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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Fli1 (spascer ID:14247)

Gene summary for Fli1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Fli1
	Gene ID	14247
	Gene name	Friend leukemia integration 1
	Synonyms	EWSR2\|Fli-1\|SIC-1\|Sic1
	Cytomap	9 A4\|9 17.74 cM
	Type of gene	protein-coding
	Description	Friend leukemia integration 1 transcription factorretroviral integration site protein Fli-1
	Modification date	20220424
	UniProtAcc	P26323

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Fli1	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	21873635	Function
Fli1	GO:0005634	nucleus	21873635	Component
Fli1	GO:0006357	regulation of transcription by RNA polymerase II	21873635	Process
Fli1	GO:0030154	cell differentiation	21873635	Process

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Spatial pattern events for Fli1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Fli1	Mouse	Embryo	4E	34210887	7.12e-06
Fli1	Mouse	Embryo	rep_1	33188776	4.59e-09
Fli1	Mouse	Embryo	rep_2	33188776	1.97e-14
Fli1	Mouse	Embryo	rep_4	33188776	1.53e-14
Fli1	Mouse	Embryo	rep_5	33188776	2.73e-11
Fli1	Mouse	Embryo	rep_13	33188776	4.49e-15
Fli1	Mouse	Embryo	rep_1	34489600	3.74e-16
Fli1	Mouse	Embryo	rep_2	34489600	4.14e-16
Fli1	Mouse	Embryo	rep_3	34489600	4.04e-16
Fli1	Mouse	Embryo	rep_4	34489600	3.67e-16
Fli1	Mouse	Embryo	rep_5	34489600	4.08e-16
Fli1	Mouse	Embryo	rep_6	34489600	3.64e-16
Fli1	Mouse	Intestine	rep_2	35149721	6.79e-08
Fli1	Mouse	Lung	rep_1	35290801	9.06e-13
Fli1	Mouse	Lung	rep_3	35290801	3.23e-06

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Lung_rep_1_H&E
Lung_rep_3_H&E

