SPASCER Logo

Home

Download & Upload

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Spatial pattern gene: Mcm4 (spascer ID:17217)

Gene summary for Mcm4

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Mcm4

Gene ID

17217

Gene nameminichromosome maintenance complex component 4
Synonyms19G|AI325074|AU045576|Cdc21|Mcmd4|mKIAA4003|mcdc21
Cytomap16 A2|16 10.09 cM
Type of geneprotein-coding
DescriptionDNA replication licensing factor MCM4CDC21 homologP1-CDC21mini chromosome maintenance deficient 4 homologminichromosome maintenance deficient 4 homolog
Modification date20220424
UniProtAcc

P49717


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Mcm4

GO:0000727

double-strand break repair via break-induced replication

21873635

Process
Mcm4

GO:0003697

single-stranded DNA binding

21873635

Function
Mcm4

GO:0005634

nucleus

21873635

Component
Mcm4

GO:0006268

DNA unwinding involved in DNA replication

21873635

Process
Mcm4

GO:0006271

DNA strand elongation involved in DNA replication

21873635

Process
Mcm4

GO:0017116

single-stranded DNA helicase activity

21873635

Function
Mcm4

GO:0042555

MCM complex

21873635

Component
Mcm4

GO:1902975

mitotic DNA replication initiation

21873635

Process

Top

Spatial pattern events for Mcm4

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Mcm4MouseBrainS4 344135154.24e-06
Mcm4MouseEmbryo4E 342108876.49e-12
Mcm4MouseEmbryorep_2 331887761.83e-07
Mcm4MouseEmbryorep_5 331887761.05e-06
Mcm4MouseEmbryorep_7 331887761.11e-11
Mcm4MouseEmbryorep_12 331887761.27e-09
Mcm4MouseEmbryorep_13 331887768.40e-10
Mcm4MouseKidneyCLP 340037976.92e-15
Mcm4MouseKidneyrep_1 348531511.89e-09
Mcm4MouseKidneyrep_5 348531512.79e-10
Mcm4MouseBrainrep_1 334690252.37e-15
Mcm4MouseLymphA1 03.29e-15
Mcm4MouseLymphB1 03.66e-15
Mcm4MouseLungrep_1 352908011.55e-08

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Kidney_CLP_H&E
boxplot
boxplot
Kidney_rep_1_H&E
boxplot
boxplot
Kidney_rep_5_H&E
boxplot
boxplot
Brain_rep_1_H&E
boxplot
Lung_rep_1_H&E
boxplot
boxplot


