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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Cap1 (spascer ID:12331)

Gene summary for Cap1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Cap1
	Gene ID	12331
	Gene name	CAP, adenylate cyclase-associated protein 1 (yeast)
	Synonyms	-
	Cytomap	4\|4 D2.2
	Type of gene	protein-coding
	Description	adenylyl cyclase-associated protein 1adenylyl cyclase-associated CAP protein, yeast homolog 1
	Modification date	20220424
	UniProtAcc	P40124

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Cap1	GO:0000902	cell morphogenesis	21873635	Process
Cap1	GO:0003779	actin binding	21873635	Function
Cap1	GO:0005737	cytoplasm	21873635	Component
Cap1	GO:0008179	adenylate cyclase binding	21873635	Function
Cap1	GO:0019933	cAMP-mediated signaling	21873635	Process
Cap1	GO:0045761	regulation of adenylate cyclase activity	21873635	Process

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Spatial pattern events for Cap1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Cap1	Mouse	Brain	S1	34413515	3.73e-15
Cap1	Mouse	Brain	S2	34413515	1.56e-15
Cap1	Mouse	Brain	S3	34413515	1.64e-15
Cap1	Mouse	Brain	S4	34413515	1.37e-15
Cap1	Mouse	Brain	S6	34413515	1.46e-15
Cap1	Mouse	Brain	S7	34413515	1.55e-15
Cap1	Mouse	Brain	22A	32637622	1.39e-09
Cap1	Mouse	Brain	rep_1	35141374	2.02e-15
Cap1	Mouse	Brain	rep_2	35141374	1.69e-15
Cap1	Mouse	Brain	rep_3	35141374	1.64e-15
Cap1	Mouse	Brain	rep_4	35141374	1.57e-15
Cap1	Mouse	Brain	rep_5	35141374	5.13e-15
Cap1	Mouse	Brain	rep_6	35141374	1.73e-15
Cap1	Mouse	Kidney	CLP	34003797	3.77e-15
Cap1	Mouse	Kidney	IRI	34003797	2.29e-15
Cap1	Mouse	Kidney	Sham	34003797	2.58e-15
Cap1	Mouse	Brain	rep_1	33469025	1.30e-15
Cap1	Mouse	Liver	rep_20	35021063	1.65e-14
Cap1	Mouse	Brain	rep_1	35027729	1.66e-15
Cap1	Mouse	Brain	rep_2	35027729	1.57e-15
Cap1	Mouse	Brain	rep_3	35027729	1.32e-15
Cap1	Mouse	Brain	rep_4	35027729	1.76e-15
Cap1	Mouse	Brain	rep_5	35027729	1.46e-15
Cap1	Mouse	Intestine	rep_1	35149721	5.26e-09
Cap1	Mouse	Intestine	rep_2	35149721	3.44e-15
Cap1	Mouse	Intestine	rep_3	35149721	3.25e-15
Cap1	Mouse	Intestine	rep_4	35149721	3.21e-10
Cap1	Mouse	Brain	N03_C2	32702314	5.13e-10
Cap1	Mouse	Brain	N03_D2	32702314	1.08e-12
Cap1	Mouse	Lung	rep_2	35290801	3.27e-11
Cap1	Mouse	Lung	rep_3	35290801	9.17e-08
Cap1	Mouse	Brain	rep_1	35210624	1.74e-15
Cap1	Mouse	Brain	rep_2	35210624	1.74e-15
Cap1	Mouse	Brain	rep_3	35210624	1.82e-15
Cap1	Mouse	Brain	rep_4	35210624	2.79e-09
Cap1	Mouse	Brain	rep_5	35210624	3.62e-15
Cap1	Mouse	Brain	rep_6	35210624	3.65e-15
Cap1	Mouse	Brain	rep_7	35210624	1.87e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Brain_rep_1_H&E
Liver_rep_20_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_N03_C2_H&E
Brain_N03_D2_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E

