysosomal_TransportMouseLymphMS-1 6.7e-08
Mgrn1GOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionMouseLymphMS-1 1.5e-16
Mgrn1GOBP_Negative_Regulation_Of_Response_To_StimulusMouseLymphMS-1 1.5e-11
Mgrn1GOBP_Negative_Regulation_Of_SignalingMouseLymphMS-1 1.0e-14
Mgrn1GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseLymphMS-1 1.4e-09
Mgrn1GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseLymphMS-1 1.4e-09
Mgrn1GOBP_Regulation_Of_Camp_Mediated_SignalingMouseLymphMS-1 4.7e-11
Mgrn1GOBP_Regulation_Of_Intracellular_Signal_TransductionMouseLymphMS-1 1.0e-14
Mgrn1GOBP_Regulation_Of_Smoothened_Signaling_PathwayMouseLymphMS-1 1.5e-07
Mgrn1GOBP_Second_Messenger_Mediated_SignalingMouseLymphMS-1 1.1e-10
Mgrn1GOBP_Vacuolar_TransportMouseLymphMS-1 1.1e-08
Mgrn1GOBP_Cyclic_Nucleotide_Mediated_SignalingMouseLungrep_1 1.7e-11
Mgrn1GOBP_Camp_Mediated_SignalingMouseBrainrep_4 2.0e-24
Mgrn1GOBP_Endosome_To_Lysosome_TransportMouseBrainrep_4 7.0e-15
Mgrn1GOBP_G_Protein_Coupled_Receptor_Signaling_PathwayMouseBrainrep_4 1.7e-17
Mgrn1GOBP_Negative_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseBrainrep_4 4.5e-17
Mgrn1GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseBrainrep_4 3.8e-61
Mgrn1GOBP_Second_Messenger_Mediated_SignalingMouseBrainrep_4 9.1e-14
Mgrn1GOBP_Smoothened_Signaling_PathwayMouseBrainrep_7 3.2e-08
Mgrn1GOBP_Camp_Mediated_SignalingMouseBrainHP_ad_rep7 2.2e-12
Mgrn1GOBP_Endosome_To_Lysosome_TransportMouseBrainHP_ad_rep7 8.5e-10
Mgrn1GOBP_Intracellular_TransportMouseBrainHP_ad_rep7 3.1e-08
Mgrn1GOBP_Lysosomal_TransportMouseBrainHP_ad_rep7 3.3e-09
Mgrn1GOBP_Negative_Regulation_Of_Camp_Mediated_SignalingMouseBrainHP_ad_rep7 1.6e-11
Mgrn1GOBP_Negative_Regulation_Of_Smoothened_Signaling_PathwayMouseBrainHP_ad_rep7 8.8e-11
Mgrn1GOBP_Protein_Modification_By_Small_Protein_ConjugationMouseBrainHP_ad_rep7 1.7e-09
Mgrn1GOBP_Protein_Modification_By_Small_Protein_Conjugation_Or_RemovalMouseBrainHP_ad_rep7 6.9e-09
Mgrn1GOBP_Protein_MonoubiquitinationMouseBrainHP_ad_rep7 3.3e-07
Mgrn1GOBP_Regulation_Of_Camp_Mediated_SignalingMouseBrainHP_ad_rep7 1.4e-11
Mgrn1GOBP_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseBrainHP_ad_rep7 2.3e-11
Mgrn1GOBP_Vacuolar_TransportMouseBrainHP_ad_rep7 1.2e-09
Mgrn1GOBP_Negative_Regulation_Of_G_Protein_Coupled_Receptor_Signaling_PathwayMouseBrainHP_adpolb_rep1 5.0e-08
Mgrn1GOBP_Cyclic_Nucleotide_Mediated_SignalingMouseBrainHP_polb_rep9 6.5e-09
Mgrn1GOBP_G_Protein_Coupled_Receptor_Signaling_PathwayMouseBrainHP_polb_rep9 6.4e-16
Mgrn1GOBP_Negative_Regulation_Of_Intracellular_Signal_TransductionMouseBrainHP_polb_rep9 9.4e-11
Mgrn1GOBP_Negative_Regulation_Of_Response_To_StimulusMouseBrainHP_polb_rep9 3.1e-09
Mgrn1GOBP_Negative_Regulation_Of_SignalingMouseBrainHP_polb_rep9 1.4e-11
Mgrn1GOBP_Regulation_Of_Intracellular_Signal_TransductionMouseBrainHP_polb_rep9 3.9e-11
Mgrn1GOBP_Regulation_Of_Smoothened_Signaling_PathwayMouseBrainHP_polb_rep9 6.8e-09
Mgrn1GOBP_Smoothened_Signaling_PathwayMouseBrainHP_polb_rep9 5.0e-12
Mgrn1GOBP_Second_Messenger_Mediated_SignalingMouseBrainHP_wt_rep2 2.8e-08

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Mgrn1 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Mgrn1 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Mgrn1 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Mgrn1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Mgrn1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource