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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Sh3pxd2a (spascer ID:14218)

Gene summary for Sh3pxd2a

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Sh3pxd2a
	Gene ID	14218
	Gene name	SH3 and PX domains 2A
	Synonyms	2310014D11Rik\|AA589508\|AI256723\|AI413738\|C230050L11\|EG329070\|Fish\|Gm5098\|Sh3md1\|TSK5\|Tks5
	Cytomap	19\|19 C3
	Type of gene	protein-coding
	Description	SH3 and PX domain-containing protein 2ASH3 multiple domains 1SH3 multiple domains protein 1five SH3 domain-containing proteinfive SH3 domainstyrosine kinase substrate with five SH3 domains
	Modification date	20220424
	UniProtAcc	O89032

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Sh3pxd2a	GO:0005737	cytoplasm	21873635	Component
Sh3pxd2a	GO:0016176	superoxide-generating NADPH oxidase activator activity	21873635	Function
Sh3pxd2a	GO:0042554	superoxide anion generation	21873635	Process

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Spatial pattern events for Sh3pxd2a

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Sh3pxd2a	Mouse	Brain	S1	34413515	1.55e-08
Sh3pxd2a	Mouse	Brain	S2	34413515	1.56e-15
Sh3pxd2a	Mouse	Brain	S3	34413515	7.38e-06
Sh3pxd2a	Mouse	Brain	S4	34413515	1.37e-15
Sh3pxd2a	Mouse	Brain	S6	34413515	7.45e-11
Sh3pxd2a	Mouse	Brain	S7	34413515	4.46e-13
Sh3pxd2a	Mouse	Embryo	1F	34210887	4.20e-06
Sh3pxd2a	Mouse	Embryo	4E	34210887	3.28e-12
Sh3pxd2a	Mouse	Embryo	rep_3	33188776	5.86e-06
Sh3pxd2a	Mouse	Embryo	rep_4	33188776	7.71e-11
Sh3pxd2a	Mouse	Embryo	rep_13	33188776	7.68e-10
Sh3pxd2a	Mouse	Kidney	CLP	34003797	6.92e-15
Sh3pxd2a	Mouse	Kidney	IRI	34003797	2.29e-15
Sh3pxd2a	Mouse	Kidney	Sham	34003797	2.58e-15
Sh3pxd2a	Mouse	Kidney	rep_1	34853151	4.13e-15
Sh3pxd2a	Mouse	Kidney	rep_3	34853151	6.23e-06
Sh3pxd2a	Mouse	Kidney	rep_5	34853151	8.92e-11
Sh3pxd2a	Mouse	Brain	rep_1	33469025	1.10e-08
Sh3pxd2a	Mouse	Brain	rep_4	35027729	2.68e-06
Sh3pxd2a	Mouse	Brain	rep_5	35027729	1.46e-15
Sh3pxd2a	Mouse	Intestine	rep_2	35149721	5.49e-15
Sh3pxd2a	Mouse	Lymph	A1	0	1.90e-06
Sh3pxd2a	Mouse	Lymph	B1	0	5.70e-13
Sh3pxd2a	Mouse	Lung	rep_4	35290801	9.24e-07