Top

Spatial pattern pathway has Mcm4 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Mcm4GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseSpinal cordCN90_C1 3.8e-06
Mcm4GOBP_Cell_CycleMouseSpinal cordCN94_E1 1.1e-06
Mcm4GOBP_Cell_Cycle_Dna_ReplicationMouseSpinal cordCN94_E1 7.4e-07
Mcm4GOBP_Cell_Cycle_ProcessMouseSpinal cordCN94_E1 3.8e-06
Mcm4GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseSpinal cordCN94_E1 8.0e-06
Mcm4GOBP_Dna_Metabolic_ProcessMouseSpinal cordCN94_E1 2.7e-06
Mcm4GOBP_Recombinational_RepairMouseSpinal cordCN94_E1 8.5e-06
Mcm4GOBP_Cell_Cycle_Phase_TransitionMouseSpinal cordL7bCN02_E1 1.5e-06
Mcm4GOBP_Protein_Dna_Complex_Subunit_OrganizationMouseSpinal cordL7bCN02_E1 3.4e-06
Mcm4GOBP_Dna_Strand_Elongation_Involved_In_Dna_ReplicationMouseSpinal cordL7CN30_C2 3.2e-06
Mcm4GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseSpinal cordL7CN45_C1 6.7e-08
Mcm4GOBP_Chromosome_OrganizationMouseSpinal cordL7CN45_C1 3.4e-08
Mcm4GOBP_Dna_Conformation_ChangeMouseSpinal cordL7CN45_C1 8.1e-07
Mcm4GOBP_Dna_RecombinationMouseSpinal cordL7CN45_C1 5.6e-07
Mcm4GOBP_Dna_RepairMouseSpinal cordL7CN45_C1 9.4e-06
Mcm4GOBP_Dna_ReplicationMouseSpinal cordL7CN45_C1 2.8e-07
Mcm4GOBP_Dna_Replication_InitiationMouseSpinal cordL7CN45_C1 6.9e-06
Mcm4GOBP_Dna_Strand_ElongationMouseSpinal cordL7CN45_C1 3.7e-06
Mcm4GOBP_Double_Strand_Break_RepairMouseSpinal cordL7CN45_C1 5.4e-06
Mcm4GOBP_Mitotic_Cell_CycleMouseSpinal cordL7CN45_C1 2.4e-08
Mcm4GOBP_Mitotic_Dna_ReplicationMouseSpinal cordL7CN45_E1 9.7e-08
Mcm4GOBP_Dna_Dependent_Dna_ReplicationMouseSpinal cordL7CN47_C1 6.6e-06
Mcm4GOBP_Dna_Geometric_ChangeMouseSpinal cordL7CN47_C1 2.6e-06
Mcm4GOBP_Cell_Cycle_Dna_Replication_InitiationMouseSpinal cordL7CN47_C2 3.1e-07
Mcm4GOBP_Dna_Conformation_ChangeMouseBrainrep_11 3.6e-05
Mcm4GOBP_Dna_Geometric_ChangeMouseBrainrep_11 2.1e-05
Mcm4GOBP_Dna_Unwinding_Involved_In_Dna_ReplicationMouseBrainrep_21 4.2e-05
Mcm4GOBP_Cell_CycleMouseBrainrep_27 8.4e-07
Mcm4GOBP_Dna_ReplicationMouseBrainrep_27 6.4e-06
Mcm4GOBP_Mitotic_Cell_CycleMouseBrainrep_27 1.1e-05
Mcm4GOBP_Cell_Cycle_Dna_Replication_InitiationMouseBrainrep_30 1.2e-08
Mcm4GOBP_Dna_Strand_ElongationMouseBrainrep_41 1.1e-05
Mcm4GOBP_Cell_CycleMouseBrainrep_1 7.0e-10
Mcm4GOBP_Cell_Cycle_Dna_ReplicationMouseBrainrep_1 3.4e-08
Mcm4GOBP_Cell_Cycle_Phase_TransitionMouseBrainrep_1 1.6e-31
Mcm4GOBP_Cell_Cycle_ProcessMouseBrainrep_1 6.7e-14
Mcm4GOBP_Chromosome_OrganizationMouseBrainrep_1 3.9e-07
Mcm4GOBP_Dna_Dependent_Dna_ReplicationMouseBrainrep_1 1.5e-17
Mcm4GOBP_Dna_Metabolic_ProcessMouseBrainrep_1 1.1e-07
Mcm4GOBP_Dna_RecombinationMouseBrainrep_1 6.8e-13
Mcm4GOBP_Dna_ReplicationMouseBrainrep_1 4.3e-10
Mcm4GOBP_Dna_Replication_InitiationMouseBrainrep_1 1.9e-10
Mcm4GOBP_Dna_Strand_ElongationMouseBrainrep_1 5.6e-11
Mcm4GOBP_Double_Strand_Break_RepairMouseBrainrep_1 5.6e-13
Mcm4GOBP_Mitotic_Cell_CycleMouseBrainrep_1 1.5e-25
Mcm4GOBP_Recombinational_RepairMouseBrainrep_1 5.8e-08
Mcm4GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseBrainrep_33.0e-140
Mcm4GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseBrainrep_35.0e-192
Mcm4GOBP_Dna_Conformation_ChangeMouseBrainrep_3 7.4e-54
Mcm4GOBP_Dna_Geometric_ChangeMouseBrainrep_34.9e-189
