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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

Spatial pattern genes

Soverview

Spatial pattern pathway

Soverview

Cell cell interactions using single cell data

Soverview

Cell-cell/spot-spot interactions using spatial data

Soverview

Transcription factors events

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Spatial pattern gene: Fbl (spascer ID:14113)

Gene summary for Fbl

check button Gene summary
Gene information
SpeciesMouse
Gene symbol

Fbl

Gene ID

14113

Gene namefibrillarin
SynonymsAL022665|FIB|FLRN|RNU3IP1
Cytomap7|7 A3
Type of geneprotein-coding
DescriptionrRNA 2'-O-methyltransferase fibrillarinU6 snRNA 2'-O-methyltransferase fibrillarinhistone-glutamine methyltransferasenucleolar protein 1
Modification date20220424
UniProtAcc

P35550


check button Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).
GeneGO IDGO termPubMed IDCategory
Fbl

GO:0000494

box C/D RNA 3'-end processing

21873635

Process
Fbl

GO:0003723

RNA binding

21873635

Function
Fbl

GO:0005730

nucleolus

21873635

Component
Fbl

GO:0008649

rRNA methyltransferase activity

21873635

Function
Fbl

GO:0015030

Cajal body

21873635

Component
Fbl

GO:0031167

rRNA methylation

21873635

Process
Fbl

GO:0031428

box C/D RNP complex

21873635

Component
Fbl

GO:0032040

small-subunit processome

21873635

Component
Fbl

GO:1990258

histone glutamine methylation

21873635

Process
Fbl

GO:1990259

histone-glutamine methyltransferase activity

21873635

Function

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Spatial pattern events for Fbl

check buttonspatial pattern gene list.
Gene symbolSpeciesTissueReplicationPMIDAdj p-value
FblMouseBrainS2 344135152.85e-15
FblMouseBrainS3 344135157.57e-09
FblMouseBrainS4 344135152.77e-08
FblMouseBrainS6 344135153.35e-07
FblMouseBrainrep_3 351413741.09e-11
FblMouseBrainrep_4 351413745.42e-15
FblMouseBrainrep_5 351413741.47e-15
FblMouseBrainrep_6 351413742.24e-07
FblMouseEmbryorep_1 331887764.29e-06
FblMouseEmbryorep_2 331887761.64e-09
FblMouseKidneyIRI 340037972.29e-15
FblMouseBrainrep_1 334690251.30e-15
FblMouseIntestinerep_2 351497211.00e-11
FblMouseIntestinerep_4 351497212.41e-10
FblMouseLymphA1 03.29e-15
FblMouseLymphB1 03.66e-15
FblMouseLungrep_1 352908011.87e-11
FblMouseLungrep_3 352908017.04e-07

check buttonspatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)Singel gene map
Brain_rep_3_H&E
boxplot
boxplot
Brain_rep_4_H&E
boxplot
boxplot
Brain_rep_5_H&E
boxplot
boxplot
Brain_rep_6_H&E
boxplot
boxplot
Kidney_IRI_H&E
boxplot
boxplot
Brain_rep_1_H&E
boxplot
Lung_rep_1_H&E
boxplot
boxplot
Lung_rep_3_H&E
boxplot
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Spatial pattern pathway has Fbl envolved