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_3_H&E
Kidney_rep_5_H&E
Brain_rep_1_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Sh3pxd2a envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Sh3pxd2a	GOBP_External_Encapsulating_Structure_Organization	Mouse	Spinal cord	CN94_E1	1.2e-06
Sh3pxd2a	GOBP_Myeloid_Cell_Differentiation	Mouse	Spinal cord	CN94_E1	2.9e-06
Sh3pxd2a	GOBP_Superoxide_Metabolic_Process	Mouse	Spinal cord	CN94_E1	1.0e-07
Sh3pxd2a	GOBP_Syncytium_Formation	Mouse	Spinal cord	CN94_E1	1.0e-06
Sh3pxd2a	GOBP_Myeloid_Leukocyte_Differentiation	Mouse	Spinal cord	L7bCN02_E1	7.2e-06
Sh3pxd2a	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Sh3pxd2a	GOBP_Embryo_Development	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Sh3pxd2a	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Spinal cord	L7CN45_C1	3.9e-07
Sh3pxd2a	GOBP_Immune_System_Development	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Sh3pxd2a	GOBP_Leukocyte_Differentiation	Mouse	Spinal cord	L7CN45_C1	2.8e-06
Sh3pxd2a	GOBP_Osteoclast_Differentiation	Mouse	Spinal cord	L7CN45_C1	2.0e-07
Sh3pxd2a	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Sh3pxd2a	GOBP_Multinuclear_Osteoclast_Differentiation	Mouse	Spinal cord	L7CN47_D1	4.8e-07
Sh3pxd2a	GOBP_Osteoclast_Fusion	Mouse	Spinal cord	L7CN47_D1	4.8e-07
Sh3pxd2a	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Brain	rep_61	5.5e-05
Sh3pxd2a	GOBP_Myeloid_Leukocyte_Differentiation	Mouse	Brain	rep_71	1.3e-05
Sh3pxd2a	GOBP_Multinuclear_Osteoclast_Differentiation	Mouse	Brain	rep_75	5.3e-05
Sh3pxd2a	GOBP_Osteoclast_Fusion	Mouse	Brain	rep_75	2.9e-07
Sh3pxd2a	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Brain	rep_1	1.0e-08
Sh3pxd2a	GOBP_In_Utero_Embryonic_Development	Mouse	Brain	rep_1	1.0e-19
Sh3pxd2a	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Brain	rep_1	1.7e-58
Sh3pxd2a	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Brain	rep_3	5.3e-58
Sh3pxd2a	GOBP_Embryo_Development	Mouse	Brain	rep_3	1.3e-126
Sh3pxd2a	GOBP_External_Encapsulating_Structure_Organization	Mouse	Brain	rep_3	8.9e-180
Sh3pxd2a	GOBP_Immune_System_Development	Mouse	Brain	rep_3	1.3e-52
Sh3pxd2a	GOBP_Myeloid_Cell_Differentiation	Mouse	Brain	rep_3	1.8e-21
Sh3pxd2a	GOBP_Osteoclast_Differentiation	Mouse	Brain	rep_3	5.7e-120
Sh3pxd2a	GOBP_Superoxide_Metabolic_Process	Mouse	Brain	rep_3	1.1e-172
Sh3pxd2a	GOBP_Syncytium_Formation	Mouse	Brain	rep_3	3.4e-52
Sh3pxd2a	GOBP_Leukocyte_Differentiation	Mouse	Brain	rep_7	9.1e-15
Sh3pxd2a	GOBP_Osteoclast_Fusion	Mouse	Brain	rep_7	8.4e-07
Sh3pxd2a	GOBP_Osteoclast_Differentiation	Mouse	Embryo	rep_6	1.4e-14
Sh3pxd2a	GOBP_Leukocyte_Differentiation	Mouse	Embryo	rep_14	2.4e-09
Sh3pxd2a	GOBP_Multinuclear_Osteoclast_Differentiation	Mouse	Embryo	rep_14	7.1e-135
Sh3pxd2a	GOBP_Myeloid_Cell_Differentiation	Mouse	Embryo	rep_14	1.3e-11
Sh3pxd2a	GOBP_Osteoclast_Fusion	Mouse	Embryo	rep_14	1.8e-130
