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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Guca2a (spascer ID:14915)

Gene summary for Guca2a

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Guca2a
	Gene ID	14915
	Gene name	guanylate cyclase activator 2a (guanylin)
	Synonyms	Guca2
	Cytomap	4 D2.1\|4 55.47 cM
	Type of gene	protein-coding
	Description	guanylinguanylate cyclase activator 2 (guanylin 2, intestinal, heatstable)
	Modification date	20220424
	UniProtAcc	P33680

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Guca2a	GO:0030250	guanylate cyclase activator activity	21873635	Function

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Spatial pattern events for Guca2a

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Guca2a	Mouse	Kidney	CLP	34003797	6.92e-15
Guca2a	Mouse	Kidney	IRI	34003797	1.32e-12
Guca2a	Mouse	Kidney	Sham	34003797	7.83e-15
Guca2a	Mouse	Kidney	rep_4	34853151	4.07e-15
Guca2a	Mouse	Kidney	rep_5	34853151	3.18e-15
Guca2a	Mouse	Intestine	rep_1	35149721	6.08e-15
Guca2a	Mouse	Intestine	rep_2	35149721	3.44e-15
Guca2a	Mouse	Intestine	rep_3	35149721	3.25e-15
Guca2a	Mouse	Intestine	rep_4	35149721	2.30e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_4_H&E
Kidney_rep_5_H&E

