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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Hdgf (spascer ID:15191)

Gene summary for Hdgf

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Hdgf
	Gene ID	15191
	Gene name	heparin binding growth factor
	Synonyms	AI118077\|D3Ertd299e
	Cytomap	3 F1\|3 38.78 cM
	Type of gene	protein-coding
	Description	hepatoma-derived growth factor
	Modification date	20220424
	UniProtAcc	P51859

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Hdgf	GO:0003690	double-stranded DNA binding	21873635	Function
Hdgf	GO:0003712	transcription coregulator activity	21873635	Function
Hdgf	GO:0005634	nucleus	21873635	Component
Hdgf	GO:0006357	regulation of transcription by RNA polymerase II	21873635	Process

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Spatial pattern events for Hdgf

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Hdgf	Mouse	Brain	13B	32637622	5.45e-06
Hdgf	Mouse	Brain	22A	32637622	1.12e-07
Hdgf	Mouse	Brain	29B	32637622	9.89e-06
Hdgf	Mouse	Brain	rep_2	35141374	5.23e-12
Hdgf	Mouse	Brain	rep_3	35141374	8.57e-13
Hdgf	Mouse	Brain	rep_4	35141374	2.29e-07
Hdgf	Mouse	Brain	rep_5	35141374	1.48e-10
Hdgf	Mouse	Brain	rep_6	35141374	5.05e-10
Hdgf	Mouse	Embryo	1D	34210887	2.73e-06
Hdgf	Mouse	Embryo	3D	34210887	1.84e-09
Hdgf	Mouse	Embryo	3H	34210887	3.41e-06
Hdgf	Mouse	Embryo	4E	34210887	5.57e-14
Hdgf	Mouse	Embryo	rep_2	33188776	1.25e-11
Hdgf	Mouse	Embryo	rep_4	33188776	5.08e-15
Hdgf	Mouse	Embryo	rep_5	33188776	1.40e-14
Hdgf	Mouse	Embryo	rep_12	33188776	2.10e-06
Hdgf	Mouse	Embryo	rep_13	33188776	3.08e-07
Hdgf	Mouse	Embryo	rep_15	33188776	7.14e-08
Hdgf	Mouse	Kidney	CLP	34003797	2.72e-14
Hdgf	Mouse	Kidney	IRI	34003797	4.62e-13
Hdgf	Mouse	Kidney	rep_3	34853151	2.99e-09
Hdgf	Mouse	Kidney	rep_4	34853151	2.25e-06
Hdgf	Mouse	Brain	rep_1	33469025	1.30e-15
Hdgf	Mouse	Brain	rep_2	35027729	2.46e-10
Hdgf	Mouse	Brain	rep_3	35027729	2.54e-07
Hdgf	Mouse	Intestine	rep_2	35149721	1.64e-09
Hdgf	Mouse	Intestine	rep_3	35149721	5.21e-15
Hdgf	Mouse	Intestine	rep_4	35149721	2.30e-15
Hdgf	Mouse	Lymph	A1	0	1.35e-06
Hdgf	Mouse	Lymph	B1	0	3.66e-15
Hdgf	Mouse	Lung	rep_1	35290801	4.52e-15
Hdgf	Mouse	Lung	rep_2	35290801	1.42e-14
Hdgf	Mouse	Lung	rep_3	35290801	5.26e-15
Hdgf	Mouse	Lung	rep_4	35290801	3.04e-15
Hdgf	Mouse	Brain	rep_6	35210624	2.42e-08
Hdgf	Mouse	Brain	rep_7	35210624	1.46e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_rep_3_H&E
Kidney_rep_4_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Hdgf envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Hdgf	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Spinal cord	CN94_E1	1.6e-06
Hdgf	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	CN94_E1	6.2e-07
Hdgf	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	CN94_E1	2.2e-06
Hdgf	GOBP_Cellular_Response_To_Topologically_Incorrect_Protein	Mouse	Spinal cord	L7CN45_C1	7.6e-08
Hdgf	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Spinal cord	L7CN45_C1	2.2e-07
Hdgf	GOBP_Ire1_Mediated_Unfolded_Protein_Response	Mouse	Spinal cord	L7CN45_C1	5.7e-09
Hdgf	GOBP_Response_To_Cytokine	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Hdgf	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Spinal cord	L7CN45_C1	2.7e-07
Hdgf	GOBP_Response_To_Interleukin_7	Mouse	Spinal cord	L7CN45_C1	1.9e-07
Hdgf	GOBP_Response_To_Topologically_Incorrect_Protein	Mouse	Spinal cord	L7CN45_C1	5.1e-07
Hdgf	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_27	7.2e-05
Hdgf	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_27	2.8e-05
Hdgf	GOBP_Ire1_Mediated_Unfolded_Protein_Response	Mouse	Brain	rep_37	3.1e-05
Hdgf	GOBP_Cellular_Response_To_Topologically_Incorrect_Protein	Mouse	Brain	rep_3	1.4e-162
Hdgf	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Brain	rep_3	3.4e-151
Hdgf	GOBP_Ire1_Mediated_Unfolded_Protein_Response	Mouse	Brain	rep_3	3.9e-131
Hdgf	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_3	1.4e-196
Hdgf	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_3	9.4e-206
