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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

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Related drugs with this gene

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Related diseases with this gene

Spatial pattern gene: Lhx2 (spascer ID:16870)

Gene summary for Lhx2

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Lhx2

Gene ID

16870

Gene nameLIM homeobox protein 2
SynonymsLH2A|Lh-2|Lim2|ap|apterous
Cytomap2|2 B
Type of geneprotein-coding
DescriptionLIM/homeobox protein Lhx2LIM homeo box protein 2homeobox protein LH-2
Modification date20220426
UniProtAcc

Q9Z0S2


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Lhx2

GO:0000977

RNA polymerase II transcription regulatory region sequence-specific DNA binding

21873635

Function
Lhx2

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

21873635

Function
Lhx2

GO:0005634

nucleus

21873635

Component
Lhx2

GO:0006357

regulation of transcription by RNA polymerase II

21873635

Process
Lhx2

GO:0030182

neuron differentiation

21873635

Process

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Spatial pattern events for Lhx2

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
Lhx2MouseBrainS1 344135152.07e-15
Lhx2MouseBrainS2 344135151.56e-15
Lhx2MouseBrainS3 344135151.64e-15
Lhx2MouseBrainS4 344135151.37e-15
Lhx2MouseBrainS6 344135151.46e-15
Lhx2MouseBrainS7 344135151.55e-15
Lhx2MouseBrain07A 326376226.93e-06
Lhx2MouseBrain12B 326376221.03e-11
Lhx2MouseBrain13A 326376222.37e-06
Lhx2MouseBrain13B 326376221.19e-07
Lhx2MouseBrain14A 326376228.37e-08
Lhx2MouseBrain14B 326376225.57e-06
Lhx2MouseBrain16A 326376221.49e-11
Lhx2MouseBrain17A 326376221.19e-14
Lhx2MouseBrain17B 326376221.21e-13
Lhx2MouseBrain18A 326376222.55e-11
Lhx2MouseBrain18B 326376224.36e-14
Lhx2MouseBrain19A 326376221.20e-10
Lhx2MouseBrain19B 326376221.14e-07
Lhx2MouseBrain20A 326376225.12e-12
Lhx2MouseBrain21A 326376221.62e-13
Lhx2MouseBrain21B 326376229.07e-10
Lhx2MouseBrain22A 326376228.87e-15
Lhx2MouseBrain22B 326376228.81e-15
Lhx2MouseBrain23A 326376222.44e-10
Lhx2MouseBrain23B 326376222.60e-10
Lhx2MouseBrain24A 326376221.19e-11
Lhx2MouseBrain24B 326376224.32e-12
Lhx2MouseBrain25A 326376224.48e-10
Lhx2MouseBrain26A 326376221.34e-14
Lhx2MouseBrain26B 326376224.97e-08
Lhx2MouseBrain27A 326376221.03e-14
Lhx2MouseBrain27B 326376221.06e-14
Lhx2MouseBrain28A 326376221.86e-14
Lhx2MouseBrain28B 326376221.24e-14
Lhx2MouseBrain29A 326376221.08e-14
Lhx2MouseBrain29B 326376221.91e-14
Lhx2MouseBrain30A 326376221.48e-14
Lhx2MouseBrain31A 326376221.59e-14
Lhx2MouseBrain32A 326376221.52e-14
Lhx2MouseBrain33A 326376221.50e-14
Lhx2MouseBrain33B 326376226.26e-14
Lhx2MouseBrain34A 326376221.42e-14
Lhx2MouseBrain34B 326376221.67e-14
Lhx2MouseBrain35A 326376221.48e-14
Lhx2MouseBrain35B 326376221.78e-14
Lhx2MouseBrain36A 326376224.63e-14
Lhx2MouseBrain36B 326376223.18e-14
Lhx2MouseBrain38B 326376224.04e-07
Lhx2MouseBrain39A 326376221.65e-12
Lhx2MouseBrainrep_1 351413742.02e-15
Lhx2MouseBrainrep_2 351413741.69e-15
Lhx2MouseBrainrep_3 351413741.64e-15
Lhx2MouseBrainrep_4 351413741.57e-15
Lhx2MouseBrainrep_5 351413741.47e-15
Lhx2MouseBrainrep_6 351413741.73e-15
Lhx2MouseEmbryorep_1 331887769.94e-15
Lhx2MouseEmbryorep_2 331887761.37e-14
Lhx2MouseEmbryorep_3 331887761.13e-14
Lhx2MouseEmbryorep_5 331887761.40e-14
Lhx2MouseEmbryorep_6 331887761.27e-14
Lhx2MouseEmbryorep_7 331887766.94e-15
Lhx2MouseEmbryorep_1 344896007.15e-16
Lhx2MouseEmbryorep_2 344896004.14e-16
Lhx2MouseEmbryorep_3 344896004.04e-16
Lhx2MouseEmbryorep_4 344896003.67e-16
Lhx2MouseEmbryorep_5 344896004.08e-16
Lhx2MouseEmbryorep_6 344896003.64e-16
Lhx2MouseBrainrep_1 334690251.30e-15
Lhx2MouseBrainrep_1 350277291.66e-15
Lhx2MouseBrainrep_2 350277291.57e-15
Lhx2MouseBrainrep_3 350277291.32e-15
Lhx2MouseBrainrep_4 350277291.76e-15
Lhx2MouseBrainrep_5 350277291.46e-15
Lhx2MouseBrainB02_D1 327023147.07e-08
Lhx2MouseBrainB02_E1 327023141.42e-13
Lhx2MouseBrainB03_D2 327023141.78e-07
Lhx2MouseBrainN02_D1 327023143.13e-09
Lhx2MouseBrainN03_C2 327023141.55e-08
Lhx2MouseBrainN03_D2 327023144.29e-14
Lhx2MouseBrainN04_D1 327023142.90e-08
Lhx2MouseBrainN05_C2 327023141.37e-09
Lhx2MouseBrainN05_D2 327023143.30e-09
Lhx2MouseTesticlerep_5 347316004.51e-07
Lhx2MouseBrainrep_1 352106241.74e-15
Lhx2MouseBrainrep_2 352106241.74e-15
Lhx2MouseBrainrep_3 352106241.82e-15
Lhx2MouseBrainrep_5 352106242.07e-15
Lhx2MouseBrainrep_6 352106242.05e-15
Lhx2MouseBrainrep_7 352106241.87e-15