Mcm4GOBP_Dna_RepairMouseBrainrep_34.0e-216
Mcm4GOBP_Dna_Strand_Elongation_Involved_In_Dna_ReplicationMouseBrainrep_3 1.8e-40
Mcm4GOBP_Dna_Unwinding_Involved_In_Dna_ReplicationMouseBrainrep_3 7.8e-86
Mcm4GOBP_Mitotic_Dna_ReplicationMouseBrainrep_3 3.5e-61
Mcm4GOBP_Protein_Dna_Complex_Subunit_OrganizationMouseBrainrep_35.3e-122
Mcm4GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseBrainrep_5 5.3e-09
Mcm4GOBP_Cell_Cycle_Dna_Replication_InitiationMouseEmbryorep_6 1.9e-20
Mcm4GOBP_Dna_Conformation_ChangeMouseEmbryorep_14 2.1e-08
Mcm4GOBP_Dna_Geometric_ChangeMouseEmbryorep_14 5.1e-11
Mcm4GOBP_Dna_Replication_InitiationMouseEmbryorep_14 3.1e-28
Mcm4GOBP_Dna_Strand_Elongation_Involved_In_Dna_ReplicationMouseEmbryorep_14 3.6e-17
Mcm4GOBP_Dna_Unwinding_Involved_In_Dna_ReplicationMouseEmbryorep_14 1.0e-37
Mcm4GOBP_Double_Strand_Break_RepairMouseEmbryorep_14 1.4e-07
Mcm4GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseEmbryorep_14 1.6e-37
Mcm4GOBP_Mitotic_Dna_ReplicationMouseEmbryorep_14 2.5e-26
Mcm4GOBP_Protein_Dna_Complex_Subunit_OrganizationMouseEmbryorep_14 2.2e-11
Mcm4GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseEmbryorep_2 1.4e-08
Mcm4GOBP_Dna_Metabolic_ProcessMouseEmbryorep_27.2e-216
Mcm4GOBP_Dna_RecombinationMouseEmbryorep_2 0.0e+00
Mcm4GOBP_Dna_RepairMouseEmbryorep_21.6e-282
Mcm4GOBP_Double_Strand_Break_RepairMouseEmbryorep_2 4.2e-15
Mcm4GOBP_Chromosome_OrganizationMouseEmbryorep_3 1.4e-57
Mcm4GOBP_Dna_Conformation_ChangeMouseEmbryorep_3 1.5e-48
Mcm4GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseEmbryorep_4 1.2e-08
Mcm4GOBP_Cell_CycleMouseKidneyrep_2 1.0e-24
Mcm4GOBP_Cell_Cycle_Dna_ReplicationMouseKidneyrep_2 3.6e-23
Mcm4GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseKidneyrep_2 5.1e-80
Mcm4GOBP_Cell_Cycle_Phase_TransitionMouseKidneyrep_2 6.8e-67
Mcm4GOBP_Cell_Cycle_ProcessMouseKidneyrep_2 3.0e-21
Mcm4GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseKidneyrep_25.5e-146
Mcm4GOBP_Chromosome_OrganizationMouseKidneyrep_2 1.0e-14
Mcm4GOBP_Dna_Conformation_ChangeMouseKidneyrep_2 1.4e-38
Mcm4GOBP_Dna_Dependent_Dna_ReplicationMouseKidneyrep_21.1e-109
Mcm4GOBP_Dna_Geometric_ChangeMouseKidneyrep_2 2.0e-24
Mcm4GOBP_Dna_Metabolic_ProcessMouseKidneyrep_2 1.4e-12
Mcm4GOBP_Dna_RecombinationMouseKidneyrep_2 2.7e-14
Mcm4GOBP_Dna_RepairMouseKidneyrep_2 5.5e-70
Mcm4GOBP_Dna_ReplicationMouseKidneyrep_2 5.9e-43
Mcm4GOBP_Dna_Replication_InitiationMouseKidneyrep_2 3.5e-30
Mcm4GOBP_Dna_Strand_ElongationMouseKidneyrep_2 2.0e-61
Mcm4GOBP_Dna_Strand_Elongation_Involved_In_Dna_ReplicationMouseKidneyrep_2 2.3e-26
Mcm4GOBP_Double_Strand_Break_RepairMouseKidneyrep_2 1.5e-20
Mcm4GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseKidneyrep_2 3.5e-28
Mcm4GOBP_Mitotic_Cell_CycleMouseKidneyrep_2 1.1e-15
Mcm4GOBP_Mitotic_Dna_ReplicationMouseKidneyrep_2 2.1e-53
Mcm4GOBP_Protein_Dna_Complex_Subunit_OrganizationMouseKidneyrep_2 1.1e-35
Mcm4GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseLiverCN16-D2 8.1e-07
Mcm4GOBP_Dna_Dependent_Dna_ReplicationMouseLiverCN16-D2 3.1e-08
Mcm4GOBP_Dna_Metabolic_ProcessMouseLiverCN16-D2 2.6e-07
Mcm4GOBP_Mitotic_Dna_ReplicationMouseLiverCN73-C1 4.1e-07
Mcm4GOBP_Dna_Replication_InitiationMouseLiverrep_15 9.0e-18
Mcm4GOBP_Dna_Strand_Elongation_Involved_In_Dna_ReplicationMouseLiverrep_15 1.1e-13
