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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Igfbp6 (spascer ID:16012)

Gene summary for Igfbp6

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Igfbp6
	Gene ID	16012
	Gene name	insulin-like growth factor binding protein 6
	Synonyms	IGFBP-6
	Cytomap	15\|15 F2
	Type of gene	protein-coding
	Description	insulin-like growth factor-binding protein 6IBP-6IGF-binding protein 6INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 6 PRECURSOR (IGFBP-6) (IBP-6) (IGF-BINDING PROTEIN 6)
	Modification date	20220424
	UniProtAcc	P47880

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Igfbp6	GO:0001968	fibronectin binding	21873635	Function
Igfbp6	GO:0005615	extracellular space	21873635	Component
Igfbp6	GO:0031994	insulin-like growth factor I binding	21873635	Function
Igfbp6	GO:0031995	insulin-like growth factor II binding	21873635	Function
Igfbp6	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	21873635	Process

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Spatial pattern events for Igfbp6

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Igfbp6	Mouse	Brain	S1	34413515	2.07e-15
Igfbp6	Mouse	Brain	S2	34413515	1.56e-15
Igfbp6	Mouse	Brain	S3	34413515	1.64e-15
Igfbp6	Mouse	Brain	S4	34413515	1.37e-15
Igfbp6	Mouse	Brain	S6	34413515	1.46e-15
Igfbp6	Mouse	Brain	S7	34413515	1.55e-15
Igfbp6	Mouse	Brain	03B	32637622	3.19e-08
Igfbp6	Mouse	Brain	05A	32637622	2.28e-09
Igfbp6	Mouse	Brain	05B	32637622	3.13e-06
Igfbp6	Mouse	Brain	06B	32637622	4.61e-08
Igfbp6	Mouse	Brain	07A	32637622	9.98e-06
Igfbp6	Mouse	Brain	07B	32637622	9.70e-08
Igfbp6	Mouse	Brain	08A	32637622	9.02e-06
Igfbp6	Mouse	Brain	12A	32637622	3.43e-08
Igfbp6	Mouse	Brain	12B	32637622	9.45e-12
Igfbp6	Mouse	Brain	13B	32637622	7.68e-09
Igfbp6	Mouse	Brain	14A	32637622	1.51e-06
Igfbp6	Mouse	Brain	14B	32637622	4.90e-09
Igfbp6	Mouse	Brain	17B	32637622	1.09e-06
Igfbp6	Mouse	Brain	18A	32637622	1.29e-08
Igfbp6	Mouse	Brain	18B	32637622	4.49e-06
Igfbp6	Mouse	Brain	19A	32637622	1.43e-08
Igfbp6	Mouse	Brain	21A	32637622	1.77e-08
Igfbp6	Mouse	Brain	22A	32637622	4.13e-13
Igfbp6	Mouse	Brain	22B	32637622	1.53e-11
Igfbp6	Mouse	Brain	23B	32637622	1.99e-09
Igfbp6	Mouse	Brain	26B	32637622	1.45e-10
Igfbp6	Mouse	Brain	27A	32637622	5.01e-13
Igfbp6	Mouse	Brain	27B	32637622	1.70e-09
Igfbp6	Mouse	Brain	28A	32637622	3.22e-13
Igfbp6	Mouse	Brain	29A	32637622	1.12e-07
Igfbp6	Mouse	Brain	30A	32637622	4.89e-06
Igfbp6	Mouse	Brain	32A	32637622	5.28e-06
Igfbp6	Mouse	Brain	33A	32637622	3.12e-06
Igfbp6	Mouse	Brain	34A	32637622	5.52e-06
Igfbp6	Mouse	Brain	34B	32637622	3.66e-06
Igfbp6	Mouse	Brain	rep_1	35141374	2.02e-15
Igfbp6	Mouse	Brain	rep_2	35141374	1.69e-15
Igfbp6	Mouse	Brain	rep_3	35141374	1.64e-15
Igfbp6	Mouse	Brain	rep_4	35141374	1.57e-15
Igfbp6	Mouse	Brain	rep_5	35141374	1.47e-15
Igfbp6	Mouse	Brain	rep_6	35141374	1.73e-15
Igfbp6	Mouse	Kidney	CLP	34003797	1.99e-10
Igfbp6	Mouse	Kidney	Sham	34003797	2.58e-15
Igfbp6	Mouse	Liver	rep_18	35021063	4.83e-14
Igfbp6	Mouse	Brain	rep_1	35027729	1.66e-15
Igfbp6	Mouse	Brain	rep_2	35027729	1.57e-15
Igfbp6	Mouse	Brain	rep_3	35027729	1.32e-15
Igfbp6	Mouse	Brain	rep_4	35027729	1.76e-15
Igfbp6	Mouse	Brain	rep_5	35027729	1.46e-15
Igfbp6	Mouse	Intestine	rep_1	35149721	2.05e-13
Igfbp6	Mouse	Intestine	rep_2	35149721	5.49e-15
Igfbp6	Mouse	Brain	B02_D1	32702314	1.50e-14
Igfbp6	Mouse	Brain	B02_E1	32702314	2.23e-14
Igfbp6	Mouse	Brain	B03_C2	32702314	5.01e-09
