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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Mark3 (spascer ID:17169)

Gene summary for Mark3

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Mark3
	Gene ID	17169
	Gene name	MAP/microtubule affinity regulating kinase 3
	Synonyms	1600015G02Rik\|A430080F22Rik\|C-TAK1\|ETK-1\|ETK1\|Emk2\|MPK10
	Cytomap	12\|12 F1
	Type of gene	protein-coding
	Description	MAP/microtubule affinity-regulating kinase 3ELKL motif kinase 2EMK-2EMK2/MARK3 serine-threonine protein kinaseMPK-10
	Modification date	20220424
	UniProtAcc	Q03141

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Mark3	GO:0000226	microtubule cytoskeleton organization	21873635	Process
Mark3	GO:0004674	protein serine/threonine kinase activity	21873635	Function
Mark3	GO:0005737	cytoplasm	21873635	Component
Mark3	GO:0005886	plasma membrane	21873635	Component
Mark3	GO:0035556	intracellular signal transduction	21873635	Process
Mark3	GO:0050321	tau-protein kinase activity	21873635	Function

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Spatial pattern events for Mark3

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Mark3	Mouse	Brain	S2	34413515	1.56e-15
Mark3	Mouse	Brain	S3	34413515	1.55e-07
Mark3	Mouse	Brain	S4	34413515	2.39e-06
Mark3	Mouse	Brain	S6	34413515	1.46e-15
Mark3	Mouse	Brain	S7	34413515	1.55e-15
Mark3	Mouse	Brain	rep_3	35141374	1.00e-05
Mark3	Mouse	Brain	rep_4	35141374	2.00e-10
Mark3	Mouse	Kidney	IRI	34003797	2.95e-07
Mark3	Mouse	Brain	rep_1	33469025	2.75e-13
Mark3	Mouse	Brain	rep_3	35027729	3.79e-08
Mark3	Mouse	Lymph	A1	0	3.29e-15
Mark3	Mouse	Lymph	B1	0	4.31e-14
Mark3	Mouse	Brain	rep_1	35210624	6.02e-15
Mark3	Mouse	Brain	rep_2	35210624	1.74e-15
Mark3	Mouse	Brain	rep_3	35210624	3.68e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_3_H&E
Brain_rep_4_H&E
Kidney_IRI_H&E
Brain_rep_1_H&E
Brain_rep_3_H&E

