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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Ccs (spascer ID:12460)

Gene summary for Ccs

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Ccs
	Gene ID	12460
	Gene name	copper chaperone for superoxide dismutase
	Synonyms	Ccsd
	Cytomap	19 A\|19 4.11 cM
	Type of gene	protein-coding
	Description	copper chaperone for superoxide dismutasesuperoxide dismutase copper chaperone
	Modification date	20220424
	UniProtAcc	Q9WU84

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Ccs	GO:0004784	superoxide dismutase activity	21873635	Function
Ccs	GO:0005507	copper ion binding	21873635	Function
Ccs	GO:0019430	removal of superoxide radicals	21873635	Process

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Spatial pattern events for Ccs

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Ccs	Mouse	Brain	S4	34413515	1.86e-06
Ccs	Mouse	Brain	rep_1	35141374	1.54e-07
Ccs	Mouse	Brain	rep_2	35141374	2.49e-07
Ccs	Mouse	Brain	rep_5	35141374	6.23e-09
Ccs	Mouse	Brain	rep_6	35141374	9.62e-09
Ccs	Mouse	Kidney	CLP	34003797	2.19e-15
Ccs	Mouse	Kidney	IRI	34003797	2.29e-15
Ccs	Mouse	Kidney	Sham	34003797	2.58e-15
Ccs	Mouse	Kidney	rep_1	34853151	8.39e-13
Ccs	Mouse	Kidney	rep_2	34853151	1.72e-07
Ccs	Mouse	Kidney	rep_3	34853151	9.10e-15
Ccs	Mouse	Brain	rep_1	33469025	1.43e-13
Ccs	Mouse	Liver	rep_14	35021063	8.70e-09
Ccs	Mouse	Liver	rep_17	35021063	2.18e-14
Ccs	Mouse	Liver	rep_18	35021063	9.41e-09
Ccs	Mouse	Liver	rep_20	35021063	9.91e-15
Ccs	Mouse	Liver	rep_21	35021063	1.09e-07
Ccs	Mouse	Brain	rep_3	35027729	4.57e-15
Ccs	Mouse	Intestine	rep_3	35149721	1.61e-06
Ccs	Mouse	Brain	rep_2	35210624	8.27e-10

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_2_H&E
Kidney_rep_3_H&E
Brain_rep_1_H&E
Liver_rep_14_H&E
Liver_rep_17_H&E
Liver_rep_18_H&E
Liver_rep_20_H&E
Liver_rep_21_H&E
Brain_rep_3_H&E

