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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Eif4a2 (spascer ID:13682)

Gene summary for Eif4a2

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Eif4a2
	Gene ID	13682
	Gene name	eukaryotic translation initiation factor 4A2
	Synonyms	4833432N07Rik\|BM-010\|Ddx2b\|Eif4\|eIF-4A-II\|eIF4A-II
	Cytomap	16 B1\|16 13.93 cM
	Type of gene	protein-coding
	Description	eukaryotic initiation factor 4A-IIATP-dependent RNA helicase eIF4A-2
	Modification date	20220424
	UniProtAcc	P10630

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Eif4a2	GO:0002183	cytoplasmic translational initiation	21873635	Process
Eif4a2	GO:0003743	translation initiation factor activity	21873635	Function

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Spatial pattern events for Eif4a2

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Eif4a2	Mouse	Brain	S1	34413515	2.07e-15
Eif4a2	Mouse	Brain	S2	34413515	1.56e-15
Eif4a2	Mouse	Brain	S3	34413515	1.64e-15
Eif4a2	Mouse	Brain	S4	34413515	1.37e-15
Eif4a2	Mouse	Brain	S6	34413515	1.46e-15
Eif4a2	Mouse	Brain	S7	34413515	1.55e-15
Eif4a2	Mouse	Brain	rep_1	35141374	2.02e-15
Eif4a2	Mouse	Brain	rep_2	35141374	1.69e-15
Eif4a2	Mouse	Brain	rep_3	35141374	1.64e-15
Eif4a2	Mouse	Brain	rep_4	35141374	1.57e-15
Eif4a2	Mouse	Brain	rep_5	35141374	1.47e-15
Eif4a2	Mouse	Brain	rep_6	35141374	1.73e-15
Eif4a2	Mouse	Kidney	CLP	34003797	2.75e-09
Eif4a2	Mouse	Kidney	IRI	34003797	2.29e-15
Eif4a2	Mouse	Kidney	rep_3	34853151	9.10e-15
Eif4a2	Mouse	Kidney	rep_5	34853151	3.18e-15
Eif4a2	Mouse	Brain	rep_1	33469025	1.30e-15
Eif4a2	Mouse	Liver	rep_17	35021063	5.08e-06
Eif4a2	Mouse	Liver	rep_20	35021063	9.91e-15
Eif4a2	Mouse	Brain	rep_1	35027729	1.66e-15
Eif4a2	Mouse	Brain	rep_2	35027729	1.57e-15
Eif4a2	Mouse	Brain	rep_3	35027729	1.32e-15
Eif4a2	Mouse	Brain	rep_4	35027729	1.76e-15
Eif4a2	Mouse	Brain	rep_5	35027729	1.46e-15
Eif4a2	Mouse	Intestine	rep_1	35149721	4.07e-06
Eif4a2	Mouse	Intestine	rep_2	35149721	5.49e-15
Eif4a2	Mouse	Intestine	rep_4	35149721	2.30e-15
Eif4a2	Mouse	Brain	B04_E1	32702314	5.16e-06
Eif4a2	Mouse	Brain	B05_D2	32702314	2.20e-10
Eif4a2	Mouse	Lymph	A1	0	3.29e-15
Eif4a2	Mouse	Lung	rep_1	35290801	2.17e-08
Eif4a2	Mouse	Lung	rep_3	35290801	1.52e-14
Eif4a2	Mouse	Lung	rep_4	35290801	3.04e-15
Eif4a2	Mouse	Brain	rep_2	35210624	2.58e-06
Eif4a2	Mouse	Brain	rep_3	35210624	1.08e-12
Eif4a2	Mouse	Brain	rep_5	35210624	9.50e-07