Igfbp6	Mouse	Brain	B03_D2	32702314	3.38e-08
Igfbp6	Mouse	Brain	N02_D1	32702314	1.84e-07
Igfbp6	Mouse	Brain	N03_C2	32702314	1.93e-13
Igfbp6	Mouse	Brain	N03_D2	32702314	1.38e-14
Igfbp6	Mouse	Brain	N05_D2	32702314	4.50e-10
Igfbp6	Mouse	Lymph	A1	0	3.29e-15
Igfbp6	Mouse	Lymph	B1	0	3.66e-15
Igfbp6	Mouse	Lung	rep_1	35290801	4.52e-15
Igfbp6	Mouse	Lung	rep_2	35290801	7.23e-15
Igfbp6	Mouse	Lung	rep_3	35290801	5.26e-15
Igfbp6	Mouse	Lung	rep_4	35290801	3.04e-15
Igfbp6	Mouse	Brain	rep_1	35210624	1.74e-15
Igfbp6	Mouse	Brain	rep_3	35210624	1.82e-15
Igfbp6	Mouse	Brain	OFB_ad_rep4	33083725	1.25e-02
Igfbp6	Mouse	Brain	OFB_adpolb_rep2	33083725	5.51e-05
Igfbp6	Mouse	Brain	OFB_adpolb_rep3	33083725	1.63e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_CLP_H&E
Kidney_Sham_H&E
Liver_rep_18_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_B02_D1_H&E
Brain_B02_E1_H&E
Brain_B03_C2_H&E
Brain_B03_D2_H&E
Brain_N02_D1_H&E
Brain_N03_C2_H&E
Brain_N03_D2_H&E
Brain_N05_D2_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E
Brain_OFB_ad_rep4_H&E
Brain_OFB_adpolb_rep2_H&E
Brain_OFB_adpolb_rep3_H&E

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Spatial pattern pathway has Igfbp6 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Igfbp6	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Spinal cord	CN94_E1	4.4e-07
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Kinase_Activity	Mouse	Spinal cord	CN94_E1	5.6e-06
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Spinal cord	CN94_E1	7.8e-06
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Spinal cord	CN94_E1	5.1e-06
Igfbp6	GOBP_Positive_Regulation_Of_Transferase_Activity	Mouse	Spinal cord	CN94_E1	7.9e-07
Igfbp6	GOBP_Activation_Of_Protein_Kinase_Activity	Mouse	Spinal cord	L7CN45_C1	9.3e-06
Igfbp6	GOBP_Cell_Cell_Signaling	Mouse	Spinal cord	L7CN45_C1	3.5e-08
Igfbp6	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Spinal cord	L7CN45_C1	5.6e-07
Igfbp6	GOBP_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	1.5e-08
Igfbp6	GOBP_Mapk_Cascade	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Igfbp6	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	4.8e-06
Igfbp6	GOBP_Negative_Regulation_Of_Cell_Population_Proliferation	Mouse	Spinal cord	L7CN45_C1	1.3e-08
Igfbp6	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	4.8e-06
Igfbp6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Igfbp6	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Igfbp6	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Igfbp6	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Mouse	Spinal cord	L7CN45_C1	4.2e-08
Igfbp6	GOBP_Positive_Regulation_Of_Signaling	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Igfbp6	GOBP_Regulation_Of_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	8.0e-10
Igfbp6	GOBP_Regulation_Of_Protein_Modification_Process	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Igfbp6	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Igfbp6	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	8.2e-06
Igfbp6	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	5.7e-08
Igfbp6	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Spinal cord	L7CN97_E2	4.9e-06
Igfbp6	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Spinal cord	L8CN11_C1	3.6e-13
Igfbp6	GOBP_Cell_Migration	Mouse	Spinal cord	L8CN11_D1	8.5e-06
Igfbp6	GOBP_Locomotion	Mouse	Spinal cord	L8CN11_D1	8.5e-06
