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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Spatial pattern gene: Lig1 (spascer ID:16881)

Gene summary for Lig1

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Lig1

Gene ID

16881

Gene nameligase I, DNA, ATP-dependent
SynonymsAL033288|LigI
Cytomap7 A1|7 7.82 cM
Type of geneprotein-coding
DescriptionDNA ligase 1DNA ligase Ipolydeoxyribonucleotide synthase [ATP] 1
Modification date20220424
UniProtAcc

P37913


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Lig1

GO:0003910

DNA ligase (ATP) activity

21873635

Function
Lig1

GO:0005634

nucleus

21873635

Component
Lig1

GO:0005737

cytoplasm

21873635

Component
Lig1

GO:0005739

mitochondrion

21873635

Component
Lig1

GO:0006266

DNA ligation

21873635

Process
Lig1

GO:0006273

lagging strand elongation

21873635

Process
Lig1

GO:1903461

Okazaki fragment processing involved in mitotic DNA replication

21873635

Process

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Spatial pattern events for Lig1

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Lig1MouseBrainS6 344135151.20e-07
Lig1MouseBrainS7 344135158.66e-10
Lig1MouseEmbryo4E 342108876.84e-06
Lig1MouseEmbryorep_5 331887763.85e-09
Lig1MouseKidneyrep_1 348531512.40e-06
Lig1MouseKidneyrep_5 348531515.45e-15
Lig1MouseBrainrep_1 334690251.30e-15
Lig1MouseIntestinerep_3 351497214.65e-08
Lig1MouseIntestinerep_4 351497211.10e-09
Lig1MouseTesticlerep_4 347316008.89e-14
Lig1MouseLymphA1 03.29e-15
Lig1MouseLymphB1 03.66e-15

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Kidney_rep_1_H&E
boxplot
boxplot
Kidney_rep_5_H&E
boxplot
boxplot
Brain_rep_1_H&E
boxplot


