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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Lyve1 (spascer ID:114332)

Gene summary for Lyve1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Lyve1
	Gene ID	114332
	Gene name	lymphatic vessel endothelial hyaluronan receptor 1
	Synonyms	1200012G08Rik\|Crsbp-1\|Lyve-1\|Xlkd1
	Cytomap	7\|7 E3
	Type of gene	protein-coding
	Description	lymphatic vessel endothelial hyaluronic acid receptor 1cell surface retention sequence binding protein-1extra cellular link domain-containing 1extracellular link domain-containing protein 1lymphatic vessel endothelial HA receptor-1lymphatic vessel en
	Modification date	20220510
	UniProtAcc	Q8BHC0

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Lyve1	GO:0004888	transmembrane signaling receptor activity	21873635	Function
Lyve1	GO:0005540	hyaluronic acid binding	21873635	Function
Lyve1	GO:0005886	plasma membrane	21873635	Component

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Spatial pattern events for Lyve1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Lyve1	Mouse	Liver	rep_20	35021063	1.33e-12
Lyve1	Mouse	Testicle	rep_3	34731600	8.11e-08
Lyve1	Mouse	Lymph	MS-1	0	3.72e-14
Lyve1	Mouse	Lung	rep_1	35290801	4.52e-15
Lyve1	Mouse	Lung	rep_2	35290801	7.23e-15
Lyve1	Mouse	Lung	rep_3	35290801	5.26e-15
Lyve1	Mouse	Lung	rep_4	35290801	3.04e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Liver_rep_20_H&E
Lung_rep_1_H&E
Lung_rep_2_H&E
Lung_rep_3_H&E
Lung_rep_4_H&E

