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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Elk3 (spascer ID:13713)

Gene summary for Elk3

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Elk3
	Gene ID	13713
	Gene name	ELK3, member of ETS oncogene family
	Synonyms	D430049E23Rik\|Erp\|Etrp\|Net\|Sap-2
	Cytomap	10 C2\|10 48.04 cM
	Type of gene	protein-coding
	Description	ETS domain-containing protein Elk-3ETS-domain protein ELK-3ETS-related protein ERPETS-related protein NET
	Modification date	20220424
	UniProtAcc	P41971

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Elk3	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	21873635	Function
Elk3	GO:0005634	nucleus	21873635	Component
Elk3	GO:0006357	regulation of transcription by RNA polymerase II	21873635	Process
Elk3	GO:0030154	cell differentiation	21873635	Process

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Spatial pattern events for Elk3

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Elk3	Mouse	Brain	S4	34413515	4.84e-08
Elk3	Mouse	Embryo	4E	34210887	3.42e-07
Elk3	Mouse	Embryo	rep_3	33188776	5.96e-07
Elk3	Mouse	Embryo	rep_13	33188776	4.49e-15
Elk3	Mouse	Kidney	CLP	34003797	2.72e-14
Elk3	Mouse	Kidney	IRI	34003797	2.29e-15
Elk3	Mouse	Kidney	Sham	34003797	4.75e-06
Elk3	Mouse	Kidney	rep_1	34853151	3.84e-11
Elk3	Mouse	Kidney	rep_5	34853151	2.54e-14
Elk3	Mouse	Intestine	rep_2	35149721	3.44e-15
Elk3	Mouse	Intestine	rep_3	35149721	9.99e-06
Elk3	Mouse	Intestine	rep_4	35149721	5.42e-07
Elk3	Mouse	Lymph	A1	0	5.84e-15
Elk3	Mouse	Lymph	B1	0	3.66e-15
Elk3	Mouse	Lung	rep_1	35290801	1.53e-07
Elk3	Mouse	Lung	rep_3	35290801	8.14e-10
Elk3	Mouse	Lung	rep_4	35290801	1.34e-10

