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Spatial pattern gene: Mxd4 (spascer ID:17122) |
Gene summary for Mxd4 |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Mxd4 | Gene ID | 17122 |
| Gene name | Max dimerization protein 4 |
| Synonyms | 2810410A03Rik|Mad4|bHLHc12 |
| Cytomap | 5 B2|5 17.84 cM |
| Type of gene | protein-coding |
| Description | max dimerization protein 4max dimerizer 4max-associated protein 4max-interacting transcriptional repressor MAD4 |
| Modification date | 20220428 |
| UniProtAcc | Q60948 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Mxd4 | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 21873635 | Function |
| Mxd4 | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | 21873635 | Function |
| Mxd4 | GO:0006357 | regulation of transcription by RNA polymerase II | 21873635 | Process |
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Spatial pattern events for Mxd4 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Mxd4 | Mouse | Brain | S1 | 34413515 | 2.07e-15 |
| Mxd4 | Mouse | Brain | S2 | 34413515 | 1.36e-11 |
| Mxd4 | Mouse | Brain | S3 | 34413515 | 9.08e-14 |
| Mxd4 | Mouse | Brain | S6 | 34413515 | 5.07e-15 |
| Mxd4 | Mouse | Brain | S7 | 34413515 | 2.04e-13 |
| Mxd4 | Mouse | Brain | rep_2 | 35141374 | 3.95e-08 |
| Mxd4 | Mouse | Brain | rep_4 | 35141374 | 3.76e-12 |
| Mxd4 | Mouse | Brain | rep_5 | 35141374 | 2.02e-14 |
| Mxd4 | Mouse | Embryo | rep_3 | 33188776 | 5.13e-07 |
| Mxd4 | Mouse | Embryo | rep_4 | 33188776 | 2.20e-10 |
| Mxd4 | Mouse | Embryo | rep_7 | 33188776 | 1.53e-13 |
| Mxd4 | Mouse | Embryo | rep_12 | 33188776 | 4.58e-10 |
| Mxd4 | Mouse | Embryo | rep_13 | 33188776 | 2.69e-07 |
| Mxd4 | Mouse | Kidney | CLP | 34003797 | 2.19e-15 |
| Mxd4 | Mouse | Kidney | IRI | 34003797 | 2.29e-15 |
| Mxd4 | Mouse | Kidney | Sham | 34003797 | 2.58e-15 |
| Mxd4 | Mouse | Kidney | rep_1 | 34853151 | 2.42e-15 |
| Mxd4 | Mouse | Kidney | rep_3 | 34853151 | 2.94e-15 |
| Mxd4 | Mouse | Kidney | rep_4 | 34853151 | 1.26e-14 |
| Mxd4 | Mouse | Kidney | rep_5 | 34853151 | 3.18e-15 |
| Mxd4 | Mouse | Brain | rep_1 | 33469025 | 1.30e-15 |
| Mxd4 | Mouse | Brain | rep_1 | 35027729 | 1.58e-11 |
| Mxd4 | Mouse | Brain | rep_2 | 35027729 | 6.13e-13 |
| Mxd4 | Mouse | Brain | rep_3 | 35027729 | 6.05e-11 |
| Mxd4 | Mouse | Brain | rep_4 | 35027729 | 2.53e-09 |
| Mxd4 | Mouse | Brain | rep_5 | 35027729 | 2.62e-15 |
| Mxd4 | Mouse | Testicle | rep_2 | 34731600 | 8.12e-16 |
| Mxd4 | Mouse | Lung | rep_1 | 35290801 | 4.52e-15 |
| Mxd4 | Mouse | Lung | rep_2 | 35290801 | 7.23e-15 |
| Mxd4 | Mouse | Lung | rep_3 | 35290801 | 1.02e-13 |
| Mxd4 | Mouse | Lung | rep_4 | 35290801 | 3.04e-15 |
| Mxd4 | Mouse | Brain | rep_5 | 35210624 | 4.36e-06 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_2_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Kidney_CLP_H&E  |  |
Kidney_IRI_H&E  |  |
Kidney_Sham_H&E  |  |
Kidney_rep_1_H&E  |  |
Kidney_rep_3_H&E  |  |
Kidney_rep_4_H&E  |  |
Kidney_rep_5_H&E  |  |
Brain_rep_1_H&E  | |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Lung_rep_1_H&E  |  |
Lung_rep_2_H&E  |  |
Lung_rep_3_H&E  |  |
Lung_rep_4_H&E  |  |
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Spatial pattern pathway has Mxd4 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Mxd4 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Spinal cord | CN94_E1 | 1.6e-06 |
