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Spatial pattern gene: Mafk (spascer ID:17135) |
Gene summary for Mafk |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Mafk | Gene ID | 17135 |
| Gene name | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) |
| Synonyms | AW061068|NF-E2|Nfe2u |
| Cytomap | 5 G2|5 78.81 cM |
| Type of gene | protein-coding |
| Description | transcription factor MafKerythroid transcription factor NF-E2 p18 subunitnuclear factor, erythroid derived 2, ubiquitousp18 NF-E2 |
| Modification date | 20220424 |
| UniProtAcc | Q61827 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Mafk | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 21873635 | Function |
| Mafk | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | 21873635 | Function |
| Mafk | GO:0005634 | nucleus | 21873635 | Component |
| Mafk | GO:0006357 | regulation of transcription by RNA polymerase II | 21873635 | Process |
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Spatial pattern events for Mafk |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Mafk | Mouse | Brain | rep_3 | 35141374 | 1.64e-15 |
| Mafk | Mouse | Brain | rep_4 | 35141374 | 6.05e-13 |
| Mafk | Mouse | Kidney | IRI | 34003797 | 1.41e-12 |
| Mafk | Mouse | Brain | rep_1 | 33469025 | 7.81e-07 |
| Mafk | Mouse | Intestine | rep_1 | 35149721 | 4.88e-06 |
| Mafk | Mouse | Intestine | rep_3 | 35149721 | 2.66e-10 |
| Mafk | Mouse | Intestine | rep_4 | 35149721 | 9.10e-11 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Kidney_IRI_H&E  |  |
Brain_rep_1_H&E  |
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Spatial pattern pathway has Mafk envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Mafk | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Spinal cord | CN94_E1 | 1.6e-06 |
| Mafk | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Spinal cord | CN94_E1 | 6.2e-07 |
| Mafk | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Spinal cord | CN94_E1 | 2.2e-06 |
| Mafk | GOBP_Response_To_Wounding | Mouse | Spinal cord | CN94_E1 | 4.7e-06 |
| Mafk | GOBP_Regulation_Of_Body_Fluid_Levels | Mouse | Spinal cord | L7CN45_C1 | 9.1e-06 |
| Mafk | GOBP_Wound_Healing | Mouse | Spinal cord | L7CN47_C1 | 8.4e-07 |
| Mafk | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | rep_27 | 7.2e-05 |
| Mafk | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Brain | rep_27 | 2.8e-05 |
| Mafk | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | rep_3 | 1.4e-196 |
| Mafk | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | rep_3 | 9.4e-206 |
| Mafk | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Brain | rep_3 | 7.5e-168 |
| Mafk | GOBP_Regulation_Of_Body_Fluid_Levels | Mouse | Brain | rep_3 | 1.1e-62 |
| Mafk | GOBP_Response_To_Wounding | Mouse | Brain | rep_3 | 6.2e-112 |
| Mafk | GOBP_Wound_Healing | Mouse | Brain | rep_3 | 6.2e-109 |
| Mafk | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Embryo | rep_2 | 8.0e-13 |
| Mafk | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Embryo | rep_3 | 1.5e-267 |
| Mafk | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Embryo | rep_3 | 0.0e+00 |
| Mafk | GOBP_Regulation_Of_Body_Fluid_Levels | Mouse | Kidney | Nep | 1.6e-16 |
| Mafk | GOBP_Response_To_Wounding | Mouse | Kidney | Nep | 1.6e-16 |
| Mafk | GOBP_Wound_Healing | Mouse | Kidney | Nep | 1.6e-16 |
| Mafk | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Kidney | rep_2 | 7.3e-42 |