SymbolPathwaySpeciesTissue typeReplicationP-value
FblGOBP_MethylationMouseSpinal cordCN94_E1 7.7e-06
FblGOBP_OssificationMouseSpinal cordCN94_E1 7.4e-06
FblGOBP_Osteoblast_DifferentiationMouseSpinal cordCN94_E1 9.0e-07
FblGOBP_Protein_MethylationMouseSpinal cordCN94_E1 2.5e-06
FblGOBP_Rna_LocalizationMouseSpinal cordCN94_E1 3.7e-06
FblGOBP_Rna_3_End_ProcessingMouseSpinal cordL7bCN02_E1 8.2e-06
FblGOBP_Sno_S_Rna_Metabolic_ProcessMouseSpinal cordL7bCN02_E1 5.6e-08
FblGOBP_Chromatin_OrganizationMouseSpinal cordL7CN45_C1 3.5e-07
FblGOBP_Chromosome_OrganizationMouseSpinal cordL7CN45_C1 3.4e-08
FblGOBP_Histone_MethylationMouseSpinal cordL7CN45_C1 5.2e-09
FblGOBP_Ncrna_Metabolic_ProcessMouseSpinal cordL7CN45_C1 1.5e-07
FblGOBP_Ncrna_ProcessingMouseSpinal cordL7CN45_C1 1.4e-06
FblGOBP_Ribonucleoprotein_Complex_BiogenesisMouseSpinal cordL7CN45_C1 1.4e-06
FblGOBP_Ribosome_BiogenesisMouseSpinal cordL7CN45_C1 1.4e-06
FblGOBP_Rna_MethylationMouseSpinal cordL7CN45_C1 8.4e-07
FblGOBP_Rna_ProcessingMouseSpinal cordL7CN45_C1 2.2e-09
FblGOBP_Rrna_Metabolic_ProcessMouseSpinal cordL7CN45_C1 6.3e-07
FblGOBP_Rrna_ModificationMouseSpinal cordL7CN45_C1 2.0e-07
FblGOBP_Ncrna_3_End_ProcessingMouseSpinal cordL7CN47_D1 3.2e-06
FblGOBP_Peptidyl_Glutamine_MethylationMouseSpinal cordL7CN47_D1 3.1e-07
FblGOBP_Rrna_MethylationMouseSpinal cordL7CN47_D1 5.0e-06
FblGOBP_Snorna_LocalizationMouseSpinal cordL7CN81_C1 3.8e-06
FblGOBP_Rna_ModificationMouseSpinal cordL8CN17_E1 4.8e-08
FblGOBP_Peptidyl_Glutamine_MethylationMouseBrainrep_9 3.1e-06
FblGOBP_Snorna_LocalizationMouseBrainrep_19 4.6e-05
FblGOBP_Rna_3_End_ProcessingMouseBrainrep_27 4.5e-09
FblGOBP_Rna_MethylationMouseBrainrep_27 1.7e-10
FblGOBP_Rrna_ModificationMouseBrainrep_27 3.6e-05
FblGOBP_Sno_S_Rna_Metabolic_ProcessMouseBrainrep_27 4.3e-09
FblGOBP_Rrna_MethylationMouseBrainrep_36 5.7e-05
FblGOBP_Chromosome_OrganizationMouseBrainrep_1 3.9e-07
FblGOBP_Histone_MethylationMouseBrainrep_1 1.3e-09
FblGOBP_Protein_MethylationMouseBrainrep_1 1.8e-08
FblGOBP_Rrna_ModificationMouseBrainrep_1 6.7e-09
FblGOBP_Sno_S_Rna_Metabolic_ProcessMouseBrainrep_1 7.6e-12
FblGOBP_Snorna_LocalizationMouseBrainrep_1 1.8e-39
FblGOBP_Chromatin_OrganizationMouseBrainrep_35.1e-215
FblGOBP_MethylationMouseBrainrep_33.9e-199
FblGOBP_Ncrna_Metabolic_ProcessMouseBrainrep_3 1.8e-46
FblGOBP_Ncrna_ProcessingMouseBrainrep_3 5.1e-21
FblGOBP_OssificationMouseBrainrep_3 6.7e-28
FblGOBP_Osteoblast_DifferentiationMouseBrainrep_3 7.4e-84
FblGOBP_Peptidyl_Glutamine_MethylationMouseBrainrep_3 1.3e-71
FblGOBP_Ribonucleoprotein_Complex_BiogenesisMouseBrainrep_3 5.6e-32
FblGOBP_Ribosome_BiogenesisMouseBrainrep_3 1.8e-14
FblGOBP_Rna_3_End_ProcessingMouseBrainrep_32.2e-166
FblGOBP_Rna_LocalizationMouseBrainrep_36.0e-194
FblGOBP_Rna_MethylationMouseBrainrep_3 9.0e-81
FblGOBP_Rna_ModificationMouseBrainrep_31.8e-211
FblGOBP_Rna_ProcessingMouseBrainrep_34.3e-140
FblGOBP_Rrna_Metabolic_ProcessMouseBrainrep_3 1.7e-24
FblGOBP_Rrna_MethylationMouseBrainrep_34.2e-236
FblGOBP_Ncrna_3_End_ProcessingMouseBrainrep_79.2e-180
FblGOBP_Ncrna_3_End_ProcessingMouseEmbryorep_14 9.7e-35
FblGOBP_Ncrna_ProcessingMouseEmbryorep_14 2.7e-41
FblGOBP_Peptidyl_Glutamine_MethylationMouseEmbryorep_14 1.0e-33
