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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

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Transcription factors events

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Related drugs with this gene

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Related diseases with this gene

Spatial pattern gene: Mcm6 (spascer ID:17219)

Gene summary for Mcm6

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Mcm6

Gene ID

17219

Gene nameminichromosome maintenance complex component 6
SynonymsASP-l1|D1Wsu22e|Mcmd6
Cytomap1 E3|1 55.8 cM
Type of geneprotein-coding
DescriptionDNA replication licensing factor MCM6mini chromosome maintenance deficient 6minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
Modification date20220424
UniProtAcc

P97311


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Mcm6

GO:0000727

double-strand break repair via break-induced replication

21873635

Process
Mcm6

GO:0003697

single-stranded DNA binding

21873635

Function
Mcm6

GO:0005634

nucleus

21873635

Component
Mcm6

GO:0006268

DNA unwinding involved in DNA replication

21873635

Process
Mcm6

GO:0017116

single-stranded DNA helicase activity

21873635

Function
Mcm6

GO:0042555

MCM complex

21873635

Component
Mcm6

GO:1902969

mitotic DNA replication

21873635

Process
Mcm6

GO:1990518

single-stranded 3'-5' DNA helicase activity

21873635

Function

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Spatial pattern events for Mcm6

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Mcm6MouseBrainS2 344135151.75e-11
Mcm6MouseBrainS4 344135153.59e-08
Mcm6MouseBrainS6 344135152.05e-06
Mcm6MouseBrainS7 344135151.55e-15
Mcm6MouseBrain27A 326376221.01e-06
Mcm6MouseEmbryo2H 342108874.35e-07
Mcm6MouseEmbryo3D 342108878.57e-07
Mcm6MouseEmbryo3F 342108871.00e-09
Mcm6MouseEmbryo4E 342108876.48e-08
Mcm6MouseEmbryorep_2 331887763.90e-08
Mcm6MouseEmbryorep_4 331887761.05e-06
Mcm6MouseEmbryorep_12 331887765.95e-06
Mcm6MouseEmbryorep_13 331887763.18e-07
Mcm6MouseKidneyrep_5 348531513.18e-15
Mcm6MouseBrainrep_1 334690252.37e-15
Mcm6MouseIntestinerep_4 351497213.70e-13
Mcm6MouseTesticlerep_5 347316001.06e-09
Mcm6MouseLymphA1 03.29e-15
Mcm6MouseLymphB1 03.66e-15
Mcm6MouseLungrep_1 352908014.52e-15
Mcm6MouseLungrep_2 352908011.64e-06
Mcm6MouseLungrep_3 352908011.09e-07

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Kidney_rep_5_H&E
boxplot
boxplot
Brain_rep_1_H&E
boxplot
Lung_rep_1_H&E
boxplot
boxplot
Lung_rep_2_H&E
boxplot
boxplot
Lung_rep_3_H&E
boxplot
boxplot