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_5_H&E
Lung_rep_1_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Elk3 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Elk3	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Spinal cord	CN94_E1	1.6e-06
Elk3	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	CN94_E1	6.2e-07
Elk3	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	CN94_E1	2.2e-06
Elk3	GOBP_Response_To_Wounding	Mouse	Spinal cord	CN94_E1	4.7e-06
Elk3	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Elk3	GOBP_Blood_Vessel_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	1.0e-07
Elk3	GOBP_Circulatory_System_Development	Mouse	Spinal cord	L7CN45_C1	5.7e-08
Elk3	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Elk3	GOBP_Tube_Development	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Elk3	GOBP_Tube_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Elk3	GOBP_Vasculature_Development	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Elk3	GOBP_Wound_Healing	Mouse	Spinal cord	L7CN47_C1	8.4e-07
Elk3	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_27	7.2e-05
Elk3	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_27	2.8e-05
Elk3	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_1	2.5e-12
Elk3	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_1	1.6e-17
Elk3	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Brain	rep_3	5.3e-58
Elk3	GOBP_Blood_Vessel_Morphogenesis	Mouse	Brain	rep_3	7.4e-87
Elk3	GOBP_Circulatory_System_Development	Mouse	Brain	rep_3	1.3e-81
Elk3	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_3	1.4e-196
Elk3	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_3	9.4e-206
Elk3	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_3	7.5e-168
Elk3	GOBP_Response_To_Wounding	Mouse	Brain	rep_3	6.2e-112
Elk3	GOBP_Tube_Development	Mouse	Brain	rep_3	9.0e-136
Elk3	GOBP_Tube_Morphogenesis	Mouse	Brain	rep_3	4.7e-120
Elk3	GOBP_Vasculature_Development	Mouse	Brain	rep_3	2.6e-82
Elk3	GOBP_Wound_Healing	Mouse	Brain	rep_3	6.2e-109
Elk3	GOBP_Circulatory_System_Development	Mouse	Embryo	rep_6	1.6e-12
Elk3	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Embryo	rep_2	8.0e-13
Elk3	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	1.5e-267
Elk3	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
Elk3	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	0.0e+00
Elk3	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
Elk3	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Embryo	rep_6	3.8e-28
Elk3	GOBP_Blood_Vessel_Morphogenesis	Mouse	Embryo	rep_6	1.6e-86
Elk3	GOBP_Vasculature_Development	Mouse	Embryo	rep_6	1.9e-41
Elk3	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Kidney	Nep	5.6e-37
Elk3	GOBP_Blood_Vessel_Morphogenesis	Mouse	Kidney	Nep	5.6e-37
Elk3	GOBP_Circulatory_System_Development	Mouse	Kidney	Nep	5.6e-37
Elk3	GOBP_Response_To_Wounding	Mouse	Kidney	Nep	1.6e-16
Elk3	GOBP_Tube_Development	Mouse	Kidney	Nep	5.6e-37
Elk3	GOBP_Tube_Morphogenesis	Mouse	Kidney	Nep	5.6e-37
Elk3	GOBP_Vasculature_Development	Mouse	Kidney	Nep	5.6e-37
Elk3	GOBP_Wound_Healing	Mouse	Kidney	Nep	1.6e-16
Elk3	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Kidney	rep_2	5.6e-148
Elk3	GOBP_Blood_Vessel_Morphogenesis	Mouse	Kidney	rep_2	3.2e-114
Elk3	GOBP_Circulatory_System_Development	Mouse	Kidney	rep_2	6.7e-139
Elk3	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Kidney	rep_2	7.3e-42
Elk3	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	7.7e-30
Elk3	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	2.2e-14
Elk3	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	4.5e-10
Elk3	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	8.3e-40
Elk3	GOBP_Response_To_Wounding	Mouse	Kidney	rep_2	2.1e-60
Elk3	GOBP_Tube_Development	Mouse	Kidney	rep_2	1.2e-129
Elk3	GOBP_Tube_Morphogenesis	Mouse	Kidney	rep_2	2.1e-134
Elk3	GOBP_Vasculature_Development	Mouse	Kidney	rep_2	2.3e-129
Elk3	GOBP_Wound_Healing	Mouse	Kidney	rep_2	6.5e-45
Elk3	GOBP_Response_To_Wounding	Mouse	Liver	CN73-C1	1.1e-07
Elk3	GOBP_Wound_Healing	Mouse	Liver	CN73-C1	1.1e-08
Elk3	GOBP_Response_To_Wounding	Mouse	Liver	rep_16	1.3e-13
Elk3	GOBP_Wound_Healing	Mouse	Liver	rep_16	3.5e-11
Elk3	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Lymph	MS-1	6.4e-13
Elk3	GOBP_Blood_Vessel_Morphogenesis	Mouse	Lymph	MS-1	3.6e-10
Elk3	GOBP_Circulatory_System_Development	Mouse	Lymph	MS-1	1.6e-11
Elk3	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lymph	MS-1	6.1e-11
Elk3	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	1.8e-10
Elk3	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	2.2e-09
Elk3	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	4.4e-12
Elk3	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	1.7e-12
Elk3	GOBP_Tube_Development	Mouse	Lymph	MS-1	4.6e-09
Elk3	GOBP_Tube_Morphogenesis	Mouse	Lymph	MS-1	9.1e-10
Elk3	GOBP_Vasculature_Development	Mouse	Lymph	MS-1	3.0e-12
Elk3	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lung	rep_1	7.5e-20
Elk3	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lung	rep_1	5.8e-10
Elk3	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.3e-12
Elk3	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-11
Elk3	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.1e-13
Elk3	GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-11
Elk3	GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.3e-11
Elk3	GOBP_Response_To_Wounding	Mouse	Brain	HP_ad_rep7	4.3e-07
Elk3	GOBP_Tube_Development	Mouse	Brain	HP_ad_rep7	2.0e-08
Elk3	GOBP_Anatomical_Structure_Formation_Involved_In_Morphogenesis	Mouse	Brain	HP_polb_rep9	6.3e-08
Elk3	GOBP_Blood_Vessel_Morphogenesis	Mouse	Brain	HP_polb_rep9	1.0e-11
Elk3	GOBP_Circulatory_System_Development	Mouse	Brain	HP_polb_rep9	3.1e-09
Elk3	GOBP_Tube_Morphogenesis	Mouse	Brain	HP_polb_rep9	4.0e-10
Elk3	GOBP_Vasculature_Development	Mouse	Brain	HP_polb_rep9	3.4e-10

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Elk3 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Elk3 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Elk3 envolved

Transcription factor analysis using single cell data.

