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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Cbx5 (spascer ID:12419)

Gene summary for Cbx5

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Cbx5
	Gene ID	12419
	Gene name	chromobox 5
	Synonyms	2610029O15Rik\|C75991\|HP1\|Hp1a\|Hp1alpha
	Cytomap	15\|15 F3
	Type of gene	protein-coding
	Description	chromobox protein homolog 5HP1 alphachromobox homolog 5heterochromatin protein 1 alphaheterochromatin protein 1 homolog alphamHP1(alpha)
	Modification date	20220424
	UniProtAcc	Q61686

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Cbx5	GO:0000122	negative regulation of transcription by RNA polymerase II	21873635	Process
Cbx5	GO:0003682	chromatin binding	21873635	Function
Cbx5	GO:0005721	pericentric heterochromatin	21873635	Component
Cbx5	GO:0006325	chromatin organization	21873635	Process
Cbx5	GO:0035064	methylated histone binding	21873635	Function

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Spatial pattern events for Cbx5

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Cbx5	Mouse	Brain	S1	34413515	2.65e-06
Cbx5	Mouse	Brain	S3	34413515	3.72e-08
Cbx5	Mouse	Brain	S4	34413515	1.84e-14
Cbx5	Mouse	Brain	S6	34413515	5.15e-10
Cbx5	Mouse	Brain	S7	34413515	1.73e-10
Cbx5	Mouse	Brain	rep_1	35141374	6.80e-15
Cbx5	Mouse	Brain	rep_2	35141374	2.79e-13
Cbx5	Mouse	Brain	rep_3	35141374	1.64e-15
Cbx5	Mouse	Brain	rep_4	35141374	9.74e-07
Cbx5	Mouse	Brain	rep_5	35141374	2.48e-09
Cbx5	Mouse	Brain	rep_6	35141374	4.06e-14
Cbx5	Mouse	Embryo	rep_1	33188776	3.27e-14
Cbx5	Mouse	Embryo	rep_2	33188776	1.92e-12
Cbx5	Mouse	Embryo	rep_3	33188776	1.13e-14
Cbx5	Mouse	Embryo	rep_4	33188776	5.08e-15
Cbx5	Mouse	Embryo	rep_5	33188776	3.86e-14
Cbx5	Mouse	Embryo	rep_7	33188776	6.94e-15
Cbx5	Mouse	Embryo	rep_13	33188776	4.49e-15
Cbx5	Mouse	Kidney	CLP	34003797	3.77e-15
Cbx5	Mouse	Kidney	IRI	34003797	7.37e-15
Cbx5	Mouse	Kidney	Sham	34003797	4.30e-15
Cbx5	Mouse	Kidney	rep_1	34853151	7.62e-07
Cbx5	Mouse	Kidney	rep_3	34853151	5.36e-10
Cbx5	Mouse	Brain	rep_1	33469025	1.30e-15
Cbx5	Mouse	Brain	rep_1	35027729	1.66e-15
Cbx5	Mouse	Brain	rep_2	35027729	1.57e-15
Cbx5	Mouse	Brain	rep_3	35027729	1.32e-15
Cbx5	Mouse	Brain	rep_4	35027729	1.76e-15
Cbx5	Mouse	Brain	rep_5	35027729	1.46e-15
Cbx5	Mouse	Intestine	rep_3	35149721	6.27e-06
Cbx5	Mouse	Intestine	rep_4	35149721	3.44e-13
Cbx5	Mouse	Brain	B02_D1	32702314	2.82e-06
Cbx5	Mouse	Brain	B03_D2	32702314	1.15e-06
Cbx5	Mouse	Testicle	rep_4	34731600	3.84e-06
Cbx5	Mouse	Testicle	rep_6	34731600	3.02e-14
Cbx5	Mouse	Lymph	A1	0	5.62e-13
Cbx5	Mouse	Lymph	B1	0	6.08e-15
Cbx5	Mouse	Brain	rep_1	35210624	1.98e-06
Cbx5	Mouse	Brain	rep_2	35210624	1.80e-14
Cbx5	Mouse	Brain	rep_3	35210624	5.24e-12
Cbx5	Mouse	Brain	rep_4	35210624	1.37e-09
Cbx5	Mouse	Brain	rep_5	35210624	3.26e-06
Cbx5	Mouse	Brain	rep_6	35210624	1.38e-14
Cbx5	Mouse	Brain	rep_7	35210624	1.87e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_3_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_B02_D1_H&E
Brain_B03_D2_H&E

