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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Efna4 (spascer ID:13639)

Gene summary for Efna4

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Efna4
	Gene ID	13639
	Gene name	ephrin A4
	Synonyms	EFL-4\|Epl4\|LERK-4
	Cytomap	3 F1\|3 39.07 cM
	Type of gene	protein-coding
	Description	ephrin-A4EPH-related receptor tyrosine kinase ligand 4
	Modification date	20220424
	UniProtAcc	O08542

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Efna4	GO:0005886	plasma membrane	21873635	Component
Efna4	GO:0007411	axon guidance	21873635	Process
Efna4	GO:0046875	ephrin receptor binding	21873635	Function
Efna4	GO:0048013	ephrin receptor signaling pathway	21873635	Process

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Spatial pattern events for Efna4

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Efna4	Mouse	Embryo	rep_4	33188776	1.31e-08
Efna4	Mouse	Kidney	CLP	34003797	6.92e-15
Efna4	Mouse	Kidney	Sham	34003797	2.58e-15
Efna4	Mouse	Kidney	rep_1	34853151	7.83e-15
Efna4	Mouse	Testicle	rep_4	34731600	1.73e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E

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Spatial pattern pathway has Efna4 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Efna4	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Spinal cord	CN94_E1	4.4e-07
Efna4	GOBP_Ephrin_Receptor_Signaling_Pathway	Mouse	Spinal cord	L7bCN01_D2	4.6e-06
Efna4	GOBP_Axon_Development	Mouse	Spinal cord	L7bCN02_E1	6.5e-06
Efna4	GOBP_Cell_Cell_Signaling	Mouse	Spinal cord	L7CN45_C1	3.5e-08
Efna4	GOBP_Cell_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Differentiation	Mouse	Spinal cord	L7CN45_C1	2.8e-06
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Neuron_Differentiation	Mouse	Spinal cord	L7CN45_C1	2.8e-06
Efna4	GOBP_Cell_Part_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Efna4	GOBP_Cell_Projection_Organization	Mouse	Spinal cord	L7CN45_C1	1.2e-07
Efna4	GOBP_Cellular_Component_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Efna4	GOBP_Neurogenesis	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Efna4	GOBP_Neuron_Development	Mouse	Spinal cord	L7CN45_C1	5.6e-08
Efna4	GOBP_Neuron_Differentiation	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Efna4	GOBP_Neuron_Projection_Guidance	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Efna4	GOBP_Taxis	Mouse	Spinal cord	L7CN45_C1	4.2e-06
Efna4	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Spinal cord	L7CN45_C1	5.7e-08
Efna4	GOBP_Locomotion	Mouse	Spinal cord	L8CN11_D1	8.5e-06
Efna4	GOBP_Axon_Development	Mouse	Brain	rep_1	8.7e-20
Efna4	GOBP_Cell_Cell_Signaling	Mouse	Brain	rep_1	5.1e-48
Efna4	GOBP_Cell_Morphogenesis	Mouse	Brain	rep_1	7.6e-08
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Differentiation	Mouse	Brain	rep_1	5.7e-33
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Neuron_Differentiation	Mouse	Brain	rep_1	2.1e-36
Efna4	GOBP_Cell_Part_Morphogenesis	Mouse	Brain	rep_1	1.1e-13
Efna4	GOBP_Cell_Projection_Organization	Mouse	Brain	rep_1	2.6e-08
Efna4	GOBP_Cellular_Component_Morphogenesis	Mouse	Brain	rep_1	1.4e-14
Efna4	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Brain	rep_1	9.9e-07
Efna4	GOBP_Ephrin_Receptor_Signaling_Pathway	Mouse	Brain	rep_1	1.2e-43
Efna4	GOBP_Neurogenesis	Mouse	Brain	rep_1	6.4e-19