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Spatial pattern pathway has Guca2a envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Metabolic_Process	Mouse	Spinal cord	CN94_E1	6.6e-06
Guca2a	GOBP_Regulation_Of_Lyase_Activity	Mouse	Spinal cord	CN94_E1	3.2e-06
Guca2a	GOBP_Regulation_Of_Cyclase_Activity	Mouse	Spinal cord	L7bCN02_E1	6.0e-07
Guca2a	GOBP_Digestion	Mouse	Spinal cord	L7CN45_C1	7.1e-06
Guca2a	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.1e-07
Guca2a	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	1.4e-07
Guca2a	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	5.6e-08
Guca2a	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Guca2a	GOBP_Organophosphate_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	2.0e-07
Guca2a	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Guca2a	GOBP_Positive_Regulation_Of_Lyase_Activity	Mouse	Spinal cord	L7CN45_C1	1.9e-07
Guca2a	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Guca2a	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Guca2a	GOBP_Positive_Regulation_Of_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.0e-06
Guca2a	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-07
Guca2a	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.7e-07
Guca2a	GOBP_Regulation_Of_Nucleotide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Guca2a	GOBP_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Guca2a	GOBP_Positive_Regulation_Of_Guanylate_Cyclase_Activity	Mouse	Spinal cord	L7CN45_E1	2.3e-09
Guca2a	GOBP_Positive_Regulation_Of_Cyclase_Activity	Mouse	Spinal cord	L7CN47_D1	1.2e-06
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Spinal cord	L7CN47_D1	2.9e-07
Guca2a	GOBP_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Spinal cord	L7CN60_D1	3.4e-06
Guca2a	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Spinal cord	L8CN11_C1	3.6e-13
Guca2a	GOBP_Positive_Regulation_Of_Lyase_Activity	Mouse	Brain	rep_9	3.9e-05
Guca2a	GOBP_Positive_Regulation_Of_Guanylate_Cyclase_Activity	Mouse	Brain	rep_21	2.3e-05
Guca2a	GOBP_Positive_Regulation_Of_Cyclase_Activity	Mouse	Brain	rep_75	7.7e-06
Guca2a	GOBP_Regulation_Of_Guanylate_Cyclase_Activity	Mouse	Brain	rep_75	2.4e-05
Guca2a	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Brain	rep_1	3.5e-11
Guca2a	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_1	2.5e-12
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Brain	rep_1	3.3e-22
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Metabolic_Process	Mouse	Brain	rep_1	2.3e-42
Guca2a	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Brain	rep_1	1.3e-08
Guca2a	GOBP_Positive_Regulation_Of_Small_Molecule_Metabolic_Process	Mouse	Brain	rep_1	7.6e-22
Guca2a	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Brain	rep_1	3.6e-14
Guca2a	GOBP_Regulation_Of_Cyclase_Activity	Mouse	Brain	rep_1	1.2e-36
Guca2a	GOBP_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Brain	rep_1	3.4e-19
Guca2a	GOBP_Regulation_Of_Nucleotide_Metabolic_Process	Mouse	Brain	rep_1	8.8e-44
Guca2a	GOBP_Regulation_Of_Small_Molecule_Metabolic_Process	Mouse	Brain	rep_1	2.9e-09
Guca2a	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	rep_3	2.9e-144
Guca2a	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Brain	rep_3	2.9e-25
Guca2a	GOBP_Organophosphate_Metabolic_Process	Mouse	Brain	rep_3	8.1e-43
Guca2a	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_3	8.5e-79
Guca2a	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	rep_3	2.6e-94
Guca2a	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Brain	rep_3	3.0e-62
Guca2a	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	rep_3	2.7e-19
Guca2a	GOBP_Digestion	Mouse	Brain	rep_7	1.8e-18
Guca2a	GOBP_Digestion	Mouse	Embryo	rep_6	2.4e-50
Guca2a	GOBP_Positive_Regulation_Of_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_6	2.0e-10
Guca2a	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_14	1.8e-12
Guca2a	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Embryo	rep_14	4.8e-21
Guca2a	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	2.4e-12
Guca2a	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Embryo	rep_14	1.8e-11
Guca2a	GOBP_Organophosphate_Metabolic_Process	Mouse	Embryo	rep_14	2.0e-09
Guca2a	GOBP_Positive_Regulation_Of_Cyclase_Activity	Mouse	Embryo	rep_14	9.3e-39
Guca2a	GOBP_Positive_Regulation_Of_Lyase_Activity	Mouse	Embryo	rep_14	5.1e-47
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Embryo	rep_14	1.0e-48
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Metabolic_Process	Mouse	Embryo	rep_14	3.2e-30
Guca2a	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	4.8e-28
Guca2a	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_14	6.5e-20
Guca2a	GOBP_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Embryo	rep_14	2.1e-44
Guca2a	GOBP_Regulation_Of_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_14	4.1e-08
Guca2a	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Embryo	rep_1	2.2e-98
Guca2a	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Embryo	rep_1	9.7e-27
Guca2a	GOBP_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_1	1.4e-55
Guca2a	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	0.0e+00
Guca2a	GOBP_Positive_Regulation_Of_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_3	1.2e-69
Guca2a	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	Nep	1.8e-46
Guca2a	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	Nep	1.8e-46
Guca2a	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Kidney	Nep	4.2e-26
Guca2a	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Kidney	Nep	4.6e-22
Guca2a	GOBP_Digestion	Mouse	Kidney	rep_2	1.8e-12
Guca2a	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	2.4e-27
Guca2a	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Kidney	rep_2	4.6e-07
Guca2a	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Kidney	rep_2	8.9e-78
Guca2a	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Kidney	rep_2	1.2e-09
