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Spatial pattern gene: Nr1i3 (spascer ID:12355) |
Gene summary for Nr1i3 |
 Gene summary |
| Gene information | |
| Species | Mouse | Gene symbol | Nr1i3 | Gene ID | 12355 |
| Gene name | nuclear receptor subfamily 1, group I, member 3 |
| Synonyms | AA209988|AI551208|CAR|CAR-beta|Care2|ESTM32|MB67 |
| Cytomap | 1 H3|1 79.21 cM |
| Type of gene | protein-coding |
| Description | nuclear receptor subfamily 1 group I member 3constitutive androstane receptorconstitutively transactivates RAREsorphan nuclear receptor MB67 |
| Modification date | 20220510 |
| UniProtAcc | O35627 |
| Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA). |
| Gene | GO ID | GO term | PubMed ID | Category |
| Nr1i3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21873635 | Process |
| Nr1i3 | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 21873635 | Function |
| Nr1i3 | GO:0004879 | nuclear receptor activity | 21873635 | Function |
| Nr1i3 | GO:0030154 | cell differentiation | 21873635 | Process |
| Nr1i3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 21873635 | Process |
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Spatial pattern events for Nr1i3 |
| spatial pattern gene list. |
| Gene symbol | Species | Tissue | Replication | PMID | Adj p-value |
| Nr1i3 | Mouse | Liver | rep_14 | 35021063 | 4.82e-14 |
| Nr1i3 | Mouse | Liver | rep_15 | 35021063 | 7.21e-14 |
| Nr1i3 | Mouse | Liver | rep_16 | 35021063 | 6.45e-14 |
| Nr1i3 | Mouse | Liver | rep_17 | 35021063 | 2.18e-14 |
| Nr1i3 | Mouse | Liver | rep_19 | 35021063 | 1.33e-09 |
| Nr1i3 | Mouse | Liver | rep_20 | 35021063 | 1.65e-14 |
| Nr1i3 | Mouse | Liver | rep_21 | 35021063 | 1.40e-14 |
| Nr1i3 | Mouse | Liver | rep_22 | 35021063 | 1.07e-14 |
| Nr1i3 | Mouse | Liver | rep_23 | 35021063 | 2.29e-14 |
| spatial pattern gene map.(click to enlarge the image in a new window) |
| H&E staining (if available) | Singel gene map |
Liver_rep_14_H&E  |
Liver_rep_15_H&E  |
Liver_rep_16_H&E  |
Liver_rep_17_H&E  |
Liver_rep_19_H&E  |
Liver_rep_20_H&E  |
Liver_rep_21_H&E  |
Liver_rep_22_H&E  |
Liver_rep_23_H&E  |
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Spatial pattern pathway has Nr1i3 envolved |
| Symbol | Pathway | Species | Tissue type | Replication | P-value |
| Nr1i3 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Spinal cord | CN94_E1 | 1.6e-06 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Spinal cord | CN94_E1 | 6.2e-07 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Spinal cord | CN94_E1 | 2.2e-06 |
| Nr1i3 | GOBP_Dna_Templated_Transcription_Initiation | Mouse | Spinal cord | L7CN45_C1 | 1.5e-08 |
| Nr1i3 | GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Spinal cord | L7CN45_C1 | 1.4e-06 |
| Nr1i3 | GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter | Mouse | Spinal cord | L7CN45_C1 | 1.3e-08 |
| Nr1i3 | GOBP_Intracellular_Receptor_Signaling_Pathway | Mouse | Spinal cord | L7CN47_C1 | 3.1e-07 |
| Nr1i3 | GOBP_Dna_Templated_Transcription_Initiation | Mouse | Brain | rep_27 | 1.0e-06 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | rep_27 | 7.2e-05 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Brain | rep_27 | 2.8e-05 |
| Nr1i3 | GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter | Mouse | Brain | rep_27 | 1.7e-05 |
| Nr1i3 | GOBP_Dna_Templated_Transcription_Initiation | Mouse | Brain | rep_1 | 2.3e-11 |
| Nr1i3 | GOBP_Intracellular_Receptor_Signaling_Pathway | Mouse | Brain | rep_1 | 6.5e-10 |
| Nr1i3 | GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | rep_1 | 2.5e-12 |