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Spatial pattern pathway has Mark3 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Mark3	GOBP_Microtubule_Based_Process	Mouse	Spinal cord	CN94_E1	2.4e-06
Mark3	GOBP_Positive_Regulation_Of_Binding	Mouse	Spinal cord	CN94_E1	2.3e-06
Mark3	GOBP_Positive_Regulation_Of_Protein_Binding	Mouse	Spinal cord	CN94_E1	3.4e-06
Mark3	GOBP_Regulation_Of_Binding	Mouse	Spinal cord	CN94_E1	1.4e-06
Mark3	GOBP_Regulation_Of_Protein_Binding	Mouse	Spinal cord	CN94_E1	5.5e-06
Mark3	GOBP_Cytoskeleton_Organization	Mouse	Spinal cord	L7bCN02_E1	8.3e-06
Mark3	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Spinal cord	L7CN44_C1	3.2e-08
Mark3	GOBP_Hippo_Signaling	Mouse	Spinal cord	L7CN45_C1	6.6e-08
Mark3	GOBP_Mapk_Cascade	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Mark3	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Spinal cord	L7CN45_C1	1.6e-07
Mark3	GOBP_Peptidyl_Serine_Modification	Mouse	Spinal cord	L7CN45_C1	2.8e-08
Mark3	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Mark3	GOBP_Protein_Autophosphorylation	Mouse	Spinal cord	L7CN45_C1	3.8e-08
Mark3	GOBP_Peptidyl_Serine_Autophosphorylation	Mouse	Spinal cord	L7CN47_D1	8.8e-07
Mark3	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L8CN11_D1	5.6e-09
Mark3	GOBP_Negative_Regulation_Of_Signaling	Mouse	Spinal cord	L8CN17_E1	8.3e-06
Mark3	GOBP_Hippo_Signaling	Mouse	Brain	rep_75	5.3e-05
Mark3	GOBP_Regulation_Of_Hippo_Signaling	Mouse	Brain	rep_75	5.0e-05
Mark3	GOBP_Cytoskeleton_Organization	Mouse	Brain	rep_1	1.1e-11
Mark3	GOBP_Microtubule_Based_Process	Mouse	Brain	rep_1	1.6e-07
Mark3	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Brain	rep_1	9.0e-07
Mark3	GOBP_Peptidyl_Serine_Modification	Mouse	Brain	rep_1	5.2e-23
Mark3	GOBP_Protein_Autophosphorylation	Mouse	Brain	rep_1	1.5e-46
Mark3	GOBP_Regulation_Of_Binding	Mouse	Brain	rep_1	3.2e-09
Mark3	GOBP_Hippo_Signaling	Mouse	Brain	rep_3	7.8e-89
Mark3	GOBP_Mapk_Cascade	Mouse	Brain	rep_3	4.8e-123
Mark3	GOBP_Microtubule_Cytoskeleton_Organization	Mouse	Brain	rep_3	8.5e-140
Mark3	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Brain	rep_3	5.2e-78
Mark3	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	9.2e-120
Mark3	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	rep_3	1.3e-138
Mark3	GOBP_Negative_Regulation_Of_Signaling	Mouse	Brain	rep_3	7.8e-106
Mark3	GOBP_Peptidyl_Serine_Autophosphorylation	Mouse	Brain	rep_3	7.3e-40
Mark3	GOBP_Positive_Regulation_Of_Binding	Mouse	Brain	rep_3	1.6e-131
Mark3	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	rep_3	2.6e-94
Mark3	GOBP_Positive_Regulation_Of_Protein_Binding	Mouse	Brain	rep_3	9.0e-128
Mark3	GOBP_Regulation_Of_Hippo_Signaling	Mouse	Brain	rep_3	3.4e-114
Mark3	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	1.3e-132
Mark3	GOBP_Regulation_Of_Protein_Binding	Mouse	Brain	rep_3	1.9e-150
Mark3	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Embryo	rep_14	1.3e-30
Mark3	GOBP_Peptidyl_Serine_Autophosphorylation	Mouse	Embryo	rep_14	3.6e-48
Mark3	GOBP_Positive_Regulation_Of_Binding	Mouse	Embryo	rep_14	1.0e-12
Mark3	GOBP_Positive_Regulation_Of_Protein_Binding	Mouse	Embryo	rep_14	6.7e-11
Mark3	GOBP_Regulation_Of_Protein_Binding	Mouse	Embryo	rep_14	9.4e-12
Mark3	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Embryo	rep_1	1.0e-64
Mark3	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Embryo	rep_1	1.1e-25
Mark3	GOBP_Negative_Regulation_Of_Signaling	Mouse	Embryo	rep_1	5.6e-10
Mark3	GOBP_Peptidyl_Serine_Modification	Mouse	Embryo	rep_1	2.5e-276
Mark3	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Embryo	rep_3	0.0e+00
Mark3	GOBP_Positive_Regulation_Of_Protein_Binding	Mouse	Embryo	rep_5	1.7e-08
Mark3	GOBP_Protein_Autophosphorylation	Mouse	Embryo	rep_6	9.9e-40
Mark3	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	Nep	1.8e-46
Mark3	GOBP_Cytoskeleton_Organization	Mouse	Kidney	rep_2	1.5e-44
Mark3	GOBP_Hippo_Signaling	Mouse	Kidney	rep_2	8.2e-18
Mark3	GOBP_Mapk_Cascade	Mouse	Kidney	rep_2	1.1e-19
Mark3	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	9.1e-83
Mark3	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Kidney	rep_2	1.7e-39
Mark3	GOBP_Negative_Regulation_Of_Signaling	Mouse	Kidney	rep_2	4.0e-40
Mark3	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Kidney	rep_2	6.9e-23
Mark3	GOBP_Peptidyl_Serine_Autophosphorylation	Mouse	Kidney	rep_2	2.0e-66