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Spatial pattern pathway has Mcm6 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Mcm6GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseSpinal cordCN90_C1 3.8e-06
Mcm6GOBP_Cell_CycleMouseSpinal cordCN94_E1 1.1e-06
Mcm6GOBP_Cell_Cycle_Dna_ReplicationMouseSpinal cordCN94_E1 7.4e-07
Mcm6GOBP_Cell_Cycle_ProcessMouseSpinal cordCN94_E1 3.8e-06
Mcm6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseSpinal cordCN94_E1 8.0e-06
Mcm6GOBP_Dna_Metabolic_ProcessMouseSpinal cordCN94_E1 2.7e-06
Mcm6GOBP_Recombinational_RepairMouseSpinal cordCN94_E1 8.5e-06
Mcm6GOBP_Cell_Cycle_Phase_TransitionMouseSpinal cordL7bCN02_E1 1.5e-06
Mcm6GOBP_Protein_Dna_Complex_Subunit_OrganizationMouseSpinal cordL7bCN02_E1 3.4e-06
Mcm6GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseSpinal cordL7CN45_C1 6.7e-08
Mcm6GOBP_Chromosome_OrganizationMouseSpinal cordL7CN45_C1 3.4e-08
Mcm6GOBP_Dna_Conformation_ChangeMouseSpinal cordL7CN45_C1 8.1e-07
Mcm6GOBP_Dna_RecombinationMouseSpinal cordL7CN45_C1 5.6e-07
Mcm6GOBP_Dna_RepairMouseSpinal cordL7CN45_C1 9.4e-06
Mcm6GOBP_Dna_ReplicationMouseSpinal cordL7CN45_C1 2.8e-07
Mcm6GOBP_Dna_Replication_InitiationMouseSpinal cordL7CN45_C1 6.9e-06
Mcm6GOBP_Double_Strand_Break_RepairMouseSpinal cordL7CN45_C1 5.4e-06
Mcm6GOBP_Mitotic_Cell_CycleMouseSpinal cordL7CN45_C1 2.4e-08
Mcm6GOBP_Mitotic_Dna_ReplicationMouseSpinal cordL7CN45_E1 9.7e-08
Mcm6GOBP_Dna_Dependent_Dna_ReplicationMouseSpinal cordL7CN47_C1 6.6e-06
Mcm6GOBP_Dna_Geometric_ChangeMouseSpinal cordL7CN47_C1 2.6e-06
Mcm6GOBP_Dna_Conformation_ChangeMouseBrainrep_11 3.6e-05
Mcm6GOBP_Dna_Geometric_ChangeMouseBrainrep_11 2.1e-05
Mcm6GOBP_Dna_Unwinding_Involved_In_Dna_ReplicationMouseBrainrep_21 4.2e-05
Mcm6GOBP_Cell_CycleMouseBrainrep_27 8.4e-07
Mcm6GOBP_Dna_ReplicationMouseBrainrep_27 6.4e-06
Mcm6GOBP_Mitotic_Cell_CycleMouseBrainrep_27 1.1e-05
Mcm6GOBP_Cell_CycleMouseBrainrep_1 7.0e-10
Mcm6GOBP_Cell_Cycle_Dna_ReplicationMouseBrainrep_1 3.4e-08
Mcm6GOBP_Cell_Cycle_Phase_TransitionMouseBrainrep_1 1.6e-31
Mcm6GOBP_Cell_Cycle_ProcessMouseBrainrep_1 6.7e-14
Mcm6GOBP_Chromosome_OrganizationMouseBrainrep_1 3.9e-07
Mcm6GOBP_Dna_Dependent_Dna_ReplicationMouseBrainrep_1 1.5e-17
Mcm6GOBP_Dna_Metabolic_ProcessMouseBrainrep_1 1.1e-07
Mcm6GOBP_Dna_RecombinationMouseBrainrep_1 6.8e-13
Mcm6GOBP_Dna_ReplicationMouseBrainrep_1 4.3e-10
Mcm6GOBP_Dna_Replication_InitiationMouseBrainrep_1 1.9e-10
Mcm6GOBP_Double_Strand_Break_RepairMouseBrainrep_1 5.6e-13
Mcm6GOBP_Mitotic_Cell_CycleMouseBrainrep_1 1.5e-25
Mcm6GOBP_Recombinational_RepairMouseBrainrep_1 5.8e-08
Mcm6GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseBrainrep_33.0e-140
Mcm6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseBrainrep_35.0e-192
Mcm6GOBP_Dna_Conformation_ChangeMouseBrainrep_3 7.4e-54