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Spatial pattern pathway has Lyve1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Lyve1	GOBP_Response_To_Wounding	Mouse	Spinal cord	CN94_E1	4.7e-06
Lyve1	GOBP_Hyaluronan_Metabolic_Process	Mouse	Spinal cord	L7CN44_C1	1.1e-08
Lyve1	GOBP_Aminoglycan_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	8.7e-07
Lyve1	GOBP_Biological_Adhesion	Mouse	Spinal cord	L7CN45_C1	2.4e-08
Lyve1	GOBP_Carbohydrate_Derivative_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	2.7e-07
Lyve1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.8e-07
Lyve1	GOBP_Hyaluronan_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-06
Lyve1	GOBP_Macromolecule_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	7.5e-06
Lyve1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	5.1e-08
Lyve1	GOBP_Aminoglycan_Metabolic_Process	Mouse	Spinal cord	L7CN47_D1	4.0e-07
Lyve1	GOBP_Mucopolysaccharide_Metabolic_Process	Mouse	Spinal cord	L7CN47_D1	1.8e-08
Lyve1	GOBP_Cell_Substrate_Adhesion	Mouse	Spinal cord	L7CN97_E2	2.2e-06
Lyve1	GOBP_Hyaluronan_Catabolic_Process	Mouse	Brain	rep_20	7.9e-05
Lyve1	GOBP_Aminoglycan_Catabolic_Process	Mouse	Brain	rep_27	5.0e-07
Lyve1	GOBP_Hyaluronan_Metabolic_Process	Mouse	Brain	rep_1	6.0e-09
Lyve1	GOBP_Aminoglycan_Catabolic_Process	Mouse	Brain	rep_3	3.0e-90
Lyve1	GOBP_Aminoglycan_Metabolic_Process	Mouse	Brain	rep_3	3.9e-113
Lyve1	GOBP_Biological_Adhesion	Mouse	Brain	rep_3	4.3e-106
Lyve1	GOBP_Carbohydrate_Derivative_Catabolic_Process	Mouse	Brain	rep_3	3.4e-221
Lyve1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Brain	rep_3	4.5e-61
Lyve1	GOBP_Cell_Substrate_Adhesion	Mouse	Brain	rep_3	1.8e-27
Lyve1	GOBP_Macromolecule_Catabolic_Process	Mouse	Brain	rep_3	1.7e-159
Lyve1	GOBP_Mucopolysaccharide_Metabolic_Process	Mouse	Brain	rep_3	1.4e-123
Lyve1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Brain	rep_3	7.1e-166
Lyve1	GOBP_Response_To_Wounding	Mouse	Brain	rep_3	6.2e-112
Lyve1	GOBP_Hyaluronan_Catabolic_Process	Mouse	Brain	rep_7	1.7e-34
Lyve1	GOBP_Aminoglycan_Catabolic_Process	Mouse	Embryo	rep_6	1.1e-09
Lyve1	GOBP_Hyaluronan_Catabolic_Process	Mouse	Embryo	rep_6	1.0e-11
Lyve1	GOBP_Hyaluronan_Metabolic_Process	Mouse	Embryo	rep_6	2.9e-19
Lyve1	GOBP_Aminoglycan_Metabolic_Process	Mouse	Embryo	rep_14	8.7e-35
Lyve1	GOBP_Carbohydrate_Derivative_Catabolic_Process	Mouse	Embryo	rep_14	1.7e-43
Lyve1	GOBP_Mucopolysaccharide_Metabolic_Process	Mouse	Embryo	rep_14	5.1e-28
Lyve1	GOBP_Biological_Adhesion	Mouse	Embryo	rep_1	2.2e-19
Lyve1	GOBP_Cell_Matrix_Adhesion	Mouse	Embryo	rep_1	1.6e-47
Lyve1	GOBP_Cell_Substrate_Adhesion	Mouse	Embryo	rep_1	2.0e-34
Lyve1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Embryo	rep_1	5.7e-21
Lyve1	GOBP_Response_To_Wounding	Mouse	Kidney	Nep	1.6e-16
Lyve1	GOBP_Aminoglycan_Catabolic_Process	Mouse	Kidney	rep_2	1.4e-63
Lyve1	GOBP_Biological_Adhesion	Mouse	Kidney	rep_2	1.3e-48
Lyve1	GOBP_Carbohydrate_Derivative_Catabolic_Process	Mouse	Kidney	rep_2	5.9e-48
Lyve1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-42
Lyve1	GOBP_Cell_Matrix_Adhesion	Mouse	Kidney	rep_2	2.0e-31
Lyve1	GOBP_Cell_Substrate_Adhesion	Mouse	Kidney	rep_2	4.0e-46
Lyve1	GOBP_Macromolecule_Catabolic_Process	Mouse	Kidney	rep_2	7.0e-40