| Mxd4 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Spinal cord | CN94_E1 | 6.2e-07 |
| Mxd4 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Spinal cord | CN94_E1 | 2.2e-06 |
| Mxd4 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | rep_27 | 7.2e-05 |
| Mxd4 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Brain | rep_27 | 2.8e-05 |
| Mxd4 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | rep_3 | 1.4e-196 |
| Mxd4 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | rep_3 | 9.4e-206 |
| Mxd4 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Brain | rep_3 | 7.5e-168 |
| Mxd4 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Embryo | rep_2 | 8.0e-13 |
| Mxd4 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Embryo | rep_3 | 1.5e-267 |
| Mxd4 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Embryo | rep_3 | 0.0e+00 |
| Mxd4 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Kidney | rep_2 | 7.3e-42 |
| Mxd4 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Kidney | rep_2 | 7.7e-30 |
| Mxd4 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Kidney | rep_2 | 2.2e-14 |
| Mxd4 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Lymph | MS-1 | 6.1e-11 |
| Mxd4 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lymph | MS-1 | 1.8e-10 |
| Mxd4 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Lymph | MS-1 | 2.2e-09 |
| Mxd4 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Lung | rep_1 | 7.5e-20 |
| Mxd4 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lung | rep_1 | 5.8e-10 |
| Mxd4 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | HP_ad_rep7 | 3.3e-12 |
| Mxd4 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | HP_ad_rep7 | 5.9e-11 |
| Mxd4 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Brain | HP_ad_rep7 | 7.1e-13 |
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Mxd4 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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Mxd4 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for Mxd4 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| MXD4 | Uterus | early | Glandular | MGA,DVL2,U2AF2, etc. | 0.351 |
| MXD4 | Uterus | early | Glandular_secretory | MGA,DVL2,U2AF2, etc. | 0.273 |
| MXD4 | Uterus | early | SOX9_LGR5 | MGA,DVL2,U2AF2, etc. | 0.349 |
| MXD4 | Uterus | early | SOX9 | MGA,DVL2,U2AF2, etc. | 0.447 |
| MXD4 | Uterus | late | Glandular_secretory | CTSZ,ALPK3,SPNS1, etc. | 0.765 |
| MXD4 | Uterus | late | Ciliated | CTSZ,ALPK3,SPNS1, etc. | 0.271 |
| MXD4 | Intestine | development | Epithelium | ZMAT3,PKNOX2,TRIM73, etc. | 0.41 |
| MXD4 | Intestine | development | Fibroblasts | ZMAT3,PKNOX2,TRIM73, etc. | 0.438 |
| MXD4 | Intestine | development | MyoFibroblasts | ZMAT3,PKNOX2,TRIM73, etc. | 0.279 |
| MXD4 | Intestine | development | Neural | ZMAT3,PKNOX2,TRIM73, etc. | 0.253 |
| MXD4 | Uterus | proliferative | SOX9 | LINC01003,WBP1,TSC22D4, etc. | 0.563 |
| MXD4 | Uterus | proliferative | Ciliated | LINC01003,WBP1,TSC22D4, etc. | 0.251 |
| MXD4 | Uterus | proliferative | SOX9_LGR5 | LINC01003,WBP1,TSC22D4, etc. | 0.321 |
| MXD4 | Uterus | proliferative | SOX9_prolif | LINC01003,WBP1,TSC22D4, etc. | 0.32 |
| Motif information. |
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Related Drugs for Mxd4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for Mxd4 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
