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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Canx (spascer ID:12330)

Gene summary for Canx

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Canx
	Gene ID	12330
	Gene name	calnexin
	Synonyms	1110069N15Rik\|AI988026\|Cnx\|D11Ertd153e
	Cytomap	11 B1.3\|11 30.46 cM
	Type of gene	protein-coding
	Description	calnexin
	Modification date	20220424
	UniProtAcc	P35564

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Canx	GO:0005509	calcium ion binding	21873635	Function
Canx	GO:0005789	endoplasmic reticulum membrane	21873635	Component
Canx	GO:0006457	protein folding	21873635	Process
Canx	GO:0030433	ubiquitin-dependent ERAD pathway	21873635	Process

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Spatial pattern events for Canx

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Canx	Mouse	Brain	S1	34413515	9.27e-14
Canx	Mouse	Brain	S2	34413515	2.85e-15
Canx	Mouse	Brain	S3	34413515	1.64e-15
Canx	Mouse	Brain	S4	34413515	1.37e-15
Canx	Mouse	Brain	S6	34413515	1.46e-15
Canx	Mouse	Brain	S7	34413515	1.55e-15
Canx	Mouse	Brain	11A	32637622	2.98e-07
Canx	Mouse	Brain	17A	32637622	2.71e-09
Canx	Mouse	Brain	18A	32637622	1.30e-08
Canx	Mouse	Brain	19A	32637622	4.22e-12
Canx	Mouse	Brain	22A	32637622	1.50e-14
Canx	Mouse	Brain	27A	32637622	3.09e-09
Canx	Mouse	Brain	rep_1	35141374	2.02e-15
Canx	Mouse	Brain	rep_2	35141374	1.69e-15
Canx	Mouse	Brain	rep_3	35141374	1.64e-15
Canx	Mouse	Brain	rep_4	35141374	2.84e-15
Canx	Mouse	Brain	rep_5	35141374	1.47e-15
Canx	Mouse	Brain	rep_6	35141374	1.73e-15
Canx	Mouse	Embryo	1E	34210887	1.51e-06
Canx	Mouse	Embryo	rep_1	33188776	6.42e-06
Canx	Mouse	Embryo	rep_4	33188776	1.53e-14
Canx	Mouse	Embryo	rep_5	33188776	1.33e-13
Canx	Mouse	Embryo	rep_13	33188776	5.11e-07
Canx	Mouse	Kidney	IRI	34003797	2.29e-15
Canx	Mouse	Kidney	Sham	34003797	1.11e-10
Canx	Mouse	Kidney	rep_1	34853151	8.80e-10
Canx	Mouse	Kidney	rep_2	34853151	3.97e-14
Canx	Mouse	Kidney	rep_4	34853151	9.34e-12
Canx	Mouse	Brain	rep_1	33469025	1.30e-15
Canx	Mouse	Liver	rep_20	35021063	3.00e-14
Canx	Mouse	Brain	rep_1	35027729	1.66e-15
Canx	Mouse	Brain	rep_2	35027729	1.57e-15
Canx	Mouse	Brain	rep_3	35027729	1.32e-15
Canx	Mouse	Brain	rep_4	35027729	1.76e-15
Canx	Mouse	Brain	rep_5	35027729	1.46e-15
Canx	Mouse	Intestine	rep_1	35149721	6.08e-15
Canx	Mouse	Intestine	rep_2	35149721	3.44e-15
Canx	Mouse	Intestine	rep_3	35149721	3.25e-15
Canx	Mouse	Intestine	rep_4	35149721	2.30e-15
Canx	Mouse	Brain	B02_D1	32702314	4.71e-09
Canx	Mouse	Brain	B02_E1	32702314	3.10e-13
Canx	Mouse	Brain	B03_D2	32702314	7.10e-07
Canx	Mouse	Brain	B07_C2	32702314	1.26e-12
Canx	Mouse	Brain	N03_D2	32702314	3.62e-06
Canx	Mouse	Lymph	A1	0	1.14e-12
Canx	Mouse	Lung	rep_1	35290801	1.72e-13
Canx	Mouse	Lung	rep_2	35290801	8.55e-06
Canx	Mouse	Lung	rep_3	35290801	2.00e-09
Canx	Mouse	Lung	rep_4	35290801	3.04e-15