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_1_H&E
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Brain_rep_2_H&E
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Brain_rep_3_H&E
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Brain_rep_4_H&E
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Brain_rep_5_H&E
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Brain_rep_6_H&E
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Brain_rep_1_H&E
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Brain_rep_1_H&E
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Brain_rep_2_H&E
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Brain_rep_3_H&E
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Brain_rep_4_H&E
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Brain_rep_5_H&E
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Brain_B02_D1_H&E
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Brain_B02_E1_H&E
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Brain_B03_D2_H&E
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Brain_N02_D1_H&E
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Brain_N03_C2_H&E
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Brain_N03_D2_H&E
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Brain_N04_D1_H&E
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Brain_N05_C2_H&E
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Brain_N05_D2_H&E
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Spatial pattern pathway has Lhx2 envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
Lhx2GOBP_NeurogenesisMouseSpinal cordL7CN45_C1 3.4e-09
Lhx2GOBP_Neuron_DifferentiationMouseSpinal cordL7CN45_C1 3.4e-09
Lhx2GOBP_NeurogenesisMouseBrainrep_1 6.4e-19
Lhx2GOBP_Neuron_DifferentiationMouseBrainrep_1 8.7e-25
Lhx2GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseBrainrep_1 2.5e-12
Lhx2GOBP_NeurogenesisMouseEmbryorep_1 8.2e-08
Lhx2GOBP_Neuron_DifferentiationMouseEmbryorep_32.1e-193
Lhx2GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseEmbryorep_3 0.0e+00
Lhx2GOBP_NeurogenesisMouseKidneyNep 4.6e-22
Lhx2GOBP_Neuron_DifferentiationMouseKidneyNep 8.3e-23
Lhx2GOBP_NeurogenesisMouseKidneyrep_2 2.4e-78
Lhx2GOBP_Neuron_DifferentiationMouseKidneyrep_2 3.9e-32
Lhx2GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseKidneyrep_2 4.5e-10
Lhx2GOBP_Neuron_DifferentiationMouseLiverCN16-D2 5.1e-07
Lhx2GOBP_NeurogenesisMouseLymphMS-1 4.1e-08
Lhx2GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseLymphMS-1 4.4e-12
Lhx2GOBP_NeurogenesisMouseBrainHP_ad_rep7 3.9e-07
Lhx2GOBP_Neuron_DifferentiationMouseBrainHP_ad_rep7 3.9e-07
Lhx2GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_ProcessMouseBrainHP_ad_rep7 2.8e-11

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Lhx2 function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Lhx2 function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Lhx2 envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Lhx2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Lhx2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
Lhx2C0003873Rheumatoid Arthritis1CTD_human