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Spatial pattern pathway has Fli1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Fli1	GOBP_Animal_Organ_Morphogenesis	Mouse	Spinal cord	CN94_E1	6.6e-06
Fli1	GOBP_Bone_Cell_Development	Mouse	Spinal cord	CN94_E1	4.2e-08
Fli1	GOBP_Bone_Development	Mouse	Spinal cord	CN94_E1	6.4e-06
Fli1	GOBP_Megakaryocyte_Differentiation	Mouse	Spinal cord	CN94_E1	2.9e-07
Fli1	GOBP_Myeloid_Cell_Differentiation	Mouse	Spinal cord	CN94_E1	2.9e-06
Fli1	GOBP_Skeletal_System_Development	Mouse	Spinal cord	CN94_E1	5.6e-06
Fli1	GOBP_Myeloid_Cell_Development	Mouse	Spinal cord	L7bCN02_E1	2.0e-06
Fli1	GOBP_Immune_System_Development	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Fli1	GOBP_Megakaryocyte_Development	Mouse	Spinal cord	L7CN45_C1	1.7e-06
Fli1	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Fli1	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Spinal cord	L7CN45_C1	9.1e-06
Fli1	GOBP_Circulatory_System_Process	Mouse	Spinal cord	L8CN17_E1	2.2e-06
Fli1	GOBP_Animal_Organ_Morphogenesis	Mouse	Brain	rep_27	2.0e-06
Fli1	GOBP_Megakaryocyte_Differentiation	Mouse	Brain	rep_41	5.2e-09
Fli1	GOBP_Bone_Cell_Development	Mouse	Brain	rep_1	4.6e-13
Fli1	GOBP_Megakaryocyte_Differentiation	Mouse	Brain	rep_1	9.3e-27
Fli1	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_1	2.5e-12
Fli1	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_1	1.6e-17
Fli1	GOBP_Animal_Organ_Morphogenesis	Mouse	Brain	rep_3	5.4e-57
Fli1	GOBP_Bone_Development	Mouse	Brain	rep_3	4.6e-171
Fli1	GOBP_Circulatory_System_Process	Mouse	Brain	rep_3	2.0e-61
Fli1	GOBP_Immune_System_Development	Mouse	Brain	rep_3	1.3e-52
Fli1	GOBP_Megakaryocyte_Development	Mouse	Brain	rep_3	1.8e-33
Fli1	GOBP_Myeloid_Cell_Development	Mouse	Brain	rep_3	2.7e-159
Fli1	GOBP_Myeloid_Cell_Differentiation	Mouse	Brain	rep_3	1.8e-21
Fli1	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Brain	rep_3	1.1e-62
Fli1	GOBP_Skeletal_System_Development	Mouse	Brain	rep_3	3.3e-190
Fli1	GOBP_Bone_Cell_Development	Mouse	Embryo	rep_6	6.4e-07
Fli1	GOBP_Bone_Development	Mouse	Embryo	rep_6	8.5e-14
Fli1	GOBP_Megakaryocyte_Differentiation	Mouse	Embryo	rep_6	3.2e-18
Fli1	GOBP_Megakaryocyte_Development	Mouse	Embryo	rep_14	1.6e-22
Fli1	GOBP_Myeloid_Cell_Development	Mouse	Embryo	rep_14	8.6e-32
Fli1	GOBP_Myeloid_Cell_Differentiation	Mouse	Embryo	rep_14	1.3e-11
Fli1	GOBP_Animal_Organ_Morphogenesis	Mouse	Embryo	rep_1	1.7e-10
Fli1	GOBP_Immune_System_Development	Mouse	Embryo	rep_1	0.0e+00
Fli1	GOBP_Myeloid_Cell_Differentiation	Mouse	Embryo	rep_1	2.4e-139
Fli1	GOBP_Bone_Development	Mouse	Embryo	rep_2	1.6e-238
Fli1	GOBP_Bone_Cell_Development	Mouse	Embryo	rep_3	3.0e-250
Fli1	GOBP_Megakaryocyte_Development	Mouse	Embryo	rep_3	3.0e-250
Fli1	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	0.0e+00
Fli1	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
Fli1	GOBP_Skeletal_System_Development	Mouse	Embryo	rep_6	3.1e-59
Fli1	GOBP_Circulatory_System_Process	Mouse	Kidney	IRI	1.5e-08
Fli1	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Kidney	Nep	1.6e-16
Fli1	GOBP_Animal_Organ_Morphogenesis	Mouse	Kidney	rep_2	4.2e-71
Fli1	GOBP_Bone_Cell_Development	Mouse	Kidney	rep_2	1.2e-09
Fli1	GOBP_Bone_Development	Mouse	Kidney	rep_2	4.4e-35
Fli1	GOBP_Circulatory_System_Process	Mouse	Kidney	rep_2	1.4e-100
Fli1	GOBP_Immune_System_Development	Mouse	Kidney	rep_2	4.6e-22
Fli1	GOBP_Megakaryocyte_Development	Mouse	Kidney	rep_2	4.3e-20
Fli1	GOBP_Megakaryocyte_Differentiation	Mouse	Kidney	rep_2	1.2e-34
Fli1	GOBP_Myeloid_Cell_Development	Mouse	Kidney	rep_2	4.3e-29
Fli1	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	4.5e-10
Fli1	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	8.3e-40
Fli1	GOBP_Skeletal_System_Development	Mouse	Kidney	rep_2	7.5e-46
Fli1	GOBP_Bone_Cell_Development	Mouse	Liver	CN16-D2	1.7e-07
Fli1	GOBP_Immune_System_Development	Mouse	Liver	CN73-C1	2.2e-07
Fli1	GOBP_Skeletal_System_Development	Mouse	Liver	CN73-C1	9.4e-07
Fli1	GOBP_Bone_Cell_Development	Mouse	Liver	rep_15	4.5e-07
Fli1	GOBP_Immune_System_Development	Mouse	Liver	rep_16	5.3e-11
Fli1	GOBP_Megakaryocyte_Development	Mouse	Liver	rep_16	2.3e-12
Fli1	GOBP_Myeloid_Cell_Development	Mouse	Liver	rep_16	1.5e-11
Fli1	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Liver	rep_16	6.1e-20
Fli1	GOBP_Megakaryocyte_Differentiation	Mouse	Brain	rep_1	9.6e-06
Fli1	GOBP_Animal_Organ_Morphogenesis	Mouse	Lymph	MS-1	4.4e-09
Fli1	GOBP_Bone_Cell_Development	Mouse	Lymph	MS-1	1.9e-17
Fli1	GOBP_Bone_Development	Mouse	Lymph	MS-1	5.9e-11
Fli1	GOBP_Circulatory_System_Process	Mouse	Lymph	MS-1	3.9e-08
Fli1	GOBP_Immune_System_Development	Mouse	Lymph	MS-1	1.2e-13
Fli1	GOBP_Megakaryocyte_Development	Mouse	Lymph	MS-1	1.3e-10
Fli1	GOBP_Megakaryocyte_Differentiation	Mouse	Lymph	MS-1	3.8e-10
Fli1	GOBP_Myeloid_Cell_Development	Mouse	Lymph	MS-1	8.4e-14
Fli1	GOBP_Myeloid_Cell_Differentiation	Mouse	Lymph	MS-1	1.9e-13
Fli1	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	4.4e-12
Fli1	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	1.7e-12
Fli1	GOBP_Skeletal_System_Development	Mouse	Lymph	MS-1	2.6e-12
Fli1	GOBP_Bone_Cell_Development	Mouse	Brain	HP_ad_rep7	5.0e-12
Fli1	GOBP_Bone_Development	Mouse	Brain	HP_ad_rep7	5.0e-14
Fli1	GOBP_Immune_System_Development	Mouse	Brain	HP_ad_rep7	8.3e-09
Fli1	GOBP_Myeloid_Cell_Development	Mouse	Brain	HP_ad_rep7	3.8e-09
Fli1	GOBP_Myeloid_Cell_Differentiation	Mouse	Brain	HP_ad_rep7	1.2e-09
Fli1	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-11
Fli1	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.3e-11
Fli1	GOBP_Skeletal_System_Development	Mouse	Brain	HP_ad_rep7	3.7e-09
Fli1	GOBP_Megakaryocyte_Development	Mouse	Brain	HP_adpolb_rep1	7.8e-11
Fli1	GOBP_Megakaryocyte_Differentiation	Mouse	Brain	HP_adpolb_rep5	2.4e-07
Fli1	GOBP_Circulatory_System_Process	Mouse	Brain	HP_polb_rep9	5.3e-09
Fli1	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Brain	HP_polb_rep9	2.9e-10