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Spatial pattern pathway has Cap1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Cap1	GOBP_Endocytosis	Mouse	Spinal cord	CN94_E1	8.2e-06
Cap1	GOBP_Regulation_Of_Lyase_Activity	Mouse	Spinal cord	CN94_E1	3.2e-06
Cap1	GOBP_Cytoskeleton_Organization	Mouse	Spinal cord	L7bCN02_E1	8.3e-06
Cap1	GOBP_Regulation_Of_Cyclase_Activity	Mouse	Spinal cord	L7bCN02_E1	6.0e-07
Cap1	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Spinal cord	L7bCN02_E1	7.8e-06
Cap1	GOBP_Camp_Mediated_Signaling	Mouse	Spinal cord	L7CN45_C1	1.1e-07
Cap1	GOBP_Cell_Activation	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Cap1	GOBP_Cell_Activation_Involved_In_Immune_Response	Mouse	Spinal cord	L7CN45_C1	9.9e-07
Cap1	GOBP_Cell_Morphogenesis	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Cap1	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Spinal cord	L7CN45_C1	3.7e-06
Cap1	GOBP_Establishment_Or_Maintenance_Of_Cell_Polarity	Mouse	Spinal cord	L7CN45_C1	4.7e-06
Cap1	GOBP_Immune_Effector_Process	Mouse	Spinal cord	L7CN45_C1	3.1e-07
Cap1	GOBP_Leukocyte_Mediated_Immunity	Mouse	Spinal cord	L7CN45_C1	2.4e-06
Cap1	GOBP_Myeloid_Leukocyte_Activation	Mouse	Spinal cord	L7CN45_C1	2.2e-07
Cap1	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Mouse	Spinal cord	L7CN45_C1	6.7e-06
Cap1	GOBP_Receptor_Mediated_Endocytosis	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Cap1	GOBP_Secretion	Mouse	Spinal cord	L7CN45_C1	8.1e-09
Cap1	GOBP_Actin_Filament_Based_Process	Mouse	Spinal cord	L7CN47_C1	3.4e-06
Cap1	GOBP_Exocytosis	Mouse	Spinal cord	L7CN47_C1	7.4e-07
Cap1	GOBP_Regulation_Of_Adenylate_Cyclase_Activity	Mouse	Spinal cord	L7CN60_D1	2.9e-07
Cap1	GOBP_Cell_Migration	Mouse	Spinal cord	L8CN11_D1	8.5e-06
Cap1	GOBP_Locomotion	Mouse	Spinal cord	L8CN11_D1	8.5e-06
Cap1	GOBP_Ameboidal_Type_Cell_Migration	Mouse	Spinal cord	L8CN17_E1	8.8e-06
Cap1	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Mouse	Brain	rep_27	3.0e-05
Cap1	GOBP_Secretion	Mouse	Brain	rep_27	8.9e-05
Cap1	GOBP_Camp_Mediated_Signaling	Mouse	Brain	rep_42	5.1e-05
Cap1	GOBP_Cell_Activation	Mouse	Brain	rep_72	4.6e-06
Cap1	GOBP_Actin_Filament_Based_Process	Mouse	Brain	rep_1	2.1e-24
Cap1	GOBP_Activation_Of_Adenylate_Cyclase_Activity	Mouse	Brain	rep_1	1.3e-39
Cap1	GOBP_Camp_Mediated_Signaling	Mouse	Brain	rep_1	1.1e-31
Cap1	GOBP_Cell_Activation	Mouse	Brain	rep_1	1.8e-07
Cap1	GOBP_Cell_Activation_Involved_In_Immune_Response	Mouse	Brain	rep_1	2.6e-13
Cap1	GOBP_Cell_Morphogenesis	Mouse	Brain	rep_1	7.6e-08
Cap1	GOBP_Cytoskeleton_Organization	Mouse	Brain	rep_1	1.1e-11
Cap1	GOBP_Exocytosis	Mouse	Brain	rep_1	3.4e-73
Cap1	GOBP_Immune_Effector_Process	Mouse	Brain	rep_1	1.5e-12
Cap1	GOBP_Myeloid_Leukocyte_Activation	Mouse	Brain	rep_1	2.1e-07
Cap1	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Mouse	Brain	rep_1	1.3e-13
Cap1	GOBP_Regulation_Of_Cyclase_Activity	Mouse	Brain	rep_1	1.2e-36