Igfbp6	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L8CN11_D1	5.6e-09
Igfbp6	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Spinal cord	L8CN17_E1	1.6e-07
Igfbp6	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Spinal cord	L8CN17_E1	3.7e-07
Igfbp6	GOBP_Negative_Regulation_Of_Signaling	Mouse	Spinal cord	L8CN17_E1	8.3e-06
Igfbp6	GOBP_Positive_Regulation_Of_Map_Kinase_Activity	Mouse	Spinal cord	L8CN17_E1	3.0e-06
Igfbp6	GOBP_Regulation_Of_Protein_Kinase_Activity	Mouse	Spinal cord	L8CN17_E1	5.8e-07
Igfbp6	GOBP_Regulation_Of_Transferase_Activity	Mouse	Spinal cord	L8CN17_E1	9.1e-06
Igfbp6	GOBP_Regulation_Of_Protein_Kinase_Activity	Mouse	Brain	rep_27	2.9e-05
Igfbp6	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Brain	rep_27	5.2e-05
Igfbp6	GOBP_Regulation_Of_Transferase_Activity	Mouse	Brain	rep_27	1.1e-06
Igfbp6	GOBP_Regulation_Of_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Brain	rep_70	2.7e-05
Igfbp6	GOBP_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Brain	rep_75	6.4e-05
Igfbp6	GOBP_Cell_Cell_Signaling	Mouse	Brain	rep_1	5.1e-48
Igfbp6	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Brain	rep_1	9.9e-07
Igfbp6	GOBP_Positive_Regulation_Of_Map_Kinase_Activity	Mouse	Brain	rep_1	2.5e-09
Igfbp6	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Brain	rep_1	1.3e-08
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Kinase_Activity	Mouse	Brain	rep_1	6.7e-10
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Mouse	Brain	rep_1	4.6e-36
Igfbp6	GOBP_Positive_Regulation_Of_Signaling	Mouse	Brain	rep_1	3.1e-07
Igfbp6	GOBP_Positive_Regulation_Of_Transferase_Activity	Mouse	Brain	rep_1	1.5e-08
Igfbp6	GOBP_Regulation_Of_Protein_Kinase_Activity	Mouse	Brain	rep_1	5.2e-10
Igfbp6	GOBP_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Mouse	Brain	rep_1	2.3e-16
Igfbp6	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Brain	rep_1	8.6e-14
Igfbp6	GOBP_Activation_Of_Protein_Kinase_Activity	Mouse	Brain	rep_3	7.5e-137
Igfbp6	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Brain	rep_3	5.3e-174
Igfbp6	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Brain	rep_3	2.0e-124
Igfbp6	GOBP_Cell_Migration	Mouse	Brain	rep_3	4.9e-108
Igfbp6	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Brain	rep_3	3.3e-46
Igfbp6	GOBP_Locomotion	Mouse	Brain	rep_3	5.4e-74
Igfbp6	GOBP_Mapk_Cascade	Mouse	Brain	rep_3	4.8e-123
Igfbp6	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Brain	rep_3	2.3e-180
Igfbp6	GOBP_Negative_Regulation_Of_Cell_Population_Proliferation	Mouse	Brain	rep_3	1.6e-104
Igfbp6	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	rep_3	1.3e-138
Igfbp6	GOBP_Negative_Regulation_Of_Signaling	Mouse	Brain	rep_3	7.8e-106
Igfbp6	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Brain	rep_3	4.4e-159
Igfbp6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_3	8.5e-79
Igfbp6	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	3.3e-214
Igfbp6	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Brain	rep_3	4.0e-152
Igfbp6	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	rep_3	2.6e-94
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Brain	rep_3	9.9e-174
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Brain	rep_3	2.9e-128
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Brain	rep_3	6.0e-108
Igfbp6	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	1.3e-132
Igfbp6	GOBP_Regulation_Of_Map_Kinase_Activity	Mouse	Brain	rep_3	3.8e-94
