|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
|
Spatial pattern gene: Fat1 (spascer ID:14107) |
Gene summary for Fat1 |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Fat1 | Gene ID | 14107 |
| Gene name | FAT atypical cadherin 1 |
| Synonyms | 2310038E12Rik|AU023433|Fath|mFat1 |
| Cytomap | 8 B1.1|8 24.81 cM |
| Type of gene | protein-coding |
| Description | protocadherin Fat 1FAT tumor suppressor homolog 1fat 1 cadherin |
| Modification date | 20220514 |
| UniProtAcc |
|
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Fat1 | GO:0098609 | cell-cell adhesion | 21873635 | Process |
Top |
Spatial pattern events for Fat1 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Fat1 | Mouse | Brain | S1 | 34413515 | 2.00e-10 |
| Fat1 | Mouse | Brain | S3 | 34413515 | 1.64e-15 |
| Fat1 | Mouse | Brain | S4 | 34413515 | 1.37e-15 |
| Fat1 | Mouse | Brain | S6 | 34413515 | 2.97e-12 |
| Fat1 | Mouse | Brain | S7 | 34413515 | 1.55e-15 |
| Fat1 | Mouse | Brain | 01B | 32637622 | 8.44e-06 |
| Fat1 | Mouse | Brain | 36B | 32637622 | 4.39e-11 |
| Fat1 | Mouse | Brain | rep_1 | 35141374 | 2.69e-06 |
| Fat1 | Mouse | Brain | rep_2 | 35141374 | 4.97e-06 |
| Fat1 | Mouse | Brain | rep_3 | 35141374 | 1.61e-09 |
| Fat1 | Mouse | Brain | rep_5 | 35141374 | 4.81e-12 |
| Fat1 | Mouse | Brain | rep_6 | 35141374 | 2.68e-06 |
| Fat1 | Mouse | Embryo | 1E | 34210887 | 2.17e-14 |
| Fat1 | Mouse | Embryo | 1F | 34210887 | 1.16e-08 |
| Fat1 | Mouse | Embryo | 4E | 34210887 | 2.95e-07 |
| Fat1 | Mouse | Embryo | rep_3 | 33188776 | 2.40e-09 |
| Fat1 | Mouse | Embryo | rep_4 | 33188776 | 5.08e-15 |
| Fat1 | Mouse | Embryo | rep_12 | 33188776 | 2.77e-08 |
| Fat1 | Mouse | Embryo | rep_13 | 33188776 | 4.19e-12 |
| Fat1 | Mouse | Kidney | CLP | 34003797 | 2.19e-15 |
| Fat1 | Mouse | Kidney | IRI | 34003797 | 3.92e-15 |
| Fat1 | Mouse | Kidney | Sham | 34003797 | 2.58e-15 |
| Fat1 | Mouse | Kidney | rep_1 | 34853151 | 3.04e-09 |
| Fat1 | Mouse | Kidney | rep_5 | 34853151 | 4.18e-11 |
| Fat1 | Mouse | Brain | rep_1 | 33469025 | 1.30e-15 |
| Fat1 | Mouse | Brain | rep_1 | 35027729 | 2.98e-15 |
| Fat1 | Mouse | Brain | rep_2 | 35027729 | 2.83e-15 |
| Fat1 | Mouse | Brain | rep_3 | 35027729 | 1.32e-15 |
| Fat1 | Mouse | Brain | rep_4 | 35027729 | 5.87e-15 |
| Fat1 | Mouse | Brain | rep_5 | 35027729 | 1.46e-15 |
| Fat1 | Mouse | Intestine | rep_1 | 35149721 | 1.03e-14 |
| Fat1 | Mouse | Intestine | rep_2 | 35149721 | 3.44e-15 |
| Fat1 | Mouse | Intestine | rep_3 | 35149721 | 9.19e-08 |
| Fat1 | Mouse | Intestine | rep_4 | 35149721 | 2.30e-15 |
| Fat1 | Mouse | Lymph | B1 | 0 | 2.61e-10 |
