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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: En2 (spascer ID:13799)

Gene summary for En2

Gene summary

Gene information
	Species	Mouse
	Gene symbol	En2
	Gene ID	13799
	Gene name	engrailed 2
	Synonyms	BB131122\|En-2\|mo-En-2
	Cytomap	5 B1\|5 13.94 cM
	Type of gene	protein-coding
	Description	homeobox protein engrailed-2homeobox protein en-2
	Modification date	20220424
	UniProtAcc	P09066

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
En2	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	21873635	Function
En2	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	21873635	Function
En2	GO:0005634	nucleus	21873635	Component
En2	GO:0006357	regulation of transcription by RNA polymerase II	21873635	Process
En2	GO:0030182	neuron differentiation	21873635	Process

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Spatial pattern events for En2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
En2	Mouse	Brain	36A	32637622	4.72e-08
En2	Mouse	Brain	36B	32637622	4.83e-14
En2	Mouse	Embryo	rep_2	33188776	1.37e-14
En2	Mouse	Embryo	rep_5	33188776	1.40e-14

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)

Singel gene map

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Spatial pattern pathway has En2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
En2	GOBP_Central_Nervous_System_Development	Mouse	Spinal cord	L7CN45_C1	5.5e-10
En2	GOBP_Embryo_Development	Mouse	Spinal cord	L7CN45_C1	3.4e-09
En2	GOBP_Embryonic_Organ_Development	Mouse	Spinal cord	L7CN45_C1	5.1e-08
En2	GOBP_Head_Development	Mouse	Spinal cord	L7CN45_C1	3.4e-09
En2	GOBP_Hindbrain_Development	Mouse	Spinal cord	L7CN45_C1	6.1e-06
En2	GOBP_Midbrain_Development	Mouse	Spinal cord	L7CN45_C1	8.2e-08
En2	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Spinal cord	L7CN45_C1	2.0e-06
En2	GOBP_Neurogenesis	Mouse	Spinal cord	L7CN45_C1	3.4e-09
En2	GOBP_Neuron_Apoptotic_Process	Mouse	Spinal cord	L7CN45_C1	3.0e-06
En2	GOBP_Neuron_Development	Mouse	Spinal cord	L7CN45_C1	5.6e-08
En2	GOBP_Neuron_Differentiation	Mouse	Spinal cord	L7CN45_C1	3.4e-09
En2	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	L7CN45_C1	1.4e-06
En2	GOBP_Embryonic_Brain_Development	Mouse	Spinal cord	L7CN97_E2	1.2e-06
En2	GOBP_Regulation_Of_Cell_Death	Mouse	Brain	rep_27	6.3e-05
En2	GOBP_Central_Nervous_System_Development	Mouse	Brain	rep_1	8.6e-30
En2	GOBP_Head_Development	Mouse	Brain	rep_1	3.9e-29
En2	GOBP_Hindbrain_Development	Mouse	Brain	rep_1	1.6e-70
En2	GOBP_Neurogenesis	Mouse	Brain	rep_1	6.4e-19
En2	GOBP_Neuron_Development	Mouse	Brain	rep_1	3.8e-29
En2	GOBP_Neuron_Differentiation	Mouse	Brain	rep_1	8.7e-25
En2	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_1	2.5e-12
En2	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_1	1.6e-17
En2	GOBP_Embryo_Development	Mouse	Brain	rep_3	1.3e-126
En2	GOBP_Embryonic_Organ_Development	Mouse	Brain	rep_3	4.3e-190
En2	GOBP_Midbrain_Development	Mouse	Brain	rep_3	2.8e-62