Igfbp6	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Brain	rep_3	3.0e-62
Igfbp6	GOBP_Regulation_Of_Protein_Modification_Process	Mouse	Brain	rep_3	2.2e-188
Igfbp6	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Brain	rep_3	8.6e-94
Igfbp6	GOBP_Regulation_Of_Transferase_Activity	Mouse	Brain	rep_3	4.6e-186
Igfbp6	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Brain	rep_3	1.7e-164
Igfbp6	GOBP_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Brain	rep_4	1.7e-11
Igfbp6	GOBP_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Embryo	rep_6	5.3e-13
Igfbp6	GOBP_Activation_Of_Protein_Kinase_Activity	Mouse	Embryo	rep_14	1.8e-08
Igfbp6	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Embryo	rep_14	1.1e-07
Igfbp6	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Embryo	rep_14	5.8e-09
Igfbp6	GOBP_Positive_Regulation_Of_Map_Kinase_Activity	Mouse	Embryo	rep_14	4.3e-66
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Mouse	Embryo	rep_14	2.9e-12
Igfbp6	GOBP_Regulation_Of_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Embryo	rep_14	3.8e-12
Igfbp6	GOBP_Regulation_Of_Map_Kinase_Activity	Mouse	Embryo	rep_14	7.2e-52
Igfbp6	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Embryo	rep_1	2.6e-12
Igfbp6	GOBP_Cell_Migration	Mouse	Embryo	rep_1	7.4e-36
Igfbp6	GOBP_Locomotion	Mouse	Embryo	rep_1	1.7e-10
Igfbp6	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Embryo	rep_1	6.8e-306
Igfbp6	GOBP_Negative_Regulation_Of_Cell_Population_Proliferation	Mouse	Embryo	rep_1	3.5e-170
Igfbp6	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Embryo	rep_1	1.1e-25
Igfbp6	GOBP_Negative_Regulation_Of_Signaling	Mouse	Embryo	rep_1	5.6e-10
Igfbp6	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Embryo	rep_1	2.0e-10
Igfbp6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Embryo	rep_1	2.2e-98
Igfbp6	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Embryo	rep_1	9.7e-27
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Embryo	rep_1	2.2e-69
Igfbp6	GOBP_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Mouse	Embryo	rep_1	2.0e-13
Igfbp6	GOBP_Activation_Of_Protein_Kinase_Activity	Mouse	Embryo	rep_2	9.0e-34
Igfbp6	GOBP_Positive_Regulation_Of_Signaling	Mouse	Embryo	rep_2	1.4e-07
Igfbp6	GOBP_Positive_Regulation_Of_Transferase_Activity	Mouse	Embryo	rep_2	1.1e-280
Igfbp6	GOBP_Positive_Regulation_Of_Map_Kinase_Activity	Mouse	Embryo	rep_3	1.7e-287
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Kinase_Activity	Mouse	Embryo	rep_3	4.2e-94
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Mouse	Embryo	rep_3	8.5e-93
Igfbp6	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Embryo	rep_3	2.7e-115
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Embryo	rep_5	1.2e-28
Igfbp6	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Embryo	rep_6	1.7e-33
Igfbp6	GOBP_Cell_Migration	Mouse	Kidney	Nep	5.3e-07
Igfbp6	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Kidney	Nep	4.4e-12
Igfbp6	GOBP_Locomotion	Mouse	Kidney	Nep	5.3e-07
Igfbp6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	Nep	1.8e-46
Igfbp6	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	Nep	5.3e-07
Igfbp6	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	Nep	1.8e-46
Igfbp6	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Kidney	Nep	4.2e-26
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Kidney	Nep	4.3e-38
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Kidney	Nep	4.2e-26