Cap1	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Brain	rep_1	5.1e-20
Cap1	GOBP_Secretion	Mouse	Brain	rep_1	4.1e-45
Cap1	GOBP_Ameboidal_Type_Cell_Migration	Mouse	Brain	rep_3	1.6e-67
Cap1	GOBP_Cell_Migration	Mouse	Brain	rep_3	4.9e-108
Cap1	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Brain	rep_3	2.3e-101
Cap1	GOBP_Endocytosis	Mouse	Brain	rep_3	2.6e-20
Cap1	GOBP_Establishment_Or_Maintenance_Of_Cell_Polarity	Mouse	Brain	rep_3	6.8e-85
Cap1	GOBP_Locomotion	Mouse	Brain	rep_3	5.4e-74
Cap1	GOBP_Receptor_Mediated_Endocytosis	Mouse	Brain	rep_3	3.1e-52
Cap1	GOBP_Leukocyte_Mediated_Immunity	Mouse	Brain	rep_4	3.3e-32
Cap1	GOBP_Cell_Activation_Involved_In_Immune_Response	Mouse	Embryo	rep_6	1.4e-16
Cap1	GOBP_Activation_Of_Adenylate_Cyclase_Activity	Mouse	Embryo	rep_14	6.8e-30
Cap1	GOBP_Camp_Mediated_Signaling	Mouse	Embryo	rep_14	1.0e-48
Cap1	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Embryo	rep_14	1.3e-22
Cap1	GOBP_Immune_Effector_Process	Mouse	Embryo	rep_14	3.3e-15
Cap1	GOBP_Leukocyte_Mediated_Immunity	Mouse	Embryo	rep_14	3.8e-12
Cap1	GOBP_Myeloid_Leukocyte_Activation	Mouse	Embryo	rep_14	2.9e-28
Cap1	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Mouse	Embryo	rep_14	1.7e-32
Cap1	GOBP_Ameboidal_Type_Cell_Migration	Mouse	Embryo	rep_1	9.7e-13
Cap1	GOBP_Cell_Migration	Mouse	Embryo	rep_1	7.4e-36
Cap1	GOBP_Locomotion	Mouse	Embryo	rep_1	1.7e-10
Cap1	GOBP_Cell_Activation_Involved_In_Immune_Response	Mouse	Embryo	rep_2	3.4e-34
Cap1	GOBP_Immune_Effector_Process	Mouse	Embryo	rep_2	1.7e-23
Cap1	GOBP_Receptor_Mediated_Endocytosis	Mouse	Embryo	rep_2	1.2e-141
Cap1	GOBP_Cell_Morphogenesis	Mouse	Embryo	rep_5	2.2e-13
Cap1	GOBP_Cell_Migration	Mouse	Kidney	Nep	5.3e-07
Cap1	GOBP_Cell_Morphogenesis	Mouse	Kidney	Nep	1.1e-16
Cap1	GOBP_Endocytosis	Mouse	Kidney	Nep	8.3e-23
Cap1	GOBP_Locomotion	Mouse	Kidney	Nep	5.3e-07
Cap1	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Mouse	Kidney	Nep	4.2e-26
Cap1	GOBP_Actin_Filament_Based_Process	Mouse	Kidney	rep_2	2.6e-107
Cap1	GOBP_Activation_Of_Adenylate_Cyclase_Activity	Mouse	Kidney	rep_2	3.2e-18
Cap1	GOBP_Ameboidal_Type_Cell_Migration	Mouse	Kidney	rep_2	5.5e-78
Cap1	GOBP_Cell_Activation	Mouse	Kidney	rep_2	5.1e-83
Cap1	GOBP_Cell_Activation_Involved_In_Immune_Response	Mouse	Kidney	rep_2	4.3e-101
Cap1	GOBP_Cell_Migration	Mouse	Kidney	rep_2	4.7e-40
Cap1	GOBP_Cell_Morphogenesis	Mouse	Kidney	rep_2	1.7e-84
Cap1	GOBP_Cytoskeleton_Organization	Mouse	Kidney	rep_2	1.5e-44
Cap1	GOBP_Endocytosis	Mouse	Kidney	rep_2	1.4e-132
Cap1	GOBP_Exocytosis	Mouse	Kidney	rep_2	3.2e-107
Cap1	GOBP_Immune_Effector_Process	Mouse	Kidney	rep_2	3.4e-107
Cap1	GOBP_Leukocyte_Mediated_Immunity	Mouse	Kidney	rep_2	2.7e-133
Cap1	GOBP_Locomotion	Mouse	Kidney	rep_2	2.1e-43
Cap1	GOBP_Myeloid_Leukocyte_Activation	Mouse	Kidney	rep_2	2.2e-110
