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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Marco (spascer ID:17167)

Gene summary for Marco

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Marco
	Gene ID	17167
	Gene name	macrophage receptor with collagenous structure
	Synonyms	AI323439\|Ly112\|Scara2
	Cytomap	1\|1 E2.3
	Type of gene	protein-coding
	Description	macrophage receptor MARCO
	Modification date	20220424
	UniProtAcc	Q60754

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Marco	GO:0001664	G protein-coupled receptor binding	21873635	Function
Marco	GO:0005622	intracellular anatomical structure	21873635	Component
Marco	GO:0005886	plasma membrane	21873635	Component
Marco	GO:0006897	endocytosis	21873635	Process

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Spatial pattern events for Marco

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Marco	Mouse	Brain	S1	34413515	2.07e-15
Marco	Mouse	Brain	S2	34413515	1.56e-15
Marco	Mouse	Liver	rep_19	35021063	1.03e-06
Marco	Mouse	Lymph	MS-1	0	2.71e-14
Marco	Mouse	Lymph	MS-2	0	3.96e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_19_H&E

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Spatial pattern pathway has Marco envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Marco	GOBP_Endocytosis	Mouse	Spinal cord	CN94_E1	8.2e-06
Marco	GOBP_Erk1_And_Erk2_Cascade	Mouse	Spinal cord	CN94_E1	4.0e-06
Marco	GOBP_Positive_Regulation_Of_Erk1_And_Erk2_Cascade	Mouse	Spinal cord	CN94_E1	1.5e-06
Marco	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Spinal cord	CN94_E1	7.8e-06
Marco	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Spinal cord	CN94_E1	5.1e-06
Marco	GOBP_Adenylate_Cyclase_Inhibiting_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Marco	GOBP_Adenylate_Cyclase_Modulating_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	5.1e-07
Marco	GOBP_Apoptotic_Cell_Clearance	Mouse	Spinal cord	L7CN45_C1	9.5e-08
Marco	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	8.8e-08
Marco	GOBP_Mapk_Cascade	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Marco	GOBP_Membrane_Invagination	Mouse	Spinal cord	L7CN45_C1	7.1e-08
Marco	GOBP_Membrane_Organization	Mouse	Spinal cord	L7CN45_C1	2.7e-07
Marco	GOBP_Phagocytosis	Mouse	Spinal cord	L7CN45_C1	8.6e-06
Marco	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Marco	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Marco	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Marco	GOBP_Positive_Regulation_Of_Signaling	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Marco	GOBP_Receptor_Mediated_Endocytosis	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Marco	GOBP_Regulation_Of_Protein_Modification_Process	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Marco	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Marco	GOBP_Defense_Response_To_Other_Organism	Mouse	Spinal cord	L7CN97_E2	7.9e-07
Marco	GOBP_Innate_Immune_Response	Mouse	Spinal cord	L7CN97_E2	2.7e-06
Marco	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Spinal cord	L7CN97_E2	4.9e-06
Marco	GOBP_Defense_Response	Mouse	Spinal cord	L8CN11_C1	3.3e-17
Marco	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Spinal cord	L8CN11_C1	3.6e-13
Marco	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L8CN11_D1	5.6e-09
Marco	GOBP_Adenylate_Cyclase_Modulating_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_27	6.6e-06
Marco	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_27	8.0e-06
Marco	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Brain	rep_27	5.2e-05
