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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Hoxd4 (spascer ID:15436)

Gene summary for Hoxd4

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Hoxd4
	Gene ID	15436
	Gene name	homeobox D4
	Synonyms	6030436D05Rik\|Hox-4.2\|Hox-5.1
	Cytomap	2 C3\|2 44.13 cM
	Type of gene	protein-coding
	Description	homeobox protein Hox-D4homeo box D4homeobox protein Hox-4.2homeobox protein Hox-5.1
	Modification date	20220424
	UniProtAcc	P10628

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Hoxd4	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	21873635	Function
Hoxd4	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	21873635	Function
Hoxd4	GO:0005634	nucleus	21873635	Component
Hoxd4	GO:0006357	regulation of transcription by RNA polymerase II	21873635	Process
Hoxd4	GO:0009952	anterior/posterior pattern specification	21873635	Process
Hoxd4	GO:0048704	embryonic skeletal system morphogenesis	21873635	Process

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Spatial pattern events for Hoxd4

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Hoxd4	Mouse	Embryo	rep_2	33188776	1.37e-14
Hoxd4	Mouse	Embryo	rep_12	33188776	4.84e-15
Hoxd4	Mouse	Embryo	rep_13	33188776	4.49e-15
Hoxd4	Mouse	Embryo	rep_1	34489600	3.74e-16
Hoxd4	Mouse	Embryo	rep_2	34489600	7.25e-16
Hoxd4	Mouse	Embryo	rep_3	34489600	4.04e-16
Hoxd4	Mouse	Embryo	rep_4	34489600	3.67e-16
Hoxd4	Mouse	Embryo	rep_5	34489600	7.21e-16
Hoxd4	Mouse	Embryo	rep_6	34489600	3.64e-16
Hoxd4	Mouse	Testicle	rep_5	34731600	5.52e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)