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Kidney	Nep	4.2e-26
Igfbp6	GOBP_Positive_Regulation_Of_Signaling	Mouse	Kidney	Nep	1.1e-39
Igfbp6	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Kidney	Nep	4.6e-22
Igfbp6	GOBP_Regulation_Of_Protein_Modification_Process	Mouse	Kidney	Nep	4.6e-22
Igfbp6	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Kidney	Nep	4.6e-22
Igfbp6	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Kidney	Nep	4.4e-12
Igfbp6	GOBP_Activation_Of_Protein_Kinase_Activity	Mouse	Kidney	rep_2	6.9e-34
Igfbp6	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Kidney	rep_2	2.0e-101
Igfbp6	GOBP_Cell_Cell_Signaling	Mouse	Kidney	rep_2	6.2e-72
Igfbp6	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Kidney	rep_2	2.1e-78
Igfbp6	GOBP_Cell_Migration	Mouse	Kidney	rep_2	4.7e-40
Igfbp6	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Kidney	rep_2	6.7e-89
Igfbp6	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Kidney	rep_2	1.5e-13
Igfbp6	GOBP_Locomotion	Mouse	Kidney	rep_2	2.1e-43
Igfbp6	GOBP_Mapk_Cascade	Mouse	Kidney	rep_2	1.1e-19
Igfbp6	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Kidney	rep_2	1.3e-49
Igfbp6	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Kidney	rep_2	1.7e-39
Igfbp6	GOBP_Negative_Regulation_Of_Signaling	Mouse	Kidney	rep_2	4.0e-40
Igfbp6	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Kidney	rep_2	2.4e-65
Igfbp6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	rep_2	2.1e-66
Igfbp6	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Kidney	rep_2	1.8e-39
Igfbp6	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	rep_2	2.2e-45
Igfbp6	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Kidney	rep_2	7.2e-12
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Kinase_Activity	Mouse	Kidney	rep_2	1.3e-43
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Kidney	rep_2	1.7e-43
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Kidney	rep_2	7.3e-67
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Kidney	rep_2	8.4e-58
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Mouse	Kidney	rep_2	3.4e-07
Igfbp6	GOBP_Positive_Regulation_Of_Signaling	Mouse	Kidney	rep_2	3.4e-17
Igfbp6	GOBP_Positive_Regulation_Of_Transferase_Activity	Mouse	Kidney	rep_2	1.1e-59
Igfbp6	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	1.4e-17
Igfbp6	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Kidney	rep_2	1.3e-41
Igfbp6	GOBP_Regulation_Of_Protein_Kinase_Activity	Mouse	Kidney	rep_2	1.0e-67
Igfbp6	GOBP_Regulation_Of_Protein_Modification_Process	Mouse	Kidney	rep_2	2.2e-44
Igfbp6	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Kidney	rep_2	1.8e-44
Igfbp6	GOBP_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Mouse	Kidney	rep_2	8.8e-16
Igfbp6	GOBP_Regulation_Of_Transferase_Activity	Mouse	Kidney	rep_2	7.3e-90
Igfbp6	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Kidney	rep_2	5.2e-90
Igfbp6	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Kidney	rep_2	2.5e-32
Igfbp6	GOBP_Regulation_Of_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Liver	CN16-D1	1.1e-10
Igfbp6	GOBP_Positive_Regulation_Of_Map_Kinase_Activity	Mouse	Liver	CN16-D2	4.8e-10
Igfbp6	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Liver	CN16-E1	1.5e-08
Igfbp6	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Liver	rep_16	3.3e-07
Igfbp6	GOBP_Positive_Regulation_Of_Map_Kinase_Activity	Mouse	Liver	rep_16	1.0e-08