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Fli1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Fli1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Fli1 envolved

Transcription factor analysis using single cell data.

TF	Tissue	Group	Cell types	Target genes	Rss score
FLI1	Uterus	early_mid	Glandular	LEPR,FAM167B,ESAM, etc.	0.288
FLI1	Uterus	early_mid	Lumenal 1	LEPR,FAM167B,ESAM, etc.	0.36
FLI1	Uterus	early_mid	Glandular_secretory	LEPR,FAM167B,ESAM, etc.	0.266
FLI1	Uterus	early_mid	Ciliated	LEPR,FAM167B,ESAM, etc.	0.25
FLI1	Uterus	mid	Glandular_secretory	EXT1,PPP1R9B,FIZ1, etc.	0.792
FLI1	Uterus	proliferative	Ciliated	PROC,MEIS2,LTC4S, etc.	0.549

Motif information.

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Related Drugs for Fli1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Fli1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Fli1	C0279980	Extra-osseous Ewing's sarcoma	4	ORPHANET
Fli1	C0553580	Ewings sarcoma	3	CTD_human;ORPHANET
Fli1	C4479515	BLEEDING DISORDER, PLATELET-TYPE, 21	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Fli1	C0684337	Ewings sarcoma-primitive neuroectodermal tumor (PNET)	2	ORPHANET
Fli1	C1956093	Paris-Trousseau Thrombocytopenia	2	ORPHANET
Fli1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Fli1	C0025149	Medulloblastoma	1	CTD_human
Fli1	C0205833	Medullomyoblastoma	1	CTD_human
Fli1	C0278510	Childhood Medulloblastoma	1	CTD_human
Fli1	C0278876	Adult Medulloblastoma	1	CTD_human
Fli1	C0751291	Desmoplastic Medulloblastoma	1	CTD_human
Fli1	C0795841	Jacobsen Distal 11q Deletion Syndrome	1	ORPHANET
Fli1	C1275668	Melanotic medulloblastoma	1	CTD_human