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Spatial pattern gene: Runx1t1 (spascer ID:12395) |
Gene summary for Runx1t1 |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Runx1t1 | Gene ID | 12395 |
| Gene name | RUNX1 translocation partner 1 |
| Synonyms | Cbfa2t1h|ETO|MTG8 |
| Cytomap | 4 A1|4 5.88 cM |
| Type of gene | protein-coding |
| Description | protein CBFA2T1CBFA2T1 identified gene homologacute myelogenous leukemia 1 translocation 1 proteinrunt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
| Modification date | 20220424 |
| UniProtAcc | Q61909 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Runx1t1 | GO:0003714 | transcription corepressor activity | 21873635 | Function |
| Runx1t1 | GO:0005634 | nucleus | 21873635 | Component |
| Runx1t1 | GO:0045892 | negative regulation of transcription, DNA-templated | 21873635 | Process |
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Spatial pattern events for Runx1t1 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Runx1t1 | Mouse | Brain | S1 | 34413515 | 1.04e-07 |
| Runx1t1 | Mouse | Brain | S2 | 34413515 | 7.73e-08 |
| Runx1t1 | Mouse | Brain | S4 | 34413515 | 2.86e-09 |
| Runx1t1 | Mouse | Brain | S6 | 34413515 | 1.33e-07 |
| Runx1t1 | Mouse | Brain | 22A | 32637622 | 5.38e-08 |
| Runx1t1 | Mouse | Brain | 39B | 32637622 | 1.09e-07 |
| Runx1t1 | Mouse | Brain | rep_3 | 35141374 | 1.15e-07 |
| Runx1t1 | Mouse | Brain | rep_4 | 35141374 | 4.30e-09 |
| Runx1t1 | Mouse | Brain | rep_5 | 35141374 | 3.76e-06 |
| Runx1t1 | Mouse | Embryo | 1D | 34210887 | 2.39e-07 |
| Runx1t1 | Mouse | Embryo | 1E | 34210887 | 2.41e-10 |
| Runx1t1 | Mouse | Embryo | 1F | 34210887 | 1.85e-12 |
| Runx1t1 | Mouse | Embryo | 1G | 34210887 | 6.15e-15 |
| Runx1t1 | Mouse | Embryo | 2G | 34210887 | 8.88e-11 |
| Runx1t1 | Mouse | Embryo | 2H | 34210887 | 3.49e-08 |
| Runx1t1 | Mouse | Embryo | 3D | 34210887 | 1.50e-14 |
| Runx1t1 | Mouse | Embryo | 3F | 34210887 | 5.82e-15 |
| Runx1t1 | Mouse | Embryo | 3G | 34210887 | 1.30e-10 |
| Runx1t1 | Mouse | Embryo | 4D | 34210887 | 7.75e-15 |
| Runx1t1 | Mouse | Embryo | 4E | 34210887 | 4.53e-15 |
| Runx1t1 | Mouse | Embryo | rep_1 | 33188776 | 1.79e-14 |
| Runx1t1 | Mouse | Embryo | rep_2 | 33188776 | 1.97e-14 |
| Runx1t1 | Mouse | Embryo | rep_3 | 33188776 | 8.14e-14 |
| Runx1t1 | Mouse | Embryo | rep_4 | 33188776 | 5.08e-15 |
| Runx1t1 | Mouse | Embryo | rep_5 | 33188776 | 1.40e-14 |
| Runx1t1 | Mouse | Embryo | rep_7 | 33188776 | 6.94e-15 |
| Runx1t1 | Mouse | Embryo | rep_12 | 33188776 | 4.84e-15 |
| Runx1t1 | Mouse | Embryo | rep_13 | 33188776 | 4.49e-15 |
| Runx1t1 | Mouse | Brain | rep_1 | 33469025 | 2.00e-12 |
| Runx1t1 | Mouse | Brain | rep_1 | 35027729 | 4.38e-12 |
| Runx1t1 | Mouse | Brain | rep_2 | 35027729 | 5.01e-14 |
| Runx1t1 | Mouse | Brain | rep_3 | 35027729 | 1.32e-15 |
| Runx1t1 | Mouse | Brain | rep_4 | 35027729 | 1.25e-07 |
| Runx1t1 | Mouse | Brain | rep_5 | 35027729 | 1.37e-08 |
| Runx1t1 | Mouse | Brain | rep_4 | 35210624 | 4.16e-15 |
| Runx1t1 | Mouse | Brain | rep_5 | 35210624 | 1.82e-07 |
| Runx1t1 | Mouse | Brain | rep_6 | 35210624 | 3.65e-15 |
| Runx1t1 | Mouse | Brain | rep_7 | 35210624 | 3.31e-15 |
| Runx1t1 | Mouse | Brain | OFB_adpolb_rep2 | 33083725 | 1.77e-02 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Brain_rep_1_H&E  | |
Brain_rep_1_H&E  |  |
Brain_rep_2_H&E  |  |
Brain_rep_3_H&E  |  |
Brain_rep_4_H&E  |  |
Brain_rep_5_H&E  |  |
Brain_OFB_adpolb_rep2_H&E  |
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Spatial pattern pathway has Runx1t1 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Runx1t1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Spinal cord | CN94_E1 | 1.6e-06 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Spinal cord | CN94_E1 | 6.2e-07 |
| Runx1t1 | GOBP_Fat_Cell_Differentiation | Mouse | Spinal cord | L7CN45_C1 | 1.7e-08 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Cell_Differentiation | Mouse | Spinal cord | L7CN45_C1 | 4.5e-10 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Developmental_Process | Mouse | Spinal cord | L7CN45_C1 | 1.9e-10 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Fat_Cell_Differentiation | Mouse | Spinal cord | L7CN45_C1 | 1.1e-06 |
| Runx1t1 | GOBP_Regulation_Of_Cell_Differentiation | Mouse | Spinal cord | L7CN45_C1 | 8.5e-07 |
| Runx1t1 | GOBP_Regulation_Of_Fat_Cell_Differentiation | Mouse | Spinal cord | L7CN45_C1 | 1.5e-06 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | rep_27 | 7.2e-05 |
| Runx1t1 | GOBP_Fat_Cell_Differentiation | Mouse | Brain | rep_72 | 1.4e-05 |
| Runx1t1 | GOBP_Regulation_Of_Cell_Differentiation | Mouse | Brain | rep_1 | 2.3e-15 |