Mark3	GOBP_Positive_Regulation_Of_Binding	Mouse	Kidney	rep_2	7.3e-33
Mark3	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	rep_2	2.2e-45
Mark3	GOBP_Positive_Regulation_Of_Protein_Binding	Mouse	Kidney	rep_2	1.4e-39
Mark3	GOBP_Protein_Autophosphorylation	Mouse	Kidney	rep_2	7.6e-46
Mark3	GOBP_Regulation_Of_Binding	Mouse	Kidney	rep_2	1.3e-38
Mark3	GOBP_Regulation_Of_Hippo_Signaling	Mouse	Kidney	rep_2	2.7e-16
Mark3	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	1.4e-17
Mark3	GOBP_Regulation_Of_Protein_Binding	Mouse	Kidney	rep_2	6.4e-45
Mark3	GOBP_Microtubule_Based_Process	Mouse	Liver	CN16-D2	1.8e-11
Mark3	GOBP_Microtubule_Cytoskeleton_Organization	Mouse	Liver	CN16-D2	2.8e-10
Mark3	GOBP_Peptidyl_Serine_Modification	Mouse	Liver	CN16-D2	2.3e-09
Mark3	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Liver	CN16-E1	3.0e-07
Mark3	GOBP_Hippo_Signaling	Mouse	Liver	rep_16	4.9e-07
Mark3	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Liver	rep_16	1.3e-08
Mark3	GOBP_Peptidyl_Serine_Autophosphorylation	Mouse	Liver	rep_16	2.2e-15
Mark3	GOBP_Peptidyl_Serine_Modification	Mouse	Liver	rep_16	6.1e-20
Mark3	GOBP_Positive_Regulation_Of_Protein_Binding	Mouse	Liver	rep_16	7.3e-10
Mark3	GOBP_Regulation_Of_Hippo_Signaling	Mouse	Liver	rep_16	8.0e-12
Mark3	GOBP_Regulation_Of_Protein_Binding	Mouse	Liver	rep_16	2.3e-08
Mark3	GOBP_Cytoskeleton_Organization	Mouse	Lymph	MS-1	1.8e-13
Mark3	GOBP_Hippo_Signaling	Mouse	Lymph	MS-1	3.0e-09
Mark3	GOBP_Mapk_Cascade	Mouse	Lymph	MS-1	8.8e-20
Mark3	GOBP_Microtubule_Based_Process	Mouse	Lymph	MS-1	1.5e-08
Mark3	GOBP_Microtubule_Cytoskeleton_Organization	Mouse	Lymph	MS-1	7.6e-07
Mark3	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Lymph	MS-1	1.8e-10
Mark3	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.5e-16
Mark3	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Lymph	MS-1	1.5e-11
Mark3	GOBP_Negative_Regulation_Of_Signaling	Mouse	Lymph	MS-1	1.0e-14
Mark3	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Lymph	MS-1	1.2e-13
Mark3	GOBP_Peptidyl_Serine_Autophosphorylation	Mouse	Lymph	MS-1	2.2e-08
Mark3	GOBP_Positive_Regulation_Of_Binding	Mouse	Lymph	MS-1	1.6e-07
Mark3	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Lymph	MS-1	1.9e-12
Mark3	GOBP_Positive_Regulation_Of_Protein_Binding	Mouse	Lymph	MS-1	3.0e-07
Mark3	GOBP_Protein_Autophosphorylation	Mouse	Lymph	MS-1	3.0e-10
Mark3	GOBP_Regulation_Of_Binding	Mouse	Lymph	MS-1	1.9e-09
Mark3	GOBP_Regulation_Of_Hippo_Signaling	Mouse	Lymph	MS-1	3.9e-11
Mark3	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.0e-14
Mark3	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Brain	rep_7	1.1e-10
Mark3	GOBP_Negative_Regulation_Of_Hippo_Signaling	Mouse	Brain	HP_ad_rep2	8.0e-08
Mark3	GOBP_Cytoskeleton_Organization	Mouse	Brain	HP_ad_rep7	5.3e-08
Mark3	GOBP_Microtubule_Based_Process	Mouse	Brain	HP_ad_rep7	2.8e-10
Mark3	GOBP_Microtubule_Cytoskeleton_Organization	Mouse	Brain	HP_ad_rep7	3.8e-13
Mark3	GOBP_Peptidyl_Amino_Acid_Modification	Mouse	Brain	HP_ad_rep7	3.2e-08
Mark3	GOBP_Peptidyl_Serine_Autophosphorylation	Mouse	Brain	HP_ad_rep7	3.5e-13
Mark3	GOBP_Peptidyl_Serine_Modification	Mouse	Brain	HP_ad_rep7	4.6e-07
Mark3	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	HP_ad_rep7	2.8e-07
Mark3	GOBP_Protein_Autophosphorylation	Mouse	Brain	HP_ad_rep7	5.6e-08
Mark3	GOBP_Hippo_Signaling	Mouse	Brain	HP_adpolb_rep1	6.7e-07
Mark3	GOBP_Negative_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	9.4e-11
Mark3	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	HP_polb_rep9	3.1e-09
Mark3	GOBP_Negative_Regulation_Of_Signaling	Mouse	Brain	HP_polb_rep9	1.4e-11
Mark3	GOBP_Positive_Regulation_Of_Binding	Mouse	Brain	HP_polb_rep9	2.9e-09
Mark3	GOBP_Positive_Regulation_Of_Protein_Binding	Mouse	Brain	HP_polb_rep9	3.8e-13
Mark3	GOBP_Regulation_Of_Binding	Mouse	Brain	HP_polb_rep9	4.0e-08
Mark3	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	3.9e-11
Mark3	GOBP_Regulation_Of_Protein_Binding	Mouse	Brain	HP_polb_rep9	2.8e-10

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Mark3 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Mark3 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Mark3 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Mark3

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Mark3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Mark3	C4748978	VISUAL IMPAIRMENT AND PROGRESSIVE PHTHISIS BULBI	1	UNIPROT