Mcm4GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseLiverrep_15 7.8e-15
Mcm4GOBP_Cell_Cycle_Dna_Replication_InitiationMouseLiverrep_23 6.5e-52
Mcm4GOBP_Cell_Cycle_Dna_Replication_InitiationMouseIntestinerep_3 6.8e-31
Mcm4GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseIntestinerep_3 1.1e-13
Mcm4GOBP_Cell_CycleMouseLymphMS-1 1.3e-07
Mcm4GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseLymphMS-1 3.2e-07
Mcm4GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseLymphMS-1 8.5e-13
Mcm4GOBP_Chromosome_OrganizationMouseLymphMS-1 3.5e-09
Mcm4GOBP_Dna_Metabolic_ProcessMouseLymphMS-1 6.8e-10
Mcm4GOBP_Protein_Dna_Complex_Subunit_OrganizationMouseLymphMS-1 2.3e-09
Mcm4GOBP_Cell_Cycle_Dna_ReplicationMouseLymphMS-2 7.1e-08
Mcm4GOBP_Dna_Unwinding_Involved_In_Dna_ReplicationMouseLymphMS-2 5.9e-08
Mcm4GOBP_Dna_Dependent_Dna_ReplicationMouseLymphPBS 2.2e-07
Mcm4GOBP_Mitotic_Dna_ReplicationMouseLungrep_1 4.6e-11
Mcm4GOBP_Dna_Unwinding_Involved_In_Dna_ReplicationMouseBrainrep_4 1.9e-14
Mcm4GOBP_Mitotic_Dna_ReplicationMouseBrainrep_7 4.8e-18
Mcm4GOBP_Cell_Cycle_Dna_Replication_InitiationMouseBrainHP_ad_rep3 7.9e-34
Mcm4GOBP_Double_Strand_Break_Repair_Via_Break_Induced_ReplicationMouseBrainHP_ad_rep3 1.5e-15
Mcm4GOBP_Cell_CycleMouseBrainHP_ad_rep7 6.6e-08
Mcm4GOBP_Cell_Cycle_Dna_ReplicationMouseBrainHP_ad_rep7 2.9e-18
Mcm4GOBP_Cell_Cycle_G1_S_Phase_TransitionMouseBrainHP_ad_rep7 3.5e-11
Mcm4GOBP_Cell_Cycle_Phase_TransitionMouseBrainHP_ad_rep7 4.9e-09
Mcm4GOBP_Cell_Cycle_ProcessMouseBrainHP_ad_rep7 1.7e-09
Mcm4GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseBrainHP_ad_rep7 6.8e-10
Mcm4GOBP_Chromosome_OrganizationMouseBrainHP_ad_rep7 2.9e-10
Mcm4GOBP_Dna_Conformation_ChangeMouseBrainHP_ad_rep7 1.3e-13
Mcm4GOBP_Dna_Dependent_Dna_ReplicationMouseBrainHP_ad_rep7 1.6e-15
Mcm4GOBP_Dna_Geometric_ChangeMouseBrainHP_ad_rep7 1.0e-10
Mcm4GOBP_Dna_Metabolic_ProcessMouseBrainHP_ad_rep7 3.1e-11
Mcm4GOBP_Dna_RecombinationMouseBrainHP_ad_rep7 1.4e-08
Mcm4GOBP_Dna_RepairMouseBrainHP_ad_rep7 2.4e-12
Mcm4GOBP_Dna_ReplicationMouseBrainHP_ad_rep7 1.1e-10
Mcm4GOBP_Dna_Replication_InitiationMouseBrainHP_ad_rep7 2.9e-08
Mcm4GOBP_Dna_Strand_ElongationMouseBrainHP_ad_rep7 4.9e-11
Mcm4GOBP_Dna_Strand_Elongation_Involved_In_Dna_ReplicationMouseBrainHP_ad_rep7 3.6e-13
Mcm4GOBP_Dna_Unwinding_Involved_In_Dna_ReplicationMouseBrainHP_ad_rep7 7.2e-11
Mcm4GOBP_Double_Strand_Break_RepairMouseBrainHP_ad_rep7 2.7e-09
Mcm4GOBP_Mitotic_Dna_ReplicationMouseBrainHP_ad_rep7 3.5e-16
Mcm4GOBP_Protein_Dna_Complex_Subunit_OrganizationMouseBrainHP_ad_rep7 9.8e-13
Mcm4GOBP_Recombinational_RepairMouseBrainHP_ad_rep7 8.2e-08
Mcm4GOBP_Mitotic_Cell_CycleMouseBrainHP_polb_rep9 1.6e-10

Top

Mcm4 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

Top

Mcm4 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

Top

Transcription factor for Mcm4 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

Top

Related Drugs for Mcm4

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for Mcm4

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
Mcm4C1864947Natural Killer Cell Deficiency, Familial Isolated3CTD_human;GENOMICS_ENGLAND;ORPHANET
Mcm4C0342482X-linked Adrenal Hypoplasia1GENOMICS_ENGLAND