Singel gene map

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Spatial pattern pathway has Hoxd4 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Hoxd4	GOBP_Animal_Organ_Morphogenesis	Mouse	Spinal cord	CN94_E1	6.6e-06
Hoxd4	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Spinal cord	CN94_E1	7.7e-07
Hoxd4	GOBP_Regionalization	Mouse	Spinal cord	CN94_E1	7.3e-06
Hoxd4	GOBP_Skeletal_System_Development	Mouse	Spinal cord	CN94_E1	5.6e-06
Hoxd4	GOBP_Embryo_Development	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Hoxd4	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Spinal cord	L7CN45_C1	3.9e-07
Hoxd4	GOBP_Embryonic_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Hoxd4	GOBP_Embryonic_Organ_Development	Mouse	Spinal cord	L7CN45_C1	5.1e-08
Hoxd4	GOBP_Pattern_Specification_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Hoxd4	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Hoxd4	GOBP_Skeletal_System_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	2.2e-08
Hoxd4	GOBP_Embryonic_Skeletal_System_Development	Mouse	Spinal cord	L7CN47_C1	3.7e-07
Hoxd4	GOBP_Anterior_Posterior_Pattern_Specification	Mouse	Spinal cord	L8CN17_E1	2.7e-06
Hoxd4	GOBP_Animal_Organ_Morphogenesis	Mouse	Brain	rep_27	2.0e-06
Hoxd4	GOBP_Anterior_Posterior_Pattern_Specification	Mouse	Brain	rep_27	3.1e-05
Hoxd4	GOBP_Pattern_Specification_Process	Mouse	Brain	rep_27	3.2e-09
Hoxd4	GOBP_Regionalization	Mouse	Brain	rep_27	3.9e-08
Hoxd4	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Brain	rep_71	2.6e-07
Hoxd4	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Brain	rep_1	1.0e-08
Hoxd4	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_1	2.5e-12
Hoxd4	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_1	1.6e-17
Hoxd4	GOBP_Animal_Organ_Morphogenesis	Mouse	Brain	rep_3	5.4e-57
Hoxd4	GOBP_Anterior_Posterior_Pattern_Specification	Mouse	Brain	rep_3	1.2e-140
Hoxd4	GOBP_Embryo_Development	Mouse	Brain	rep_3	1.3e-126
Hoxd4	GOBP_Embryonic_Morphogenesis	Mouse	Brain	rep_3	5.0e-165
Hoxd4	GOBP_Embryonic_Organ_Development	Mouse	Brain	rep_3	4.3e-190
Hoxd4	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Brain	rep_3	1.5e-168
Hoxd4	GOBP_Embryonic_Skeletal_System_Development	Mouse	Brain	rep_3	1.0e-111
Hoxd4	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Brain	rep_3	1.2e-119
Hoxd4	GOBP_Pattern_Specification_Process	Mouse	Brain	rep_3	1.6e-118
Hoxd4	GOBP_Regionalization	Mouse	Brain	rep_3	1.3e-180
Hoxd4	GOBP_Skeletal_System_Development	Mouse	Brain	rep_3	3.3e-190
Hoxd4	GOBP_Skeletal_System_Morphogenesis	Mouse	Brain	rep_3	7.3e-51
Hoxd4	GOBP_Anterior_Posterior_Pattern_Specification	Mouse	Embryo	rep_6	1.5e-09
Hoxd4	GOBP_Skeletal_System_Morphogenesis	Mouse	Embryo	rep_6	3.8e-12
Hoxd4	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Embryo	rep_14	2.2e-13
Hoxd4	GOBP_Embryonic_Skeletal_System_Development	Mouse	Embryo	rep_14	5.5e-53
Hoxd4	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Embryo	rep_14	2.3e-45
Hoxd4	GOBP_Animal_Organ_Morphogenesis	Mouse	Embryo	rep_1	1.7e-10
Hoxd4	GOBP_Anterior_Posterior_Pattern_Specification	Mouse	Embryo	rep_2	8.6e-166
Hoxd4	GOBP_Regionalization	Mouse	Embryo	rep_2	5.4e-84
Hoxd4	GOBP_Embryo_Development	Mouse	Embryo	rep_3	1.2e-173
Hoxd4	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Embryo	rep_3	0.0e+00
Hoxd4	GOBP_Embryonic_Skeletal_System_Development	Mouse	Embryo	rep_3	4.4e-129
Hoxd4	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Embryo	rep_3	0.0e+00
Hoxd4	GOBP_Pattern_Specification_Process	Mouse	Embryo	rep_3	2.8e-168
Hoxd4	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	0.0e+00
Hoxd4	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
Hoxd4	GOBP_Skeletal_System_Morphogenesis	Mouse	Embryo	rep_3	0.0e+00
Hoxd4	GOBP_Skeletal_System_Development	Mouse	Embryo	rep_6	3.1e-59
Hoxd4	GOBP_Animal_Organ_Morphogenesis	Mouse	Kidney	rep_2	4.2e-71