| Runx1t1 | GOBP_Fat_Cell_Differentiation | Mouse | Brain | rep_3 | 1.6e-53 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | rep_3 | 1.4e-196 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Cell_Differentiation | Mouse | Brain | rep_3 | 6.9e-23 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Developmental_Process | Mouse | Brain | rep_3 | 3.9e-71 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | rep_3 | 9.4e-206 |
| Runx1t1 | GOBP_Regulation_Of_Fat_Cell_Differentiation | Mouse | Brain | rep_3 | 7.8e-70 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Fat_Cell_Differentiation | Mouse | Brain | rep_7 | 3.1e-43 |
| Runx1t1 | GOBP_Fat_Cell_Differentiation | Mouse | Embryo | rep_14 | 3.8e-14 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Fat_Cell_Differentiation | Mouse | Embryo | rep_14 | 3.3e-37 |
| Runx1t1 | GOBP_Regulation_Of_Fat_Cell_Differentiation | Mouse | Embryo | rep_14 | 1.6e-43 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Embryo | rep_2 | 8.0e-13 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Cell_Differentiation | Mouse | Embryo | rep_2 | 7.5e-38 |
| Runx1t1 | GOBP_Fat_Cell_Differentiation | Mouse | Embryo | rep_3 | 8.3e-243 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Embryo | rep_3 | 1.5e-267 |
| Runx1t1 | GOBP_Regulation_Of_Cell_Differentiation | Mouse | Embryo | rep_3 | 6.3e-72 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Fat_Cell_Differentiation | Mouse | Embryo | rep_5 | 3.3e-21 |
| Runx1t1 | GOBP_Fat_Cell_Differentiation | Mouse | Kidney | Sham | 5.0e-12 |
| Runx1t1 | GOBP_Fat_Cell_Differentiation | Mouse | Kidney | rep_2 | 1.7e-47 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Kidney | rep_2 | 7.3e-42 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Cell_Differentiation | Mouse | Kidney | rep_2 | 1.0e-68 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Developmental_Process | Mouse | Kidney | rep_2 | 4.6e-113 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Fat_Cell_Differentiation | Mouse | Kidney | rep_2 | 1.8e-56 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Kidney | rep_2 | 7.7e-30 |
| Runx1t1 | GOBP_Regulation_Of_Cell_Differentiation | Mouse | Kidney | rep_2 | 2.6e-14 |
| Runx1t1 | GOBP_Regulation_Of_Fat_Cell_Differentiation | Mouse | Kidney | rep_2 | 4.1e-29 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Fat_Cell_Differentiation | Mouse | Liver | CN16-D2 | 1.3e-09 |
| Runx1t1 | GOBP_Regulation_Of_Cell_Differentiation | Mouse | Liver | rep_16 | 3.6e-08 |
| Runx1t1 | GOBP_Regulation_Of_Fat_Cell_Differentiation | Mouse | Liver | rep_16 | 1.5e-07 |
| Runx1t1 | GOBP_Fat_Cell_Differentiation | Mouse | Lymph | MS-1 | 4.2e-09 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Lymph | MS-1 | 6.1e-11 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Cell_Differentiation | Mouse | Lymph | MS-1 | 2.2e-14 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Developmental_Process | Mouse | Lymph | MS-1 | 4.0e-14 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lymph | MS-1 | 1.8e-10 |
| Runx1t1 | GOBP_Regulation_Of_Cell_Differentiation | Mouse | Lymph | MS-1 | 1.3e-14 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Lung | rep_1 | 7.5e-20 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lung | rep_1 | 5.8e-10 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | HP_ad_rep7 | 3.3e-12 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Developmental_Process | Mouse | Brain | HP_ad_rep7 | 1.7e-11 |
| Runx1t1 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | HP_ad_rep7 | 5.9e-11 |
| Runx1t1 | GOBP_Fat_Cell_Differentiation | Mouse | Brain | HP_polb_rep9 | 1.1e-11 |
| Runx1t1 | GOBP_Regulation_Of_Cell_Differentiation | Mouse | Brain | HP_polb_rep9 | 6.5e-09 |
| Runx1t1 | GOBP_Regulation_Of_Fat_Cell_Differentiation | Mouse | Brain | HP_polb_rep9 | 8.1e-09 |
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Runx1t1 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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Runx1t1 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication |
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Transcription factor for Runx1t1 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Motif information. |
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Related Drugs for Runx1t1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for Runx1t1 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| Runx1t1 | C0023467 | Leukemia, Myelocytic, Acute | 2 | CTD_human |
| Runx1t1 | C0026998 | Acute Myeloid Leukemia, M1 | 2 | CTD_human |
| Runx1t1 | C1879321 | Acute Myeloid Leukemia (AML-M2) | 2 | CTD_human |
| Runx1t1 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