Guca2a	GOBP_Organophosphate_Metabolic_Process	Mouse	Kidney	rep_2	1.7e-41
Guca2a	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	rep_2	2.1e-66
Guca2a	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	rep_2	2.2e-45
Guca2a	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	4.5e-10
Guca2a	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Kidney	rep_2	7.2e-12
Guca2a	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-17
Guca2a	GOBP_Regulation_Of_Cyclase_Activity	Mouse	Kidney	rep_2	3.0e-09
Guca2a	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Kidney	rep_2	1.3e-41
Guca2a	GOBP_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	1.8e-43
Guca2a	GOBP_Positive_Regulation_Of_Lyase_Activity	Mouse	Liver	CN16-D1	1.6e-13
Guca2a	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Liver	CN16-D1	3.4e-08
Guca2a	GOBP_Regulation_Of_Lyase_Activity	Mouse	Liver	CN16-D1	3.1e-07
Guca2a	GOBP_Positive_Regulation_Of_Cyclase_Activity	Mouse	Liver	CN16-D2	3.8e-10
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Metabolic_Process	Mouse	Liver	CN16-D2	2.1e-08
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Liver	CN65-C1	9.7e-08
Guca2a	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Liver	CN73-C1	2.5e-07
Guca2a	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Liver	CN73-C1	3.0e-11
Guca2a	GOBP_Positive_Regulation_Of_Guanylate_Cyclase_Activity	Mouse	Liver	rep_15	6.8e-24
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Liver	rep_15	4.9e-20
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Metabolic_Process	Mouse	Liver	rep_15	9.2e-10
Guca2a	GOBP_Regulation_Of_Guanylate_Cyclase_Activity	Mouse	Liver	rep_15	1.9e-34
Guca2a	GOBP_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Liver	rep_15	2.2e-11
Guca2a	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Liver	rep_16	1.6e-18
Guca2a	GOBP_Positive_Regulation_Of_Cyclase_Activity	Mouse	Liver	rep_16	1.4e-25
Guca2a	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Liver	rep_16	1.4e-09
Guca2a	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Liver	rep_16	7.0e-15
Guca2a	GOBP_Regulation_Of_Nucleotide_Metabolic_Process	Mouse	Liver	rep_16	2.8e-35
Guca2a	GOBP_Digestion	Mouse	Lymph	MS-1	4.4e-13
Guca2a	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.7e-09
Guca2a	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Lymph	MS-1	3.6e-07
Guca2a	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	1.4e-09
Guca2a	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Lymph	MS-1	6.7e-07
Guca2a	GOBP_Organophosphate_Metabolic_Process	Mouse	Lymph	MS-1	7.3e-07
Guca2a	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Lymph	MS-1	2.2e-13
Guca2a	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Lymph	MS-1	1.9e-12
Guca2a	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	4.4e-12
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Lymph	MS-1	9.2e-07
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Metabolic_Process	Mouse	Lymph	MS-1	1.7e-08
Guca2a	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Lymph	MS-1	5.6e-12
Guca2a	GOBP_Positive_Regulation_Of_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	1.1e-13
Guca2a	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	3.6e-07
Guca2a	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	8.0e-08
Guca2a	GOBP_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Lymph	MS-1	1.8e-07
Guca2a	GOBP_Regulation_Of_Nucleotide_Metabolic_Process	Mouse	Lymph	MS-1	3.8e-08
Guca2a	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Lymph	MS-1	5.6e-12
Guca2a	GOBP_Regulation_Of_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.8e-14
Guca2a	GOBP_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.6e-11
Guca2a	GOBP_Positive_Regulation_Of_Guanylate_Cyclase_Activity	Mouse	Brain	HP_ad_rep3	3.4e-08
Guca2a	GOBP_Digestion	Mouse	Brain	HP_ad_rep7	5.9e-12
Guca2a	GOBP_Nucleoside_Phosphate_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	2.4e-07
Guca2a	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	2.8e-08
Guca2a	GOBP_Organophosphate_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.2e-11
Guca2a	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	HP_ad_rep7	2.8e-07
Guca2a	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	HP_ad_rep7	2.8e-07
Guca2a	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-11
Guca2a	GOBP_Positive_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.7e-07
Guca2a	GOBP_Regulation_Of_Cyclase_Activity	Mouse	Brain	HP_ad_rep7	1.4e-07
Guca2a	GOBP_Regulation_Of_Phosphorus_Metabolic_Process	Mouse	Brain	HP_ad_rep7	1.7e-08
Guca2a	GOBP_Positive_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Brain	HP_polb_rep1	1.8e-08
Guca2a	GOBP_Nucleobase_Containing_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	6.9e-09
Guca2a	GOBP_Organophosphate_Metabolic_Process	Mouse	Brain	HP_polb_rep9	7.1e-09
Guca2a	GOBP_Positive_Regulation_Of_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	1.7e-07
Guca2a	GOBP_Purine_Containing_Compound_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	6.8e-08
Guca2a	GOBP_Purine_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.4e-07
Guca2a	GOBP_Regulation_Of_Lyase_Activity	Mouse	Brain	HP_polb_rep9	1.5e-08
Guca2a	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.0e-09
Guca2a	GOBP_Regulation_Of_Nucleotide_Biosynthetic_Process	Mouse	Brain	HP_wt_rep2	7.7e-11

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Guca2a function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Guca2a function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand	Receptor	LR pair	Tissue	Replication
Guca2a	Gucy2c	Guca2a_Gucy2c	Intestine	rep_3
Guca2a	Gucy2c	Guca2a_Gucy2c	Intestine	rep_4

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Transcription factor for Guca2a envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Guca2a

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Guca2a

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source