TF	Tissue	Group	Cell types	Target genes	Rss score
Elk3	Kidney	LPS	PT_S3_OS	C1qc,U2surp,Tcf4, etc.	0.266
Elk3	Kidney	LPS	TAL	C1qc,U2surp,Tcf4, etc.	0.348
Elk3	Kidney	LPS	CNT	C1qc,U2surp,Tcf4, etc.	0.267
Elk3	Kidney	LPS	PT_S2	C1qc,U2surp,Tcf4, etc.	0.257
Elk3	Kidney	LPS	PT_S3_C	C1qc,U2surp,Tcf4, etc.	0.294
Elk3	Kidney	LPS	Endothelial	C1qc,U2surp,Tcf4, etc.	0.253
ELK3	Uterus	early	Glandular	EMP1,LAMB3,CX3CL1, etc.	0.32
ELK3	Uterus	early	Glandular_secretory	EMP1,LAMB3,CX3CL1, etc.	0.259
ELK3	Uterus	early	SOX9_LGR5	EMP1,LAMB3,CX3CL1, etc.	0.384
ELK3	Uterus	early	SOX9	EMP1,LAMB3,CX3CL1, etc.	0.452
ELK3	Uterus	early_mid	Glandular	ABLIM1,BLCAP,ZMYND12, etc.	0.309
ELK3	Uterus	early_mid	Lumenal 1	ABLIM1,BLCAP,ZMYND12, etc.	0.406
ELK3	Uterus	early_mid	Ciliated LRG5	ABLIM1,BLCAP,ZMYND12, etc.	0.259
ELK3	Uterus	early_mid	Ciliated	ABLIM1,BLCAP,ZMYND12, etc.	0.437
ELK3	Uterus	mid	Glandular_secretory	LPIN1,EMP1,MACC1, etc.	0.45
ELK3	Uterus	late	Glandular_secretory	LZTFL1,FHL2,BBIP1, etc.	0.62
ELK3	Uterus	late	Ciliated	LZTFL1,FHL2,BBIP1, etc.	0.419
Elk3	Lymph	control	Ifit3 high B	Myb,Cdk8,Eomes, etc.	0.267
Elk3	Lymph	control	Mature B	Myb,Cdk8,Eomes, etc.	0.367
Elk3	Lymph	control	CD4 T	Myb,Cdk8,Eomes, etc.	0.254
Elk3	Lymph	control	CD8 T	Myb,Cdk8,Eomes, etc.	0.258
Elk3	Kidney	IRI	PT_S1	Elovl7,Map2k3,Noc2l, etc.	0.305
Elk3	Kidney	IRI	CNT	Elovl7,Map2k3,Noc2l, etc.	0.257
Elk3	Kidney	IRI	PT_S3_C	Elovl7,Map2k3,Noc2l, etc.	0.285
Elk3	Kidney	IRI	PT_Fibrinogen	Elovl7,Map2k3,Noc2l, etc.	0.261
Elk3	Kidney	IRI	CD_IC	Elovl7,Map2k3,Noc2l, etc.	0.256
Elk3	Kidney	IRI	TAL	Elovl7,Map2k3,Noc2l, etc.	0.29
Elk3	Kidney	IRI	CD_PC	Elovl7,Map2k3,Noc2l, etc.	0.273
Elk3	Lymph	disease	Ifit3 high B	Tmem26,Nsl1,Mgat4a, etc.	0.317
Elk3	Lymph	disease	CD4 T	Tmem26,Nsl1,Mgat4a, etc.	0.252
Elk3	Lymph	disease	Mature B	Tmem26,Nsl1,Mgat4a, etc.	0.359
ELK3	Uterus	proliferative	SOX9	B3GNT7,LAMB3,IL11, etc.	0.488
ELK3	Uterus	proliferative	SOX9_LGR5	B3GNT7,LAMB3,IL11, etc.	0.392
ELK3	Uterus	proliferative	SOX9_prolif	B3GNT7,LAMB3,IL11, etc.	0.308
Elk3	Kidney	Sham	CNT	Id1,Adgre5,Eng, etc.	0.251
Elk3	Kidney	Sham	PT_S3_OS	Id1,Adgre5,Eng, etc.	0.258
Elk3	Kidney	Sham	PT_S3_C	Id1,Adgre5,Eng, etc.	0.343
Elk3	Kidney	Sham	PT_Fibrinogen	Id1,Adgre5,Eng, etc.	0.261
Elk3	Kidney	Sham	VSM	Id1,Adgre5,Eng, etc.	0.28
Elk3	Kidney	Sham	PT_S1	Id1,Adgre5,Eng, etc.	0.264
Elk3	Kidney	Sham	TAL	Id1,Adgre5,Eng, etc.	0.329

Motif information.

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Related Drugs for Elk3

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Elk3

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Elk3	C0006142	Malignant neoplasm of breast	1	CTD_human
Elk3	C0678222	Breast Carcinoma	1	CTD_human
Elk3	C1135196	Heart Failure, Diastolic	1	CTD_human
Elk3	C1257931	Mammary Neoplasms, Human	1	CTD_human
Elk3	C1458155	Mammary Neoplasms	1	CTD_human
Elk3	C4704874	Mammary Carcinoma, Human	1	CTD_human