Cap1	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Mouse	Kidney	rep_2	6.6e-105
Cap1	GOBP_Receptor_Mediated_Endocytosis	Mouse	Kidney	rep_2	4.7e-166
Cap1	GOBP_Regulation_Of_Adenylate_Cyclase_Activity	Mouse	Kidney	rep_2	1.3e-16
Cap1	GOBP_Regulation_Of_Cyclase_Activity	Mouse	Kidney	rep_2	3.0e-09
Cap1	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Kidney	rep_2	2.7e-12
Cap1	GOBP_Secretion	Mouse	Kidney	rep_2	1.6e-23
Cap1	GOBP_Regulation_Of_Lyase_Activity	Mouse	Liver	CN16-D1	3.1e-07
Cap1	GOBP_Establishment_Or_Maintenance_Of_Cell_Polarity	Mouse	Liver	CN16-D2	3.2e-07
Cap1	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Liver	CN16-E1	4.0e-10
Cap1	GOBP_Activation_Of_Adenylate_Cyclase_Activity	Mouse	Liver	rep_15	6.0e-28
Cap1	GOBP_Myeloid_Leukocyte_Activation	Mouse	Liver	rep_15	2.4e-09
Cap1	GOBP_Regulation_Of_Adenylate_Cyclase_Activity	Mouse	Liver	rep_15	1.1e-14
Cap1	GOBP_Cell_Activation_Involved_In_Immune_Response	Mouse	Liver	rep_16	1.6e-18
Cap1	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Liver	rep_16	4.7e-11
Cap1	GOBP_Exocytosis	Mouse	Liver	rep_16	8.5e-07
Cap1	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Mouse	Liver	rep_16	2.2e-20
Cap1	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Liver	rep_16	5.2e-08
Cap1	GOBP_Cell_Migration	Mouse	Liver	rep_26	1.6e-10
Cap1	GOBP_Locomotion	Mouse	Liver	rep_26	1.6e-10
Cap1	GOBP_Actin_Filament_Based_Process	Mouse	Lymph	MS-1	1.4e-10
Cap1	GOBP_Activation_Of_Adenylate_Cyclase_Activity	Mouse	Lymph	MS-1	2.0e-07
Cap1	GOBP_Ameboidal_Type_Cell_Migration	Mouse	Lymph	MS-1	4.7e-14
Cap1	GOBP_Camp_Mediated_Signaling	Mouse	Lymph	MS-1	3.2e-10
Cap1	GOBP_Cell_Activation	Mouse	Lymph	MS-1	1.6e-18
Cap1	GOBP_Cell_Activation_Involved_In_Immune_Response	Mouse	Lymph	MS-1	9.7e-16
Cap1	GOBP_Cell_Migration	Mouse	Lymph	MS-1	5.7e-13
Cap1	GOBP_Cell_Morphogenesis	Mouse	Lymph	MS-1	3.9e-13
Cap1	GOBP_Cytoskeleton_Organization	Mouse	Lymph	MS-1	1.8e-13
Cap1	GOBP_Endocytosis	Mouse	Lymph	MS-1	1.8e-21
Cap1	GOBP_Exocytosis	Mouse	Lymph	MS-1	1.4e-14
Cap1	GOBP_Immune_Effector_Process	Mouse	Lymph	MS-1	1.6e-18
Cap1	GOBP_Leukocyte_Mediated_Immunity	Mouse	Lymph	MS-1	5.6e-21
Cap1	GOBP_Locomotion	Mouse	Lymph	MS-1	1.2e-12
Cap1	GOBP_Myeloid_Leukocyte_Activation	Mouse	Lymph	MS-1	1.0e-18
Cap1	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Mouse	Lymph	MS-1	6.6e-07
Cap1	GOBP_Receptor_Mediated_Endocytosis	Mouse	Lymph	MS-1	2.1e-11
Cap1	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Lymph	MS-1	1.1e-10
Cap1	GOBP_Secretion	Mouse	Lymph	MS-1	2.3e-12
Cap1	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Lung	rep_1	1.7e-11
Cap1	GOBP_Activation_Of_Adenylate_Cyclase_Activity	Mouse	Brain	rep_4	2.1e-09
Cap1	GOBP_Camp_Mediated_Signaling	Mouse	Brain	rep_4	2.0e-24
Cap1	GOBP_Cell_Activation_Involved_In_Immune_Response	Mouse	Brain	rep_4	2.9e-33
Cap1	GOBP_Exocytosis	Mouse	Brain	rep_4	2.4e-43
Cap1	GOBP_Immune_Effector_Process	Mouse	Brain	rep_4	7.2e-15