En2	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Brain	rep_3	2.5e-150
En2	GOBP_Negative_Regulation_Of_Neuron_Apoptotic_Process	Mouse	Brain	rep_3	1.3e-47
En2	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Brain	rep_3	4.0e-77
En2	GOBP_Neuron_Apoptotic_Process	Mouse	Brain	rep_3	4.2e-88
En2	GOBP_Neuron_Death	Mouse	Brain	rep_3	3.6e-120
En2	GOBP_Regulation_Of_Cell_Death	Mouse	Brain	rep_3	7.6e-107
En2	GOBP_Embryonic_Brain_Development	Mouse	Brain	rep_7	5.6e-70
En2	GOBP_Embryonic_Brain_Development	Mouse	Embryo	rep_14	1.0e-09
En2	GOBP_Hindbrain_Development	Mouse	Embryo	rep_14	1.4e-07
En2	GOBP_Negative_Regulation_Of_Neuron_Apoptotic_Process	Mouse	Embryo	rep_14	2.8e-11
En2	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Embryo	rep_14	3.8e-08
En2	GOBP_Central_Nervous_System_Development	Mouse	Embryo	rep_1	3.0e-261
En2	GOBP_Head_Development	Mouse	Embryo	rep_1	1.8e-91
En2	GOBP_Hindbrain_Development	Mouse	Embryo	rep_1	0.0e+00
En2	GOBP_Negative_Regulation_Of_Neuron_Apoptotic_Process	Mouse	Embryo	rep_1	9.5e-233
En2	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Embryo	rep_1	3.6e-258
En2	GOBP_Neurogenesis	Mouse	Embryo	rep_1	8.2e-08
En2	GOBP_Neuron_Apoptotic_Process	Mouse	Embryo	rep_1	0.0e+00
En2	GOBP_Neuron_Death	Mouse	Embryo	rep_1	0.0e+00
En2	GOBP_Regulation_Of_Cell_Death	Mouse	Embryo	rep_1	8.4e-30
En2	GOBP_Neuron_Development	Mouse	Embryo	rep_2	4.8e-18
En2	GOBP_Embryo_Development	Mouse	Embryo	rep_3	1.2e-173
En2	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Embryo	rep_3	1.9e-126
En2	GOBP_Neuron_Differentiation	Mouse	Embryo	rep_3	2.1e-193
En2	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	0.0e+00
En2	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
En2	GOBP_Central_Nervous_System_Development	Mouse	Kidney	Nep	4.2e-26
En2	GOBP_Neurogenesis	Mouse	Kidney	Nep	4.6e-22
En2	GOBP_Neuron_Development	Mouse	Kidney	Nep	8.3e-23
En2	GOBP_Neuron_Differentiation	Mouse	Kidney	Nep	8.3e-23
En2	GOBP_Central_Nervous_System_Development	Mouse	Kidney	rep_2	1.3e-23
En2	GOBP_Embryo_Development	Mouse	Kidney	rep_2	7.4e-46
En2	GOBP_Embryonic_Brain_Development	Mouse	Kidney	rep_2	3.6e-61
En2	GOBP_Embryonic_Organ_Development	Mouse	Kidney	rep_2	1.3e-60
En2	GOBP_Head_Development	Mouse	Kidney	rep_2	1.9e-29
En2	GOBP_Hindbrain_Development	Mouse	Kidney	rep_2	7.2e-22
En2	GOBP_Midbrain_Development	Mouse	Kidney	rep_2	1.4e-46
En2	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Kidney	rep_2	4.6e-36
En2	GOBP_Negative_Regulation_Of_Neuron_Apoptotic_Process	Mouse	Kidney	rep_2	4.1e-13
En2	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Kidney	rep_2	2.7e-17
En2	GOBP_Neurogenesis	Mouse	Kidney	rep_2	2.4e-78
En2	GOBP_Neuron_Apoptotic_Process	Mouse	Kidney	rep_2	8.8e-55
En2	GOBP_Neuron_Death	Mouse	Kidney	rep_2	3.1e-123
En2	GOBP_Neuron_Development	Mouse	Kidney	rep_2	1.3e-42
En2	GOBP_Neuron_Differentiation	Mouse	Kidney	rep_2	3.9e-32
En2	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	4.5e-10
En2	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	8.3e-40