Sh3pxd2a	GOBP_Superoxide_Metabolic_Process	Mouse	Embryo	rep_14	2.4e-17
Sh3pxd2a	GOBP_Syncytium_Formation	Mouse	Embryo	rep_14	5.5e-29
Sh3pxd2a	GOBP_Immune_System_Development	Mouse	Embryo	rep_1	0.0e+00
Sh3pxd2a	GOBP_Myeloid_Cell_Differentiation	Mouse	Embryo	rep_1	2.4e-139
Sh3pxd2a	GOBP_Embryo_Development	Mouse	Embryo	rep_3	1.2e-173
Sh3pxd2a	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Embryo	rep_3	0.0e+00
Sh3pxd2a	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Embryo	rep_6	3.8e-28
Sh3pxd2a	GOBP_External_Encapsulating_Structure_Organization	Mouse	Embryo	rep_6	1.1e-18
Sh3pxd2a	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Kidney	Nep	5.6e-37
Sh3pxd2a	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Kidney	rep_2	5.6e-148
Sh3pxd2a	GOBP_Embryo_Development	Mouse	Kidney	rep_2	7.4e-46
Sh3pxd2a	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Kidney	rep_2	9.8e-28
Sh3pxd2a	GOBP_External_Encapsulating_Structure_Organization	Mouse	Kidney	rep_2	5.6e-85
Sh3pxd2a	GOBP_Immune_System_Development	Mouse	Kidney	rep_2	4.6e-22
Sh3pxd2a	GOBP_In_Utero_Embryonic_Development	Mouse	Kidney	rep_2	7.1e-20
Sh3pxd2a	GOBP_Leukocyte_Differentiation	Mouse	Kidney	rep_2	1.1e-42
Sh3pxd2a	GOBP_Multinuclear_Osteoclast_Differentiation	Mouse	Kidney	rep_2	2.2e-22
Sh3pxd2a	GOBP_Myeloid_Leukocyte_Differentiation	Mouse	Kidney	rep_2	1.1e-18
Sh3pxd2a	GOBP_Osteoclast_Differentiation	Mouse	Kidney	rep_2	1.4e-11
Sh3pxd2a	GOBP_Osteoclast_Fusion	Mouse	Kidney	rep_2	1.3e-18
Sh3pxd2a	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Kidney	rep_2	1.2e-25
Sh3pxd2a	GOBP_Syncytium_Formation	Mouse	Kidney	rep_2	8.0e-53
Sh3pxd2a	GOBP_In_Utero_Embryonic_Development	Mouse	Liver	CN16-D2	6.4e-07
Sh3pxd2a	GOBP_Multinuclear_Osteoclast_Differentiation	Mouse	Liver	CN16-D2	2.3e-10
Sh3pxd2a	GOBP_Osteoclast_Fusion	Mouse	Liver	CN16-D2	2.3e-10
Sh3pxd2a	GOBP_External_Encapsulating_Structure_Organization	Mouse	Liver	CN73-C1	1.4e-08
Sh3pxd2a	GOBP_Immune_System_Development	Mouse	Liver	CN73-C1	2.2e-07
Sh3pxd2a	GOBP_Multinuclear_Osteoclast_Differentiation	Mouse	Liver	rep_15	3.0e-08
Sh3pxd2a	GOBP_Osteoclast_Fusion	Mouse	Liver	rep_15	3.0e-08
Sh3pxd2a	GOBP_Immune_System_Development	Mouse	Liver	rep_16	5.3e-11
Sh3pxd2a	GOBP_In_Utero_Embryonic_Development	Mouse	Liver	rep_16	7.6e-16
Sh3pxd2a	GOBP_Leukocyte_Differentiation	Mouse	Liver	rep_16	1.3e-10
Sh3pxd2a	GOBP_Myeloid_Leukocyte_Differentiation	Mouse	Liver	rep_16	1.2e-17
Sh3pxd2a	GOBP_Osteoclast_Differentiation	Mouse	Liver	rep_16	7.8e-15
Sh3pxd2a	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Liver	rep_16	5.0e-08
Sh3pxd2a	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Lymph	MS-1	6.4e-13
Sh3pxd2a	GOBP_Embryo_Development	Mouse	Lymph	MS-1	2.5e-08
Sh3pxd2a	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Lymph	MS-1	4.0e-11
Sh3pxd2a	GOBP_External_Encapsulating_Structure_Organization	Mouse	Lymph	MS-1	6.5e-12