| Mafk | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Kidney | rep_2 | 7.7e-30 |
| Mafk | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Kidney | rep_2 | 2.2e-14 |
| Mafk | GOBP_Response_To_Wounding | Mouse | Kidney | rep_2 | 2.1e-60 |
| Mafk | GOBP_Wound_Healing | Mouse | Kidney | rep_2 | 6.5e-45 |
| Mafk | GOBP_Response_To_Wounding | Mouse | Liver | CN73-C1 | 1.1e-07 |
| Mafk | GOBP_Wound_Healing | Mouse | Liver | CN73-C1 | 1.1e-08 |
| Mafk | GOBP_Regulation_Of_Body_Fluid_Levels | Mouse | Liver | rep_16 | 6.1e-20 |
| Mafk | GOBP_Response_To_Wounding | Mouse | Liver | rep_16 | 1.3e-13 |
| Mafk | GOBP_Wound_Healing | Mouse | Liver | rep_16 | 3.5e-11 |
| Mafk | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Lymph | MS-1 | 6.1e-11 |
| Mafk | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lymph | MS-1 | 1.8e-10 |
| Mafk | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Lymph | MS-1 | 2.2e-09 |
| Mafk | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Lung | rep_1 | 7.5e-20 |
| Mafk | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lung | rep_1 | 5.8e-10 |
| Mafk | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | HP_ad_rep7 | 3.3e-12 |
| Mafk | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | HP_ad_rep7 | 5.9e-11 |
| Mafk | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Brain | HP_ad_rep7 | 7.1e-13 |
| Mafk | GOBP_Response_To_Wounding | Mouse | Brain | HP_ad_rep7 | 4.3e-07 |
| Mafk | GOBP_Regulation_Of_Body_Fluid_Levels | Mouse | Brain | HP_polb_rep9 | 2.9e-10 |
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Mafk function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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Mafk function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication | ||
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Transcription factor for Mafk envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| MAFK | Uterus | early | Glandular | RICTOR,GOLGA8B,C8orf4, etc. | 0.342 |
| MAFK | Uterus | early | Glandular_secretory | RICTOR,GOLGA8B,C8orf4, etc. | 0.271 |
| MAFK | Uterus | early | SOX9_LGR5 | RICTOR,GOLGA8B,C8orf4, etc. | 0.364 |
| MAFK | Uterus | early | SOX9 | RICTOR,GOLGA8B,C8orf4, etc. | 0.456 |
| MAFK | Uterus | early_mid | Glandular | SPHK1,NFKB2,NR1D2, etc. | 0.402 |
| MAFK | Uterus | early_mid | Lumenal 1 | SPHK1,NFKB2,NR1D2, etc. | 0.478 |
| MAFK | Uterus | early_mid | Glandular_secretory | SPHK1,NFKB2,NR1D2, etc. | 0.271 |
| MAFK | Uterus | mid | Glandular_secretory | SLCO4A1,HARBI1,MSRA, etc. | 0.792 |
| MAFK | Uterus | late | Glandular_secretory | HIVEP2,ACTN4,VCL, etc. | 0.741 |
| MAFK | Uterus | late | Ciliated | HIVEP2,ACTN4,VCL, etc. | 0.297 |
| Mafk | Kidney | IRI | PT_S1 | Stab1,Tiparp,Snrpd1, etc. | 0.333 |
| Mafk | Kidney | IRI | PT_S3_C | Stab1,Tiparp,Snrpd1, etc. | 0.306 |
| Mafk | Kidney | IRI | PT_Fibrinogen | Stab1,Tiparp,Snrpd1, etc. | 0.304 |
| Mafk | Kidney | IRI | TAL | Stab1,Tiparp,Snrpd1, etc. | 0.271 |
| Mafk | Kidney | IRI | PT_S3_OS | Stab1,Tiparp,Snrpd1, etc. | 0.255 |
| MAFK | Uterus | proliferative | SOX9 | ST8SIA6,SAMD4B,OVOL1, etc. | 0.528 |
| MAFK | Uterus | proliferative | SOX9_LGR5 | ST8SIA6,SAMD4B,OVOL1, etc. | 0.359 |
| MAFK | Uterus | proliferative | SOX9_prolif | ST8SIA6,SAMD4B,OVOL1, etc. | 0.312 |
| Motif information. |
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Related Drugs for Mafk |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for Mafk |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