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Spatial pattern pathway has Cbx5 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Cbx5	GOBP_Cell_Cycle	Mouse	Spinal cord	CN94_E1	1.1e-06
Cbx5	GOBP_Cell_Cycle_Process	Mouse	Spinal cord	CN94_E1	3.8e-06
Cbx5	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Spinal cord	CN94_E1	8.0e-06
Cbx5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Spinal cord	CN94_E1	1.6e-06
Cbx5	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Spinal cord	CN94_E1	3.2e-06
Cbx5	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Mouse	Spinal cord	CN94_E1	5.0e-07
Cbx5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Spinal cord	CN94_E1	6.2e-07
Cbx5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Spinal cord	CN94_E1	2.2e-06
Cbx5	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Spinal cord	CN94_E1	7.5e-07
Cbx5	GOBP_Response_To_Wounding	Mouse	Spinal cord	CN94_E1	4.7e-06
Cbx5	GOBP_G0_To_G1_Transition	Mouse	Spinal cord	L7CN45_C1	1.3e-07
Cbx5	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Spinal cord	L7CN45_C1	9.1e-06
Cbx5	GOBP_Regulation_Of_Cell_Cycle	Mouse	Spinal cord	L7CN45_C1	3.0e-07
Cbx5	GOBP_Wound_Healing	Mouse	Spinal cord	L7CN47_C1	8.4e-07
Cbx5	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Spinal cord	L7CN97_E2	6.8e-06
Cbx5	GOBP_Cell_Cycle	Mouse	Brain	rep_27	8.4e-07
Cbx5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_27	7.2e-05
Cbx5	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Brain	rep_27	1.7e-08
Cbx5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_27	2.8e-05
Cbx5	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	rep_27	4.4e-08
Cbx5	GOBP_Cell_Cycle	Mouse	Brain	rep_1	7.0e-10
Cbx5	GOBP_Cell_Cycle_Process	Mouse	Brain	rep_1	6.7e-14
Cbx5	GOBP_G0_To_G1_Transition	Mouse	Brain	rep_1	3.9e-25
Cbx5	GOBP_Regulation_Of_Cell_Cycle	Mouse	Brain	rep_1	3.9e-14
Cbx5	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	rep_1	4.4e-18
Cbx5	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Brain	rep_3	1.9e-146
Cbx5	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Brain	rep_3	5.0e-192
Cbx5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	rep_3	1.4e-196
Cbx5	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Brain	rep_3	1.9e-186
Cbx5	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	rep_3	4.5e-183
Cbx5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	rep_3	9.4e-206
Cbx5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	rep_3	7.5e-168
Cbx5	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Brain	rep_3	1.1e-62
Cbx5	GOBP_Response_To_Wounding	Mouse	Brain	rep_3	6.2e-112
Cbx5	GOBP_Wound_Healing	Mouse	Brain	rep_3	6.2e-109
Cbx5	GOBP_G0_To_G1_Transition	Mouse	Embryo	rep_6	5.9e-16
Cbx5	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Embryo	rep_2	7.4e-121
Cbx5	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Embryo	rep_2	1.4e-08
Cbx5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Embryo	rep_2	8.0e-13
Cbx5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Embryo	rep_3	1.5e-267
Cbx5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Embryo	rep_3	0.0e+00
Cbx5	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Kidney	Nep	1.6e-16
Cbx5	GOBP_Response_To_Wounding	Mouse	Kidney	Nep	1.6e-16
Cbx5	GOBP_Wound_Healing	Mouse	Kidney	Nep	1.6e-16
Cbx5	GOBP_Cell_Cycle	Mouse	Kidney	rep_2	1.0e-24
Cbx5	GOBP_Cell_Cycle_Process	Mouse	Kidney	rep_2	3.0e-21