Sh3pxd2a	GOBP_Immune_System_Development	Mouse	Lymph	MS-1	1.2e-13
Sh3pxd2a	GOBP_In_Utero_Embryonic_Development	Mouse	Lymph	MS-1	5.3e-13
Sh3pxd2a	GOBP_Leukocyte_Differentiation	Mouse	Lymph	MS-1	9.5e-18
Sh3pxd2a	GOBP_Multinuclear_Osteoclast_Differentiation	Mouse	Lymph	MS-1	1.7e-07
Sh3pxd2a	GOBP_Myeloid_Cell_Differentiation	Mouse	Lymph	MS-1	1.9e-13
Sh3pxd2a	GOBP_Myeloid_Leukocyte_Differentiation	Mouse	Lymph	MS-1	3.2e-19
Sh3pxd2a	GOBP_Osteoclast_Differentiation	Mouse	Lymph	MS-1	1.6e-13
Sh3pxd2a	GOBP_Osteoclast_Fusion	Mouse	Lymph	MS-1	1.7e-07
Sh3pxd2a	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Lymph	MS-1	2.4e-10
Sh3pxd2a	GOBP_Superoxide_Metabolic_Process	Mouse	Lymph	MS-1	2.6e-12
Sh3pxd2a	GOBP_Syncytium_Formation	Mouse	Lymph	MS-1	8.3e-15
Sh3pxd2a	GOBP_External_Encapsulating_Structure_Organization	Mouse	Lung	rep_1	1.3e-11
Sh3pxd2a	GOBP_Osteoclast_Fusion	Mouse	Brain	HP_ad_rep3	2.0e-07
Sh3pxd2a	GOBP_Embryo_Development_Ending_In_Birth_Or_Egg_Hatching	Mouse	Brain	HP_ad_rep7	7.5e-07
Sh3pxd2a	GOBP_External_Encapsulating_Structure_Organization	Mouse	Brain	HP_ad_rep7	1.9e-11
Sh3pxd2a	GOBP_Immune_System_Development	Mouse	Brain	HP_ad_rep7	8.3e-09
Sh3pxd2a	GOBP_Myeloid_Cell_Differentiation	Mouse	Brain	HP_ad_rep7	1.2e-09
Sh3pxd2a	GOBP_Osteoclast_Differentiation	Mouse	Brain	HP_ad_rep7	3.3e-12
Sh3pxd2a	GOBP_Multinuclear_Osteoclast_Differentiation	Mouse	Brain	HP_ad_rep8	1.3e-08
Sh3pxd2a	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Brain	HP_polb_rep9	6.3e-08
Sh3pxd2a	GOBP_Embryo_Development	Mouse	Brain	HP_polb_rep9	1.5e-10
Sh3pxd2a	GOBP_In_Utero_Embryonic_Development	Mouse	Brain	HP_polb_rep9	2.4e-10
Sh3pxd2a	GOBP_Leukocyte_Differentiation	Mouse	Brain	HP_polb_rep9	2.1e-12
Sh3pxd2a	GOBP_Myeloid_Leukocyte_Differentiation	Mouse	Brain	HP_polb_rep9	5.4e-12
Sh3pxd2a	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Brain	HP_polb_rep9	8.1e-07
Sh3pxd2a	GOBP_Syncytium_Formation	Mouse	Brain	HP_polb_rep9	1.9e-22

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Sh3pxd2a function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Sh3pxd2a function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Sh3pxd2a envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Sh3pxd2a

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Sh3pxd2a

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Sh3pxd2a	C0004238	Atrial Fibrillation	1	CTD_human
Sh3pxd2a	C0036341	Schizophrenia	1	PSYGENET
Sh3pxd2a	C0038454	Cerebrovascular accident	1	CTD_human
Sh3pxd2a	C0206729	Neurofibrosarcoma	1	ORPHANET
Sh3pxd2a	C0235480	Paroxysmal atrial fibrillation	1	CTD_human
Sh3pxd2a	C0751690	Malignant Peripheral Nerve Sheath Tumor	1	ORPHANET
Sh3pxd2a	C0751956	Acute Cerebrovascular Accidents	1	CTD_human
Sh3pxd2a	C2585653	Persistent atrial fibrillation	1	CTD_human
Sh3pxd2a	C3468561	familial atrial fibrillation	1	CTD_human