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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Serpina6 (spascer ID:12401)

Gene summary for Serpina6

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Serpina6
	Gene ID	12401
	Gene name	serine (or cysteine) peptidase inhibitor, clade A, member 6
	Synonyms	Cbg
	Cytomap	12 E\|12 52.98 cM
	Type of gene	protein-coding
	Description	corticosteroid-binding globulinserine (or cysteine) proteinase inhibitor, clade A, member 6serpin A6transcortin
	Modification date	20220426
	UniProtAcc	Q06770

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Serpina6	GO:0004867	serine-type endopeptidase inhibitor activity	21873635	Function
Serpina6	GO:0005615	extracellular space	21873635	Component
Serpina6	GO:0010951	negative regulation of endopeptidase activity	21873635	Process

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Spatial pattern events for Serpina6

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Serpina6	Mouse	Embryo	rep_4	33188776	5.08e-15
Serpina6	Mouse	Liver	rep_14	35021063	4.82e-14
Serpina6	Mouse	Liver	rep_15	35021063	2.79e-13
Serpina6	Mouse	Liver	rep_16	35021063	2.10e-11
Serpina6	Mouse	Liver	rep_17	35021063	1.84e-13
Serpina6	Mouse	Liver	rep_20	35021063	1.65e-14
Serpina6	Mouse	Liver	rep_21	35021063	8.03e-15
Serpina6	Mouse	Liver	rep_22	35021063	1.07e-14
Serpina6	Mouse	Liver	rep_23	35021063	1.59e-07

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_14_H&E
Liver_rep_15_H&E
Liver_rep_16_H&E
Liver_rep_17_H&E
Liver_rep_20_H&E
Liver_rep_21_H&E
Liver_rep_22_H&E
Liver_rep_23_H&E

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Spatial pattern pathway has Serpina6 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Serpina6	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Spinal cord	CN94_E1	2.4e-06
Serpina6	GOBP_Steroid_Metabolic_Process	Mouse	Spinal cord	CN94_E1	4.1e-06
Serpina6	GOBP_Lipid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	8.9e-07
Serpina6	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Serpina6	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Spinal cord	L7CN45_C1	3.2e-07
Serpina6	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Serpina6	GOBP_Negative_Regulation_Of_Peptidase_Activity	Mouse	Spinal cord	L7CN45_C1	2.8e-06
Serpina6	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.6e-07
Serpina6	GOBP_Proteolysis	Mouse	Spinal cord	L7CN45_C1	1.1e-06
Serpina6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Spinal cord	L7CN45_C1	2.3e-07
Serpina6	GOBP_Regulation_Of_Proteolysis	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Serpina6	GOBP_Negative_Regulation_Of_Proteolysis	Mouse	Spinal cord	L8CN11_D2	2.5e-11
Serpina6	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_27	8.1e-06
Serpina6	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Mouse	Brain	rep_27	1.2e-06
Serpina6	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Brain	rep_61	2.0e-05
Serpina6	GOBP_Glucocorticoid_Metabolic_Process	Mouse	Brain	rep_1	1.3e-173
Serpina6	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Brain	rep_1	1.0e-08
Serpina6	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Brain	rep_3	5.2e-181
Serpina6	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Brain	rep_3	3.5e-163
Serpina6	GOBP_Negative_Regulation_Of_Peptidase_Activity	Mouse	Brain	rep_3	2.0e-154
Serpina6	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Mouse	Brain	rep_3	5.5e-184
Serpina6	GOBP_Negative_Regulation_Of_Proteolysis	Mouse	Brain	rep_3	1.6e-155
Serpina6	GOBP_Proteolysis	Mouse	Brain	rep_3	1.8e-168
Serpina6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Brain	rep_3	1.4e-120
Serpina6	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Brain	rep_3	9.5e-157
Serpina6	GOBP_Regulation_Of_Proteolysis	Mouse	Brain	rep_3	6.6e-161
Serpina6	GOBP_Steroid_Metabolic_Process	Mouse	Brain	rep_3	3.0e-174
Serpina6	GOBP_Glucocorticoid_Metabolic_Process	Mouse	Embryo	rep_14	4.1e-52
Serpina6	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_14	4.4e-26
Serpina6	GOBP_Negative_Regulation_Of_Peptidase_Activity	Mouse	Embryo	rep_14	4.7e-19
Serpina6	GOBP_Negative_Regulation_Of_Proteolysis	Mouse	Embryo	rep_14	6.7e-38
Serpina6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_14	8.5e-07
Serpina6	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Embryo	rep_14	6.4e-29
Serpina6	GOBP_Regulation_Of_Proteolysis	Mouse	Embryo	rep_14	3.6e-20
Serpina6	GOBP_Steroid_Metabolic_Process	Mouse	Embryo	rep_14	1.1e-10
Serpina6	GOBP_Lipid_Metabolic_Process	Mouse	Embryo	rep_1	2.1e-39
Serpina6	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Embryo	rep_1	2.5e-32
Serpina6	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Embryo	rep_1	4.6e-17
Serpina6	GOBP_Negative_Regulation_Of_Peptidase_Activity	Mouse	Embryo	rep_1	4.6e-17
Serpina6	GOBP_Steroid_Metabolic_Process	Mouse	Embryo	rep_1	1.1e-16
Serpina6	GOBP_Negative_Regulation_Of_Proteolysis	Mouse	Embryo	rep_4	8.1e-31
Serpina6	GOBP_Glucocorticoid_Metabolic_Process	Mouse	Kidney	IRI	2.2e-07
Serpina6	GOBP_Lipid_Metabolic_Process	Mouse	Kidney	Nep	4.2e-26
Serpina6	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Kidney	Nep	8.3e-23
Serpina6	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Mouse	Kidney	Nep	4.6e-22
Serpina6	GOBP_Negative_Regulation_Of_Proteolysis	Mouse	Kidney	Nep	4.2e-26
Serpina6	GOBP_Proteolysis	Mouse	Kidney	Nep	6.8e-23
Serpina6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	Nep	1.3e-36
Serpina6	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Kidney	Nep	5.6e-37
Serpina6	GOBP_Regulation_Of_Proteolysis	Mouse	Kidney	Nep	4.3e-38
Serpina6	GOBP_Glucocorticoid_Metabolic_Process	Mouse	Kidney	rep_2	2.2e-125
Serpina6	GOBP_Lipid_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-78
Serpina6	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Kidney	rep_2	5.2e-90
Serpina6	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	rep_2	5.7e-63
Serpina6	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Kidney	rep_2	2.5e-99
Serpina6	GOBP_Negative_Regulation_Of_Peptidase_Activity	Mouse	Kidney	rep_2	3.5e-56
Serpina6	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Mouse	Kidney	rep_2	1.5e-72
Serpina6	GOBP_Negative_Regulation_Of_Proteolysis	Mouse	Kidney	rep_2	4.3e-45
Serpina6	GOBP_Proteolysis	Mouse	Kidney	rep_2	6.0e-106
Serpina6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Kidney	rep_2	1.4e-60
Serpina6	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Kidney	rep_2	5.7e-75
Serpina6	GOBP_Regulation_Of_Proteolysis	Mouse	Kidney	rep_2	4.3e-62
Serpina6	GOBP_Steroid_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-60
Serpina6	GOBP_Glucocorticoid_Metabolic_Process	Mouse	Liver	CN16-E1	6.8e-12
Serpina6	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Liver	CN73-C1	9.9e-07
Serpina6	GOBP_Steroid_Metabolic_Process	Mouse	Liver	CN73-C1	3.4e-09
Serpina6	GOBP_Steroid_Metabolic_Process	Mouse	Intestine	rep_2	1.5e-21
Serpina6	GOBP_Lipid_Metabolic_Process	Mouse	Lymph	MS-1	9.7e-11
Serpina6	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Lymph	MS-1	2.2e-13
Serpina6	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Lymph	MS-1	4.3e-09
Serpina6	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Lymph	MS-1	6.9e-11
Serpina6	GOBP_Negative_Regulation_Of_Peptidase_Activity	Mouse	Lymph	MS-1	8.0e-07
Serpina6	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Mouse	Lymph	MS-1	7.3e-11
Serpina6	GOBP_Negative_Regulation_Of_Proteolysis	Mouse	Lymph	MS-1	2.8e-11
Serpina6	GOBP_Proteolysis	Mouse	Lymph	MS-1	2.8e-10
Serpina6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Lymph	MS-1	1.9e-08
Serpina6	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Lymph	MS-1	4.0e-08
Serpina6	GOBP_Regulation_Of_Proteolysis	Mouse	Lymph	MS-1	7.3e-10
Serpina6	GOBP_Steroid_Metabolic_Process	Mouse	Lymph	MS-1	5.5e-08
Serpina6	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Lung	rep_1	6.3e-10
Serpina6	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Lung	rep_1	9.4e-15
Serpina6	GOBP_Glucocorticoid_Metabolic_Process	Mouse	Brain	HP_ad_rep7	7.4e-08
Serpina6	GOBP_Negative_Regulation_Of_Catalytic_Activity	Mouse	Brain	HP_ad_rep7	4.0e-09
Serpina6	GOBP_Negative_Regulation_Of_Molecular_Function	Mouse	Brain	HP_ad_rep7	3.4e-10
Serpina6	GOBP_Negative_Regulation_Of_Protein_Metabolic_Process	Mouse	Brain	HP_ad_rep7	1.1e-09
Serpina6	GOBP_Proteolysis	Mouse	Brain	HP_ad_rep7	3.3e-07
Serpina6	GOBP_Lipid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.9e-11
Serpina6	GOBP_Negative_Regulation_Of_Hydrolase_Activity	Mouse	Brain	HP_polb_rep9	7.1e-13
Serpina6	GOBP_Negative_Regulation_Of_Peptidase_Activity	Mouse	Brain	HP_polb_rep9	4.7e-12
Serpina6	GOBP_Negative_Regulation_Of_Proteolysis	Mouse	Brain	HP_polb_rep9	4.4e-09
Serpina6	GOBP_Regulation_Of_Hydrolase_Activity	Mouse	Brain	HP_polb_rep9	6.0e-09
Serpina6	GOBP_Regulation_Of_Peptidase_Activity	Mouse	Brain	HP_polb_rep9	5.2e-09
Serpina6	GOBP_Regulation_Of_Proteolysis	Mouse	Brain	HP_polb_rep9	1.5e-07
Serpina6	GOBP_Steroid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.8e-11

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Serpina6 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Serpina6 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Serpina6 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Serpina6

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Serpina6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Serpina6	C1852529	Corticosteroid-Binding Globulin Deficiency	5	CTD_human;ORPHANET;UNIPROT
Serpina6	C0011570	Mental Depression	1	PSYGENET
Serpina6	C0011581	Depressive disorder	1	PSYGENET
Serpina6	C0015695	Fatty Liver	1	CTD_human
Serpina6	C0019193	Hepatitis, Toxic	1	CTD_human
Serpina6	C0023890	Liver Cirrhosis	1	CTD_human
Serpina6	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Serpina6	C0239946	Fibrosis, Liver	1	CTD_human
Serpina6	C0860207	Drug-Induced Liver Disease	1	CTD_human
Serpina6	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Serpina6	C2711227	Steatohepatitis	1	CTD_human
Serpina6	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Serpina6	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Serpina6	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human