Cbx5	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Kidney	rep_2	5.5e-146
Cbx5	GOBP_G0_To_G1_Transition	Mouse	Kidney	rep_2	1.3e-08
Cbx5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Kidney	rep_2	7.3e-42
Cbx5	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Kidney	rep_2	2.8e-71
Cbx5	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Mouse	Kidney	rep_2	6.0e-76
Cbx5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Kidney	rep_2	7.7e-30
Cbx5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Kidney	rep_2	2.2e-14
Cbx5	GOBP_Response_To_Wounding	Mouse	Kidney	rep_2	2.1e-60
Cbx5	GOBP_Wound_Healing	Mouse	Kidney	rep_2	6.5e-45
Cbx5	GOBP_Response_To_Wounding	Mouse	Liver	CN73-C1	1.1e-07
Cbx5	GOBP_Wound_Healing	Mouse	Liver	CN73-C1	1.1e-08
Cbx5	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Mouse	Liver	rep_16	3.1e-15
Cbx5	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Liver	rep_16	6.1e-20
Cbx5	GOBP_Response_To_Wounding	Mouse	Liver	rep_16	1.3e-13
Cbx5	GOBP_Wound_Healing	Mouse	Liver	rep_16	3.5e-11
Cbx5	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Lymph	MS-1	4.6e-18
Cbx5	GOBP_Cell_Cycle	Mouse	Lymph	MS-1	1.3e-07
Cbx5	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Lymph	MS-1	8.5e-13
Cbx5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lymph	MS-1	6.1e-11
Cbx5	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Lymph	MS-1	9.2e-07
Cbx5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lymph	MS-1	1.8e-10
Cbx5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Lymph	MS-1	2.2e-09
Cbx5	GOBP_Regulation_Of_Cell_Cycle	Mouse	Lymph	MS-1	6.4e-09
Cbx5	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Lymph	MS-1	4.1e-08
Cbx5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Lung	rep_1	7.5e-20
Cbx5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Lung	rep_1	5.8e-10
Cbx5	GOBP_G0_To_G1_Transition	Mouse	Brain	rep_4	2.7e-09
Cbx5	GOBP_Cell_Cycle	Mouse	Brain	HP_ad_rep7	6.6e-08
Cbx5	GOBP_Cell_Cycle_Process	Mouse	Brain	HP_ad_rep7	1.7e-09
Cbx5	GOBP_Cellular_Response_To_Dna_Damage_Stimulus	Mouse	Brain	HP_ad_rep7	6.8e-10
Cbx5	GOBP_Negative_Regulation_Of_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	3.3e-12
Cbx5	GOBP_Negative_Regulation_Of_Cell_Cycle	Mouse	Brain	HP_ad_rep7	9.2e-08
Cbx5	GOBP_Negative_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	HP_ad_rep7	5.3e-15
Cbx5	GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.9e-11
Cbx5	GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii	Mouse	Brain	HP_ad_rep7	7.1e-13
Cbx5	GOBP_Regulation_Of_Cell_Cycle	Mouse	Brain	HP_ad_rep7	1.6e-08
Cbx5	GOBP_Regulation_Of_Cell_Cycle_Process	Mouse	Brain	HP_ad_rep7	9.9e-08
Cbx5	GOBP_Response_To_Wounding	Mouse	Brain	HP_ad_rep7	4.3e-07
Cbx5	GOBP_G0_To_G1_Transition	Mouse	Brain	HP_adpolb_rep5	2.3e-13
Cbx5	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Brain	HP_polb_rep9	1.1e-12
Cbx5	GOBP_Regulation_Of_Body_Fluid_Levels	Mouse	Brain	HP_polb_rep9	2.9e-10

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Cbx5 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Cbx5 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Cbx5 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Cbx5

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Cbx5

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Cbx5	C0009402	Colorectal Carcinoma	1	CTD_human
Cbx5	C0009404	Colorectal Neoplasms	1	CTD_human