Marco	GOBP_Apoptotic_Cell_Clearance	Mouse	Brain	rep_37	1.4e-05
Marco	GOBP_Adenylate_Cyclase_Inhibiting_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_41	8.0e-06
Marco	GOBP_Positive_Regulation_Of_Erk1_And_Erk2_Cascade	Mouse	Brain	rep_71	2.9e-05
Marco	GOBP_Adenylate_Cyclase_Modulating_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_1	2.4e-17
Marco	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_1	4.5e-16
Marco	GOBP_Phagocytosis	Mouse	Brain	rep_1	1.8e-16
Marco	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Brain	rep_1	1.3e-08
Marco	GOBP_Positive_Regulation_Of_Signaling	Mouse	Brain	rep_1	3.1e-07
Marco	GOBP_Adenylate_Cyclase_Inhibiting_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_3	5.4e-26
Marco	GOBP_Amyloid_Beta_Clearance	Mouse	Brain	rep_3	7.3e-87
Marco	GOBP_Apoptotic_Cell_Clearance	Mouse	Brain	rep_3	2.3e-09
Marco	GOBP_Defense_Response	Mouse	Brain	rep_3	8.7e-77
Marco	GOBP_Defense_Response_To_Other_Organism	Mouse	Brain	rep_3	6.0e-105
Marco	GOBP_Endocytosis	Mouse	Brain	rep_3	2.6e-20
Marco	GOBP_Erk1_And_Erk2_Cascade	Mouse	Brain	rep_3	2.0e-29
Marco	GOBP_Innate_Immune_Response	Mouse	Brain	rep_3	7.5e-97
Marco	GOBP_Mapk_Cascade	Mouse	Brain	rep_3	4.8e-123
Marco	GOBP_Membrane_Invagination	Mouse	Brain	rep_3	9.0e-82
Marco	GOBP_Membrane_Organization	Mouse	Brain	rep_3	1.9e-41
Marco	GOBP_Positive_Regulation_Of_Erk1_And_Erk2_Cascade	Mouse	Brain	rep_3	9.3e-46
Marco	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	3.3e-214
Marco	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Brain	rep_3	4.0e-152
Marco	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Brain	rep_3	9.9e-174
Marco	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Brain	rep_3	2.9e-128
Marco	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Brain	rep_3	6.0e-108
Marco	GOBP_Receptor_Mediated_Endocytosis	Mouse	Brain	rep_3	3.1e-52
Marco	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	1.3e-132
Marco	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Brain	rep_3	3.0e-62
Marco	GOBP_Regulation_Of_Protein_Modification_Process	Mouse	Brain	rep_3	2.2e-188
Marco	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Brain	rep_3	8.6e-94
Marco	GOBP_Amyloid_Beta_Clearance	Mouse	Embryo	rep_6	1.3e-13
Marco	GOBP_Apoptotic_Cell_Clearance	Mouse	Embryo	rep_14	9.3e-58
Marco	GOBP_Erk1_And_Erk2_Cascade	Mouse	Embryo	rep_14	4.9e-11
Marco	GOBP_Membrane_Invagination	Mouse	Embryo	rep_14	9.8e-15
Marco	GOBP_Positive_Regulation_Of_Erk1_And_Erk2_Cascade	Mouse	Embryo	rep_14	3.4e-17
Marco	GOBP_Defense_Response	Mouse	Embryo	rep_1	5.2e-63
Marco	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Embryo	rep_1	9.7e-27
Marco	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Embryo	rep_1	2.2e-69
Marco	GOBP_Positive_Regulation_Of_Signaling	Mouse	Embryo	rep_2	1.4e-07
Marco	GOBP_Receptor_Mediated_Endocytosis	Mouse	Embryo	rep_2	1.2e-141
Marco	GOBP_Defense_Response_To_Other_Organism	Mouse	Embryo	rep_3	2.6e-164
Marco	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Embryo	rep_3	0.0e+00
Marco	GOBP_Innate_Immune_Response	Mouse	Embryo	rep_3	2.0e-259
Marco	GOBP_Adenylate_Cyclase_Modulating_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Embryo	rep_5	8.0e-08
Marco	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Embryo	rep_5	1.2e-28
Marco	GOBP_Membrane_Invagination	Mouse	Kidney	IRI	6.6e-07
Marco	GOBP_Apoptotic_Cell_Clearance	Mouse	Kidney	Nep	2.7e-48
Marco	GOBP_Endocytosis	Mouse	Kidney	Nep	8.3e-23
Marco	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Kidney	Nep	4.2e-26
Marco	GOBP_Phagocytosis	Mouse	Kidney	Nep	2.7e-48
Marco	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	Nep	5.3e-07