Mcm6GOBP_Dna_Geometric_ChangeMouseBrainrep_34.9e-189
Mcm6GOBP_Dna_RepairMouseBrainrep_34.0e-216
Mcm6GOBP_Dna_Unwinding_Involved_In_Dna_ReplicationMouseBrainrep_3 7.8e-86
Mcm6GOBP_Mitotic_Dna_ReplicationMouseBrainrep_3 3.5e-61
Mcm6GOBP_Protein_Dna_Complex_Subunit_OrganizationMouseBrainrep_35.3e-122
Mcm6GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseBrainrep_5 5.3e-09
Mcm6GOBP_Dna_Conformation_ChangeMouseEmbryorep_14 2.1e-08
Mcm6GOBP_Dna_Geometric_ChangeMouseEmbryorep_14 5.1e-11
Mcm6GOBP_Dna_Replication_InitiationMouseEmbryorep_14 3.1e-28
Mcm6GOBP_Dna_Unwinding_Involved_In_Dna_ReplicationMouseEmbryorep_14 1.0e-37
Mcm6GOBP_Double_Strand_Break_RepairMouseEmbryorep_14 1.4e-07
Mcm6GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseEmbryorep_14 1.6e-37
Mcm6GOBP_Mitotic_Dna_ReplicationMouseEmbryorep_14 2.5e-26
Mcm6GOBP_Protein_Dna_Complex_Subunit_OrganizationMouseEmbryorep_14 2.2e-11
Mcm6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseEmbryorep_2 1.4e-08
Mcm6GOBP_Dna_Metabolic_ProcessMouseEmbryorep_27.2e-216
Mcm6GOBP_Dna_RecombinationMouseEmbryorep_2 0.0e+00
Mcm6GOBP_Dna_RepairMouseEmbryorep_21.6e-282
Mcm6GOBP_Double_Strand_Break_RepairMouseEmbryorep_2 4.2e-15
Mcm6GOBP_Chromosome_OrganizationMouseEmbryorep_3 1.4e-57
Mcm6GOBP_Dna_Conformation_ChangeMouseEmbryorep_3 1.5e-48
Mcm6GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseEmbryorep_4 1.2e-08
Mcm6GOBP_Cell_CycleMouseKidneyrep_2 1.0e-24
Mcm6GOBP_Cell_Cycle_Dna_ReplicationMouseKidneyrep_2 3.6e-23
Mcm6GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseKidneyrep_2 5.1e-80
Mcm6GOBP_Cell_Cycle_Phase_TransitionMouseKidneyrep_2 6.8e-67
Mcm6GOBP_Cell_Cycle_ProcessMouseKidneyrep_2 3.0e-21
Mcm6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseKidneyrep_25.5e-146
Mcm6GOBP_Chromosome_OrganizationMouseKidneyrep_2 1.0e-14
Mcm6GOBP_Dna_Conformation_ChangeMouseKidneyrep_2 1.4e-38
Mcm6GOBP_Dna_Dependent_Dna_ReplicationMouseKidneyrep_21.1e-109
Mcm6GOBP_Dna_Geometric_ChangeMouseKidneyrep_2 2.0e-24
Mcm6GOBP_Dna_Metabolic_ProcessMouseKidneyrep_2 1.4e-12
Mcm6GOBP_Dna_RecombinationMouseKidneyrep_2 2.7e-14
Mcm6GOBP_Dna_RepairMouseKidneyrep_2 5.5e-70
Mcm6GOBP_Dna_ReplicationMouseKidneyrep_2 5.9e-43
Mcm6GOBP_Dna_Replication_InitiationMouseKidneyrep_2 3.5e-30
Mcm6GOBP_Double_Strand_Break_RepairMouseKidneyrep_2 1.5e-20
Mcm6GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseKidneyrep_2 3.5e-28
Mcm6GOBP_Mitotic_Cell_CycleMouseKidneyrep_2 1.1e-15
Mcm6GOBP_Mitotic_Dna_ReplicationMouseKidneyrep_2 2.1e-53
Mcm6GOBP_Protein_Dna_Complex_Subunit_OrganizationMouseKidneyrep_2 1.1e-35
Mcm6GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseLiverCN16-D2 8.1e-07
Mcm6GOBP_Dna_Dependent_Dna_ReplicationMouseLiverCN16-D2 3.1e-08
Mcm6GOBP_Dna_Metabolic_ProcessMouseLiverCN16-D2 2.6e-07