| Fat1 | Mouse | Lung | rep_1 | 35290801 | 4.52e-15 |
| Fat1 | Mouse | Lung | rep_2 | 35290801 | 8.75e-15 |
| Fat1 | Mouse | Lung | rep_3 | 35290801 | 5.26e-15 |
| Fat1 | Mouse | Lung | rep_4 | 35290801 | 3.04e-15 |
| Fat1 | Mouse | Brain | rep_1 | 35210624 | 8.31e-12 |
| Fat1 | Mouse | Brain | rep_2 | 35210624 | 4.11e-11 |
| Fat1 | Mouse | Brain | rep_3 | 35210624 | 4.02e-06 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_5_H&E  |  |
Brain_rep_6_H&E  |  |
Kidney_CLP_H&E  |  |
Kidney_IRI_H&E  |  |
Kidney_Sham_H&E  |  |
Kidney_rep_1_H&E  |  |
Kidney_rep_5_H&E  |  |
Brain_rep_1_H&E  | |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Lung_rep_1_H&E  |  |
Lung_rep_2_H&E  |  |
Lung_rep_3_H&E  |  |
Lung_rep_4_H&E  |  |
Top |
Spatial pattern pathway has Fat1 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Fat1 | GOBP_Cell_Cell_Adhesion_Via_Plasma_Membrane_Adhesion_Molecules | Mouse | Spinal cord | L7bCN02_E1 | 2.3e-06 |
| Fat1 | GOBP_Cytoskeleton_Organization | Mouse | Spinal cord | L7bCN02_E1 | 8.3e-06 |
| Fat1 | GOBP_Biological_Adhesion | Mouse | Spinal cord | L7CN45_C1 | 2.4e-08 |
| Fat1 | GOBP_Cell_Cell_Adhesion | Mouse | Spinal cord | L7CN45_C1 | 6.8e-10 |
| Fat1 | GOBP_Cell_Cell_Signaling | Mouse | Spinal cord | L7CN45_C1 | 3.5e-08 |
| Fat1 | GOBP_Establishment_Or_Maintenance_Of_Cell_Polarity | Mouse | Spinal cord | L7CN45_C1 | 4.7e-06 |
| Fat1 | GOBP_Homophilic_Cell_Adhesion_Via_Plasma_Membrane_Adhesion_Molecules | Mouse | Spinal cord | L7CN45_C1 | 1.8e-06 |
| Fat1 | GOBP_Actin_Filament_Based_Process | Mouse | Spinal cord | L7CN47_C1 | 3.4e-06 |
| Fat1 | GOBP_Cell_Migration | Mouse | Spinal cord | L8CN11_D1 | 8.5e-06 |
| Fat1 | GOBP_Locomotion | Mouse | Spinal cord | L8CN11_D1 | 8.5e-06 |
| Fat1 | GOBP_Actin_Filament_Organization | Mouse | Spinal cord | L8CN17_E1 | 2.1e-07 |
| Fat1 | GOBP_Homophilic_Cell_Adhesion_Via_Plasma_Membrane_Adhesion_Molecules | Mouse | Brain | rep_27 | 1.1e-05 |
| Fat1 | GOBP_Actin_Filament_Based_Process | Mouse | Brain | rep_1 | 2.1e-24 |
| Fat1 | GOBP_Actin_Filament_Organization | Mouse | Brain | rep_1 | 4.6e-31 |
| Fat1 | GOBP_Cell_Cell_Signaling | Mouse | Brain | rep_1 | 5.1e-48 |
| Fat1 | GOBP_Cytoskeleton_Organization | Mouse | Brain | rep_1 | 1.1e-11 |
| Fat1 | GOBP_Biological_Adhesion | Mouse | Brain | rep_3 | 4.3e-106 |
| Fat1 | GOBP_Cell_Cell_Adhesion | Mouse | Brain | rep_3 | 5.2e-118 |
| Fat1 | GOBP_Cell_Cell_Adhesion_Via_Plasma_Membrane_Adhesion_Molecules | Mouse | Brain | rep_3 | 3.5e-23 |
| Fat1 | GOBP_Cell_Migration | Mouse | Brain | rep_3 | 4.9e-108 |
| Fat1 | GOBP_Establishment_Or_Maintenance_Of_Cell_Polarity | Mouse | Brain | rep_3 | 6.8e-85 |