Canx	Mouse	Brain	rep_1	35210624	1.74e-15
Canx	Mouse	Brain	rep_2	35210624	1.74e-15
Canx	Mouse	Brain	rep_3	35210624	1.82e-15
Canx	Mouse	Brain	rep_4	35210624	4.16e-15
Canx	Mouse	Brain	rep_5	35210624	2.07e-15
Canx	Mouse	Brain	rep_6	35210624	2.05e-15
Canx	Mouse	Brain	rep_7	35210624	1.87e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_2_H&E
Kidney_rep_4_H&E
Brain_rep_1_H&E
Liver_rep_20_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_B02_D1_H&E
Brain_B02_E1_H&E
Brain_B03_D2_H&E
Brain_B07_C2_H&E
Brain_N03_D2_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Canx envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Canx	GOBP_Cytokine_Mediated_Signaling_Pathway	Mouse	Spinal cord	CN94_E1	3.0e-06
Canx	GOBP_Endocytosis	Mouse	Spinal cord	CN94_E1	8.2e-06
Canx	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Spinal cord	L7bCN02_E1	3.6e-06
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen_Via_Mhc_Class_I	Mouse	Spinal cord	L7CN44_C1	7.9e-06
Canx	GOBP_Antigen_Processing_And_Presentation	Mouse	Spinal cord	L7CN45_C1	1.1e-07
Canx	GOBP_Cellular_Response_To_Topologically_Incorrect_Protein	Mouse	Spinal cord	L7CN45_C1	7.6e-08
Canx	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Spinal cord	L7CN45_C1	2.2e-07
Canx	GOBP_Establishment_Of_Protein_Localization	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Canx	GOBP_Presynaptic_Endocytosis	Mouse	Spinal cord	L7CN45_C1	1.1e-07
Canx	GOBP_Protein_Folding_In_Endoplasmic_Reticulum	Mouse	Spinal cord	L7CN45_C1	6.4e-09
Canx	GOBP_Receptor_Mediated_Endocytosis	Mouse	Spinal cord	L7CN45_C1	2.2e-09
Canx	GOBP_Response_To_Cytokine	Mouse	Spinal cord	L7CN45_C1	8.0e-07
Canx	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Spinal cord	L7CN45_C1	2.7e-07
Canx	GOBP_Response_To_Topologically_Incorrect_Protein	Mouse	Spinal cord	L7CN45_C1	5.1e-07
Canx	GOBP_Secretion	Mouse	Spinal cord	L7CN45_C1	8.1e-09
Canx	GOBP_Synaptic_Vesicle_Recycling	Mouse	Spinal cord	L7CN45_C1	9.9e-09
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Or_Polysaccharide_Antigen_Via_Mhc_Class_Ii	Mouse	Spinal cord	L7CN47_D1	8.4e-08
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen	Mouse	Spinal cord	L7CN54_C1	2.1e-06
Canx	GOBP_Interleukin_27_Mediated_Signaling_Pathway	Mouse	Spinal cord	L7CN90A_E1	4.1e-06
Canx	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Spinal cord	L7CN97_E2	6.8e-06
Canx	GOBP_Interleukin_27_Mediated_Signaling_Pathway	Mouse	Brain	rep_9	3.0e-05
Canx	GOBP_Secretion	Mouse	Brain	rep_27	8.9e-05
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen_Via_Mhc_Class_I	Mouse	Brain	rep_36	6.4e-05
Canx	GOBP_Protein_Folding_In_Endoplasmic_Reticulum	Mouse	Brain	rep_41	2.4e-11
Canx	GOBP_Clathrin_Dependent_Endocytosis	Mouse	Brain	rep_1	2.6e-25
Canx	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	rep_1	6.6e-07
Canx	GOBP_Presynaptic_Endocytosis	Mouse	Brain	rep_1	6.2e-50