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Spatial pattern pathway has Ccs envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Ccs	GOBP_Response_To_Oxygen_Radical	Mouse	Spinal cord	CN93_D2	8.2e-06
Ccs	GOBP_Cation_Transport	Mouse	Spinal cord	CN94_E1	5.8e-06
Ccs	GOBP_Cellular_Oxidant_Detoxification	Mouse	Spinal cord	CN94_E1	7.7e-07
Ccs	GOBP_Cellular_Response_To_Oxygen_Radical	Mouse	Spinal cord	CN94_E1	2.9e-06
Ccs	GOBP_Cellular_Response_To_Reactive_Oxygen_Species	Mouse	Spinal cord	CN94_E1	3.1e-07
Ccs	GOBP_Cellular_Response_To_Toxic_Substance	Mouse	Spinal cord	CN94_E1	5.2e-06
Ccs	GOBP_Detoxification	Mouse	Spinal cord	CN94_E1	6.0e-06
Ccs	GOBP_Protein_Maturation	Mouse	Spinal cord	CN94_E1	2.2e-06
Ccs	GOBP_Response_To_Reactive_Oxygen_Species	Mouse	Spinal cord	CN94_E1	4.8e-06
Ccs	GOBP_Superoxide_Metabolic_Process	Mouse	Spinal cord	CN94_E1	1.0e-07
Ccs	GOBP_Regulation_Of_Oxidoreductase_Activity	Mouse	Spinal cord	L7bCN01_D2	9.2e-06
Ccs	GOBP_Cellular_Response_To_Chemical_Stress	Mouse	Spinal cord	L7CN45_C1	1.5e-07
Ccs	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Mouse	Spinal cord	L7CN45_C1	1.6e-07
Ccs	GOBP_Metal_Ion_Transport	Mouse	Spinal cord	L7CN45_C1	4.4e-08
Ccs	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Ccs	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Ccs	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Ccs	GOBP_Response_To_Inorganic_Substance	Mouse	Spinal cord	L7CN45_C1	3.1e-08
Ccs	GOBP_Response_To_Oxidative_Stress	Mouse	Spinal cord	L7CN45_C1	2.8e-06
Ccs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Ccs	GOBP_Response_To_Toxic_Substance	Mouse	Spinal cord	L7CN45_C1	2.1e-08
Ccs	GOBP_Positive_Regulation_Of_Oxidoreductase_Activity	Mouse	Spinal cord	L7CN97_E2	3.2e-06
Ccs	GOBP_Cellular_Response_To_Oxygen_Radical	Mouse	Brain	rep_11	5.3e-05
Ccs	GOBP_Response_To_Oxygen_Radical	Mouse	Brain	rep_11	3.0e-05
Ccs	GOBP_Positive_Regulation_Of_Oxidoreductase_Activity	Mouse	Brain	rep_61	8.0e-06
Ccs	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Brain	rep_61	5.5e-05
Ccs	GOBP_Cellular_Response_To_Toxic_Substance	Mouse	Brain	rep_71	8.6e-05
Ccs	GOBP_Detoxification	Mouse	Brain	rep_71	2.7e-05
Ccs	GOBP_Cation_Transport	Mouse	Brain	rep_1	1.5e-22
Ccs	GOBP_Metal_Ion_Transport	Mouse	Brain	rep_1	5.1e-10
Ccs	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Brain	rep_1	1.7e-58
Ccs	GOBP_Response_To_Inorganic_Substance	Mouse	Brain	rep_1	2.4e-10
Ccs	GOBP_Cellular_Oxidant_Detoxification	Mouse	Brain	rep_3	3.4e-79
Ccs	GOBP_Cellular_Response_To_Chemical_Stress	Mouse	Brain	rep_3	5.0e-121
Ccs	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Mouse	Brain	rep_3	8.2e-81
Ccs	GOBP_Cellular_Response_To_Oxygen_Radical	Mouse	Brain	rep_3	5.0e-123
Ccs	GOBP_Cellular_Response_To_Reactive_Oxygen_Species	Mouse	Brain	rep_3	3.0e-169
Ccs	GOBP_Cellular_Response_To_Toxic_Substance	Mouse	Brain	rep_3	7.4e-77
Ccs	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_3	8.5e-79
Ccs	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	rep_3	2.6e-94
Ccs	GOBP_Positive_Regulation_Of_Oxidoreductase_Activity	Mouse	Brain	rep_3	5.8e-132
Ccs	GOBP_Protein_Maturation	Mouse	Brain	rep_3	1.1e-160
Ccs	GOBP_Regulation_Of_Oxidoreductase_Activity	Mouse	Brain	rep_3	5.1e-114
Ccs	GOBP_Response_To_Oxidative_Stress	Mouse	Brain	rep_3	5.9e-30