Igfbp6	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Liver	rep_16	1.4e-09
Igfbp6	GOBP_Regulation_Of_Map_Kinase_Activity	Mouse	Liver	rep_16	9.0e-08
Igfbp6	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Liver	rep_16	1.8e-10
Igfbp6	GOBP_Cell_Migration	Mouse	Liver	rep_26	1.6e-10
Igfbp6	GOBP_Locomotion	Mouse	Liver	rep_26	1.6e-10
Igfbp6	GOBP_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Brain	rep_1	1.3e-14
Igfbp6	GOBP_Regulation_Of_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Brain	rep_1	1.9e-29
Igfbp6	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Lymph	MS-1	8.5e-09
Igfbp6	GOBP_Cell_Cell_Signaling	Mouse	Lymph	MS-1	9.7e-11
Igfbp6	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Lymph	MS-1	7.3e-10
Igfbp6	GOBP_Cell_Migration	Mouse	Lymph	MS-1	5.7e-13
Igfbp6	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Lymph	MS-1	1.6e-11
Igfbp6	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Lymph	MS-1	1.6e-14
Igfbp6	GOBP_Locomotion	Mouse	Lymph	MS-1	1.2e-12
Igfbp6	GOBP_Mapk_Cascade	Mouse	Lymph	MS-1	8.8e-20
Igfbp6	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Lymph	MS-1	9.4e-09
Igfbp6	GOBP_Negative_Regulation_Of_Cell_Population_Proliferation	Mouse	Lymph	MS-1	5.6e-14
Igfbp6	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Lymph	MS-1	1.5e-11
Igfbp6	GOBP_Negative_Regulation_Of_Signaling	Mouse	Lymph	MS-1	1.0e-14
Igfbp6	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Lymph	MS-1	9.3e-09
Igfbp6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Lymph	MS-1	2.2e-13
Igfbp6	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	2.3e-12
Igfbp6	GOBP_Positive_Regulation_Of_Map_Kinase_Activity	Mouse	Lymph	MS-1	2.1e-09
Igfbp6	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Lymph	MS-1	2.7e-14
Igfbp6	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Lymph	MS-1	1.9e-12
Igfbp6	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Lymph	MS-1	5.6e-12
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Kinase_Activity	Mouse	Lymph	MS-1	7.7e-08
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Lymph	MS-1	1.9e-12
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Lymph	MS-1	1.9e-12
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Lymph	MS-1	2.7e-14
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Mouse	Lymph	MS-1	4.2e-08
Igfbp6	GOBP_Positive_Regulation_Of_Signaling	Mouse	Lymph	MS-1	2.3e-12
Igfbp6	GOBP_Positive_Regulation_Of_Transferase_Activity	Mouse	Lymph	MS-1	1.1e-10
Igfbp6	GOBP_Regulation_Of_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Lymph	MS-1	1.3e-07
Igfbp6	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.0e-14
Igfbp6	GOBP_Regulation_Of_Map_Kinase_Activity	Mouse	Lymph	MS-1	5.6e-11
Igfbp6	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Lymph	MS-1	5.6e-12
Igfbp6	GOBP_Regulation_Of_Protein_Modification_Process	Mouse	Lymph	MS-1	1.9e-12
Igfbp6	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Lymph	MS-1	1.4e-12
Igfbp6	GOBP_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Mouse	Lymph	MS-1	7.5e-11
Igfbp6	GOBP_Regulation_Of_Transferase_Activity	Mouse	Lymph	MS-1	1.0e-08
Igfbp6	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Lymph	MS-1	6.2e-07
Igfbp6	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Lymph	MS-1	8.3e-14
Igfbp6	GOBP_Positive_Regulation_Of_Map_Kinase_Activity	Mouse	Brain	rep_4	1.3e-32
Igfbp6	GOBP_Canonical_Wnt_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	1.2e-07