Hoxd4	GOBP_Anterior_Posterior_Pattern_Specification	Mouse	Kidney	rep_2	3.0e-23
Hoxd4	GOBP_Embryo_Development	Mouse	Kidney	rep_2	7.4e-46
Hoxd4	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Kidney	rep_2	9.8e-28
Hoxd4	GOBP_Embryonic_Morphogenesis	Mouse	Kidney	rep_2	7.3e-66
Hoxd4	GOBP_Embryonic_Organ_Development	Mouse	Kidney	rep_2	1.3e-60
Hoxd4	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Kidney	rep_2	3.0e-55
Hoxd4	GOBP_Embryonic_Skeletal_System_Development	Mouse	Kidney	rep_2	2.0e-38
Hoxd4	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Kidney	rep_2	1.6e-37
Hoxd4	GOBP_Pattern_Specification_Process	Mouse	Kidney	rep_2	2.3e-36
Hoxd4	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	4.5e-10
Hoxd4	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	8.3e-40
Hoxd4	GOBP_Regionalization	Mouse	Kidney	rep_2	2.1e-25
Hoxd4	GOBP_Skeletal_System_Development	Mouse	Kidney	rep_2	7.5e-46
Hoxd4	GOBP_Skeletal_System_Morphogenesis	Mouse	Kidney	rep_2	1.2e-20
Hoxd4	GOBP_Skeletal_System_Development	Mouse	Liver	CN73-C1	9.4e-07
Hoxd4	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Liver	rep_15	1.5e-24
Hoxd4	GOBP_Pattern_Specification_Process	Mouse	Liver	rep_16	3.6e-20
Hoxd4	GOBP_Regionalization	Mouse	Liver	rep_16	1.2e-11
Hoxd4	GOBP_Animal_Organ_Morphogenesis	Mouse	Lymph	MS-1	4.4e-09
Hoxd4	GOBP_Embryo_Development	Mouse	Lymph	MS-1	2.5e-08
Hoxd4	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Lymph	MS-1	4.0e-11
Hoxd4	GOBP_Embryonic_Morphogenesis	Mouse	Lymph	MS-1	5.6e-07
Hoxd4	GOBP_Embryonic_Organ_Development	Mouse	Lymph	MS-1	1.1e-11
Hoxd4	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Lymph	MS-1	1.4e-11
Hoxd4	GOBP_Embryonic_Skeletal_System_Development	Mouse	Lymph	MS-1	5.9e-22
Hoxd4	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Lymph	MS-1	7.9e-14
Hoxd4	GOBP_Pattern_Specification_Process	Mouse	Lymph	MS-1	3.9e-12
Hoxd4	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	4.4e-12
Hoxd4	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	1.7e-12
Hoxd4	GOBP_Regionalization	Mouse	Lymph	MS-1	2.7e-12
Hoxd4	GOBP_Skeletal_System_Development	Mouse	Lymph	MS-1	2.6e-12
Hoxd4	GOBP_Skeletal_System_Morphogenesis	Mouse	Lymph	MS-1	8.7e-13
Hoxd4	GOBP_Skeletal_System_Morphogenesis	Mouse	Lung	rep_1	4.0e-16
Hoxd4	GOBP_Regionalization	Mouse	Brain	rep_4	6.3e-07
Hoxd4	GOBP_Embryonic_Organ_Development	Mouse	Brain	rep_7	7.0e-07
Hoxd4	GOBP_Embryonic_Organ_Morphogenesis	Mouse	Brain	rep_7	2.6e-14
Hoxd4	GOBP_Pattern_Specification_Process	Mouse	Brain	rep_7	1.0e-12
Hoxd4	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Brain	HP_ad_rep7	7.5e-07
Hoxd4	GOBP_Pattern_Specification_Process	Mouse	Brain	HP_ad_rep7	2.1e-10
Hoxd4	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-11
Hoxd4	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.3e-11
Hoxd4	GOBP_Regionalization	Mouse	Brain	HP_ad_rep7	2.8e-09
Hoxd4	GOBP_Skeletal_System_Development	Mouse	Brain	HP_ad_rep7	3.7e-09
Hoxd4	GOBP_Anterior_Posterior_Pattern_Specification	Mouse	Brain	HP_adpolb_rep1	3.0e-08
Hoxd4	GOBP_Embryonic_Skeletal_System_Development	Mouse	Brain	HP_adpolb_rep1	6.0e-10
Hoxd4	GOBP_Embryo_Development	Mouse	Brain	HP_polb_rep9	1.5e-10
Hoxd4	GOBP_Embryonic_Morphogenesis	Mouse	Brain	HP_polb_rep9	3.7e-09
Hoxd4	GOBP_Embryonic_Organ_Development	Mouse	Brain	HP_polb_rep9	9.6e-11
Hoxd4	GOBP_Embryonic_Skeletal_System_Morphogenesis	Mouse	Brain	HP_polb_rep9	3.5e-15
Hoxd4	GOBP_Skeletal_System_Morphogenesis	Mouse	Brain	HP_polb_rep9	1.1e-07

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Hoxd4 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Hoxd4 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Hoxd4 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Hoxd4

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Hoxd4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source