Mcm6GOBP_Mitotic_Dna_ReplicationMouseLiverCN73-C1 4.1e-07
Mcm6GOBP_Dna_Replication_InitiationMouseLiverrep_15 9.0e-18
Mcm6GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseLiverrep_15 7.8e-15
Mcm6GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseIntestinerep_3 1.1e-13
Mcm6GOBP_Cell_CycleMouseLymphMS-1 1.3e-07
Mcm6GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseLymphMS-1 3.2e-07
Mcm6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseLymphMS-1 8.5e-13
Mcm6GOBP_Chromosome_OrganizationMouseLymphMS-1 3.5e-09
Mcm6GOBP_Dna_Metabolic_ProcessMouseLymphMS-1 6.8e-10
Mcm6GOBP_Protein_Dna_Complex_Subunit_OrganizationMouseLymphMS-1 2.3e-09
Mcm6GOBP_Cell_Cycle_Dna_ReplicationMouseLymphMS-2 7.1e-08
Mcm6GOBP_Dna_Unwinding_Involved_In_Dna_ReplicationMouseLymphMS-2 5.9e-08
Mcm6GOBP_Dna_Dependent_Dna_ReplicationMouseLymphPBS 2.2e-07
Mcm6GOBP_Mitotic_Dna_ReplicationMouseLungrep_1 4.6e-11
Mcm6GOBP_Dna_Unwinding_Involved_In_Dna_ReplicationMouseBrainrep_4 1.9e-14
Mcm6GOBP_Mitotic_Dna_ReplicationMouseBrainrep_7 4.8e-18
Mcm6GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseBrainHP_ad_rep3 1.5e-15
Mcm6GOBP_Cell_CycleMouseBrainHP_ad_rep7 6.6e-08
Mcm6GOBP_Cell_Cycle_Dna_ReplicationMouseBrainHP_ad_rep7 2.9e-18
Mcm6GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseBrainHP_ad_rep7 3.5e-11
Mcm6GOBP_Cell_Cycle_Phase_TransitionMouseBrainHP_ad_rep7 4.9e-09
Mcm6GOBP_Cell_Cycle_ProcessMouseBrainHP_ad_rep7 1.7e-09
Mcm6GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseBrainHP_ad_rep7 6.8e-10
Mcm6GOBP_Chromosome_OrganizationMouseBrainHP_ad_rep7 2.9e-10
Mcm6GOBP_Dna_Conformation_ChangeMouseBrainHP_ad_rep7 1.3e-13
Mcm6GOBP_Dna_Dependent_Dna_ReplicationMouseBrainHP_ad_rep7 1.6e-15
Mcm6GOBP_Dna_Geometric_ChangeMouseBrainHP_ad_rep7 1.0e-10
Mcm6GOBP_Dna_Metabolic_ProcessMouseBrainHP_ad_rep7 3.1e-11
Mcm6GOBP_Dna_RecombinationMouseBrainHP_ad_rep7 1.4e-08
Mcm6GOBP_Dna_RepairMouseBrainHP_ad_rep7 2.4e-12
Mcm6GOBP_Dna_ReplicationMouseBrainHP_ad_rep7 1.1e-10
Mcm6GOBP_Dna_Replication_InitiationMouseBrainHP_ad_rep7 2.9e-08
Mcm6GOBP_Dna_Unwinding_Involved_In_Dna_ReplicationMouseBrainHP_ad_rep7 7.2e-11
Mcm6GOBP_Double_Strand_Break_RepairMouseBrainHP_ad_rep7 2.7e-09
Mcm6GOBP_Mitotic_Dna_ReplicationMouseBrainHP_ad_rep7 3.5e-16
Mcm6GOBP_Protein_Dna_Complex_Subunit_OrganizationMouseBrainHP_ad_rep7 9.8e-13
Mcm6GOBP_Recombinational_RepairMouseBrainHP_ad_rep7 8.2e-08
Mcm6GOBP_Mitotic_Cell_CycleMouseBrainHP_polb_rep9 1.6e-10

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Mcm6 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Mcm6 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Mcm6 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Mcm6

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Mcm6

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource