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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Smad5 (spascer ID:17129)

Gene summary for Smad5

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Smad5
	Gene ID	17129
	Gene name	SMAD family member 5
	Synonyms	1110051M15Rik\|AI451355\|Dwf-C\|Madh5\|MusMLP
	Cytomap	13 B1\|13 30.12 cM
	Type of gene	protein-coding
	Description	mothers against decapentaplegic homolog 5MAD homolog 5Smad 5dwarfin-CmSmad5mothers against DPP homolog 5
	Modification date	20220508
	UniProtAcc	P97454

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Smad5	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	21873635	Function
Smad5	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	21873635	Function
Smad5	GO:0006357	regulation of transcription by RNA polymerase II	21873635	Process
Smad5	GO:0007179	transforming growth factor beta receptor signaling pathway	21873635	Process
Smad5	GO:0009653	anatomical structure morphogenesis	21873635	Process
Smad5	GO:0030154	cell differentiation	21873635	Process
Smad5	GO:0030509	BMP signaling pathway	21873635	Process
Smad5	GO:0060395	SMAD protein signal transduction	21873635	Process
Smad5	GO:0070411	I-SMAD binding	21873635	Function
Smad5	GO:0071144	heteromeric SMAD protein complex	21873635	Component

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Spatial pattern events for Smad5

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Smad5	Mouse	Brain	S4	34413515	2.43e-15
Smad5	Mouse	Brain	rep_1	35141374	4.27e-07
Smad5	Mouse	Kidney	rep_1	34853151	2.65e-06
Smad5	Mouse	Kidney	rep_3	34853151	9.08e-12
Smad5	Mouse	Brain	rep_1	33469025	1.30e-15
Smad5	Mouse	Brain	rep_1	35027729	2.98e-15
Smad5	Mouse	Brain	rep_2	35027729	4.23e-13
Smad5	Mouse	Brain	rep_3	35027729	2.38e-15
Smad5	Mouse	Brain	rep_4	35027729	2.37e-09
Smad5	Mouse	Brain	rep_5	35027729	3.22e-08
Smad5	Mouse	Intestine	rep_4	35149721	1.70e-09
Smad5	Mouse	Brain	rep_2	35210624	9.85e-06
Smad5	Mouse	Brain	rep_3	35210624	6.25e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Kidney_rep_1_H&E
Kidney_rep_3_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E

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Spatial pattern pathway has Smad5 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Smad5	GOBP_Bone_Development	Mouse	Spinal cord	CN94_E1	6.4e-06
Smad5	GOBP_Developmental_Process_Involved_In_Reproduction	Mouse	Spinal cord	CN94_E1	3.2e-07
Smad5	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Spinal cord	CN94_E1	4.4e-07
Smad5	GOBP_Gamete_Generation	Mouse	Spinal cord	CN94_E1	3.1e-07
Smad5	GOBP_Germ_Cell_Development	Mouse	Spinal cord	CN94_E1	6.4e-06
Smad5	GOBP_Heart_Process	Mouse	Spinal cord	CN94_E1	1.2e-06
Smad5	GOBP_Kidney_Epithelium_Development	Mouse	Spinal cord	CN94_E1	6.4e-07
Smad5	GOBP_Mesonephros_Development	Mouse	Spinal cord	CN94_E1	8.2e-08
Smad5	GOBP_Myeloid_Cell_Differentiation	Mouse	Spinal cord	CN94_E1	2.9e-06
Smad5	GOBP_Myeloid_Cell_Homeostasis	Mouse	Spinal cord	CN94_E1	8.0e-06
Smad5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Spinal cord	CN94_E1	1.6e-06
Smad5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	CN94_E1	6.2e-07
Smad5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	CN94_E1	2.2e-06
Smad5	GOBP_Ossification	Mouse	Spinal cord	CN94_E1	7.4e-06
Smad5	GOBP_Osteoblast_Differentiation	Mouse	Spinal cord	CN94_E1	9.0e-07
Smad5	GOBP_Positive_Regulation_Of_Cell_Differentiation	Mouse	Spinal cord	CN94_E1	3.3e-06
Smad5	GOBP_Positive_Regulation_Of_Transcription_From_Rna_Polymerase_Ii_Promoter_Involved_In_Cellular_Response_To_Chemical_Stimulus	Mouse	Spinal cord	CN94_E1	3.8e-07
Smad5	GOBP_Reproduction	Mouse	Spinal cord	CN94_E1	7.8e-08
Smad5	GOBP_Response_To_Bmp	Mouse	Spinal cord	CN94_E1	1.4e-08
Smad5	GOBP_Response_To_Endogenous_Stimulus	Mouse	Spinal cord	CN94_E1	2.2e-06
Smad5	GOBP_Response_To_Transforming_Growth_Factor_Beta	Mouse	Spinal cord	CN94_E1	1.5e-06
Smad5	GOBP_Skeletal_System_Development	Mouse	Spinal cord	CN94_E1	5.6e-06
Smad5	GOBP_Transmembrane_Receptor_Protein_Serine_Threonine_Kinase_Signaling_Pathway	Mouse	Spinal cord	CN94_E1	2.8e-08
Smad5	GOBP_Urogenital_System_Development	Mouse	Spinal cord	CN94_E1	2.7e-06
Smad5	GOBP_Cardiac_Muscle_Contraction	Mouse	Spinal cord	L7CN45_C1	1.4e-07
Smad5	GOBP_Cell_Fate_Commitment	Mouse	Spinal cord	L7CN45_C1	5.2e-07
Smad5	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Spinal cord	L7CN45_C1	8.6e-09
Smad5	GOBP_Cellular_Response_To_Organic_Cyclic_Compound	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Smad5	GOBP_Embryo_Development	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Smad5	GOBP_Embryonic_Pattern_Specification	Mouse	Spinal cord	L7CN45_C1	1.0e-06
Smad5	GOBP_Epithelium_Development	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Smad5	GOBP_Erythrocyte_Homeostasis	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Smad5	GOBP_Homeostatic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Smad5	GOBP_Immune_System_Development	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Smad5	GOBP_Multicellular_Organism_Reproduction	Mouse	Spinal cord	L7CN45_C1	7.1e-07
Smad5	GOBP_Pattern_Specification_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Smad5	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Smad5	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Smad5	GOBP_Regulation_Of_Osteoblast_Differentiation	Mouse	Spinal cord	L7CN45_C1	8.1e-07
Smad5	GOBP_Response_To_Growth_Factor	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Smad5	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Spinal cord	L7CN45_C1	6.3e-07
Smad5	GOBP_Smad_Protein_Signal_Transduction	Mouse	Spinal cord	L7CN45_C1	1.9e-08
Smad5	GOBP_Striated_Muscle_Contraction	Mouse	Spinal cord	L7CN45_C1	2.6e-06
Smad5	GOBP_Transforming_Growth_Factor_Beta_Receptor_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	7.4e-07
Smad5	GOBP_Tube_Development	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Smad5	GOBP_Anatomical_Structure_Regression	Mouse	Spinal cord	L7CN47_C1	7.4e-06
Smad5	GOBP_Male_Sex_Differentiation	Mouse	Spinal cord	L7CN47_C1	4.2e-06
Smad5	GOBP_Connective_Tissue_Development	Mouse	Spinal cord	L7CN97_E2	8.6e-06
Smad5	GOBP_Positive_Regulation_Of_Osteoblast_Differentiation	Mouse	Spinal cord	L7CN97_E2	3.5e-06
Smad5	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Spinal cord	L8CN11_C1	7.5e-11
Smad5	GOBP_Cartilage_Development	Mouse	Spinal cord	L8CN17_E1	4.8e-07
Smad5	GOBP_Circulatory_System_Process	Mouse	Spinal cord	L8CN17_E1	2.2e-06
Smad5	GOBP_Anatomical_Structure_Regression	Mouse	Brain	rep_21	1.3e-05
Smad5	GOBP_Gamete_Generation	Mouse	Brain	rep_27	5.2e-05
Smad5	GOBP_Germ_Cell_Development	Mouse	Brain	rep_27	9.0e-05
Smad5	GOBP_Homeostasis_Of_Number_Of_Cells	Mouse	Brain	rep_27	7.1e-09
Smad5	GOBP_Kidney_Epithelium_Development	Mouse	Brain	rep_27	4.5e-09
Smad5	GOBP_Myeloid_Cell_Homeostasis	Mouse	Brain	rep_27	8.3e-07
Smad5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_27	7.2e-05
Smad5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_27	2.8e-05
Smad5	GOBP_Pattern_Specification_Process	Mouse	Brain	rep_27	3.2e-09
Smad5	GOBP_Positive_Regulation_Of_Osteoblast_Differentiation	Mouse	Brain	rep_27	7.5e-05
Smad5	GOBP_Urogenital_System_Development	Mouse	Brain	rep_27	1.1e-05
Smad5	GOBP_Embryonic_Pattern_Specification	Mouse	Brain	rep_41	4.0e-05
Smad5	GOBP_Smad_Protein_Signal_Transduction	Mouse	Brain	rep_71	1.3e-05
Smad5	GOBP_Connective_Tissue_Development	Mouse	Brain	rep_72	9.7e-06
Smad5	GOBP_Cardiac_Muscle_Contraction	Mouse	Brain	rep_1	1.1e-68
Smad5	GOBP_Cartilage_Development	Mouse	Brain	rep_1	1.2e-11
Smad5	GOBP_Embryonic_Pattern_Specification	Mouse	Brain	rep_1	1.0e-12
Smad5	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Brain	rep_1	9.9e-07
Smad5	GOBP_Muscle_Contraction	Mouse	Brain	rep_1	6.0e-18
Smad5	GOBP_Muscle_System_Process	Mouse	Brain	rep_1	8.3e-21
Smad5	GOBP_Positive_Regulation_Of_Cell_Differentiation	Mouse	Brain	rep_1	3.9e-15
Smad5	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_1	2.5e-12
Smad5	GOBP_Positive_Regulation_Of_Osteoblast_Differentiation	Mouse	Brain	rep_1	7.9e-30
Smad5	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_1	1.6e-17
Smad5	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Brain	rep_1	2.3e-15
Smad5	GOBP_Striated_Muscle_Contraction	Mouse	Brain	rep_1	7.5e-58
Smad5	GOBP_Bone_Development	Mouse	Brain	rep_3	4.6e-171
Smad5	GOBP_Cell_Fate_Commitment	Mouse	Brain	rep_3	8.8e-182
Smad5	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Brain	rep_3	3.6e-171
Smad5	GOBP_Cellular_Response_To_Organic_Cyclic_Compound	Mouse	Brain	rep_3	1.3e-60
Smad5	GOBP_Circulatory_System_Process	Mouse	Brain	rep_3	2.0e-61
Smad5	GOBP_Connective_Tissue_Development	Mouse	Brain	rep_3	3.3e-172
Smad5	GOBP_Developmental_Process_Involved_In_Reproduction	Mouse	Brain	rep_3	2.9e-159
Smad5	GOBP_Embryo_Development	Mouse	Brain	rep_3	1.3e-126
Smad5	GOBP_Epithelium_Development	Mouse	Brain	rep_3	8.3e-102
Smad5	GOBP_Erythrocyte_Homeostasis	Mouse	Brain	rep_3	2.5e-197
Smad5	GOBP_Gamete_Generation	Mouse	Brain	rep_3	1.3e-194
Smad5	GOBP_Germ_Cell_Development	Mouse	Brain	rep_3	7.6e-194
Smad5	GOBP_Heart_Process	Mouse	Brain	rep_3	1.6e-34
Smad5	GOBP_Homeostasis_Of_Number_Of_Cells	Mouse	Brain	rep_3	1.3e-214
Smad5	GOBP_Immune_System_Development	Mouse	Brain	rep_3	1.3e-52
Smad5	GOBP_Kidney_Epithelium_Development	Mouse	Brain	rep_3	6.3e-143
Smad5	GOBP_Male_Sex_Differentiation	Mouse	Brain	rep_3	4.2e-151
Smad5	GOBP_Mesonephros_Development	Mouse	Brain	rep_3	3.0e-65
Smad5	GOBP_Multicellular_Organism_Reproduction	Mouse	Brain	rep_3	1.2e-58
Smad5	GOBP_Myeloid_Cell_Differentiation	Mouse	Brain	rep_3	1.8e-21
Smad5	GOBP_Myeloid_Cell_Homeostasis	Mouse	Brain	rep_3	1.6e-197
Smad5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_3	1.4e-196
Smad5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_3	9.4e-206
Smad5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_3	7.5e-168
Smad5	GOBP_Ossification	Mouse	Brain	rep_3	6.7e-28
Smad5	GOBP_Osteoblast_Differentiation	Mouse	Brain	rep_3	7.4e-84
Smad5	GOBP_Pattern_Specification_Process	Mouse	Brain	rep_3	1.6e-118
Smad5	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Brain	rep_3	9.3e-50
Smad5	GOBP_Positive_Regulation_Of_Transcription_From_Rna_Polymerase_Ii_Promoter_Involved_In_Cellular_Response_To_Chemical_Stimulus	Mouse	Brain	rep_3	1.2e-79
Smad5	GOBP_Regulation_Of_Osteoblast_Differentiation	Mouse	Brain	rep_3	1.2e-161
Smad5	GOBP_Reproduction	Mouse	Brain	rep_3	3.4e-125
Smad5	GOBP_Response_To_Bmp	Mouse	Brain	rep_3	6.5e-174
Smad5	GOBP_Response_To_Endogenous_Stimulus	Mouse	Brain	rep_3	6.4e-96
Smad5	GOBP_Response_To_Growth_Factor	Mouse	Brain	rep_3	2.7e-45
Smad5	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Brain	rep_3	3.4e-98
Smad5	GOBP_Sex_Differentiation	Mouse	Brain	rep_3	6.9e-174
Smad5	GOBP_Skeletal_System_Development	Mouse	Brain	rep_3	3.3e-190
Smad5	GOBP_Smad_Protein_Signal_Transduction	Mouse	Brain	rep_3	1.2e-66
Smad5	GOBP_Transforming_Growth_Factor_Beta_Receptor_Signaling_Pathway	Mouse	Brain	rep_3	5.2e-55
Smad5	GOBP_Transmembrane_Receptor_Protein_Serine_Threonine_Kinase_Signaling_Pathway	Mouse	Brain	rep_3	2.7e-106
Smad5	GOBP_Tube_Development	Mouse	Brain	rep_3	9.0e-136
Smad5	GOBP_Urogenital_System_Development	Mouse	Brain	rep_3	2.4e-187
Smad5	GOBP_Homeostatic_Process	Mouse	Brain	rep_7	2.5e-13
Smad5	GOBP_Response_To_Transforming_Growth_Factor_Beta	Mouse	Brain	rep_7	1.1e-15
Smad5	GOBP_Anatomical_Structure_Regression	Mouse	Embryo	rep_6	2.3e-32
Smad5	GOBP_Bone_Development	Mouse	Embryo	rep_6	8.5e-14
Smad5	GOBP_Cartilage_Development	Mouse	Embryo	rep_6	6.1e-26
Smad5	GOBP_Connective_Tissue_Development	Mouse	Embryo	rep_6	1.0e-16
Smad5	GOBP_Kidney_Epithelium_Development	Mouse	Embryo	rep_6	6.9e-12
Smad5	GOBP_Mesonephros_Development	Mouse	Embryo	rep_6	1.3e-16
Smad5	GOBP_Response_To_Bmp	Mouse	Embryo	rep_6	1.1e-16
Smad5	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Embryo	rep_14	4.3e-09
Smad5	GOBP_Embryonic_Pattern_Specification	Mouse	Embryo	rep_14	4.8e-42
Smad5	GOBP_Erythrocyte_Homeostasis	Mouse	Embryo	rep_14	1.9e-23
Smad5	GOBP_Gamete_Generation	Mouse	Embryo	rep_14	6.5e-07
Smad5	GOBP_Germ_Cell_Development	Mouse	Embryo	rep_14	2.1e-19
Smad5	GOBP_Homeostasis_Of_Number_Of_Cells	Mouse	Embryo	rep_14	2.7e-16
Smad5	GOBP_Male_Sex_Differentiation	Mouse	Embryo	rep_14	5.8e-13
Smad5	GOBP_Multicellular_Organism_Reproduction	Mouse	Embryo	rep_14	5.9e-07
Smad5	GOBP_Muscle_Contraction	Mouse	Embryo	rep_14	1.7e-07
Smad5	GOBP_Myeloid_Cell_Differentiation	Mouse	Embryo	rep_14	1.3e-11
Smad5	GOBP_Myeloid_Cell_Homeostasis	Mouse	Embryo	rep_14	4.1e-22
Smad5	GOBP_Positive_Regulation_Of_Transcription_From_Rna_Polymerase_Ii_Promoter_Involved_In_Cellular_Response_To_Chemical_Stimulus	Mouse	Embryo	rep_14	1.6e-45
Smad5	GOBP_Sex_Differentiation	Mouse	Embryo	rep_14	1.7e-14
Smad5	GOBP_Cell_Fate_Commitment	Mouse	Embryo	rep_1	6.8e-22
Smad5	GOBP_Epithelium_Development	Mouse	Embryo	rep_1	1.7e-09
Smad5	GOBP_Erythrocyte_Homeostasis	Mouse	Embryo	rep_1	2.4e-98
Smad5	GOBP_Homeostasis_Of_Number_Of_Cells	Mouse	Embryo	rep_1	1.7e-89
Smad5	GOBP_Homeostatic_Process	Mouse	Embryo	rep_1	2.0e-30
Smad5	GOBP_Immune_System_Development	Mouse	Embryo	rep_1	0.0e+00
Smad5	GOBP_Kidney_Epithelium_Development	Mouse	Embryo	rep_1	1.6e-223
Smad5	GOBP_Mesonephros_Development	Mouse	Embryo	rep_1	9.5e-09
Smad5	GOBP_Myeloid_Cell_Differentiation	Mouse	Embryo	rep_1	2.4e-139
Smad5	GOBP_Myeloid_Cell_Homeostasis	Mouse	Embryo	rep_1	2.7e-63
Smad5	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Embryo	rep_1	5.0e-13
Smad5	GOBP_Positive_Regulation_Of_Transcription_From_Rna_Polymerase_Ii_Promoter_Involved_In_Cellular_Response_To_Chemical_Stimulus	Mouse	Embryo	rep_1	0.0e+00
Smad5	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Embryo	rep_1	2.5e-19
Smad5	GOBP_Sex_Differentiation	Mouse	Embryo	rep_1	7.0e-66
Smad5	GOBP_Urogenital_System_Development	Mouse	Embryo	rep_1	1.8e-45
Smad5	GOBP_Anatomical_Structure_Regression	Mouse	Embryo	rep_2	0.0e+00
Smad5	GOBP_Bone_Development	Mouse	Embryo	rep_2	1.6e-238
Smad5	GOBP_Germ_Cell_Development	Mouse	Embryo	rep_2	2.4e-67
Smad5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Embryo	rep_2	8.0e-13
Smad5	GOBP_Ossification	Mouse	Embryo	rep_2	6.7e-25
Smad5	GOBP_Osteoblast_Differentiation	Mouse	Embryo	rep_2	8.5e-10
Smad5	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Embryo	rep_3	6.9e-27
Smad5	GOBP_Embryo_Development	Mouse	Embryo	rep_3	1.2e-173
Smad5	GOBP_Embryonic_Pattern_Specification	Mouse	Embryo	rep_3	0.0e+00
Smad5	GOBP_Gamete_Generation	Mouse	Embryo	rep_3	2.1e-220
Smad5	GOBP_Multicellular_Organism_Reproduction	Mouse	Embryo	rep_3	8.7e-222
Smad5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	1.5e-267
Smad5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
Smad5	GOBP_Pattern_Specification_Process	Mouse	Embryo	rep_3	2.8e-168
Smad5	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	0.0e+00
Smad5	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
Smad5	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Embryo	rep_3	6.3e-72
Smad5	GOBP_Positive_Regulation_Of_Cell_Differentiation	Mouse	Embryo	rep_5	5.2e-15
Smad5	GOBP_Response_To_Endogenous_Stimulus	Mouse	Embryo	rep_6	2.0e-17
Smad5	GOBP_Skeletal_System_Development	Mouse	Embryo	rep_6	3.1e-59
Smad5	GOBP_Circulatory_System_Process	Mouse	Kidney	IRI	1.5e-08
Smad5	GOBP_Mesonephros_Development	Mouse	Kidney	IRI	5.8e-44
Smad5	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Kidney	Nep	4.4e-12
Smad5	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Kidney	Nep	5.6e-37
Smad5	GOBP_Response_To_Endogenous_Stimulus	Mouse	Kidney	Nep	6.3e-23
Smad5	GOBP_Tube_Development	Mouse	Kidney	Nep	5.6e-37
Smad5	GOBP_Anatomical_Structure_Regression	Mouse	Kidney	rep_2	3.7e-47
Smad5	GOBP_Bone_Development	Mouse	Kidney	rep_2	4.4e-35
Smad5	GOBP_Cardiac_Muscle_Contraction	Mouse	Kidney	rep_2	8.5e-125
Smad5	GOBP_Cell_Fate_Commitment	Mouse	Kidney	rep_2	1.1e-65
Smad5	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Kidney	rep_2	1.1e-18
Smad5	GOBP_Cellular_Response_To_Organic_Cyclic_Compound	Mouse	Kidney	rep_2	2.5e-50
Smad5	GOBP_Circulatory_System_Process	Mouse	Kidney	rep_2	1.4e-100
Smad5	GOBP_Connective_Tissue_Development	Mouse	Kidney	rep_2	9.8e-08
Smad5	GOBP_Developmental_Process_Involved_In_Reproduction	Mouse	Kidney	rep_2	3.6e-46
Smad5	GOBP_Embryo_Development	Mouse	Kidney	rep_2	7.4e-46
Smad5	GOBP_Embryonic_Pattern_Specification	Mouse	Kidney	rep_2	1.2e-21
Smad5	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Kidney	rep_2	1.5e-13
Smad5	GOBP_Epithelium_Development	Mouse	Kidney	rep_2	3.5e-92
Smad5	GOBP_Gamete_Generation	Mouse	Kidney	rep_2	5.0e-33
Smad5	GOBP_Germ_Cell_Development	Mouse	Kidney	rep_2	1.5e-12
Smad5	GOBP_Heart_Process	Mouse	Kidney	rep_2	9.4e-105
Smad5	GOBP_Homeostatic_Process	Mouse	Kidney	rep_2	2.2e-10
Smad5	GOBP_Immune_System_Development	Mouse	Kidney	rep_2	4.6e-22
Smad5	GOBP_Kidney_Epithelium_Development	Mouse	Kidney	rep_2	4.2e-66
Smad5	GOBP_Male_Sex_Differentiation	Mouse	Kidney	rep_2	5.6e-14
Smad5	GOBP_Mesonephros_Development	Mouse	Kidney	rep_2	9.0e-31
Smad5	GOBP_Multicellular_Organism_Reproduction	Mouse	Kidney	rep_2	1.6e-53
Smad5	GOBP_Muscle_Contraction	Mouse	Kidney	rep_2	1.1e-89
Smad5	GOBP_Muscle_System_Process	Mouse	Kidney	rep_2	1.2e-86
Smad5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Kidney	rep_2	7.3e-42
Smad5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	7.7e-30
Smad5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	2.2e-14
Smad5	GOBP_Ossification	Mouse	Kidney	rep_2	3.5e-66
Smad5	GOBP_Osteoblast_Differentiation	Mouse	Kidney	rep_2	1.6e-54
Smad5	GOBP_Pattern_Specification_Process	Mouse	Kidney	rep_2	2.3e-36
Smad5	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Kidney	rep_2	3.1e-09
Smad5	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	4.5e-10
Smad5	GOBP_Positive_Regulation_Of_Osteoblast_Differentiation	Mouse	Kidney	rep_2	2.8e-22
Smad5	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	8.3e-40
Smad5	GOBP_Positive_Regulation_Of_Transcription_From_Rna_Polymerase_Ii_Promoter_Involved_In_Cellular_Response_To_Chemical_Stimulus	Mouse	Kidney	rep_2	4.9e-27
Smad5	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Kidney	rep_2	2.6e-14
Smad5	GOBP_Regulation_Of_Osteoblast_Differentiation	Mouse	Kidney	rep_2	9.1e-24
Smad5	GOBP_Reproduction	Mouse	Kidney	rep_2	9.0e-46
Smad5	GOBP_Response_To_Bmp	Mouse	Kidney	rep_2	2.5e-29
Smad5	GOBP_Response_To_Endogenous_Stimulus	Mouse	Kidney	rep_2	1.1e-44
Smad5	GOBP_Response_To_Growth_Factor	Mouse	Kidney	rep_2	4.7e-31
Smad5	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Kidney	rep_2	1.3e-60
Smad5	GOBP_Sex_Differentiation	Mouse	Kidney	rep_2	4.6e-19
Smad5	GOBP_Skeletal_System_Development	Mouse	Kidney	rep_2	7.5e-46
Smad5	GOBP_Striated_Muscle_Contraction	Mouse	Kidney	rep_2	1.9e-162
Smad5	GOBP_Tube_Development	Mouse	Kidney	rep_2	1.2e-129
Smad5	GOBP_Urogenital_System_Development	Mouse	Kidney	rep_2	2.5e-57
Smad5	GOBP_Positive_Regulation_Of_Osteoblast_Differentiation	Mouse	Liver	CN16-D2	4.8e-08
Smad5	GOBP_Anatomical_Structure_Regression	Mouse	Liver	CN16-E1	4.9e-10
Smad5	GOBP_Embryonic_Pattern_Specification	Mouse	Liver	CN16-E1	9.0e-09
Smad5	GOBP_Smad_Protein_Signal_Transduction	Mouse	Liver	CN16-E1	3.7e-19
Smad5	GOBP_Immune_System_Development	Mouse	Liver	CN73-C1	2.2e-07
Smad5	GOBP_Skeletal_System_Development	Mouse	Liver	CN73-C1	9.4e-07
Smad5	GOBP_Anatomical_Structure_Regression	Mouse	Liver	rep_15	4.4e-07
Smad5	GOBP_Muscle_System_Process	Mouse	Liver	rep_15	9.3e-22
Smad5	GOBP_Immune_System_Development	Mouse	Liver	rep_16	5.3e-11
Smad5	GOBP_Pattern_Specification_Process	Mouse	Liver	rep_16	3.6e-20
Smad5	GOBP_Positive_Regulation_Of_Cell_Differentiation	Mouse	Liver	rep_16	4.7e-08
Smad5	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Liver	rep_16	3.6e-08
Smad5	GOBP_Smad_Protein_Signal_Transduction	Mouse	Liver	rep_16	8.7e-12
Smad5	GOBP_Bone_Development	Mouse	Lymph	MS-1	5.9e-11
Smad5	GOBP_Cardiac_Muscle_Contraction	Mouse	Lymph	MS-1	1.1e-08
Smad5	GOBP_Cartilage_Development	Mouse	Lymph	MS-1	1.7e-14
Smad5	GOBP_Cell_Fate_Commitment	Mouse	Lymph	MS-1	2.1e-11
Smad5	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Lymph	MS-1	2.1e-08
Smad5	GOBP_Cellular_Response_To_Organic_Cyclic_Compound	Mouse	Lymph	MS-1	4.3e-09
Smad5	GOBP_Circulatory_System_Process	Mouse	Lymph	MS-1	3.9e-08
Smad5	GOBP_Connective_Tissue_Development	Mouse	Lymph	MS-1	1.4e-07
Smad5	GOBP_Developmental_Process_Involved_In_Reproduction	Mouse	Lymph	MS-1	2.2e-10
Smad5	GOBP_Embryo_Development	Mouse	Lymph	MS-1	2.5e-08
Smad5	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Lymph	MS-1	1.6e-14
Smad5	GOBP_Epithelium_Development	Mouse	Lymph	MS-1	8.5e-09
Smad5	GOBP_Erythrocyte_Homeostasis	Mouse	Lymph	MS-1	4.6e-10
Smad5	GOBP_Gamete_Generation	Mouse	Lymph	MS-1	7.7e-08
Smad5	GOBP_Germ_Cell_Development	Mouse	Lymph	MS-1	4.9e-12
Smad5	GOBP_Heart_Process	Mouse	Lymph	MS-1	1.3e-13
Smad5	GOBP_Homeostasis_Of_Number_Of_Cells	Mouse	Lymph	MS-1	3.0e-13
Smad5	GOBP_Homeostatic_Process	Mouse	Lymph	MS-1	2.3e-12
Smad5	GOBP_Immune_System_Development	Mouse	Lymph	MS-1	1.2e-13
Smad5	GOBP_Kidney_Epithelium_Development	Mouse	Lymph	MS-1	2.3e-09
Smad5	GOBP_Male_Sex_Differentiation	Mouse	Lymph	MS-1	5.2e-09
Smad5	GOBP_Mesonephros_Development	Mouse	Lymph	MS-1	6.4e-10
Smad5	GOBP_Multicellular_Organism_Reproduction	Mouse	Lymph	MS-1	1.1e-09
Smad5	GOBP_Muscle_Contraction	Mouse	Lymph	MS-1	3.4e-09
Smad5	GOBP_Muscle_System_Process	Mouse	Lymph	MS-1	1.6e-08
Smad5	GOBP_Myeloid_Cell_Differentiation	Mouse	Lymph	MS-1	1.9e-13
Smad5	GOBP_Myeloid_Cell_Homeostasis	Mouse	Lymph	MS-1	4.6e-10
Smad5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lymph	MS-1	6.1e-11
Smad5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	1.8e-10
Smad5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	2.2e-09
Smad5	GOBP_Ossification	Mouse	Lymph	MS-1	3.4e-11
Smad5	GOBP_Osteoblast_Differentiation	Mouse	Lymph	MS-1	7.1e-09
Smad5	GOBP_Pattern_Specification_Process	Mouse	Lymph	MS-1	3.9e-12
Smad5	GOBP_Positive_Regulation_Of_Cell_Differentiation	Mouse	Lymph	MS-1	2.3e-12
Smad5	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Lymph	MS-1	8.9e-15
Smad5	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	4.4e-12
Smad5	GOBP_Positive_Regulation_Of_Osteoblast_Differentiation	Mouse	Lymph	MS-1	7.1e-17
Smad5	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	1.7e-12
Smad5	GOBP_Positive_Regulation_Of_Transcription_From_Rna_Polymerase_Ii_Promoter_Involved_In_Cellular_Response_To_Chemical_Stimulus	Mouse	Lymph	MS-1	2.5e-09
Smad5	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Lymph	MS-1	1.3e-14
Smad5	GOBP_Regulation_Of_Osteoblast_Differentiation	Mouse	Lymph	MS-1	5.4e-11
Smad5	GOBP_Reproduction	Mouse	Lymph	MS-1	1.1e-09
Smad5	GOBP_Response_To_Bmp	Mouse	Lymph	MS-1	2.8e-10
