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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Masp1 (spascer ID:17174)

Gene summary for Masp1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Masp1
	Gene ID	17174
	Gene name	mannan-binding lectin serine peptidase 1
	Synonyms	AW048060\|CCPII\|Crarf\|Masp1/3
	Cytomap	16\|16 B1
	Type of gene	protein-coding
	Description	mannan-binding lectin serine protease 1MASP-1complement factor MASP-3complement-activating component of Ra-reactive factormannose-binding lectin-associated serine protease 1mannose-binding protein-associated serine proteasera-reactive factor serine
	Modification date	20220424
	UniProtAcc	P98064

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Masp1	GO:0001867	complement activation, lectin pathway	21873635	Process
Masp1	GO:0004252	serine-type endopeptidase activity	21873635	Function
Masp1	GO:0005615	extracellular space	21873635	Component

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Spatial pattern events for Masp1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Masp1	Mouse	Brain	S1	34413515	1.85e-07
Masp1	Mouse	Brain	S2	34413515	9.56e-08
Masp1	Mouse	Brain	S6	34413515	2.12e-09
Masp1	Mouse	Kidney	IRI	34003797	2.29e-15
Masp1	Mouse	Kidney	Sham	34003797	2.58e-15
Masp1	Mouse	Brain	rep_1	33469025	1.30e-15
Masp1	Mouse	Brain	rep_3	35027729	8.39e-12
Masp1	Mouse	Lymph	A1	0	3.29e-15
Masp1	Mouse	Lymph	B1	0	3.66e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_IRI_H&E
Kidney_Sham_H&E
Brain_rep_1_H&E
Brain_rep_3_H&E