Ccs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Brain	rep_3	6.3e-92
Ccs	GOBP_Response_To_Oxygen_Radical	Mouse	Brain	rep_3	3.0e-125
Ccs	GOBP_Response_To_Reactive_Oxygen_Species	Mouse	Brain	rep_3	9.5e-90
Ccs	GOBP_Superoxide_Metabolic_Process	Mouse	Brain	rep_3	1.1e-172
Ccs	GOBP_Detoxification	Mouse	Embryo	rep_6	7.3e-17
Ccs	GOBP_Positive_Regulation_Of_Oxidoreductase_Activity	Mouse	Embryo	rep_6	3.1e-21
Ccs	GOBP_Response_To_Toxic_Substance	Mouse	Embryo	rep_6	8.4e-07
Ccs	GOBP_Cellular_Oxidant_Detoxification	Mouse	Embryo	rep_14	1.2e-41
Ccs	GOBP_Cellular_Response_To_Chemical_Stress	Mouse	Embryo	rep_14	6.0e-13
Ccs	GOBP_Cellular_Response_To_Oxygen_Radical	Mouse	Embryo	rep_14	2.0e-70
Ccs	GOBP_Cellular_Response_To_Reactive_Oxygen_Species	Mouse	Embryo	rep_14	2.4e-38
Ccs	GOBP_Cellular_Response_To_Toxic_Substance	Mouse	Embryo	rep_14	8.2e-33
Ccs	GOBP_Protein_Maturation	Mouse	Embryo	rep_14	6.3e-10
Ccs	GOBP_Regulation_Of_Oxidoreductase_Activity	Mouse	Embryo	rep_14	3.5e-10
Ccs	GOBP_Response_To_Oxidative_Stress	Mouse	Embryo	rep_14	6.9e-10
Ccs	GOBP_Response_To_Oxygen_Radical	Mouse	Embryo	rep_14	2.5e-80
Ccs	GOBP_Response_To_Reactive_Oxygen_Species	Mouse	Embryo	rep_14	3.2e-27
Ccs	GOBP_Superoxide_Metabolic_Process	Mouse	Embryo	rep_14	2.4e-17
Ccs	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Embryo	rep_1	2.2e-98
Ccs	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Mouse	Embryo	rep_3	0.0e+00
Ccs	GOBP_Cellular_Response_To_Reactive_Oxygen_Species	Mouse	Embryo	rep_3	5.7e-186
Ccs	GOBP_Response_To_Inorganic_Substance	Mouse	Embryo	rep_3	2.3e-136
Ccs	GOBP_Response_To_Oxidative_Stress	Mouse	Embryo	rep_3	2.3e-12
Ccs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Embryo	rep_3	0.0e+00
Ccs	GOBP_Response_To_Reactive_Oxygen_Species	Mouse	Embryo	rep_3	1.4e-232
Ccs	GOBP_Protein_Maturation	Mouse	Kidney	IRI	2.5e-33
Ccs	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	Nep	1.8e-46
Ccs	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	Nep	1.8e-46
Ccs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Kidney	Nep	6.8e-28
Ccs	GOBP_Cation_Transport	Mouse	Kidney	rep_2	5.9e-23
Ccs	GOBP_Cellular_Oxidant_Detoxification	Mouse	Kidney	rep_2	2.1e-114
Ccs	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Mouse	Kidney	rep_2	4.5e-89
Ccs	GOBP_Cellular_Response_To_Oxygen_Radical	Mouse	Kidney	rep_2	2.0e-39
Ccs	GOBP_Cellular_Response_To_Reactive_Oxygen_Species	Mouse	Kidney	rep_2	2.6e-16
Ccs	GOBP_Cellular_Response_To_Toxic_Substance	Mouse	Kidney	rep_2	7.7e-123
Ccs	GOBP_Detoxification	Mouse	Kidney	rep_2	1.3e-34
Ccs	GOBP_Metal_Ion_Transport	Mouse	Kidney	rep_2	7.0e-69
Ccs	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Kidney	rep_2	2.1e-66
Ccs	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Kidney	rep_2	2.2e-45
Ccs	GOBP_Positive_Regulation_Of_Oxidoreductase_Activity	Mouse	Kidney	rep_2	6.7e-65
Ccs	GOBP_Protein_Maturation	Mouse	Kidney	rep_2	5.4e-103
Ccs	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Kidney	rep_2	1.2e-25
Ccs	GOBP_Regulation_Of_Oxidoreductase_Activity	Mouse	Kidney	rep_2	1.9e-89
Ccs	GOBP_Response_To_Oxidative_Stress	Mouse	Kidney	rep_2	2.2e-39
Ccs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Kidney	rep_2	6.6e-112
Ccs	GOBP_Response_To_Oxygen_Radical	Mouse	Kidney	rep_2	7.0e-29