| Fat1 | GOBP_Homophilic_Cell_Adhesion_Via_Plasma_Membrane_Adhesion_Molecules | Mouse | Brain | rep_3 | 1.8e-39 |
| Fat1 | GOBP_Locomotion | Mouse | Brain | rep_3 | 5.4e-74 |
| Fat1 | GOBP_Supramolecular_Fiber_Organization | Mouse | Brain | rep_3 | 6.7e-78 |
| Fat1 | GOBP_Homophilic_Cell_Adhesion_Via_Plasma_Membrane_Adhesion_Molecules | Mouse | Embryo | rep_14 | 5.8e-12 |
| Fat1 | GOBP_Biological_Adhesion | Mouse | Embryo | rep_1 | 2.2e-19 |
| Fat1 | GOBP_Cell_Migration | Mouse | Embryo | rep_1 | 7.4e-36 |
| Fat1 | GOBP_Locomotion | Mouse | Embryo | rep_1 | 1.7e-10 |
| Fat1 | GOBP_Supramolecular_Fiber_Organization | Mouse | Embryo | rep_3 | 0.0e+00 |
| Fat1 | GOBP_Cell_Migration | Mouse | Kidney | Nep | 5.3e-07 |
| Fat1 | GOBP_Locomotion | Mouse | Kidney | Nep | 5.3e-07 |
| Fat1 | GOBP_Actin_Filament_Based_Process | Mouse | Kidney | rep_2 | 2.6e-107 |
| Fat1 | GOBP_Actin_Filament_Organization | Mouse | Kidney | rep_2 | 4.0e-81 |
| Fat1 | GOBP_Biological_Adhesion | Mouse | Kidney | rep_2 | 1.3e-48 |
| Fat1 | GOBP_Cell_Cell_Adhesion | Mouse | Kidney | rep_2 | 1.1e-24 |
| Fat1 | GOBP_Cell_Cell_Signaling | Mouse | Kidney | rep_2 | 6.2e-72 |
| Fat1 | GOBP_Cell_Migration | Mouse | Kidney | rep_2 | 4.7e-40 |
| Fat1 | GOBP_Cytoskeleton_Organization | Mouse | Kidney | rep_2 | 1.5e-44 |
| Fat1 | GOBP_Homophilic_Cell_Adhesion_Via_Plasma_Membrane_Adhesion_Molecules | Mouse | Kidney | rep_2 | 1.6e-83 |
| Fat1 | GOBP_Locomotion | Mouse | Kidney | rep_2 | 2.1e-43 |
| Fat1 | GOBP_Supramolecular_Fiber_Organization | Mouse | Kidney | rep_2 | 9.5e-65 |
| Fat1 | GOBP_Establishment_Or_Maintenance_Of_Cell_Polarity | Mouse | Liver | CN16-D2 | 3.2e-07 |
| Fat1 | GOBP_Biological_Adhesion | Mouse | Liver | rep_16 | 2.1e-07 |
| Fat1 | GOBP_Cell_Cell_Adhesion | Mouse | Liver | rep_16 | 1.4e-11 |
| Fat1 | GOBP_Cell_Migration | Mouse | Liver | rep_26 | 1.6e-10 |
| Fat1 | GOBP_Locomotion | Mouse | Liver | rep_26 | 1.6e-10 |
| Fat1 | GOBP_Actin_Filament_Based_Process | Mouse | Lymph | MS-1 | 1.4e-10 |
| Fat1 | GOBP_Actin_Filament_Organization | Mouse | Lymph | MS-1 | 4.2e-11 |
| Fat1 | GOBP_Biological_Adhesion | Mouse | Lymph | MS-1 | 8.0e-14 |
| Fat1 | GOBP_Cell_Cell_Adhesion | Mouse | Lymph | MS-1 | 1.9e-13 |
| Fat1 | GOBP_Cell_Cell_Signaling | Mouse | Lymph | MS-1 | 9.7e-11 |
| Fat1 | GOBP_Cell_Migration | Mouse | Lymph | MS-1 | 5.7e-13 |
| Fat1 | GOBP_Cytoskeleton_Organization | Mouse | Lymph | MS-1 | 1.8e-13 |
| Fat1 | GOBP_Homophilic_Cell_Adhesion_Via_Plasma_Membrane_Adhesion_Molecules | Mouse | Lymph | MS-1 | 1.0e-10 |
| Fat1 | GOBP_Locomotion | Mouse | Lymph | MS-1 | 1.2e-12 |