Marco	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Kidney	Nep	4.2e-26
Marco	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Kidney	Nep	4.3e-38
Marco	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Kidney	Nep	4.2e-26
Marco	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Kidney	Nep	4.2e-26
Marco	GOBP_Positive_Regulation_Of_Signaling	Mouse	Kidney	Nep	1.1e-39
Marco	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Kidney	Nep	4.6e-22
Marco	GOBP_Regulation_Of_Protein_Modification_Process	Mouse	Kidney	Nep	4.6e-22
Marco	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Kidney	Nep	4.6e-22
Marco	GOBP_Adenylate_Cyclase_Inhibiting_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Kidney	rep_2	3.9e-30
Marco	GOBP_Adenylate_Cyclase_Modulating_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Kidney	rep_2	8.6e-64
Marco	GOBP_Amyloid_Beta_Clearance	Mouse	Kidney	rep_2	1.6e-144
Marco	GOBP_Apoptotic_Cell_Clearance	Mouse	Kidney	rep_2	7.5e-71
Marco	GOBP_Defense_Response	Mouse	Kidney	rep_2	6.8e-127
Marco	GOBP_Defense_Response_To_Other_Organism	Mouse	Kidney	rep_2	2.3e-129
Marco	GOBP_Endocytosis	Mouse	Kidney	rep_2	1.4e-132
Marco	GOBP_Erk1_And_Erk2_Cascade	Mouse	Kidney	rep_2	1.2e-29
Marco	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Kidney	rep_2	3.0e-37
Marco	GOBP_Innate_Immune_Response	Mouse	Kidney	rep_2	3.1e-117
Marco	GOBP_Mapk_Cascade	Mouse	Kidney	rep_2	1.1e-19
Marco	GOBP_Membrane_Invagination	Mouse	Kidney	rep_2	3.4e-97
Marco	GOBP_Membrane_Organization	Mouse	Kidney	rep_2	8.5e-74
Marco	GOBP_Phagocytosis	Mouse	Kidney	rep_2	3.4e-104
Marco	GOBP_Positive_Regulation_Of_Erk1_And_Erk2_Cascade	Mouse	Kidney	rep_2	1.2e-31
Marco	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Kidney	rep_2	1.8e-39
Marco	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Kidney	rep_2	7.2e-12
Marco	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Kidney	rep_2	1.7e-43
Marco	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Kidney	rep_2	7.3e-67
Marco	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Kidney	rep_2	8.4e-58
Marco	GOBP_Positive_Regulation_Of_Signaling	Mouse	Kidney	rep_2	3.4e-17
Marco	GOBP_Receptor_Mediated_Endocytosis	Mouse	Kidney	rep_2	4.7e-166
Marco	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	1.4e-17
Marco	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Kidney	rep_2	1.3e-41
Marco	GOBP_Regulation_Of_Protein_Modification_Process	Mouse	Kidney	rep_2	2.2e-44
Marco	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Kidney	rep_2	1.8e-44
Marco	GOBP_Erk1_And_Erk2_Cascade	Mouse	Liver	CN73-C1	4.0e-09
Marco	GOBP_Amyloid_Beta_Clearance	Mouse	Liver	rep_16	9.4e-12
Marco	GOBP_Apoptotic_Cell_Clearance	Mouse	Liver	rep_16	1.2e-09
Marco	GOBP_Defense_Response	Mouse	Liver	rep_16	8.0e-16
Marco	GOBP_Defense_Response_To_Other_Organism	Mouse	Liver	rep_16	1.8e-13
Marco	GOBP_Innate_Immune_Response	Mouse	Liver	rep_16	5.5e-09
Marco	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Liver	rep_16	1.4e-09
Marco	GOBP_Defense_Response	Mouse	Lymph	MS-1	8.6e-18
Marco	GOBP_Defense_Response_To_Other_Organism	Mouse	Lymph	MS-1	6.7e-20
Marco	GOBP_Endocytosis	Mouse	Lymph	MS-1	1.8e-21
Marco	GOBP_Erk1_And_Erk2_Cascade	Mouse	Lymph	MS-1	1.2e-19
Marco	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Lymph	MS-1	1.8e-08
Marco	GOBP_Innate_Immune_Response	Mouse	Lymph	MS-1	6.7e-20
Marco	GOBP_Mapk_Cascade	Mouse	Lymph	MS-1	8.8e-20
Marco	GOBP_Membrane_Invagination	Mouse	Lymph	MS-1	1.4e-20
Marco	GOBP_Membrane_Organization	Mouse	Lymph	MS-1	5.8e-20
Marco	GOBP_Phagocytosis	Mouse	Lymph	MS-1	9.1e-20