Canx	GOBP_Secretion	Mouse	Brain	rep_1	4.1e-45
Canx	GOBP_Synaptic_Vesicle_Recycling	Mouse	Brain	rep_1	6.3e-44
Canx	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Brain	rep_1	6.2e-48
Canx	GOBP_Antigen_Processing_And_Presentation	Mouse	Brain	rep_3	7.8e-88
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen	Mouse	Brain	rep_3	3.0e-31
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen_Via_Mhc_Class_I	Mouse	Brain	rep_3	4.8e-52
Canx	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Brain	rep_3	1.9e-146
Canx	GOBP_Cellular_Response_To_Topologically_Incorrect_Protein	Mouse	Brain	rep_3	1.4e-162
Canx	GOBP_Cytokine_Mediated_Signaling_Pathway	Mouse	Brain	rep_3	4.9e-10
Canx	GOBP_Endocytosis	Mouse	Brain	rep_3	2.6e-20
Canx	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Brain	rep_3	3.4e-151
Canx	GOBP_Interleukin_27_Mediated_Signaling_Pathway	Mouse	Brain	rep_3	3.4e-41
Canx	GOBP_Protein_Folding	Mouse	Brain	rep_3	5.7e-177
Canx	GOBP_Protein_Folding_In_Endoplasmic_Reticulum	Mouse	Brain	rep_3	7.7e-162
Canx	GOBP_Receptor_Mediated_Endocytosis	Mouse	Brain	rep_3	3.1e-52
Canx	GOBP_Response_To_Cytokine	Mouse	Brain	rep_3	1.2e-08
Canx	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Brain	rep_3	6.3e-133
Canx	GOBP_Response_To_Topologically_Incorrect_Protein	Mouse	Brain	rep_3	8.7e-153
Canx	GOBP_Interleukin_27_Mediated_Signaling_Pathway	Mouse	Embryo	rep_6	1.9e-11
Canx	GOBP_Antigen_Processing_And_Presentation	Mouse	Embryo	rep_14	1.0e-31
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen	Mouse	Embryo	rep_14	2.9e-38
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen_Via_Mhc_Class_I	Mouse	Embryo	rep_14	4.3e-26
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Or_Polysaccharide_Antigen_Via_Mhc_Class_Ii	Mouse	Embryo	rep_14	2.8e-35
Canx	GOBP_Cellular_Response_To_Topologically_Incorrect_Protein	Mouse	Embryo	rep_14	8.7e-22
Canx	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Embryo	rep_14	2.5e-19
Canx	GOBP_Presynaptic_Endocytosis	Mouse	Embryo	rep_14	1.1e-31
Canx	GOBP_Protein_Folding	Mouse	Embryo	rep_14	3.2e-12
Canx	GOBP_Protein_Folding_In_Endoplasmic_Reticulum	Mouse	Embryo	rep_14	1.0e-41
Canx	GOBP_Response_To_Topologically_Incorrect_Protein	Mouse	Embryo	rep_14	7.2e-14
Canx	GOBP_Synaptic_Vesicle_Recycling	Mouse	Embryo	rep_14	2.7e-09
Canx	GOBP_Clathrin_Dependent_Endocytosis	Mouse	Embryo	rep_1	9.6e-110
Canx	GOBP_Response_To_Cytokine	Mouse	Embryo	rep_1	8.2e-211
Canx	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Embryo	rep_2	7.4e-121
Canx	GOBP_Receptor_Mediated_Endocytosis	Mouse	Embryo	rep_2	1.2e-141
Canx	GOBP_Synaptic_Vesicle_Recycling	Mouse	Embryo	rep_2	0.0e+00
Canx	GOBP_Cellular_Response_To_Topologically_Incorrect_Protein	Mouse	Embryo	rep_3	0.0e+00
Canx	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Embryo	rep_3	1.7e-305
Canx	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Embryo	rep_3	1.8e-13