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_rep_3_H&E
Kidney_rep_5_H&E
Brain_rep_1_H&E
Liver_rep_17_H&E
Liver_rep_20_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_B04_E1_H&E
Brain_B05_D2_H&E
Lung_rep_1_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Eif4a2 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Eif4a2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Spinal cord	CN94_E1	1.6e-06
Eif4a2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	CN94_E1	6.2e-07
Eif4a2	GOBP_Cytoplasmic_Translational_Initiation	Mouse	Spinal cord	L7bCN02_E1	8.5e-06
Eif4a2	GOBP_Amide_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Eif4a2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Eif4a2	GOBP_Cytoplasmic_Translation	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Eif4a2	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Eif4a2	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Eif4a2	GOBP_Negative_Regulation_Of_Transferase_Activity	Mouse	Spinal cord	L7CN45_C1	5.6e-06
Eif4a2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	5.6e-08
Eif4a2	GOBP_Peptide_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	3.5e-08
Eif4a2	GOBP_Peptide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Eif4a2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Spinal cord	L7CN45_C1	7.4e-09
Eif4a2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	2.4e-08
Eif4a2	GOBP_Regulation_Of_Translational_Initiation	Mouse	Spinal cord	L7CN45_C1	7.9e-07
Eif4a2	GOBP_Response_To_Cytokine	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Eif4a2	GOBP_Response_To_Leukemia_Inhibitory_Factor	Mouse	Spinal cord	L7CN45_C1	3.3e-07
Eif4a2	GOBP_Translational_Initiation	Mouse	Spinal cord	L7CN45_C1	1.6e-08
Eif4a2	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Spinal cord	L7CN97_E2	6.8e-06
Eif4a2	GOBP_Regulation_Of_Transferase_Activity	Mouse	Spinal cord	L8CN17_E1	9.1e-06
Eif4a2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_27	7.2e-05
Eif4a2	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_27	8.1e-06
Eif4a2	GOBP_Negative_Regulation_Of_Transferase_Activity	Mouse	Brain	rep_27	2.0e-09
Eif4a2	GOBP_Regulation_Of_Transferase_Activity	Mouse	Brain	rep_27	1.1e-06
Eif4a2	GOBP_Cytoplasmic_Translational_Initiation	Mouse	Brain	rep_75	4.9e-05
Eif4a2	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Brain	rep_1	1.0e-08
Eif4a2	GOBP_Amide_Biosynthetic_Process	Mouse	Brain	rep_3	2.5e-86
Eif4a2	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Brain	rep_3	1.9e-146
Eif4a2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	rep_3	2.1e-87
Eif4a2	GOBP_Cytoplasmic_Translation	Mouse	Brain	rep_3	2.1e-11
Eif4a2	GOBP_Cytoplasmic_Translational_Initiation	Mouse	Brain	rep_3	1.1e-199
Eif4a2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_3	1.4e-196
Eif4a2	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_3	5.2e-181
Eif4a2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_3	9.4e-206
Eif4a2	GOBP_Negative_Regulation_Of_Transferase_Activity	Mouse	Brain	rep_3	1.6e-186
Eif4a2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	rep_3	2.9e-144
Eif4a2	GOBP_Peptide_Biosynthetic_Process	Mouse	Brain	rep_3	2.1e-69
Eif4a2	GOBP_Peptide_Metabolic_Process	Mouse	Brain	rep_3	1.3e-86
Eif4a2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Brain	rep_3	8.5e-206
Eif4a2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Mouse	Brain	rep_3	5.2e-187
Eif4a2	GOBP_Regulation_Of_Transferase_Activity	Mouse	Brain	rep_3	4.6e-186
Eif4a2	GOBP_Regulation_Of_Translational_Initiation	Mouse	Brain	rep_3	1.0e-196
Eif4a2	GOBP_Response_To_Cytokine	Mouse	Brain	rep_3	1.2e-08