Marco	GOBP_Positive_Regulation_Of_Erk1_And_Erk2_Cascade	Mouse	Lymph	MS-1	6.5e-14
Marco	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	2.3e-12
Marco	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Lymph	MS-1	2.7e-14
Marco	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Lymph	MS-1	5.6e-12
Marco	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Lymph	MS-1	1.9e-12
Marco	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Lymph	MS-1	1.9e-12
Marco	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Lymph	MS-1	2.7e-14
Marco	GOBP_Positive_Regulation_Of_Signaling	Mouse	Lymph	MS-1	2.3e-12
Marco	GOBP_Receptor_Mediated_Endocytosis	Mouse	Lymph	MS-1	2.1e-11
Marco	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.0e-14
Marco	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Lymph	MS-1	5.6e-12
Marco	GOBP_Regulation_Of_Protein_Modification_Process	Mouse	Lymph	MS-1	1.9e-12
Marco	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Lymph	MS-1	1.4e-12
Marco	GOBP_Adenylate_Cyclase_Modulating_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_4	3.9e-13
Marco	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	rep_4	1.7e-17
Marco	GOBP_Amyloid_Beta_Clearance	Mouse	Brain	HP_ad_rep7	3.9e-07
Marco	GOBP_Apoptotic_Cell_Clearance	Mouse	Brain	HP_ad_rep7	6.8e-09
Marco	GOBP_Defense_Response	Mouse	Brain	HP_ad_rep7	5.6e-10
Marco	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.7e-07
Marco	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Brain	HP_ad_rep7	2.8e-07
Marco	GOBP_Receptor_Mediated_Endocytosis	Mouse	Brain	HP_ad_rep7	1.4e-08
Marco	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Brain	HP_ad_rep7	1.7e-08
Marco	GOBP_Regulation_Of_Protein_Modification_Process	Mouse	Brain	HP_ad_rep7	1.1e-07
Marco	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Brain	HP_ad_rep7	4.0e-09
Marco	GOBP_Membrane_Invagination	Mouse	Brain	HP_adpolb_rep1	3.6e-07
Marco	GOBP_Adenylate_Cyclase_Inhibiting_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	2.2e-08
Marco	GOBP_Adenylate_Cyclase_Modulating_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	2.6e-10
Marco	GOBP_Defense_Response_To_Other_Organism	Mouse	Brain	HP_polb_rep9	2.1e-11
Marco	GOBP_Endocytosis	Mouse	Brain	HP_polb_rep9	3.2e-09
Marco	GOBP_Erk1_And_Erk2_Cascade	Mouse	Brain	HP_polb_rep9	2.8e-07
Marco	GOBP_G_Protein_Coupled_Receptor_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	6.4e-16
Marco	GOBP_Innate_Immune_Response	Mouse	Brain	HP_polb_rep9	3.9e-11
Marco	GOBP_Membrane_Organization	Mouse	Brain	HP_polb_rep9	1.4e-13
Marco	GOBP_Phagocytosis	Mouse	Brain	HP_polb_rep9	2.5e-08
Marco	GOBP_Positive_Regulation_Of_Erk1_And_Erk2_Cascade	Mouse	Brain	HP_polb_rep9	1.9e-08
Marco	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	1.7e-14
Marco	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Brain	HP_polb_rep9	6.9e-10
Marco	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Brain	HP_polb_rep9	6.0e-11
Marco	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Brain	HP_polb_rep9	9.8e-11
Marco	GOBP_Positive_Regulation_Of_Signaling	Mouse	Brain	HP_polb_rep9	1.3e-14
Marco	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	3.9e-11

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Marco function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Marco function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Marco envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Marco

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Marco

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Marco	C2239176	Liver carcinoma	1	CTD_human