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Spatial pattern pathway has Lig1 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Lig1GOBP_Cell_CycleMouseSpinal cordCN94_E1 1.1e-06
Lig1GOBP_Cell_Cycle_Dna_ReplicationMouseSpinal cordCN94_E1 7.4e-07
Lig1GOBP_Cell_Cycle_ProcessMouseSpinal cordCN94_E1 3.8e-06
Lig1GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseSpinal cordCN94_E1 8.0e-06
Lig1GOBP_Dna_Metabolic_ProcessMouseSpinal cordCN94_E1 2.7e-06
Lig1GOBP_Dna_Strand_Elongation_Involved_In_Dna_ReplicationMouseSpinal cordL7CN30_C2 3.2e-06
Lig1GOBP_Nucleotide_Excision_Repair_Dna_Gap_FillingMouseSpinal cordL7CN30_D2 5.6e-08
Lig1GOBP_Dna_LigationMouseSpinal cordL7CN44_C1 3.6e-06
Lig1GOBP_Base_Excision_RepairMouseSpinal cordL7CN45_C1 3.0e-09
Lig1GOBP_Cell_DivisionMouseSpinal cordL7CN45_C1 2.6e-06
Lig1GOBP_Dna_RepairMouseSpinal cordL7CN45_C1 9.4e-06
Lig1GOBP_Dna_ReplicationMouseSpinal cordL7CN45_C1 2.8e-07
Lig1GOBP_Dna_Strand_ElongationMouseSpinal cordL7CN45_C1 3.7e-06
Lig1GOBP_Mitotic_Cell_CycleMouseSpinal cordL7CN45_C1 2.4e-08
Lig1GOBP_Nucleotide_Excision_RepairMouseSpinal cordL7CN45_C1 1.1e-09
Lig1GOBP_Transcription_Coupled_Nucleotide_Excision_RepairMouseSpinal cordL7CN45_C1 1.3e-08
Lig1GOBP_Mitotic_Dna_ReplicationMouseSpinal cordL7CN45_E1 9.7e-08
Lig1GOBP_Dna_Dependent_Dna_ReplicationMouseSpinal cordL7CN47_C1 6.6e-06
Lig1GOBP_Mismatch_RepairMouseSpinal cordL7CN47_D1 2.0e-07
Lig1GOBP_Cell_CycleMouseBrainrep_27 8.4e-07
Lig1GOBP_Cell_DivisionMouseBrainrep_27 3.6e-05
Lig1GOBP_Dna_ReplicationMouseBrainrep_27 6.4e-06
Lig1GOBP_Mitotic_Cell_CycleMouseBrainrep_27 1.1e-05
Lig1GOBP_Dna_Strand_ElongationMouseBrainrep_41 1.1e-05
Lig1GOBP_Nucleotide_Excision_Repair_Dna_Gap_FillingMouseBrainrep_41 4.1e-08
Lig1GOBP_Cell_CycleMouseBrainrep_1 7.0e-10
Lig1GOBP_Cell_Cycle_Dna_ReplicationMouseBrainrep_1 3.4e-08
Lig1GOBP_Cell_Cycle_ProcessMouseBrainrep_1 6.7e-14
Lig1GOBP_Cell_DivisionMouseBrainrep_1 9.7e-23
Lig1GOBP_Dna_Dependent_Dna_ReplicationMouseBrainrep_1 1.5e-17
Lig1GOBP_Dna_Metabolic_ProcessMouseBrainrep_1 1.1e-07
Lig1GOBP_Dna_ReplicationMouseBrainrep_1 4.3e-10
Lig1GOBP_Dna_Strand_ElongationMouseBrainrep_1 5.6e-11
Lig1GOBP_Mismatch_RepairMouseBrainrep_1 2.8e-24
Lig1GOBP_Mitotic_Cell_CycleMouseBrainrep_1 1.5e-25
Lig1GOBP_Nucleotide_Excision_Repair_Dna_Gap_FillingMouseBrainrep_1 1.3e-13
Lig1GOBP_Transcription_Coupled_Nucleotide_Excision_RepairMouseBrainrep_1 5.3e-15
Lig1GOBP_Base_Excision_RepairMouseBrainrep_31.2e-148
Lig1GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseBrainrep_35.0e-192
Lig1GOBP_Dna_Biosynthetic_ProcessMouseBrainrep_31.9e-141
Lig1GOBP_Dna_LigationMouseBrainrep_32.5e-210
Lig1GOBP_Dna_RepairMouseBrainrep_34.0e-216
Lig1GOBP_Dna_Strand_Elongation_Involved_In_Dna_ReplicationMouseBrainrep_3 1.8e-40
Lig1GOBP_Mitotic_Dna_ReplicationMouseBrainrep_3 3.5e-61
Lig1GOBP_Nucleotide_Excision_RepairMouseBrainrep_36.1e-152
Lig1GOBP_Mismatch_RepairMouseEmbryorep_6 1.0e-24
Lig1GOBP_Transcription_Coupled_Nucleotide_Excision_RepairMouseEmbryorep_6 1.9e-07
Lig1GOBP_Base_Excision_RepairMouseEmbryorep_14 1.7e-28
Lig1GOBP_Dna_Biosynthetic_ProcessMouseEmbryorep_14 9.7e-10
Lig1GOBP_Dna_LigationMouseEmbryorep_14 3.0e-43
Lig1GOBP_Dna_Strand_Elongation_Involved_In_Dna_ReplicationMouseEmbryorep_14 3.6e-17
Lig1GOBP_Mitotic_Dna_ReplicationMouseEmbryorep_14 2.5e-26
Lig1GOBP_Nucleotide_Excision_RepairMouseEmbryorep_14 1.6e-22
Lig1GOBP_Nucleotide_Excision_Repair_Dna_Gap_FillingMouseEmbryorep_14 1.4e-59
Lig1GOBP_Cell_DivisionMouseEmbryorep_1 0.0e+00
Lig1GOBP_Mismatch_RepairMouseEmbryorep_1 0.0e+00
Lig1GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseEmbryorep_2 1.4e-08
Lig1GOBP_Dna_Metabolic_ProcessMouseEmbryorep_27.2e-216
Lig1GOBP_Dna_RepairMouseEmbryorep_21.6e-282
Lig1GOBP_Base_Excision_RepairMouseKidneyrep_2 1.5e-78
Lig1GOBP_Cell_CycleMouseKidneyrep_2 1.0e-24
Lig1GOBP_Cell_Cycle_Dna_ReplicationMouseKidneyrep_2 3.6e-23