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Spatial pattern pathway has Masp1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Masp1	GOBP_Complement_Activation_Lectin_Pathway	Mouse	Spinal cord	CN90_C1	7.6e-08
Masp1	GOBP_Endocytosis	Mouse	Spinal cord	CN94_E1	8.2e-06
Masp1	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Spinal cord	CN94_E1	6.6e-06
Masp1	GOBP_Activation_Of_Immune_Response	Mouse	Spinal cord	L7CN45_C1	7.8e-08
Masp1	GOBP_Humoral_Immune_Response	Mouse	Spinal cord	L7CN45_C1	1.3e-07
Masp1	GOBP_Immune_Effector_Process	Mouse	Spinal cord	L7CN45_C1	3.1e-07
Masp1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Spinal cord	L7CN45_C1	8.7e-09
Masp1	GOBP_Proteolysis	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Masp1	GOBP_Receptor_Mediated_Endocytosis	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Masp1	GOBP_Regulation_Of_Immune_System_Process	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Masp1	GOBP_Defense_Response_To_Other_Organism	Mouse	Spinal cord	L7CN97_E2	7.9e-07
Masp1	GOBP_Innate_Immune_Response	Mouse	Spinal cord	L7CN97_E2	2.7e-06
Masp1	GOBP_Complement_Activation	Mouse	Spinal cord	L8CN11_C1	4.7e-22
Masp1	GOBP_Defense_Response	Mouse	Spinal cord	L8CN11_C1	3.3e-17
Masp1	GOBP_Regulation_Of_Immune_Response	Mouse	Spinal cord	L8CN11_C1	4.7e-22
Masp1	GOBP_Complement_Activation_Lectin_Pathway	Mouse	Brain	rep_7	7.7e-10
Masp1	GOBP_Regulation_Of_Immune_Response	Mouse	Brain	rep_27	7.5e-06
Masp1	GOBP_Humoral_Immune_Response	Mouse	Brain	rep_41	1.6e-05
Masp1	GOBP_Immune_Effector_Process	Mouse	Brain	rep_1	1.5e-12
Masp1	GOBP_Activation_Of_Immune_Response	Mouse	Brain	rep_3	6.5e-108
Masp1	GOBP_Defense_Response	Mouse	Brain	rep_3	8.7e-77
Masp1	GOBP_Defense_Response_To_Other_Organism	Mouse	Brain	rep_3	6.0e-105
Masp1	GOBP_Endocytosis	Mouse	Brain	rep_3	2.6e-20
Masp1	GOBP_Humoral_Immune_Response	Mouse	Brain	rep_3	2.5e-108
Masp1	GOBP_Innate_Immune_Response	Mouse	Brain	rep_3	7.5e-97
Masp1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Brain	rep_3	7.6e-125
Masp1	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Brain	rep_3	6.9e-97
Masp1	GOBP_Proteolysis	Mouse	Brain	rep_3	1.8e-168
Masp1	GOBP_Receptor_Mediated_Endocytosis	Mouse	Brain	rep_3	3.1e-52
Masp1	GOBP_Regulation_Of_Immune_Response	Mouse	Brain	rep_3	1.1e-86
Masp1	GOBP_Regulation_Of_Immune_System_Process	Mouse	Brain	rep_3	6.4e-111
Masp1	GOBP_Complement_Activation	Mouse	Embryo	rep_14	4.8e-55
Masp1	GOBP_Humoral_Immune_Response	Mouse	Embryo	rep_14	6.4e-58
Masp1	GOBP_Immune_Effector_Process	Mouse	Embryo	rep_14	3.3e-15
Masp1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Embryo	rep_14	9.6e-07
Masp1	GOBP_Defense_Response	Mouse	Embryo	rep_1	5.2e-63
Masp1	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Embryo	rep_1	7.3e-23
Masp1	GOBP_Regulation_Of_Immune_System_Process	Mouse	Embryo	rep_1	9.5e-143
Masp1	GOBP_Immune_Effector_Process	Mouse	Embryo	rep_2	1.7e-23
Masp1	GOBP_Receptor_Mediated_Endocytosis	Mouse	Embryo	rep_2	1.2e-141
Masp1	GOBP_Defense_Response_To_Other_Organism	Mouse	Embryo	rep_3	2.6e-164
Masp1	GOBP_Innate_Immune_Response	Mouse	Embryo	rep_3	2.0e-259
Masp1	GOBP_Complement_Activation	Mouse	Kidney	IRI	6.7e-07
Masp1	GOBP_Endocytosis	Mouse	Kidney	Nep	8.3e-23
Masp1	GOBP_Proteolysis	Mouse	Kidney	Nep	6.8e-23
Masp1	GOBP_Activation_Of_Immune_Response	Mouse	Kidney	rep_2	5.4e-134
Masp1	GOBP_Complement_Activation	Mouse	Kidney	rep_2	1.1e-201
Masp1	GOBP_Defense_Response	Mouse	Kidney	rep_2	6.8e-127
Masp1	GOBP_Defense_Response_To_Other_Organism	Mouse	Kidney	rep_2	2.3e-129
Masp1	GOBP_Endocytosis	Mouse	Kidney	rep_2	1.4e-132
Masp1	GOBP_Humoral_Immune_Response	Mouse	Kidney	rep_2	7.8e-96
Masp1	GOBP_Immune_Effector_Process	Mouse	Kidney	rep_2	3.4e-107
Masp1	GOBP_Innate_Immune_Response	Mouse	Kidney	rep_2	3.1e-117
Masp1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Kidney	rep_2	8.3e-94
Masp1	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Kidney	rep_2	1.2e-85