| Fat1 | GOBP_Supramolecular_Fiber_Organization | Mouse | Lymph | MS-1 | 1.5e-12 |
| Fat1 | GOBP_Biological_Adhesion | Mouse | Lung | rep_1 | 3.0e-22 |
| Fat1 | GOBP_Cell_Cell_Adhesion | Mouse | Lung | rep_1 | 2.9e-07 |
| Fat1 | GOBP_Homophilic_Cell_Adhesion_Via_Plasma_Membrane_Adhesion_Molecules | Mouse | Brain | rep_4 | 8.5e-80 |
| Fat1 | GOBP_Cell_Cell_Signaling | Mouse | Brain | HP_ad_rep7 | 1.6e-08 |
| Fat1 | GOBP_Cell_Migration | Mouse | Brain | HP_ad_rep7 | 2.2e-07 |
| Fat1 | GOBP_Cytoskeleton_Organization | Mouse | Brain | HP_ad_rep7 | 5.3e-08 |
| Fat1 | GOBP_Establishment_Or_Maintenance_Of_Cell_Polarity | Mouse | Brain | HP_ad_rep7 | 4.1e-10 |
| Fat1 | GOBP_Homophilic_Cell_Adhesion_Via_Plasma_Membrane_Adhesion_Molecules | Mouse | Brain | HP_ad_rep7 | 6.4e-10 |
| Fat1 | GOBP_Locomotion | Mouse | Brain | HP_ad_rep7 | 3.8e-07 |
| Fat1 | GOBP_Supramolecular_Fiber_Organization | Mouse | Brain | HP_ad_rep7 | 5.2e-07 |
| Fat1 | GOBP_Actin_Filament_Based_Process | Mouse | Brain | HP_polb_rep9 | 3.0e-07 |
| Fat1 | GOBP_Biological_Adhesion | Mouse | Brain | HP_polb_rep9 | 1.5e-07 |
| Fat1 | GOBP_Cell_Cell_Adhesion | Mouse | Brain | HP_polb_rep9 | 3.6e-11 |
| Fat1 | GOBP_Cell_Cell_Adhesion_Via_Plasma_Membrane_Adhesion_Molecules | Mouse | Brain | HP_polb_rep9 | 1.0e-07 |
Top |
Fat1 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
Top |
Fat1 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
Top |
Transcription factor for Fat1 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
Top |
Related Drugs for Fat1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for Fat1 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| Fat1 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| Fat1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Fat1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Fat1 | C0017636 | Glioblastoma | 1 | CTD_human |
| Fat1 | C0018671 | Head and Neck Neoplasms | 1 | CTD_human |
| Fat1 | C0018675 | Head Neoplasms | 1 | CTD_human |
| Fat1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Fat1 | C0027533 | Neck Neoplasms | 1 | CTD_human |
| Fat1 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
| Fat1 | C0220636 | Malignant neoplasm of salivary gland | 1 | CTD_human |
| Fat1 | C0278996 | Malignant Head and Neck Neoplasm | 1 | CTD_human |
| Fat1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Fat1 | C0334588 | Giant Cell Glioblastoma | 1 | CTD_human |
| Fat1 | C0746787 | Cancer of Neck | 1 | CTD_human |
| Fat1 | C0751177 | Cancer of Head | 1 | CTD_human |
| Fat1 | C0887900 | Upper Aerodigestive Tract Neoplasms | 1 | CTD_human |
| Fat1 | C1621958 | Glioblastoma Multiforme | 1 | CTD_human |