Cap1	GOBP_Leukocyte_Mediated_Immunity	Mouse	Brain	rep_4	6.4e-19
Cap1	GOBP_Myeloid_Leukocyte_Activation	Mouse	Brain	rep_4	3.5e-20
Cap1	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Mouse	Brain	rep_4	3.7e-62
Cap1	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Brain	rep_4	9.1e-14
Cap1	GOBP_Ameboidal_Type_Cell_Migration	Mouse	Brain	HP_ad_rep7	1.1e-07
Cap1	GOBP_Camp_Mediated_Signaling	Mouse	Brain	HP_ad_rep7	2.2e-12
Cap1	GOBP_Cell_Migration	Mouse	Brain	HP_ad_rep7	2.2e-07
Cap1	GOBP_Cell_Morphogenesis	Mouse	Brain	HP_ad_rep7	8.4e-10
Cap1	GOBP_Cytoskeleton_Organization	Mouse	Brain	HP_ad_rep7	5.3e-08
Cap1	GOBP_Establishment_Or_Maintenance_Of_Cell_Polarity	Mouse	Brain	HP_ad_rep7	4.1e-10
Cap1	GOBP_Locomotion	Mouse	Brain	HP_ad_rep7	3.8e-07
Cap1	GOBP_Myeloid_Leukocyte_Mediated_Immunity	Mouse	Brain	HP_ad_rep7	4.4e-14
Cap1	GOBP_Receptor_Mediated_Endocytosis	Mouse	Brain	HP_ad_rep7	1.4e-08
Cap1	GOBP_Regulation_Of_Cyclase_Activity	Mouse	Brain	HP_ad_rep7	1.4e-07
Cap1	GOBP_Secretion	Mouse	Brain	HP_ad_rep7	1.6e-08
Cap1	GOBP_Activation_Of_Adenylate_Cyclase_Activity	Mouse	Brain	HP_polb_rep1	4.6e-08
Cap1	GOBP_Actin_Filament_Based_Process	Mouse	Brain	HP_polb_rep9	3.0e-07
Cap1	GOBP_Cell_Activation	Mouse	Brain	HP_polb_rep9	1.5e-08
Cap1	GOBP_Cell_Activation_Involved_In_Immune_Response	Mouse	Brain	HP_polb_rep9	8.8e-09
Cap1	GOBP_Cyclic_Nucleotide_Mediated_Signaling	Mouse	Brain	HP_polb_rep9	6.5e-09
Cap1	GOBP_Endocytosis	Mouse	Brain	HP_polb_rep9	3.2e-09
Cap1	GOBP_Exocytosis	Mouse	Brain	HP_polb_rep9	2.3e-13
Cap1	GOBP_Immune_Effector_Process	Mouse	Brain	HP_polb_rep9	1.0e-08
Cap1	GOBP_Leukocyte_Mediated_Immunity	Mouse	Brain	HP_polb_rep9	2.8e-07
Cap1	GOBP_Myeloid_Leukocyte_Activation	Mouse	Brain	HP_polb_rep9	2.6e-11
Cap1	GOBP_Regulation_Of_Adenylate_Cyclase_Activity	Mouse	Brain	HP_polb_rep9	8.5e-07
Cap1	GOBP_Regulation_Of_Lyase_Activity	Mouse	Brain	HP_polb_rep9	1.5e-08
Cap1	GOBP_Second_Messenger_Mediated_Signaling	Mouse	Brain	HP_wt_rep2	2.8e-08

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Cap1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Cap1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Cap1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Cap1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Cap1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Cap1	C0001787	Osteoporosis, Age-Related	1	CTD_human
Cap1	C0019193	Hepatitis, Toxic	1	CTD_human
Cap1	C0029456	Osteoporosis	1	CTD_human
Cap1	C0029459	Osteoporosis, Senile	1	CTD_human
Cap1	C0751406	Post-Traumatic Osteoporosis	1	CTD_human
Cap1	C0860207	Drug-Induced Liver Disease	1	CTD_human
Cap1	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Cap1	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Cap1	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Cap1	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human