FblGOBP_Ribonucleoprotein_Complex_BiogenesisMouseEmbryorep_14 2.1e-33
FblGOBP_Ribosome_BiogenesisMouseEmbryorep_14 2.1e-33
FblGOBP_Rna_3_End_ProcessingMouseEmbryorep_14 4.1e-27
FblGOBP_Rna_LocalizationMouseEmbryorep_14 4.6e-13
FblGOBP_Rna_MethylationMouseEmbryorep_14 2.0e-39
FblGOBP_Rna_ModificationMouseEmbryorep_14 3.1e-46
FblGOBP_Rna_ProcessingMouseEmbryorep_14 3.5e-14
FblGOBP_Rrna_Metabolic_ProcessMouseEmbryorep_14 2.2e-54
FblGOBP_Rrna_MethylationMouseEmbryorep_14 1.2e-57
FblGOBP_Rrna_ModificationMouseEmbryorep_14 1.3e-64
FblGOBP_Sno_S_Rna_Metabolic_ProcessMouseEmbryorep_14 5.1e-52
FblGOBP_Snorna_LocalizationMouseEmbryorep_14 7.3e-55
FblGOBP_Histone_MethylationMouseEmbryorep_2 5.9e-67
FblGOBP_OssificationMouseEmbryorep_2 6.7e-25
FblGOBP_Osteoblast_DifferentiationMouseEmbryorep_2 8.5e-10
FblGOBP_Protein_MethylationMouseEmbryorep_2 2.4e-42
FblGOBP_Rna_3_End_ProcessingMouseEmbryorep_2 2.8e-16
FblGOBP_Rna_LocalizationMouseEmbryorep_2 4.2e-15
FblGOBP_Rna_ProcessingMouseEmbryorep_2 2.4e-14
FblGOBP_Chromatin_OrganizationMouseEmbryorep_3 2.9e-87
FblGOBP_Chromosome_OrganizationMouseEmbryorep_3 1.4e-57
FblGOBP_MethylationMouseEmbryorep_3 0.0e+00
FblGOBP_Chromatin_OrganizationMouseKidneyrep_2 3.0e-63
FblGOBP_Chromosome_OrganizationMouseKidneyrep_2 1.0e-14
FblGOBP_Histone_MethylationMouseKidneyrep_2 3.8e-43
FblGOBP_MethylationMouseKidneyrep_2 2.7e-54
FblGOBP_Ncrna_3_End_ProcessingMouseKidneyrep_24.6e-111
FblGOBP_Ncrna_Metabolic_ProcessMouseKidneyrep_2 6.2e-81
FblGOBP_Ncrna_ProcessingMouseKidneyrep_2 5.7e-81
FblGOBP_OssificationMouseKidneyrep_2 3.5e-66
FblGOBP_Osteoblast_DifferentiationMouseKidneyrep_2 1.6e-54
FblGOBP_Peptidyl_Glutamine_MethylationMouseKidneyrep_2 3.4e-18
FblGOBP_Protein_MethylationMouseKidneyrep_2 3.1e-51
FblGOBP_Ribonucleoprotein_Complex_BiogenesisMouseKidneyrep_2 1.3e-69
FblGOBP_Ribosome_BiogenesisMouseKidneyrep_2 2.5e-90
FblGOBP_Rna_3_End_ProcessingMouseKidneyrep_2 2.8e-70
FblGOBP_Rna_LocalizationMouseKidneyrep_2 1.1e-66
FblGOBP_Rna_MethylationMouseKidneyrep_2 1.2e-52
FblGOBP_Rna_ModificationMouseKidneyrep_2 7.1e-48
FblGOBP_Rna_ProcessingMouseKidneyrep_2 1.1e-71
FblGOBP_Rrna_Metabolic_ProcessMouseKidneyrep_2 6.8e-87
FblGOBP_Rrna_MethylationMouseKidneyrep_2 2.0e-15
FblGOBP_Rrna_ModificationMouseKidneyrep_2 5.6e-14
FblGOBP_Sno_S_Rna_Metabolic_ProcessMouseKidneyrep_2 3.7e-14
FblGOBP_Ncrna_3_End_ProcessingMouseLiverCN16-D1 8.1e-11
FblGOBP_Sno_S_Rna_Metabolic_ProcessMouseLiverCN16-D1 1.2e-18
FblGOBP_Snorna_LocalizationMouseLiverCN16-E1 2.2e-16
FblGOBP_Rna_MethylationMouseLiverCN65-C1 6.8e-09
FblGOBP_Ncrna_Metabolic_ProcessMouseLiverCN73-C1 1.4e-08
FblGOBP_Rna_MethylationMouseLiverrep_15 5.5e-08
FblGOBP_Sno_S_Rna_Metabolic_ProcessMouseLiverrep_15 5.4e-17
FblGOBP_Peptidyl_Glutamine_MethylationMouseBrainrep_1 1.8e-06
FblGOBP_Chromatin_OrganizationMouseLymphMS-1 9.1e-11
FblGOBP_Chromosome_OrganizationMouseLymphMS-1 3.5e-09
FblGOBP_MethylationMouseLymphMS-1 2.5e-08
FblGOBP_Ncrna_3_End_ProcessingMouseLymphMS-1 1.8e-09
FblGOBP_Ncrna_Metabolic_ProcessMouseLymphMS-1 1.4e-09
FblGOBP_Ncrna_ProcessingMouseLymphMS-1 7.2e-09
FblGOBP_OssificationMouseLymphMS-1 3.4e-11
FblGOBP_Osteoblast_DifferentiationMouseLymphMS-1 7.1e-09