Lig1GOBP_Cell_Cycle_ProcessMouseKidneyrep_2 3.0e-21
Lig1GOBP_Cell_DivisionMouseKidneyrep_2 5.3e-77
Lig1GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseKidneyrep_25.5e-146
Lig1GOBP_Dna_Dependent_Dna_ReplicationMouseKidneyrep_21.1e-109
Lig1GOBP_Dna_Metabolic_ProcessMouseKidneyrep_2 1.4e-12
Lig1GOBP_Dna_RepairMouseKidneyrep_2 5.5e-70
Lig1GOBP_Dna_ReplicationMouseKidneyrep_2 5.9e-43
Lig1GOBP_Dna_Strand_ElongationMouseKidneyrep_2 2.0e-61
Lig1GOBP_Dna_Strand_Elongation_Involved_In_Dna_ReplicationMouseKidneyrep_2 2.3e-26
Lig1GOBP_Mismatch_RepairMouseKidneyrep_2 7.4e-31
Lig1GOBP_Mitotic_Cell_CycleMouseKidneyrep_2 1.1e-15
Lig1GOBP_Mitotic_Dna_ReplicationMouseKidneyrep_2 2.1e-53
Lig1GOBP_Nucleotide_Excision_RepairMouseKidneyrep_2 3.6e-78
Lig1GOBP_Transcription_Coupled_Nucleotide_Excision_RepairMouseKidneyrep_2 2.5e-67
Lig1GOBP_Dna_Dependent_Dna_ReplicationMouseLiverCN16-D2 3.1e-08
Lig1GOBP_Dna_Metabolic_ProcessMouseLiverCN16-D2 2.6e-07
Lig1GOBP_Mitotic_Dna_ReplicationMouseLiverCN73-C1 4.1e-07
Lig1GOBP_Dna_LigationMouseLiverrep_15 5.7e-17
Lig1GOBP_Dna_Strand_Elongation_Involved_In_Dna_ReplicationMouseLiverrep_15 1.1e-13
Lig1GOBP_Nucleotide_Excision_Repair_Dna_Gap_FillingMouseLiverrep_15 2.2e-21
Lig1GOBP_Transcription_Coupled_Nucleotide_Excision_RepairMouseLiverrep_16 1.2e-37
Lig1GOBP_Transcription_Coupled_Nucleotide_Excision_RepairMouseBrainrep_1 1.1e-13
Lig1GOBP_Cell_CycleMouseLymphMS-1 1.3e-07
Lig1GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseLymphMS-1 8.5e-13
Lig1GOBP_Dna_Metabolic_ProcessMouseLymphMS-1 6.8e-10
Lig1GOBP_Nucleotide_Excision_RepairMouseLymphMS-1 3.7e-09
Lig1GOBP_Cell_Cycle_Dna_ReplicationMouseLymphMS-2 7.1e-08
Lig1GOBP_Dna_LigationMouseLymphMS-2 6.9e-07
Lig1GOBP_Dna_Dependent_Dna_ReplicationMouseLymphPBS 2.2e-07
Lig1GOBP_Transcription_Coupled_Nucleotide_Excision_RepairMouseLymphPBS 7.7e-07
Lig1GOBP_Mitotic_Dna_ReplicationMouseLungrep_1 4.6e-11
Lig1GOBP_Nucleotide_Excision_Repair_Dna_Gap_FillingMouseLungrep_1 8.0e-09
Lig1GOBP_Mitotic_Dna_ReplicationMouseBrainrep_7 4.8e-18
Lig1GOBP_Transcription_Coupled_Nucleotide_Excision_RepairMouseBrainrep_7 2.2e-16
Lig1GOBP_Transcription_Coupled_Nucleotide_Excision_RepairMouseBrainHP_ad_rep2 3.4e-13
Lig1GOBP_Dna_LigationMouseBrainHP_ad_rep3 1.4e-20
Lig1GOBP_Nucleotide_Excision_Repair_Dna_Gap_FillingMouseBrainHP_ad_rep3 2.9e-07
Lig1GOBP_Base_Excision_RepairMouseBrainHP_ad_rep7 6.3e-12
Lig1GOBP_Cell_CycleMouseBrainHP_ad_rep7 6.6e-08
Lig1GOBP_Cell_Cycle_Dna_ReplicationMouseBrainHP_ad_rep7 2.9e-18
Lig1GOBP_Cell_Cycle_ProcessMouseBrainHP_ad_rep7 1.7e-09
Lig1GOBP_Cell_DivisionMouseBrainHP_ad_rep7 2.6e-09
Lig1GOBP_Cellular_Response_To_Dna_Damage_StimulusMouseBrainHP_ad_rep7 6.8e-10
Lig1GOBP_Dna_Biosynthetic_ProcessMouseBrainHP_ad_rep7 1.2e-12
Lig1GOBP_Dna_Dependent_Dna_ReplicationMouseBrainHP_ad_rep7 1.6e-15
Lig1GOBP_Dna_Metabolic_ProcessMouseBrainHP_ad_rep7 3.1e-11
Lig1GOBP_Dna_RepairMouseBrainHP_ad_rep7 2.4e-12
Lig1GOBP_Dna_ReplicationMouseBrainHP_ad_rep7 1.1e-10
Lig1GOBP_Dna_Strand_ElongationMouseBrainHP_ad_rep7 4.9e-11
Lig1GOBP_Dna_Strand_Elongation_Involved_In_Dna_ReplicationMouseBrainHP_ad_rep7 3.6e-13
Lig1GOBP_Mitotic_Dna_ReplicationMouseBrainHP_ad_rep7 3.5e-16
Lig1GOBP_Nucleotide_Excision_RepairMouseBrainHP_ad_rep7 4.3e-08
Lig1GOBP_Mismatch_RepairMouseBrainHP_polb_rep9 5.4e-17
Lig1GOBP_Mitotic_Cell_CycleMouseBrainHP_polb_rep9 1.6e-10

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Lig1 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Lig1 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Lig1 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Lig1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Lig1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
Lig1C0005684Malignant neoplasm of urinary bladder1CTD_human
Lig1C0005695Bladder Neoplasm1CTD_human
Lig1C4016019DNA Ligase I Deficiency1GENOMICS_ENGLAND