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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Aff3 (spascer ID:16764)

Gene summary for Aff3

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Aff3
	Gene ID	16764
	Gene name	AF4/FMR2 family, member 3
	Synonyms	3222402O04Rik\|A730046J16\|LAF-4\|Laf4
	Cytomap	1 B\|1 16.58 cM
	Type of gene	protein-coding
	Description	AF4/FMR2 family member 3lymphoid nuclear protein 4lymphoid nuclear protein related to AF4protein LAF-4
	Modification date	20220424
	UniProtAcc	P51827

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Aff3	GO:0010468	regulation of gene expression	21873635	Process
Aff3	GO:0032783	super elongation complex	21873635	Component

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Spatial pattern events for Aff3

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Aff3	Mouse	Brain	S2	34413515	3.86e-06
Aff3	Mouse	Brain	S4	34413515	2.61e-06
Aff3	Mouse	Brain	S6	34413515	2.66e-15
Aff3	Mouse	Brain	rep_4	35141374	5.55e-07
Aff3	Mouse	Embryo	1E	34210887	4.81e-08
Aff3	Mouse	Embryo	1F	34210887	5.75e-06
Aff3	Mouse	Embryo	1G	34210887	2.73e-06
Aff3	Mouse	Embryo	3G	34210887	1.56e-07
Aff3	Mouse	Embryo	4D	34210887	2.08e-06
Aff3	Mouse	Embryo	4E	34210887	4.30e-07
Aff3	Mouse	Embryo	rep_2	33188776	1.83e-07
Aff3	Mouse	Embryo	rep_3	33188776	5.55e-08
Aff3	Mouse	Embryo	rep_4	33188776	5.08e-15
Aff3	Mouse	Embryo	rep_12	33188776	1.60e-14
Aff3	Mouse	Embryo	rep_13	33188776	4.49e-15
Aff3	Mouse	Brain	rep_1	33469025	1.50e-10
Aff3	Mouse	Brain	rep_1	35027729	4.49e-09
Aff3	Mouse	Brain	rep_2	35027729	5.01e-08
Aff3	Mouse	Brain	rep_3	35027729	2.38e-15
Aff3	Mouse	Brain	rep_4	35027729	7.77e-10
Aff3	Mouse	Brain	rep_5	35027729	3.62e-12
Aff3	Mouse	Lung	rep_1	35290801	8.41e-07

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_4_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Lung_rep_1_H&E