Smad5	GOBP_Response_To_Endogenous_Stimulus	Mouse	Lymph	MS-1	3.9e-13
Smad5	GOBP_Response_To_Growth_Factor	Mouse	Lymph	MS-1	2.1e-10
Smad5	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Lymph	MS-1	1.9e-09
Smad5	GOBP_Response_To_Transforming_Growth_Factor_Beta	Mouse	Lymph	MS-1	2.3e-15
Smad5	GOBP_Sex_Differentiation	Mouse	Lymph	MS-1	4.7e-12
Smad5	GOBP_Skeletal_System_Development	Mouse	Lymph	MS-1	2.6e-12
Smad5	GOBP_Smad_Protein_Signal_Transduction	Mouse	Lymph	MS-1	3.5e-17
Smad5	GOBP_Striated_Muscle_Contraction	Mouse	Lymph	MS-1	1.1e-09
Smad5	GOBP_Transforming_Growth_Factor_Beta_Receptor_Signaling_Pathway	Mouse	Lymph	MS-1	6.5e-08
Smad5	GOBP_Transmembrane_Receptor_Protein_Serine_Threonine_Kinase_Signaling_Pathway	Mouse	Lymph	MS-1	3.2e-11
Smad5	GOBP_Tube_Development	Mouse	Lymph	MS-1	4.6e-09
Smad5	GOBP_Urogenital_System_Development	Mouse	Lymph	MS-1	5.4e-09
Smad5	GOBP_Cartilage_Development	Mouse	Lung	rep_1	1.8e-13
Smad5	GOBP_Connective_Tissue_Development	Mouse	Lung	rep_1	2.6e-08
Smad5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lung	rep_1	7.5e-20
Smad5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lung	rep_1	5.8e-10
Smad5	GOBP_Positive_Regulation_Of_Osteoblast_Differentiation	Mouse	Lung	rep_1	5.7e-10
Smad5	GOBP_Reproduction	Mouse	Lung	rep_1	9.6e-12
Smad5	GOBP_Response_To_Endogenous_Stimulus	Mouse	Lung	rep_1	2.0e-30
Smad5	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Lung	rep_1	5.0e-17
Smad5	GOBP_Transforming_Growth_Factor_Beta_Receptor_Signaling_Pathway	Mouse	Lung	rep_1	1.9e-09
Smad5	GOBP_Pattern_Specification_Process	Mouse	Brain	rep_7	1.0e-12
Smad5	GOBP_Urogenital_System_Development	Mouse	Brain	rep_7	8.1e-17
Smad5	GOBP_Regulation_Of_Osteoblast_Differentiation	Mouse	Brain	HP_ad_rep2	7.9e-07
Smad5	GOBP_Positive_Regulation_Of_Osteoblast_Differentiation	Mouse	Brain	HP_ad_rep3	1.7e-15
Smad5	GOBP_Bone_Development	Mouse	Brain	HP_ad_rep7	5.0e-14
Smad5	GOBP_Cell_Fate_Commitment	Mouse	Brain	HP_ad_rep7	1.5e-09
Smad5	GOBP_Cellular_Process_Involved_In_Reproduction_In_Multicellular_Organism	Mouse	Brain	HP_ad_rep7	6.0e-15
Smad5	GOBP_Cellular_Response_To_Organic_Cyclic_Compound	Mouse	Brain	HP_ad_rep7	2.6e-09
Smad5	GOBP_Connective_Tissue_Development	Mouse	Brain	HP_ad_rep7	1.6e-08
Smad5	GOBP_Developmental_Process_Involved_In_Reproduction	Mouse	Brain	HP_ad_rep7	2.5e-08
Smad5	GOBP_Embryonic_Pattern_Specification	Mouse	Brain	HP_ad_rep7	7.4e-11
Smad5	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	2.5e-10
Smad5	GOBP_Epithelium_Development	Mouse	Brain	HP_ad_rep7	2.8e-08
Smad5	GOBP_Erythrocyte_Homeostasis	Mouse	Brain	HP_ad_rep7	1.9e-11
Smad5	GOBP_Gamete_Generation	Mouse	Brain	HP_ad_rep7	1.3e-11
Smad5	GOBP_Germ_Cell_Development	Mouse	Brain	HP_ad_rep7	3.3e-13
Smad5	GOBP_Homeostasis_Of_Number_Of_Cells	Mouse	Brain	HP_ad_rep7	3.4e-11
Smad5	GOBP_Immune_System_Development	Mouse	Brain	HP_ad_rep7	8.3e-09
Smad5	GOBP_Kidney_Epithelium_Development	Mouse	Brain	HP_ad_rep7	1.1e-25
Smad5	GOBP_Male_Sex_Differentiation	Mouse	Brain	HP_ad_rep7	5.6e-07
Smad5	GOBP_Mesonephros_Development	Mouse	Brain	HP_ad_rep7	2.1e-17
Smad5	GOBP_Multicellular_Organism_Reproduction	Mouse	Brain	HP_ad_rep7	6.1e-08
Smad5	GOBP_Myeloid_Cell_Differentiation	Mouse	Brain	HP_ad_rep7	1.2e-09
Smad5	GOBP_Myeloid_Cell_Homeostasis	Mouse	Brain	HP_ad_rep7	9.6e-10
Smad5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.3e-12
Smad5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-11
Smad5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.1e-13
Smad5	GOBP_Ossification	Mouse	Brain	HP_ad_rep7	2.8e-09
Smad5	GOBP_Pattern_Specification_Process	Mouse	Brain	HP_ad_rep7	2.1e-10
Smad5	GOBP_Positive_Regulation_Of_Cell_Differentiation	Mouse	Brain	HP_ad_rep7	3.3e-07
Smad5	GOBP_Positive_Regulation_Of_Developmental_Process	Mouse	Brain	HP_ad_rep7	4.0e-07