Ccs	GOBP_Response_To_Toxic_Substance	Mouse	Kidney	rep_2	1.3e-34
Ccs	GOBP_Positive_Regulation_Of_Oxidoreductase_Activity	Mouse	Liver	CN16-D1	1.7e-07
Ccs	GOBP_Cellular_Response_To_Oxygen_Radical	Mouse	Liver	CN16-E1	5.9e-09
Ccs	GOBP_Cellular_Oxidant_Detoxification	Mouse	Liver	CN65-D1	8.6e-10
Ccs	GOBP_Metal_Ion_Transport	Mouse	Liver	CN73-C1	6.4e-08
Ccs	GOBP_Cation_Transport	Mouse	Liver	rep_16	1.2e-18
Ccs	GOBP_Positive_Regulation_Of_Oxidoreductase_Activity	Mouse	Liver	rep_16	1.2e-09
Ccs	GOBP_Protein_Maturation	Mouse	Liver	rep_16	4.5e-09
Ccs	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Liver	rep_16	5.0e-08
Ccs	GOBP_Regulation_Of_Oxidoreductase_Activity	Mouse	Liver	rep_16	6.1e-07
Ccs	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Mouse	Lymph	MS-1	7.5e-11
Ccs	GOBP_Detoxification	Mouse	Lymph	MS-1	2.9e-07
Ccs	GOBP_Metal_Ion_Transport	Mouse	Lymph	MS-1	1.4e-09
Ccs	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Lymph	MS-1	2.2e-13
Ccs	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Lymph	MS-1	1.9e-12
Ccs	GOBP_Positive_Regulation_Of_Oxidoreductase_Activity	Mouse	Lymph	MS-1	9.3e-08
Ccs	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Lymph	MS-1	2.4e-10
Ccs	GOBP_Regulation_Of_Oxidoreductase_Activity	Mouse	Lymph	MS-1	2.3e-08
Ccs	GOBP_Response_To_Inorganic_Substance	Mouse	Lymph	MS-1	5.1e-09
Ccs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Lymph	MS-1	1.8e-09
Ccs	GOBP_Superoxide_Metabolic_Process	Mouse	Lymph	MS-1	2.6e-12
Ccs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Lung	rep_1	1.2e-19
Ccs	GOBP_Response_To_Toxic_Substance	Mouse	Lung	rep_1	3.0e-08
Ccs	GOBP_Cation_Transport	Mouse	Brain	HP_ad_rep7	7.5e-07
Ccs	GOBP_Cellular_Response_To_Oxygen_Containing_Compound	Mouse	Brain	HP_ad_rep7	2.6e-10
Ccs	GOBP_Cellular_Response_To_Oxygen_Radical	Mouse	Brain	HP_ad_rep7	2.0e-08
Ccs	GOBP_Positive_Regulation_Of_Catalytic_Activity	Mouse	Brain	HP_ad_rep7	2.8e-07
Ccs	GOBP_Positive_Regulation_Of_Molecular_Function	Mouse	Brain	HP_ad_rep7	2.8e-07
Ccs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Brain	HP_ad_rep7	4.2e-09
Ccs	GOBP_Detoxification	Mouse	Brain	HP_adpolb_rep1	9.8e-11
Ccs	GOBP_Response_To_Oxygen_Radical	Mouse	Brain	HP_adpolb_rep1	3.4e-10
Ccs	GOBP_Cellular_Oxidant_Detoxification	Mouse	Brain	HP_polb_rep9	2.0e-12
Ccs	GOBP_Cellular_Response_To_Chemical_Stress	Mouse	Brain	HP_polb_rep9	1.2e-09
Ccs	GOBP_Cellular_Response_To_Toxic_Substance	Mouse	Brain	HP_polb_rep9	3.1e-11
Ccs	GOBP_Protein_Maturation	Mouse	Brain	HP_polb_rep9	9.1e-14
Ccs	GOBP_Reactive_Oxygen_Species_Metabolic_Process	Mouse	Brain	HP_polb_rep9	8.1e-07
Ccs	GOBP_Response_To_Inorganic_Substance	Mouse	Brain	HP_polb_rep9	2.6e-07
Ccs	GOBP_Response_To_Oxidative_Stress	Mouse	Brain	HP_polb_rep9	1.1e-09

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Ccs function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Ccs function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Ccs envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Ccs

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Ccs

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Ccs	C0019189	Hepatitis, Chronic	1	CTD_human
Ccs	C0149519	Chronic Persistent Hepatitis	1	CTD_human
Ccs	C0520463	Chronic active hepatitis	1	CTD_human
Ccs	C0524611	Cryptogenic Chronic Hepatitis	1	CTD_human