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Spatial pattern gene: Cbx1 (spascer ID:12412) |
Gene summary for Cbx1 |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Cbx1 | Gene ID | 12412 |
| Gene name | chromobox 1 |
| Synonyms | Cbx|Cbx-rs2|E430007M08Rik|HP1B|Hp1beta|M31|MOD1 |
| Cytomap | 11 D|11 60.11 cM |
| Type of gene | protein-coding |
| Description | chromobox protein homolog 1chromobox homolog 1heterochromatin protein 1 homolog betaheterochromatin protein p25modifier 1 protein |
| Modification date | 20220424 |
| UniProtAcc | P83917 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Cbx1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21873635 | Process |
| Cbx1 | GO:0003682 | chromatin binding | 21873635 | Function |
| Cbx1 | GO:0005721 | pericentric heterochromatin | 21873635 | Component |
| Cbx1 | GO:0006325 | chromatin organization | 21873635 | Process |
| Cbx1 | GO:0035064 | methylated histone binding | 21873635 | Function |
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Spatial pattern events for Cbx1 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Cbx1 | Mouse | Brain | rep_2 | 35141374 | 7.76e-06 |
| Cbx1 | Mouse | Embryo | rep_3 | 33188776 | 8.55e-07 |
| Cbx1 | Mouse | Embryo | rep_4 | 33188776 | 4.95e-06 |
| Cbx1 | Mouse | Embryo | rep_12 | 33188776 | 1.60e-14 |
| Cbx1 | Mouse | Embryo | rep_13 | 33188776 | 4.49e-15 |
| Cbx1 | Mouse | Brain | rep_1 | 33469025 | 6.78e-06 |
| Cbx1 | Mouse | Intestine | rep_4 | 35149721 | 2.41e-07 |
| Cbx1 | Mouse | Testicle | rep_6 | 34731600 | 1.08e-15 |
| Cbx1 | Mouse | Brain | rep_3 | 35210624 | 2.45e-06 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_2_H&E  |  |
Brain_rep_1_H&E  |
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Spatial pattern pathway has Cbx1 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Cbx1 | GOBP_Cellular_Response_To_Dna_Damage_Stimulus | Mouse | Spinal cord | CN94_E1 | 8.0e-06 |
| Cbx1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Spinal cord | CN94_E1 | 1.6e-06 |
| Cbx1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Spinal cord | CN94_E1 | 6.2e-07 |
| Cbx1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | rep_27 | 7.2e-05 |
| Cbx1 | GOBP_Cellular_Response_To_Dna_Damage_Stimulus | Mouse | Brain | rep_3 | 5.0e-192 |
| Cbx1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | rep_3 | 1.4e-196 |
| Cbx1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | rep_3 | 9.4e-206 |
| Cbx1 | GOBP_Cellular_Response_To_Dna_Damage_Stimulus | Mouse | Embryo | rep_2 | 1.4e-08 |
| Cbx1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Embryo | rep_2 | 8.0e-13 |
| Cbx1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Embryo | rep_3 | 1.5e-267 |
| Cbx1 | GOBP_Cellular_Response_To_Dna_Damage_Stimulus | Mouse | Kidney | rep_2 | 5.5e-146 |
| Cbx1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Kidney | rep_2 | 7.3e-42 |
| Cbx1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Kidney | rep_2 | 7.7e-30 |
| Cbx1 | GOBP_Cellular_Response_To_Dna_Damage_Stimulus | Mouse | Lymph | MS-1 | 8.5e-13 |
| Cbx1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Lymph | MS-1 | 6.1e-11 |
| Cbx1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lymph | MS-1 | 1.8e-10 |
| Cbx1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Lung | rep_1 | 7.5e-20 |
| Cbx1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lung | rep_1 | 5.8e-10 |
| Cbx1 | GOBP_Cellular_Response_To_Dna_Damage_Stimulus | Mouse | Brain | HP_ad_rep7 | 6.8e-10 |
| Cbx1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | HP_ad_rep7 | 3.3e-12 |
| Cbx1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | HP_ad_rep7 | 5.9e-11 |
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Cbx1 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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Cbx1 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for Cbx1 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for Cbx1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for Cbx1 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| Cbx1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Cbx1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