Canx	GOBP_Response_To_Topologically_Incorrect_Protein	Mouse	Embryo	rep_3	2.3e-263
Canx	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Embryo	rep_3	1.2e-12
Canx	GOBP_Endocytosis	Mouse	Kidney	Nep	8.3e-23
Canx	GOBP_Antigen_Processing_And_Presentation	Mouse	Kidney	rep_2	2.7e-43
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen	Mouse	Kidney	rep_2	7.0e-34
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen_Via_Mhc_Class_I	Mouse	Kidney	rep_2	7.2e-34
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Or_Polysaccharide_Antigen_Via_Mhc_Class_Ii	Mouse	Kidney	rep_2	1.5e-22
Canx	GOBP_Clathrin_Dependent_Endocytosis	Mouse	Kidney	rep_2	3.3e-122
Canx	GOBP_Endocytosis	Mouse	Kidney	rep_2	1.4e-132
Canx	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Kidney	rep_2	5.3e-42
Canx	GOBP_Establishment_Of_Protein_Localization	Mouse	Kidney	rep_2	9.8e-86
Canx	GOBP_Interleukin_27_Mediated_Signaling_Pathway	Mouse	Kidney	rep_2	1.2e-48
Canx	GOBP_Protein_Folding_In_Endoplasmic_Reticulum	Mouse	Kidney	rep_2	9.4e-32
Canx	GOBP_Receptor_Mediated_Endocytosis	Mouse	Kidney	rep_2	4.7e-166
Canx	GOBP_Response_To_Cytokine	Mouse	Kidney	rep_2	3.1e-14
Canx	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Kidney	rep_2	1.2e-89
Canx	GOBP_Secretion	Mouse	Kidney	rep_2	1.6e-23
Canx	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Kidney	rep_2	1.0e-23
Canx	GOBP_Protein_Folding_In_Endoplasmic_Reticulum	Mouse	Liver	CN16-D2	7.2e-15
Canx	GOBP_Interleukin_27_Mediated_Signaling_Pathway	Mouse	Liver	rep_15	1.2e-33
Canx	GOBP_Antigen_Processing_And_Presentation	Mouse	Liver	rep_16	2.8e-07
Canx	GOBP_Response_To_Cytokine	Mouse	Liver	rep_16	1.4e-13
Canx	GOBP_Synaptic_Vesicle_Recycling	Mouse	Liver	rep_16	1.5e-08
Canx	GOBP_Antigen_Processing_And_Presentation	Mouse	Lymph	MS-1	1.2e-25
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen	Mouse	Lymph	MS-1	5.6e-23
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Or_Polysaccharide_Antigen_Via_Mhc_Class_Ii	Mouse	Lymph	MS-1	3.4e-19
Canx	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Lymph	MS-1	4.6e-18
Canx	GOBP_Clathrin_Dependent_Endocytosis	Mouse	Lymph	MS-1	6.0e-20
Canx	GOBP_Cytokine_Mediated_Signaling_Pathway	Mouse	Lymph	MS-1	6.7e-17
Canx	GOBP_Endocytosis	Mouse	Lymph	MS-1	1.8e-21
Canx	GOBP_Establishment_Of_Protein_Localization	Mouse	Lymph	MS-1	2.5e-11
Canx	GOBP_Protein_Folding	Mouse	Lymph	MS-1	1.6e-14
Canx	GOBP_Protein_Folding_In_Endoplasmic_Reticulum	Mouse	Lymph	MS-1	3.9e-16
Canx	GOBP_Receptor_Mediated_Endocytosis	Mouse	Lymph	MS-1	2.1e-11
Canx	GOBP_Response_To_Cytokine	Mouse	Lymph	MS-1	5.7e-15
Canx	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Lymph	MS-1	1.7e-11
Canx	GOBP_Response_To_Topologically_Incorrect_Protein	Mouse	Lymph	MS-1	2.8e-07
Canx	GOBP_Secretion	Mouse	Lymph	MS-1	2.3e-12
Canx	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Lymph	MS-1	1.2e-07