Eif4a2	GOBP_Response_To_Leukemia_Inhibitory_Factor	Mouse	Brain	rep_3	9.6e-172
Eif4a2	GOBP_Translational_Initiation	Mouse	Brain	rep_3	1.2e-197
Eif4a2	GOBP_Amide_Biosynthetic_Process	Mouse	Embryo	rep_14	3.7e-18
Eif4a2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Eif4a2	GOBP_Cytoplasmic_Translation	Mouse	Embryo	rep_14	4.6e-30
Eif4a2	GOBP_Cytoplasmic_Translational_Initiation	Mouse	Embryo	rep_14	2.5e-22
Eif4a2	GOBP_Negative_Regulation_Of_Transferase_Activity	Mouse	Embryo	rep_14	2.4e-21
Eif4a2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	2.4e-12
Eif4a2	GOBP_Peptide_Biosynthetic_Process	Mouse	Embryo	rep_14	2.8e-15
Eif4a2	GOBP_Peptide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Eif4a2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Embryo	rep_14	1.4e-11
Eif4a2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Mouse	Embryo	rep_14	9.9e-25
Eif4a2	GOBP_Regulation_Of_Translational_Initiation	Mouse	Embryo	rep_14	1.2e-21
Eif4a2	GOBP_Response_To_Leukemia_Inhibitory_Factor	Mouse	Embryo	rep_14	5.8e-43
Eif4a2	GOBP_Translational_Initiation	Mouse	Embryo	rep_14	1.2e-37
Eif4a2	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Embryo	rep_1	2.5e-32
Eif4a2	GOBP_Response_To_Cytokine	Mouse	Embryo	rep_1	8.2e-211
Eif4a2	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Embryo	rep_2	7.4e-121
Eif4a2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Embryo	rep_2	8.0e-13
Eif4a2	GOBP_Response_To_Leukemia_Inhibitory_Factor	Mouse	Embryo	rep_2	9.5e-207
Eif4a2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	1.5e-267
Eif4a2	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Kidney	Nep	8.3e-23
Eif4a2	GOBP_Amide_Biosynthetic_Process	Mouse	Kidney	rep_2	1.9e-84
Eif4a2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-85
Eif4a2	GOBP_Cytoplasmic_Translation	Mouse	Kidney	rep_2	2.1e-75
Eif4a2	GOBP_Cytoplasmic_Translational_Initiation	Mouse	Kidney	rep_2	2.9e-68
Eif4a2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Kidney	rep_2	7.3e-42
Eif4a2	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Kidney	rep_2	5.2e-90
Eif4a2	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Kidney	rep_2	2.5e-99
Eif4a2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	7.7e-30
Eif4a2	GOBP_Negative_Regulation_Of_Transferase_Activity	Mouse	Kidney	rep_2	6.7e-85
Eif4a2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Kidney	rep_2	8.9e-78
Eif4a2	GOBP_Peptide_Biosynthetic_Process	Mouse	Kidney	rep_2	2.9e-85
Eif4a2	GOBP_Peptide_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-80
Eif4a2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Kidney	rep_2	1.1e-92
Eif4a2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Mouse	Kidney	rep_2	9.8e-137
Eif4a2	GOBP_Regulation_Of_Transferase_Activity	Mouse	Kidney	rep_2	7.3e-90
Eif4a2	GOBP_Regulation_Of_Translational_Initiation	Mouse	Kidney	rep_2	3.5e-71
Eif4a2	GOBP_Response_To_Cytokine	Mouse	Kidney	rep_2	3.1e-14
Eif4a2	GOBP_Response_To_Leukemia_Inhibitory_Factor	Mouse	Kidney	rep_2	1.8e-20
Eif4a2	GOBP_Translational_Initiation	Mouse	Kidney	rep_2	1.3e-103
Eif4a2	GOBP_Regulation_Of_Translational_Initiation	Mouse	Liver	CN16-D2	6.4e-08
Eif4a2	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Liver	CN73-C1	9.9e-07
Eif4a2	GOBP_Response_To_Cytokine	Mouse	Liver	rep_16	1.4e-13
Eif4a2	GOBP_Amide_Biosynthetic_Process	Mouse	Lymph	MS-1	1.3e-09
Eif4a2	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Lymph	MS-1	4.6e-18
Eif4a2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Eif4a2	GOBP_Cytoplasmic_Translation	Mouse	Lymph	MS-1	7.1e-07
Eif4a2	GOBP_Cytoplasmic_Translational_Initiation	Mouse	Lymph	MS-1	9.3e-07