| Nr1i3 | GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Brain | rep_1 | 1.6e-17 |
| Nr1i3 | GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter | Mouse | Brain | rep_1 | 4.4e-10 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | rep_3 | 1.4e-196 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | rep_3 | 9.4e-206 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Brain | rep_3 | 7.5e-168 |
| Nr1i3 | GOBP_Dna_Templated_Transcription_Initiation | Mouse | Embryo | rep_14 | 3.3e-18 |
| Nr1i3 | GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter | Mouse | Embryo | rep_14 | 1.9e-16 |
| Nr1i3 | GOBP_Intracellular_Receptor_Signaling_Pathway | Mouse | Embryo | rep_1 | 5.7e-69 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Embryo | rep_2 | 8.0e-13 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Embryo | rep_3 | 1.5e-267 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Embryo | rep_3 | 0.0e+00 |
| Nr1i3 | GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Embryo | rep_3 | 0.0e+00 |
| Nr1i3 | GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Embryo | rep_3 | 0.0e+00 |
| Nr1i3 | GOBP_Dna_Templated_Transcription_Initiation | Mouse | Kidney | rep_2 | 6.1e-40 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Kidney | rep_2 | 7.3e-42 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Kidney | rep_2 | 7.7e-30 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Kidney | rep_2 | 2.2e-14 |
| Nr1i3 | GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Kidney | rep_2 | 4.5e-10 |
| Nr1i3 | GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Kidney | rep_2 | 8.3e-40 |
| Nr1i3 | GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter | Mouse | Kidney | rep_2 | 2.1e-58 |
| Nr1i3 | GOBP_Intracellular_Receptor_Signaling_Pathway | Mouse | Liver | rep_16 | 1.6e-08 |
| Nr1i3 | GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter | Mouse | Liver | rep_16 | 2.6e-10 |
| Nr1i3 | GOBP_Dna_Templated_Transcription_Initiation | Mouse | Lymph | MS-1 | 3.5e-13 |
| Nr1i3 | GOBP_Intracellular_Receptor_Signaling_Pathway | Mouse | Lymph | MS-1 | 2.7e-11 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Lymph | MS-1 | 6.1e-11 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lymph | MS-1 | 1.8e-10 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Lymph | MS-1 | 2.2e-09 |
| Nr1i3 | GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lymph | MS-1 | 4.4e-12 |
| Nr1i3 | GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Lymph | MS-1 | 1.7e-12 |
| Nr1i3 | GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter | Mouse | Lymph | MS-1 | 2.9e-07 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Lung | rep_1 | 7.5e-20 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Lung | rep_1 | 5.8e-10 |
| Nr1i3 | GOBP_Dna_Templated_Transcription_Initiation | Mouse | Brain | rep_7 | 7.7e-09 |
| Nr1i3 | GOBP_Intracellular_Receptor_Signaling_Pathway | Mouse | Brain | HP_ad_rep7 | 2.5e-10 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Biosynthetic_Process | Mouse | Brain | HP_ad_rep7 | 3.3e-12 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | HP_ad_rep7 | 5.9e-11 |
| Nr1i3 | GOBP_Negative_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Brain | HP_ad_rep7 | 7.1e-13 |
| Nr1i3 | GOBP_Positive_Regulation_Of_Nucleobase_Containing_Compound_Metabolic_Process | Mouse | Brain | HP_ad_rep7 | 2.8e-11 |
| Nr1i3 | GOBP_Positive_Regulation_Of_Transcription_By_Rna_Polymerase_Ii | Mouse | Brain | HP_ad_rep7 | 7.3e-11 |
| Nr1i3 | GOBP_Transcription_Initiation_From_Rna_Polymerase_Ii_Promoter | Mouse | Brain | HP_ad_rep7 | 6.1e-11 |