Canx	GOBP_Cellular_Response_To_Topologically_Incorrect_Protein	Mouse	Lymph	PBS	1.2e-07
Canx	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Lymph	PBS	2.4e-07
Canx	GOBP_Response_To_Cytokine	Mouse	Lung	rep_1	1.2e-17
Canx	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Brain	rep_4	2.9e-13
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen	Mouse	Brain	HP_ad_rep3	5.6e-09
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Antigen_Via_Mhc_Class_I	Mouse	Brain	HP_ad_rep3	1.2e-09
Canx	GOBP_Antigen_Processing_And_Presentation_Of_Peptide_Or_Polysaccharide_Antigen_Via_Mhc_Class_Ii	Mouse	Brain	HP_ad_rep3	3.6e-13
Canx	GOBP_Interleukin_27_Mediated_Signaling_Pathway	Mouse	Brain	HP_ad_rep3	7.9e-24
Canx	GOBP_Antigen_Processing_And_Presentation	Mouse	Brain	HP_ad_rep7	3.0e-10
Canx	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	HP_ad_rep7	8.7e-10
Canx	GOBP_Receptor_Mediated_Endocytosis	Mouse	Brain	HP_ad_rep7	1.4e-08
Canx	GOBP_Response_To_Cytokine	Mouse	Brain	HP_ad_rep7	2.1e-08
Canx	GOBP_Secretion	Mouse	Brain	HP_ad_rep7	1.6e-08
Canx	GOBP_Clathrin_Dependent_Endocytosis	Mouse	Brain	HP_adpolb_rep1	3.4e-07
Canx	GOBP_Protein_Folding	Mouse	Brain	HP_adpolb_rep1	5.2e-07
Canx	GOBP_Protein_Folding_In_Endoplasmic_Reticulum	Mouse	Brain	HP_adpolb_rep1	4.0e-11
Canx	GOBP_Biological_Process_Involved_In_Symbiotic_Interaction	Mouse	Brain	HP_polb_rep9	1.1e-12
Canx	GOBP_Cellular_Response_To_Topologically_Incorrect_Protein	Mouse	Brain	HP_polb_rep9	2.8e-08
Canx	GOBP_Cytokine_Mediated_Signaling_Pathway	Mouse	Brain	HP_polb_rep9	5.5e-07
Canx	GOBP_Endocytosis	Mouse	Brain	HP_polb_rep9	3.2e-09
Canx	GOBP_Endoplasmic_Reticulum_Unfolded_Protein_Response	Mouse	Brain	HP_polb_rep9	2.7e-13
Canx	GOBP_Response_To_Endoplasmic_Reticulum_Stress	Mouse	Brain	HP_polb_rep9	3.5e-12
Canx	GOBP_Response_To_Topologically_Incorrect_Protein	Mouse	Brain	HP_polb_rep9	5.0e-08
Canx	GOBP_Presynaptic_Endocytosis	Mouse	Brain	HP_wt_rep2	1.9e-15
Canx	GOBP_Synaptic_Vesicle_Recycling	Mouse	Brain	HP_wt_rep2	1.9e-15
Canx	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Brain	HP_wt_rep2	1.1e-15

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Canx function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Canx function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Canx envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Canx

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Canx

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Canx	C0019193	Hepatitis, Toxic	1	CTD_human
Canx	C0151744	Myocardial Ischemia	1	CTD_human
Canx	C0860207	Drug-Induced Liver Disease	1	CTD_human
Canx	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Canx	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Canx	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Canx	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human