Efna4	GOBP_Neuron_Development	Mouse	Brain	rep_1	3.8e-29
Efna4	GOBP_Neuron_Differentiation	Mouse	Brain	rep_1	8.7e-25
Efna4	GOBP_Neuron_Projection_Guidance	Mouse	Brain	rep_1	3.0e-25
Efna4	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Brain	rep_1	8.6e-14
Efna4	GOBP_Locomotion	Mouse	Brain	rep_3	5.4e-74
Efna4	GOBP_Taxis	Mouse	Brain	rep_3	1.5e-87
Efna4	GOBP_Ephrin_Receptor_Signaling_Pathway	Mouse	Embryo	rep_14	8.9e-10
Efna4	GOBP_Locomotion	Mouse	Embryo	rep_1	1.7e-10
Efna4	GOBP_Neurogenesis	Mouse	Embryo	rep_1	8.2e-08
Efna4	GOBP_Neuron_Development	Mouse	Embryo	rep_2	4.8e-18
Efna4	GOBP_Taxis	Mouse	Embryo	rep_2	1.1e-33
Efna4	GOBP_Axon_Development	Mouse	Embryo	rep_3	2.3e-205
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Differentiation	Mouse	Embryo	rep_3	1.7e-20
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Neuron_Differentiation	Mouse	Embryo	rep_3	3.3e-186
Efna4	GOBP_Cell_Part_Morphogenesis	Mouse	Embryo	rep_3	4.8e-116
Efna4	GOBP_Cell_Projection_Organization	Mouse	Embryo	rep_3	1.7e-72
Efna4	GOBP_Cellular_Component_Morphogenesis	Mouse	Embryo	rep_3	2.7e-78
Efna4	GOBP_Ephrin_Receptor_Signaling_Pathway	Mouse	Embryo	rep_3	1.4e-172
Efna4	GOBP_Neuron_Differentiation	Mouse	Embryo	rep_3	2.1e-193
Efna4	GOBP_Neuron_Projection_Guidance	Mouse	Embryo	rep_3	4.1e-45
Efna4	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Embryo	rep_3	2.7e-115
Efna4	GOBP_Cell_Morphogenesis	Mouse	Embryo	rep_5	2.2e-13
Efna4	GOBP_Cell_Morphogenesis	Mouse	Kidney	Nep	1.1e-16
Efna4	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Kidney	Nep	4.4e-12
Efna4	GOBP_Locomotion	Mouse	Kidney	Nep	5.3e-07
Efna4	GOBP_Neurogenesis	Mouse	Kidney	Nep	4.6e-22
Efna4	GOBP_Neuron_Development	Mouse	Kidney	Nep	8.3e-23
Efna4	GOBP_Neuron_Differentiation	Mouse	Kidney	Nep	8.3e-23
Efna4	GOBP_Taxis	Mouse	Kidney	Nep	4.4e-12
Efna4	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Kidney	Nep	4.4e-12
Efna4	GOBP_Axon_Development	Mouse	Kidney	rep_2	1.6e-18
Efna4	GOBP_Cell_Cell_Signaling	Mouse	Kidney	rep_2	6.2e-72
Efna4	GOBP_Cell_Morphogenesis	Mouse	Kidney	rep_2	1.7e-84
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Differentiation	Mouse	Kidney	rep_2	7.8e-42
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Neuron_Differentiation	Mouse	Kidney	rep_2	8.7e-27
Efna4	GOBP_Cell_Part_Morphogenesis	Mouse	Kidney	rep_2	2.3e-34
Efna4	GOBP_Cell_Projection_Organization	Mouse	Kidney	rep_2	4.1e-48
Efna4	GOBP_Cellular_Component_Morphogenesis	Mouse	Kidney	rep_2	8.8e-46
Efna4	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Kidney	rep_2	1.5e-13
Efna4	GOBP_Ephrin_Receptor_Signaling_Pathway	Mouse	Kidney	rep_2	3.6e-74
Efna4	GOBP_Locomotion	Mouse	Kidney	rep_2	2.1e-43
Efna4	GOBP_Neurogenesis	Mouse	Kidney	rep_2	2.4e-78
Efna4	GOBP_Neuron_Development	Mouse	Kidney	rep_2	1.3e-42
Efna4	GOBP_Neuron_Differentiation	Mouse	Kidney	rep_2	3.9e-32
Efna4	GOBP_Neuron_Projection_Guidance	Mouse	Kidney	rep_2	2.5e-82
Efna4	GOBP_Taxis	Mouse	Kidney	rep_2	3.1e-35
Efna4	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Kidney	rep_2	2.5e-32
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Neuron_Differentiation	Mouse	Liver	CN16-D2	7.7e-08
Efna4	GOBP_Neuron_Differentiation	Mouse	Liver	CN16-D2	5.1e-07
Efna4	GOBP_Neuron_Projection_Guidance	Mouse	Liver	CN16-D2	1.1e-08
Efna4	GOBP_Ephrin_Receptor_Signaling_Pathway	Mouse	Liver	CN65-C1	3.0e-10