Masp1	GOBP_Proteolysis	Mouse	Kidney	rep_2	6.0e-106
Masp1	GOBP_Receptor_Mediated_Endocytosis	Mouse	Kidney	rep_2	4.7e-166
Masp1	GOBP_Regulation_Of_Immune_Response	Mouse	Kidney	rep_2	1.3e-91
Masp1	GOBP_Regulation_Of_Immune_System_Process	Mouse	Kidney	rep_2	2.5e-84
Masp1	GOBP_Complement_Activation_Lectin_Pathway	Mouse	Liver	CN16-D1	2.4e-08
Masp1	GOBP_Complement_Activation	Mouse	Liver	CN73-C1	3.2e-10
Masp1	GOBP_Activation_Of_Immune_Response	Mouse	Liver	rep_16	5.6e-12
Masp1	GOBP_Defense_Response	Mouse	Liver	rep_16	8.0e-16
Masp1	GOBP_Defense_Response_To_Other_Organism	Mouse	Liver	rep_16	1.8e-13
Masp1	GOBP_Humoral_Immune_Response	Mouse	Liver	rep_16	6.6e-21
Masp1	GOBP_Innate_Immune_Response	Mouse	Liver	rep_16	5.5e-09
Masp1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Liver	rep_16	2.3e-11
Masp1	GOBP_Regulation_Of_Immune_Response	Mouse	Liver	rep_16	2.5e-16
Masp1	GOBP_Complement_Activation_Lectin_Pathway	Mouse	Brain	rep_1	7.5e-09
Masp1	GOBP_Complement_Activation_Lectin_Pathway	Mouse	Intestine	rep_3	1.2e-16
Masp1	GOBP_Activation_Of_Immune_Response	Mouse	Lymph	MS-1	2.3e-23
Masp1	GOBP_Complement_Activation	Mouse	Lymph	MS-1	9.7e-19
Masp1	GOBP_Defense_Response	Mouse	Lymph	MS-1	8.6e-18
Masp1	GOBP_Defense_Response_To_Other_Organism	Mouse	Lymph	MS-1	6.7e-20
Masp1	GOBP_Endocytosis	Mouse	Lymph	MS-1	1.8e-21
Masp1	GOBP_Humoral_Immune_Response	Mouse	Lymph	MS-1	3.4e-24
Masp1	GOBP_Immune_Effector_Process	Mouse	Lymph	MS-1	1.6e-18
Masp1	GOBP_Innate_Immune_Response	Mouse	Lymph	MS-1	6.7e-20
Masp1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Lymph	MS-1	1.0e-21
Masp1	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Lymph	MS-1	1.6e-18
Masp1	GOBP_Proteolysis	Mouse	Lymph	MS-1	2.8e-10
Masp1	GOBP_Receptor_Mediated_Endocytosis	Mouse	Lymph	MS-1	2.1e-11
Masp1	GOBP_Regulation_Of_Immune_Response	Mouse	Lymph	MS-1	2.3e-21
Masp1	GOBP_Regulation_Of_Immune_System_Process	Mouse	Lymph	MS-1	2.2e-14
Masp1	GOBP_Immune_Effector_Process	Mouse	Brain	rep_4	7.2e-15
Masp1	GOBP_Complement_Activation_Lectin_Pathway	Mouse	Brain	rep_7	4.2e-35
Masp1	GOBP_Complement_Activation	Mouse	Brain	HP_ad_rep7	1.9e-07
Masp1	GOBP_Defense_Response	Mouse	Brain	HP_ad_rep7	5.6e-10
Masp1	GOBP_Positive_Regulation_Of_Immune_Response	Mouse	Brain	HP_ad_rep7	4.6e-07
Masp1	GOBP_Positive_Regulation_Of_Immune_System_Process	Mouse	Brain	HP_ad_rep7	5.5e-07
Masp1	GOBP_Proteolysis	Mouse	Brain	HP_ad_rep7	3.3e-07
Masp1	GOBP_Receptor_Mediated_Endocytosis	Mouse	Brain	HP_ad_rep7	1.4e-08
Masp1	GOBP_Regulation_Of_Immune_Response	Mouse	Brain	HP_ad_rep7	2.1e-11
Masp1	GOBP_Regulation_Of_Immune_System_Process	Mouse	Brain	HP_ad_rep7	1.8e-09
Masp1	GOBP_Humoral_Immune_Response	Mouse	Brain	HP_adpolb_rep1	2.0e-13
Masp1	GOBP_Activation_Of_Immune_Response	Mouse	Brain	HP_polb_rep9	2.1e-07
Masp1	GOBP_Defense_Response_To_Other_Organism	Mouse	Brain	HP_polb_rep9	2.1e-11
Masp1	GOBP_Endocytosis	Mouse	Brain	HP_polb_rep9	3.2e-09
Masp1	GOBP_Immune_Effector_Process	Mouse	Brain	HP_polb_rep9	1.0e-08
Masp1	GOBP_Innate_Immune_Response	Mouse	Brain	HP_polb_rep9	3.9e-11
Masp1	GOBP_Complement_Activation_Lectin_Pathway	Mouse	Brain	HP_wt_rep4	5.3e-04

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Masp1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Masp1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Masp1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Masp1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Masp1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Masp1	C0796059	Oculopalatoskeletal syndrome	4	CTD_human;GENOMICS_ENGLAND
Masp1	C0022283	Incontinentia Pigmenti Achromians	1	CTD_human
Masp1	C0036305	Schamberg Disease	1	CTD_human
Masp1	C0376634	Craniofacial Abnormalities	1	CTD_human
Masp1	C0549567	Pigmentation Disorders	1	CTD_human
Masp1	C0796032	Malpuech facial clefting syndrome	1	CTD_human
Masp1	C0796279	Carnevale syndrome	1	CTD_human
Masp1	C4303860	Craniofacial ulnar renal syndrome	1	ORPHANET