Smad5	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-11
Smad5	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.3e-11
Smad5	GOBP_Positive_Regulation_Of_Transcription_From_Rna_Polymerase_Ii_Promoter_Involved_In_Cellular_Response_To_Chemical_Stimulus	Mouse	Brain	HP_ad_rep7	8.4e-07
Smad5	GOBP_Reproduction	Mouse	Brain	HP_ad_rep7	7.9e-09
Smad5	GOBP_Response_To_Bmp	Mouse	Brain	HP_ad_rep7	1.4e-10
Smad5	GOBP_Response_To_Endogenous_Stimulus	Mouse	Brain	HP_ad_rep7	6.3e-10
Smad5	GOBP_Response_To_Growth_Factor	Mouse	Brain	HP_ad_rep7	3.5e-10
Smad5	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Brain	HP_ad_rep7	1.4e-09
Smad5	GOBP_Response_To_Transforming_Growth_Factor_Beta	Mouse	Brain	HP_ad_rep7	3.1e-09
Smad5	GOBP_Sex_Differentiation	Mouse	Brain	HP_ad_rep7	6.4e-09
Smad5	GOBP_Skeletal_System_Development	Mouse	Brain	HP_ad_rep7	3.7e-09
Smad5	GOBP_Tube_Development	Mouse	Brain	HP_ad_rep7	2.0e-08
Smad5	GOBP_Urogenital_System_Development	Mouse	Brain	HP_ad_rep7	3.6e-14
Smad5	GOBP_Cartilage_Development	Mouse	Brain	HP_polb_rep9	8.8e-17
Smad5	GOBP_Circulatory_System_Process	Mouse	Brain	HP_polb_rep9	5.3e-09
Smad5	GOBP_Embryo_Development	Mouse	Brain	HP_polb_rep9	1.5e-10
Smad5	GOBP_Heart_Process	Mouse	Brain	HP_polb_rep9	9.9e-09
Smad5	GOBP_Homeostatic_Process	Mouse	Brain	HP_polb_rep9	6.4e-11
Smad5	GOBP_Muscle_Contraction	Mouse	Brain	HP_polb_rep9	8.1e-07
Smad5	GOBP_Osteoblast_Differentiation	Mouse	Brain	HP_polb_rep9	5.2e-09
Smad5	GOBP_Regulation_Of_Cell_Differentiation	Mouse	Brain	HP_polb_rep9	6.5e-09
Smad5	GOBP_Smad_Protein_Signal_Transduction	Mouse	Brain	HP_polb_rep9	2.0e-15
Smad5	GOBP_Striated_Muscle_Contraction	Mouse	Brain	HP_polb_rep9	2.7e-07
Smad5	GOBP_Transforming_Growth_Factor_Beta_Receptor_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	5.1e-12
Smad5	GOBP_Transmembrane_Receptor_Protein_Serine_Threonine_Kinase_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	4.8e-12

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Smad5 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Smad5 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Smad5 envolved

Transcription factor analysis using single cell data.

TF	Tissue	Group	Cell types	Target genes	Rss score
SMAD5	Uterus	early	Glandular	XPNPEP3,ATXN7L3,ADAP1, etc.	0.33
SMAD5	Uterus	early	Glandular_secretory	XPNPEP3,ATXN7L3,ADAP1, etc.	0.269
SMAD5	Uterus	early	SOX9_LGR5	XPNPEP3,ATXN7L3,ADAP1, etc.	0.353
SMAD5	Uterus	early	SOX9	XPNPEP3,ATXN7L3,ADAP1, etc.	0.421
SMAD5	Uterus	early_mid	Glandular	TNRC6B,ZER1,PLEKHA2, etc.	0.364
SMAD5	Uterus	early_mid	Lumenal 1	TNRC6B,ZER1,PLEKHA2, etc.	0.478
SMAD5	Uterus	early_mid	Glandular_secretory	TNRC6B,ZER1,PLEKHA2, etc.	0.263
SMAD5	Uterus	early_mid	Ciliated	TNRC6B,ZER1,PLEKHA2, etc.	0.278
SMAD5	Uterus	late	Glandular_secretory	ATL3,ANTXR2,KBTBD6, etc.	0.743
SMAD5	Uterus	late	Ciliated	ATL3,ANTXR2,KBTBD6, etc.	0.293
SMAD5	Uterus	proliferative	SOX9	ZMIZ2,MPZL3,RNF121, etc.	0.581
SMAD5	Uterus	proliferative	Ciliated	ZMIZ2,MPZL3,RNF121, etc.	0.252
SMAD5	Uterus	proliferative	SOX9_LGR5	ZMIZ2,MPZL3,RNF121, etc.	0.302
SMAD5	Uterus	proliferative	SOX9_prolif	ZMIZ2,MPZL3,RNF121, etc.	0.313

Motif information.

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Related Drugs for Smad5

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Smad5

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Smad5	C0009171	Cocaine Abuse	1	CTD_human
Smad5	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Smad5	C0036341	Schizophrenia	1	PSYGENET
Smad5	C0038587	Substance Withdrawal Syndrome	1	CTD_human
Smad5	C0086189	Drug Withdrawal Symptoms	1	CTD_human
Smad5	C0087169	Withdrawal Symptoms	1	CTD_human
Smad5	C0236736	Cocaine-Related Disorders	1	CTD_human
Smad5	C0600427	Cocaine Dependence	1	CTD_human