Hdgf	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_3	7.5e-168
Hdgf	GOBP_Response_To_Cytokine	Mouse	Brain	rep_3	1.2e-08
Hdgf	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Brain	rep_3	6.3e-133
Hdgf	GOBP_Response_To_Interleukin_7	Mouse	Brain	rep_3	2.7e-132
Hdgf	GOBP_Response_To_Topologically_Incorrect_Protein	Mouse	Brain	rep_3	8.7e-153
Hdgf	GOBP_Cellular_Response_To_Topologically_Incorrect_Protein	Mouse	Embryo	rep_14	8.7e-22
Hdgf	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Embryo	rep_14	2.5e-19
Hdgf	GOBP_Ire1_Mediated_Unfolded_Protein_Response	Mouse	Embryo	rep_14	5.5e-61
Hdgf	GOBP_Response_To_Interleukin_7	Mouse	Embryo	rep_14	6.1e-07
Hdgf	GOBP_Response_To_Topologically_Incorrect_Protein	Mouse	Embryo	rep_14	7.2e-14
Hdgf	GOBP_Response_To_Cytokine	Mouse	Embryo	rep_1	8.2e-211
Hdgf	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Embryo	rep_2	8.0e-13
Hdgf	GOBP_Cellular_Response_To_Topologically_Incorrect_Protein	Mouse	Embryo	rep_3	0.0e+00
Hdgf	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Embryo	rep_3	1.7e-305
Hdgf	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	1.5e-267
Hdgf	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
Hdgf	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Embryo	rep_3	1.8e-13
Hdgf	GOBP_Response_To_Topologically_Incorrect_Protein	Mouse	Embryo	rep_3	2.3e-263
Hdgf	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Kidney	rep_2	5.3e-42
Hdgf	GOBP_Ire1_Mediated_Unfolded_Protein_Response	Mouse	Kidney	rep_2	7.1e-13
Hdgf	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Kidney	rep_2	7.3e-42
Hdgf	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	7.7e-30
Hdgf	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	2.2e-14
Hdgf	GOBP_Response_To_Cytokine	Mouse	Kidney	rep_2	3.1e-14
Hdgf	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Kidney	rep_2	1.2e-89
Hdgf	GOBP_Response_To_Interleukin_7	Mouse	Kidney	rep_2	1.9e-25
Hdgf	GOBP_Response_To_Interleukin_7	Mouse	Liver	CN16-D2	2.4e-07
Hdgf	GOBP_Response_To_Cytokine	Mouse	Liver	rep_16	1.4e-13
Hdgf	GOBP_Ire1_Mediated_Unfolded_Protein_Response	Mouse	Lymph	MS-1	3.1e-09
Hdgf	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lymph	MS-1	6.1e-11
Hdgf	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	1.8e-10
Hdgf	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	2.2e-09
Hdgf	GOBP_Response_To_Cytokine	Mouse	Lymph	MS-1	5.7e-15
Hdgf	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Lymph	MS-1	1.7e-11
Hdgf	GOBP_Response_To_Topologically_Incorrect_Protein	Mouse	Lymph	MS-1	2.8e-07
Hdgf	GOBP_Cellular_Response_To_Topologically_Incorrect_Protein	Mouse	Lymph	PBS	1.2e-07
Hdgf	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Lymph	PBS	2.4e-07
Hdgf	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lung	rep_1	7.5e-20
Hdgf	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lung	rep_1	5.8e-10
Hdgf	GOBP_Response_To_Cytokine	Mouse	Lung	rep_1	1.2e-17
Hdgf	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.3e-12
Hdgf	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-11
Hdgf	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.1e-13
Hdgf	GOBP_Response_To_Cytokine	Mouse	Brain	HP_ad_rep7	2.1e-08
Hdgf	GOBP_Ire1_Mediated_Unfolded_Protein_Response	Mouse	Brain	HP_adpolb_rep6	1.1e-07
Hdgf	GOBP_Cellular_Response_To_Topologically_Incorrect_Protein	Mouse	Brain	HP_polb_rep9	2.8e-08
Hdgf	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Brain	HP_polb_rep9	2.7e-13
Hdgf	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Brain	HP_polb_rep9	3.5e-12
Hdgf	GOBP_Response_To_Topologically_Incorrect_Protein	Mouse	Brain	HP_polb_rep9	5.0e-08

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Hdgf function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Hdgf function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Hdgf envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Hdgf

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Hdgf

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source