| Nr1i3 | GOBP_Dna_Templated_Transcription_Initiation | Mouse | Brain | HP_polb_rep9 | 8.2e-07 |
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Nr1i3 function as liang/receptor in single cell data |
| Tissue | Source | SourceCell | Target | TargetCell | PMID | Group |
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Nr1i3 function as liang/receptor across spatial transcriptomics tissue |
| Interactions using deconvoluted spatial data. |
| Ligand | Receptor | LR pair | Tissue | Replication | ||
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Transcription factor for Nr1i3 envolved |
| Transcription factor analysis using single cell data. |
| TF | Tissue | Group | Cell types | Target genes | Rss score |
| Nr1i3 | Liver | WD_36week | Hepatocyte | Fitm1,Adh4,Car5a, etc. | 0.343 |
| Nr1i3 | Liver | WD_36week | Endothelial | Fitm1,Adh4,Car5a, etc. | 0.301 |
| Nr1i3 | Liver | WD_36week | KC | Fitm1,Adh4,Car5a, etc. | 0.281 |
| Nr1i3 | Liver | WD_36week | Monocyte | Fitm1,Adh4,Car5a, etc. | 0.376 |
| Nr1i3 | Liver | WD_36week | T cells | Fitm1,Adh4,Car5a, etc. | 0.252 |
| Nr1i3 | Liver | SD_36week | Endothelial | Slc1a2,Abcc2,Mlxipl, etc. | 0.421 |
| Nr1i3 | Liver | SD_36week | Hepatocyte | Slc1a2,Abcc2,Mlxipl, etc. | 0.393 |
| Nr1i3 | Liver | SD_36week | KC | Slc1a2,Abcc2,Mlxipl, etc. | 0.279 |
| Nr1i3 | Liver | SD_24week | KC | Cyp2c50,Cyp2e1,Pxmp4, etc. | 0.314 |
| Nr1i3 | Liver | SD_24week | Monocyte | Cyp2c50,Cyp2e1,Pxmp4, etc. | 0.262 |
| Nr1i3 | Liver | SD_24week | Unknown | Cyp2c50,Cyp2e1,Pxmp4, etc. | 0.279 |
| Nr1i3 | Liver | SD_24week | Endothelial | Cyp2c50,Cyp2e1,Pxmp4, etc. | 0.272 |
| Nr1i3 | Liver | SD_24week | Hepatocyte | Cyp2c50,Cyp2e1,Pxmp4, etc. | 0.369 |
| Nr1i3 | Liver | SD_12week | Monocyte | Klf15,Mlxipl,1700001C19Rik, etc. | 0.338 |
| Nr1i3 | Liver | SD_12week | pDCs | Klf15,Mlxipl,1700001C19Rik, etc. | 0.252 |
| Nr1i3 | Liver | SD_12week | Endothelial | Klf15,Mlxipl,1700001C19Rik, etc. | 0.353 |
| Nr1i3 | Liver | SD_12week | KC | Klf15,Mlxipl,1700001C19Rik, etc. | 0.353 |
| Nr1i3 | Liver | SD_12week | Hepatocyte | Klf15,Mlxipl,1700001C19Rik, etc. | 0.259 |
| Motif information. |
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Related Drugs for Nr1i3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.9 2022-01-04) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for Nr1i3 |
| Diseases associated with this gene. (DisGeNet 7.0) |
| Gene | Disease ID | Disease name | Pubmeds | Source |
| Nr1i3 | C0023903 | Liver neoplasms | 5 | CTD_human |
| Nr1i3 | C0345904 | Malignant neoplasm of liver | 5 | CTD_human |
| Nr1i3 | C0019193 | Hepatitis, Toxic | 3 | CTD_human |
| Nr1i3 | C0019207 | Hepatoma, Morris | 3 | CTD_human |
| Nr1i3 | C0019208 | Hepatoma, Novikoff | 3 | CTD_human |
| Nr1i3 | C0019209 | Hepatomegaly | 3 | CTD_human |
| Nr1i3 | C0023904 | Liver Neoplasms, Experimental | 3 | CTD_human |
| Nr1i3 | C0086404 | Experimental Hepatoma | 3 | CTD_human |
| Nr1i3 | C0860207 | Drug-Induced Liver Disease | 3 | CTD_human |
| Nr1i3 | C1262760 | Hepatitis, Drug-Induced | 3 | CTD_human |
| Nr1i3 | C3658290 | Drug-Induced Acute Liver Injury | 3 | CTD_human |
| Nr1i3 | C4277682 | Chemical and Drug Induced Liver Injury | 3 | CTD_human |
| Nr1i3 | C4279912 | Chemically-Induced Liver Toxicity | 3 | CTD_human |
| Nr1i3 | C0032927 | Precancerous Conditions | 2 | CTD_human |
| Nr1i3 | C0282313 | Condition, Preneoplastic | 2 | CTD_human |
| Nr1i3 | C0011849 | Diabetes Mellitus | 1 | CTD_human |
| Nr1i3 | C0028754 | Obesity | 1 | CTD_human |
| Nr1i3 | C0206669 | Hepatocellular Adenoma | 1 | CTD_human |
| Nr1i3 | C0524620 | Metabolic Syndrome X | 1 | CTD_human |