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Neuron_Differentiation	Mouse	Liver	rep_16	4.9e-07
Efna4	GOBP_Cell_Projection_Organization	Mouse	Liver	rep_16	3.4e-07
Efna4	GOBP_Cellular_Component_Morphogenesis	Mouse	Liver	rep_16	8.4e-09
Efna4	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Liver	rep_16	1.8e-10
Efna4	GOBP_Locomotion	Mouse	Liver	rep_26	1.6e-10
Efna4	GOBP_Cell_Cell_Signaling	Mouse	Lymph	MS-1	9.7e-11
Efna4	GOBP_Cell_Morphogenesis	Mouse	Lymph	MS-1	3.9e-13
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Differentiation	Mouse	Lymph	MS-1	2.1e-10
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Neuron_Differentiation	Mouse	Lymph	MS-1	1.3e-08
Efna4	GOBP_Cell_Projection_Organization	Mouse	Lymph	MS-1	1.5e-09
Efna4	GOBP_Cellular_Component_Morphogenesis	Mouse	Lymph	MS-1	5.0e-11
Efna4	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Lymph	MS-1	1.6e-14
Efna4	GOBP_Ephrin_Receptor_Signaling_Pathway	Mouse	Lymph	MS-1	8.4e-10
Efna4	GOBP_Locomotion	Mouse	Lymph	MS-1	1.2e-12
Efna4	GOBP_Neurogenesis	Mouse	Lymph	MS-1	4.1e-08
Efna4	GOBP_Neuron_Projection_Guidance	Mouse	Lymph	MS-1	7.9e-10
Efna4	GOBP_Taxis	Mouse	Lymph	MS-1	7.3e-13
Efna4	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Lymph	MS-1	8.3e-14
Efna4	GOBP_Ephrin_Receptor_Signaling_Pathway	Mouse	Lung	rep_1	2.0e-25
Efna4	GOBP_Ephrin_Receptor_Signaling_Pathway	Mouse	Brain	rep_4	1.5e-08
Efna4	GOBP_Neuron_Projection_Guidance	Mouse	Brain	rep_4	2.6e-18
Efna4	GOBP_Cell_Cell_Signaling	Mouse	Brain	HP_ad_rep7	1.6e-08
Efna4	GOBP_Cell_Morphogenesis	Mouse	Brain	HP_ad_rep7	8.4e-10
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Differentiation	Mouse	Brain	HP_ad_rep7	8.1e-09
Efna4	GOBP_Cell_Morphogenesis_Involved_In_Neuron_Differentiation	Mouse	Brain	HP_ad_rep7	1.3e-09
Efna4	GOBP_Cell_Part_Morphogenesis	Mouse	Brain	HP_ad_rep7	1.3e-09
Efna4	GOBP_Cell_Projection_Organization	Mouse	Brain	HP_ad_rep7	8.1e-09
Efna4	GOBP_Cellular_Component_Morphogenesis	Mouse	Brain	HP_ad_rep7	1.2e-08
Efna4	GOBP_Enzyme_Linked_Receptor_Protein_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	2.5e-10
Efna4	GOBP_Ephrin_Receptor_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	8.6e-08
Efna4	GOBP_Locomotion	Mouse	Brain	HP_ad_rep7	3.8e-07
Efna4	GOBP_Neurogenesis	Mouse	Brain	HP_ad_rep7	3.9e-07
Efna4	GOBP_Neuron_Development	Mouse	Brain	HP_ad_rep7	3.9e-07
Efna4	GOBP_Neuron_Differentiation	Mouse	Brain	HP_ad_rep7	3.9e-07
Efna4	GOBP_Neuron_Projection_Guidance	Mouse	Brain	HP_ad_rep7	5.6e-07
Efna4	GOBP_Taxis	Mouse	Brain	HP_ad_rep7	6.0e-07
Efna4	GOBP_Transmembrane_Receptor_Protein_Tyrosine_Kinase_Signaling_Pathway	Mouse	Brain	HP_ad_rep7	9.5e-09
Efna4	GOBP_Axon_Development	Mouse	Brain	HP_polb_rep9	7.3e-07

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Efna4 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Efna4 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand	Receptor	LR pair	Tissue	Replication
Efna4	Epha3	Efna4_Epha3	Embryo	rep_14
Efna4	Epha5	Efna4_Epha5	Brain	rep_2
Efna4	Epha4	Efna4_Epha4	Brain	33B
Efna4	Epha8	Efna4_Epha8	Brain	36B
Efna4	Epha7	Efna4_Epha7	Brain	21A
Efna4	Epha2	Efna4_Epha2	Kidney	rep_2

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Transcription factor for Efna4 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Efna4

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Efna4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source