FblGOBP_Ribonucleoprotein_Complex_BiogenesisMouseLymphMS-1 1.7e-07
FblGOBP_Ribosome_BiogenesisMouseLymphMS-1 8.8e-09
FblGOBP_Rna_3_End_ProcessingMouseLymphMS-1 1.5e-11
FblGOBP_Rna_MethylationMouseLymphMS-1 7.5e-10
FblGOBP_Rna_ModificationMouseLymphMS-1 9.8e-15
FblGOBP_Rna_ProcessingMouseLymphMS-1 2.0e-09
FblGOBP_Rrna_Metabolic_ProcessMouseLymphMS-1 7.1e-07
FblGOBP_Protein_MethylationMouseLymphMS-2 1.6e-07
FblGOBP_Histone_MethylationMouseBrainrep_4 1.7e-07
FblGOBP_MethylationMouseBrainrep_7 1.2e-08
FblGOBP_Peptidyl_Glutamine_MethylationMouseBrainrep_7 3.0e-12
FblGOBP_Rna_MethylationMouseBrainrep_7 3.1e-08
FblGOBP_Rna_ModificationMouseBrainrep_7 3.9e-16
FblGOBP_Rrna_MethylationMouseBrainrep_7 1.6e-28
FblGOBP_Rrna_ModificationMouseBrainrep_7 2.4e-36
FblGOBP_Peptidyl_Glutamine_MethylationMouseBrainHP_ad_rep3 3.1e-07
FblGOBP_Rrna_MethylationMouseBrainHP_ad_rep3 5.7e-08
FblGOBP_Sno_S_Rna_Metabolic_ProcessMouseBrainHP_ad_rep3 5.7e-15
FblGOBP_Snorna_LocalizationMouseBrainHP_ad_rep3 5.8e-26
FblGOBP_Chromatin_OrganizationMouseBrainHP_ad_rep7 7.6e-11
FblGOBP_Chromosome_OrganizationMouseBrainHP_ad_rep7 2.9e-10
FblGOBP_Histone_MethylationMouseBrainHP_ad_rep7 2.4e-09
FblGOBP_MethylationMouseBrainHP_ad_rep7 1.4e-10
FblGOBP_Ncrna_3_End_ProcessingMouseBrainHP_ad_rep7 5.0e-12
FblGOBP_Ncrna_Metabolic_ProcessMouseBrainHP_ad_rep7 5.9e-10
FblGOBP_OssificationMouseBrainHP_ad_rep7 2.8e-09
FblGOBP_Protein_MethylationMouseBrainHP_ad_rep7 6.9e-09
FblGOBP_Ribonucleoprotein_Complex_BiogenesisMouseBrainHP_ad_rep7 7.9e-07
FblGOBP_Ribosome_BiogenesisMouseBrainHP_ad_rep7 1.6e-08
FblGOBP_Rna_3_End_ProcessingMouseBrainHP_ad_rep7 1.1e-14
FblGOBP_Rna_LocalizationMouseBrainHP_ad_rep7 8.4e-16
FblGOBP_Rna_MethylationMouseBrainHP_ad_rep7 4.1e-11
FblGOBP_Rna_ProcessingMouseBrainHP_ad_rep7 2.7e-09
FblGOBP_Rrna_ModificationMouseBrainHP_ad_rep7 3.0e-08
FblGOBP_Ncrna_ProcessingMouseBrainHP_adpolb_rep1 3.5e-08
FblGOBP_Rna_ModificationMouseBrainHP_adpolb_rep1 5.1e-09
FblGOBP_Rrna_Metabolic_ProcessMouseBrainHP_adpolb_rep1 2.6e-13
FblGOBP_Osteoblast_DifferentiationMouseBrainHP_polb_rep9 5.2e-09

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Fbl function as liang/receptor in single cell data

TissueSourceSourceCellTargetTargetCellPMIDGroup

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Fbl function as liang/receptor across spatial transcriptomics tissue

check button Interactions using deconvoluted spatial data.

LigandReceptor LR pairTissueReplication

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Transcription factor for Fbl envolved

check buttonTranscription factor analysis using single cell data.
TFTissueGroupCell typesTarget genesRss score

check button Motif information.

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Related Drugs for Fbl

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for Fbl

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease namePubmedsSource
FblC0004364Autoimmune Diseases3CTD_human
FblC0006142Malignant neoplasm of breast1CTD_human
FblC0152013Adenocarcinoma of lung (disorder)1CTD_human
FblC0678222Breast Carcinoma1CTD_human
FblC1257931Mammary Neoplasms, Human1CTD_human
FblC1458155Mammary Neoplasms1CTD_human
FblC4704874Mammary Carcinoma, Human1CTD_human