Igfbp6	GOBP_Cell_Cell_Signaling	Mouse	Brain	HP_ad_rep7	1.6e-08
Igfbp6	GOBP_Cell_Migration	Mouse	Brain	HP_ad_rep7	2.2e-07
Igfbp6	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	2.5e-10
Igfbp6	GOBP_Locomotion	Mouse	Brain	HP_ad_rep7	3.8e-07
Igfbp6	GOBP_Negative_Regulation_Of_Canonical_Wnt_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	4.0e-07
Igfbp6	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	HP_ad_rep7	2.8e-07
Igfbp6	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	HP_ad_rep7	2.8e-07
Igfbp6	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.7e-07
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Kinase_Activity	Mouse	Brain	HP_ad_rep7	3.5e-08
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Phosphorylation	Mouse	Brain	HP_ad_rep7	2.8e-07
Igfbp6	GOBP_Positive_Regulation_Of_Transferase_Activity	Mouse	Brain	HP_ad_rep7	2.2e-07
Igfbp6	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Brain	HP_ad_rep7	1.7e-08
Igfbp6	GOBP_Regulation_Of_Protein_Kinase_Activity	Mouse	Brain	HP_ad_rep7	2.3e-09
Igfbp6	GOBP_Regulation_Of_Protein_Modification_Process	Mouse	Brain	HP_ad_rep7	1.1e-07
Igfbp6	GOBP_Regulation_Of_Protein_Phosphorylation	Mouse	Brain	HP_ad_rep7	4.0e-09
Igfbp6	GOBP_Regulation_Of_Transferase_Activity	Mouse	Brain	HP_ad_rep7	1.6e-08
Igfbp6	GOBP_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	3.8e-08
Igfbp6	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	9.5e-09
Igfbp6	GOBP_Cell_Cell_Signaling_By_Wnt	Mouse	Brain	HP_polb_rep9	1.7e-14
Igfbp6	GOBP_Cell_Surface_Receptor_Signaling_Pathway_Involved_In_Cell_Cell_Signaling	Mouse	Brain	HP_polb_rep9	1.2e-14
Igfbp6	GOBP_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	9.7e-15
Igfbp6	GOBP_Negative_Regulation_Of_Cell_Population_Proliferation	Mouse	Brain	HP_polb_rep9	2.8e-10
Igfbp6	GOBP_Negative_Regulation_Of_Response_To_Stimulus	Mouse	Brain	HP_polb_rep9	3.1e-09
Igfbp6	GOBP_Negative_Regulation_Of_Signaling	Mouse	Brain	HP_polb_rep9	1.4e-11
Igfbp6	GOBP_Negative_Regulation_Of_Wnt_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	4.7e-20
Igfbp6	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	1.7e-14
Igfbp6	GOBP_Positive_Regulation_Of_Map_Kinase_Activity	Mouse	Brain	HP_polb_rep9	2.3e-08
Igfbp6	GOBP_Positive_Regulation_Of_Mapk_Cascade	Mouse	Brain	HP_polb_rep9	6.9e-10
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Metabolic_Process	Mouse	Brain	HP_polb_rep9	6.0e-11
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Modification_Process	Mouse	Brain	HP_polb_rep9	9.8e-11
Igfbp6	GOBP_Positive_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Mouse	Brain	HP_polb_rep9	4.5e-08
Igfbp6	GOBP_Positive_Regulation_Of_Signaling	Mouse	Brain	HP_polb_rep9	1.3e-14
Igfbp6	GOBP_Regulation_Of_Insulin_Like_Growth_Factor_Receptor_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	4.5e-14
Igfbp6	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	3.9e-11
Igfbp6	GOBP_Regulation_Of_Map_Kinase_Activity	Mouse	Brain	HP_polb_rep9	2.4e-07
Igfbp6	GOBP_Regulation_Of_Protein_Serine_Threonine_Kinase_Activity	Mouse	Brain	HP_polb_rep9	1.0e-07

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Igfbp6 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Igfbp6 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Igfbp6 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Igfbp6

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Igfbp6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source