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Spatial pattern pathway has Aff3 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Aff3	GOBP_Embryonic_Hindlimb_Morphogenesis	Mouse	Spinal cord	L7CN44_C1	2.9e-09
Aff3	GOBP_Appendage_Development	Mouse	Spinal cord	L7CN45_C1	2.2e-06
Aff3	GOBP_Appendage_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	9.0e-08
Aff3	GOBP_Embryo_Development	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Aff3	GOBP_Embryonic_Appendage_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	6.5e-06
Aff3	GOBP_Embryonic_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Aff3	GOBP_Response_To_Cytokine	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Aff3	GOBP_Response_To_Tumor_Necrosis_Factor	Mouse	Spinal cord	L7CN45_C1	1.9e-08
Aff3	GOBP_Appendage_Development	Mouse	Brain	rep_3	9.3e-152
Aff3	GOBP_Appendage_Morphogenesis	Mouse	Brain	rep_3	1.8e-121
Aff3	GOBP_Embryo_Development	Mouse	Brain	rep_3	1.3e-126
Aff3	GOBP_Embryonic_Appendage_Morphogenesis	Mouse	Brain	rep_3	1.2e-95
Aff3	GOBP_Embryonic_Hindlimb_Morphogenesis	Mouse	Brain	rep_3	4.1e-40
Aff3	GOBP_Embryonic_Morphogenesis	Mouse	Brain	rep_3	5.0e-165
Aff3	GOBP_Hindlimb_Morphogenesis	Mouse	Brain	rep_3	5.9e-48
Aff3	GOBP_Response_To_Cytokine	Mouse	Brain	rep_3	1.2e-08
Aff3	GOBP_Response_To_Tumor_Necrosis_Factor	Mouse	Brain	rep_4	1.6e-12
Aff3	GOBP_Appendage_Development	Mouse	Embryo	rep_4	2.9e-07
Aff3	GOBP_Embryonic_Hindlimb_Morphogenesis	Mouse	Embryo	rep_4	1.6e-16
Aff3	GOBP_Hindlimb_Morphogenesis	Mouse	Embryo	rep_4	3.5e-12
Aff3	GOBP_Embryonic_Appendage_Morphogenesis	Mouse	Embryo	rep_14	2.4e-19
Aff3	GOBP_Response_To_Tumor_Necrosis_Factor	Mouse	Embryo	rep_14	4.5e-25
Aff3	GOBP_Response_To_Cytokine	Mouse	Embryo	rep_1	8.2e-211
Aff3	GOBP_Appendage_Development	Mouse	Embryo	rep_2	7.3e-30
Aff3	GOBP_Appendage_Morphogenesis	Mouse	Embryo	rep_2	7.3e-30
Aff3	GOBP_Embryonic_Appendage_Morphogenesis	Mouse	Embryo	rep_2	2.3e-43
Aff3	GOBP_Embryo_Development	Mouse	Embryo	rep_3	1.2e-173
Aff3	GOBP_Response_To_Tumor_Necrosis_Factor	Mouse	Kidney	Sham	1.8e-10
Aff3	GOBP_Appendage_Development	Mouse	Kidney	rep_2	7.9e-84
Aff3	GOBP_Appendage_Morphogenesis	Mouse	Kidney	rep_2	6.0e-39
Aff3	GOBP_Embryo_Development	Mouse	Kidney	rep_2	7.4e-46
Aff3	GOBP_Embryonic_Appendage_Morphogenesis	Mouse	Kidney	rep_2	1.0e-52
Aff3	GOBP_Embryonic_Hindlimb_Morphogenesis	Mouse	Kidney	rep_2	2.3e-11
Aff3	GOBP_Embryonic_Morphogenesis	Mouse	Kidney	rep_2	7.3e-66
Aff3	GOBP_Hindlimb_Morphogenesis	Mouse	Kidney	rep_2	4.0e-39
Aff3	GOBP_Response_To_Cytokine	Mouse	Kidney	rep_2	3.1e-14
Aff3	GOBP_Appendage_Development	Mouse	Liver	CN16-E1	2.0e-11
Aff3	GOBP_Hindlimb_Morphogenesis	Mouse	Liver	CN16-E1	5.5e-11
Aff3	GOBP_Embryonic_Appendage_Morphogenesis	Mouse	Liver	CN65-C1	5.6e-08
Aff3	GOBP_Appendage_Development	Mouse	Liver	rep_15	1.7e-18
Aff3	GOBP_Embryonic_Appendage_Morphogenesis	Mouse	Liver	rep_15	1.5e-10
Aff3	GOBP_Embryonic_Hindlimb_Morphogenesis	Mouse	Liver	rep_15	2.9e-17
Aff3	GOBP_Hindlimb_Morphogenesis	Mouse	Liver	rep_16	2.3e-12
Aff3	GOBP_Response_To_Cytokine	Mouse	Liver	rep_16	1.4e-13
Aff3	GOBP_Appendage_Development	Mouse	Lymph	MS-1	2.7e-13
Aff3	GOBP_Appendage_Morphogenesis	Mouse	Lymph	MS-1	2.7e-10
Aff3	GOBP_Embryo_Development	Mouse	Lymph	MS-1	2.5e-08
Aff3	GOBP_Embryonic_Appendage_Morphogenesis	Mouse	Lymph	MS-1	4.4e-08
Aff3	GOBP_Embryonic_Hindlimb_Morphogenesis	Mouse	Lymph	MS-1	7.7e-10
Aff3	GOBP_Embryonic_Morphogenesis	Mouse	Lymph	MS-1	5.6e-07
Aff3	GOBP_Hindlimb_Morphogenesis	Mouse	Lymph	MS-1	2.7e-08
Aff3	GOBP_Response_To_Cytokine	Mouse	Lymph	MS-1	5.7e-15
Aff3	GOBP_Response_To_Tumor_Necrosis_Factor	Mouse	Lymph	MS-1	1.7e-14
Aff3	GOBP_Appendage_Morphogenesis	Mouse	Lung	rep_1	1.5e-07
Aff3	GOBP_Embryonic_Appendage_Morphogenesis	Mouse	Lung	rep_1	9.0e-11
Aff3	GOBP_Response_To_Cytokine	Mouse	Lung	rep_1	1.2e-17
Aff3	GOBP_Appendage_Development	Mouse	Brain	HP_ad_rep7	5.7e-10
Aff3	GOBP_Appendage_Morphogenesis	Mouse	Brain	HP_ad_rep7	4.6e-07
Aff3	GOBP_Response_To_Cytokine	Mouse	Brain	HP_ad_rep7	2.1e-08
Aff3	GOBP_Hindlimb_Morphogenesis	Mouse	Brain	HP_adpolb_rep3	4.3e-07
Aff3	GOBP_Embryo_Development	Mouse	Brain	HP_polb_rep9	1.5e-10
Aff3	GOBP_Embryonic_Hindlimb_Morphogenesis	Mouse	Brain	HP_polb_rep9	4.1e-08
Aff3	GOBP_Embryonic_Morphogenesis	Mouse	Brain	HP_polb_rep9	3.7e-09

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Aff3 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Aff3 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Aff3 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Aff3

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Aff3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Aff3	C0003873	Rheumatoid Arthritis	2	CTD_human
Aff3	C0013146	Drug abuse	1	CTD_human
Aff3	C0013170	Drug habituation	1	CTD_human
Aff3	C0013222	Drug Use Disorders	1	CTD_human
Aff3	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Aff3	C0036572	Seizures	1	GENOMICS_ENGLAND
Aff3	C0038580	Substance Dependence	1	CTD_human
Aff3	C0038586	Substance Use Disorders	1	CTD_human
Aff3	C0236969	Substance-Related Disorders	1	CTD_human
Aff3	C0740858	Substance abuse problem	1	CTD_human
Aff3	C1510472	Drug Dependence	1	CTD_human
Aff3	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
Aff3	C4316881	Prescription Drug Abuse	1	CTD_human