En2	GOBP_Embryonic_Brain_Development	Mouse	Liver	CN16-D2	1.8e-08
En2	GOBP_Neuron_Differentiation	Mouse	Liver	CN16-D2	5.1e-07
En2	GOBP_Hindbrain_Development	Mouse	Liver	rep_15	2.4e-21
En2	GOBP_Central_Nervous_System_Development	Mouse	Liver	rep_16	8.2e-15
En2	GOBP_Embryonic_Brain_Development	Mouse	Liver	rep_16	1.8e-12
En2	GOBP_Head_Development	Mouse	Liver	rep_16	4.3e-18
En2	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Liver	rep_16	2.7e-09
En2	GOBP_Negative_Regulation_Of_Neuron_Apoptotic_Process	Mouse	Liver	rep_16	3.2e-12
En2	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Liver	rep_16	1.4e-15
En2	GOBP_Neuron_Apoptotic_Process	Mouse	Liver	rep_16	1.6e-07
En2	GOBP_Regulation_Of_Cell_Death	Mouse	Liver	rep_16	2.0e-13
En2	GOBP_Central_Nervous_System_Development	Mouse	Lymph	MS-1	3.8e-07
En2	GOBP_Embryo_Development	Mouse	Lymph	MS-1	2.5e-08
En2	GOBP_Embryonic_Brain_Development	Mouse	Lymph	MS-1	4.3e-09
En2	GOBP_Embryonic_Organ_Development	Mouse	Lymph	MS-1	1.1e-11
En2	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Lymph	MS-1	3.9e-13
En2	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Lymph	MS-1	1.5e-09
En2	GOBP_Neurogenesis	Mouse	Lymph	MS-1	4.1e-08
En2	GOBP_Neuron_Death	Mouse	Lymph	MS-1	2.5e-07
En2	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	4.4e-12
En2	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	1.7e-12
En2	GOBP_Regulation_Of_Cell_Death	Mouse	Lymph	MS-1	1.9e-12
En2	GOBP_Embryonic_Organ_Development	Mouse	Brain	rep_7	7.0e-07
En2	GOBP_Central_Nervous_System_Development	Mouse	Brain	HP_ad_rep7	2.3e-07
En2	GOBP_Head_Development	Mouse	Brain	HP_ad_rep7	3.0e-07
En2	GOBP_Negative_Regulation_Of_Neuron_Apoptotic_Process	Mouse	Brain	HP_ad_rep7	3.6e-12
En2	GOBP_Negative_Regulation_Of_Neuron_Death	Mouse	Brain	HP_ad_rep7	4.1e-12
En2	GOBP_Neurogenesis	Mouse	Brain	HP_ad_rep7	3.9e-07
En2	GOBP_Neuron_Development	Mouse	Brain	HP_ad_rep7	3.9e-07
En2	GOBP_Neuron_Differentiation	Mouse	Brain	HP_ad_rep7	3.9e-07
En2	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-11
En2	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.3e-11
En2	GOBP_Regulation_Of_Cell_Death	Mouse	Brain	HP_ad_rep7	1.6e-07
En2	GOBP_Embryo_Development	Mouse	Brain	HP_polb_rep9	1.5e-10
En2	GOBP_Embryonic_Organ_Development	Mouse	Brain	HP_polb_rep9	9.6e-11
En2	GOBP_Hindbrain_Development	Mouse	Brain	HP_polb_rep9	8.7e-11
En2	GOBP_Negative_Regulation_Of_Cell_Death	Mouse	Brain	HP_polb_rep9	9.2e-10
En2	GOBP_Neuron_Apoptotic_Process	Mouse	Brain	HP_polb_rep9	8.7e-15
En2	GOBP_Neuron_Death	Mouse	Brain	HP_polb_rep9	8.3e-10

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En2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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En2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for En2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for En2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for En2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source