Eif4a2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lymph	MS-1	6.1e-11
Eif4a2	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Lymph	MS-1	2.2e-13
Eif4a2	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Lymph	MS-1	6.9e-11
Eif4a2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	1.8e-10
Eif4a2	GOBP_Negative_Regulation_Of_Transferase_Activity	Mouse	Lymph	MS-1	1.6e-09
Eif4a2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	1.4e-09
Eif4a2	GOBP_Peptide_Biosynthetic_Process	Mouse	Lymph	MS-1	7.1e-07
Eif4a2	GOBP_Peptide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Eif4a2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Lymph	MS-1	7.1e-09
Eif4a2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Mouse	Lymph	MS-1	2.1e-08
Eif4a2	GOBP_Regulation_Of_Transferase_Activity	Mouse	Lymph	MS-1	1.0e-08
Eif4a2	GOBP_Regulation_Of_Translational_Initiation	Mouse	Lymph	MS-1	3.5e-09
Eif4a2	GOBP_Response_To_Cytokine	Mouse	Lymph	MS-1	5.7e-15
Eif4a2	GOBP_Response_To_Leukemia_Inhibitory_Factor	Mouse	Lymph	MS-1	3.2e-08
Eif4a2	GOBP_Translational_Initiation	Mouse	Lymph	MS-1	7.5e-07
Eif4a2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lung	rep_1	7.5e-20
Eif4a2	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Lung	rep_1	6.3e-10
Eif4a2	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Lung	rep_1	9.4e-15
Eif4a2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lung	rep_1	5.8e-10
Eif4a2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Lung	rep_1	1.6e-15
Eif4a2	GOBP_Response_To_Cytokine	Mouse	Lung	rep_1	1.2e-17
Eif4a2	GOBP_Amide_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	8.0e-10
Eif4a2	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.6e-11
Eif4a2	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.3e-12
Eif4a2	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Brain	HP_ad_rep7	4.0e-09
Eif4a2	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Brain	HP_ad_rep7	3.4e-10
Eif4a2	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-11
Eif4a2	GOBP_Negative_Regulation_Of_Transferase_Activity	Mouse	Brain	HP_ad_rep7	5.3e-10
Eif4a2	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	2.8e-08
Eif4a2	GOBP_Peptide_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	4.4e-10
Eif4a2	GOBP_Peptide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.8e-10
Eif4a2	GOBP_Posttranscriptional_Regulation_Of_Gene_Expression	Mouse	Brain	HP_ad_rep7	1.9e-10
Eif4a2	GOBP_Regulation_Of_Cellular_Amide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-07
Eif4a2	GOBP_Regulation_Of_Transferase_Activity	Mouse	Brain	HP_ad_rep7	1.6e-08
Eif4a2	GOBP_Regulation_Of_Translational_Initiation	Mouse	Brain	HP_ad_rep7	3.8e-08
Eif4a2	GOBP_Response_To_Cytokine	Mouse	Brain	HP_ad_rep7	2.1e-08
Eif4a2	GOBP_Response_To_Leukemia_Inhibitory_Factor	Mouse	Brain	HP_ad_rep7	2.3e-07
Eif4a2	GOBP_Translational_Initiation	Mouse	Brain	HP_ad_rep7	6.9e-08
Eif4a2	GOBP_Cytoplasmic_Translation	Mouse	Brain	HP_ad_rep8	1.4e-08
Eif4a2	GOBP_Cytoplasmic_Translational_Initiation	Mouse	Brain	HP_adpolb_rep1	4.3e-07
Eif4a2	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Brain	HP_polb_rep9	1.1e-12

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Eif4a2 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Eif4a2 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Eif4a2 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Eif4a2

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Eif4a2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Eif4a2	C0001969	Alcoholic Intoxication	1	PSYGENET
Eif4a2	C0027627	Neoplasm Metastasis	1	CTD_human
Eif4a2	C0394996	Acute alcoholic intoxication	1	PSYGENET