Lyve1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Kidney	rep_2	1.2e-14
Lyve1	GOBP_Response_To_Wounding	Mouse	Kidney	rep_2	2.1e-60
Lyve1	GOBP_Hyaluronan_Metabolic_Process	Mouse	Liver	CN16-D1	8.0e-10
Lyve1	GOBP_Aminoglycan_Metabolic_Process	Mouse	Liver	CN73-C1	9.1e-08
Lyve1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Liver	CN73-C1	5.1e-08
Lyve1	GOBP_Mucopolysaccharide_Metabolic_Process	Mouse	Liver	CN73-C1	1.2e-07
Lyve1	GOBP_Response_To_Wounding	Mouse	Liver	CN73-C1	1.1e-07
Lyve1	GOBP_Aminoglycan_Catabolic_Process	Mouse	Liver	rep_15	5.6e-10
Lyve1	GOBP_Aminoglycan_Metabolic_Process	Mouse	Liver	rep_16	2.1e-07
Lyve1	GOBP_Biological_Adhesion	Mouse	Liver	rep_16	2.1e-07
Lyve1	GOBP_Cell_Matrix_Adhesion	Mouse	Liver	rep_16	2.7e-08
Lyve1	GOBP_Hyaluronan_Metabolic_Process	Mouse	Liver	rep_16	1.6e-12
Lyve1	GOBP_Response_To_Wounding	Mouse	Liver	rep_16	1.3e-13
Lyve1	GOBP_Hyaluronan_Catabolic_Process	Mouse	Liver	rep_23	7.5e-22
Lyve1	GOBP_Hyaluronan_Catabolic_Process	Mouse	Brain	rep_1	4.2e-11
Lyve1	GOBP_Hyaluronan_Catabolic_Process	Mouse	Intestine	rep_3	3.6e-30
Lyve1	GOBP_Aminoglycan_Catabolic_Process	Mouse	Lymph	MS-1	7.5e-16
Lyve1	GOBP_Aminoglycan_Metabolic_Process	Mouse	Lymph	MS-1	2.1e-14
Lyve1	GOBP_Biological_Adhesion	Mouse	Lymph	MS-1	8.0e-14
Lyve1	GOBP_Carbohydrate_Derivative_Catabolic_Process	Mouse	Lymph	MS-1	6.0e-17
Lyve1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Lymph	MS-1	2.8e-10
Lyve1	GOBP_Cell_Matrix_Adhesion	Mouse	Lymph	MS-1	3.5e-08
Lyve1	GOBP_Hyaluronan_Catabolic_Process	Mouse	Lymph	MS-1	5.0e-13
Lyve1	GOBP_Hyaluronan_Metabolic_Process	Mouse	Lymph	MS-1	1.4e-08
Lyve1	GOBP_Macromolecule_Catabolic_Process	Mouse	Lymph	MS-1	1.2e-13
Lyve1	GOBP_Mucopolysaccharide_Metabolic_Process	Mouse	Lymph	MS-1	2.1e-14
Lyve1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Lymph	MS-1	1.2e-13
Lyve1	GOBP_Biological_Adhesion	Mouse	Lung	rep_1	3.0e-22
Lyve1	GOBP_Macromolecule_Catabolic_Process	Mouse	Lung	rep_1	2.0e-21
Lyve1	GOBP_Cell_Matrix_Adhesion	Mouse	Brain	rep_4	7.1e-07
Lyve1	GOBP_Hyaluronan_Catabolic_Process	Mouse	Brain	rep_7	2.6e-49
Lyve1	GOBP_Aminoglycan_Catabolic_Process	Mouse	Brain	HP_ad_rep3	3.8e-18
Lyve1	GOBP_Hyaluronan_Catabolic_Process	Mouse	Brain	HP_ad_rep3	2.2e-07
Lyve1	GOBP_Hyaluronan_Metabolic_Process	Mouse	Brain	HP_ad_rep3	1.2e-07
Lyve1	GOBP_Aminoglycan_Metabolic_Process	Mouse	Brain	HP_ad_rep7	1.6e-11
Lyve1	GOBP_Cell_Matrix_Adhesion	Mouse	Brain	HP_ad_rep7	5.6e-10
Lyve1	GOBP_Macromolecule_Catabolic_Process	Mouse	Brain	HP_ad_rep7	1.3e-09
Lyve1	GOBP_Organonitrogen_Compound_Catabolic_Process	Mouse	Brain	HP_ad_rep7	3.3e-07
Lyve1	GOBP_Response_To_Wounding	Mouse	Brain	HP_ad_rep7	4.3e-07
Lyve1	GOBP_Biological_Adhesion	Mouse	Brain	HP_polb_rep9	1.5e-07
Lyve1	GOBP_Carbohydrate_Derivative_Catabolic_Process	Mouse	Brain	HP_polb_rep9	4.0e-16
Lyve1	GOBP_Carbohydrate_Derivative_Metabolic_Process	Mouse	Brain	HP_polb_rep9	5.2e-12
Lyve1	GOBP_Cell_Substrate_Adhesion	Mouse	Brain	HP_polb_rep9	3.3e-07

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Lyve1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Lyve1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Lyve1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Lyve1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Lyve1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Lyve1	C2239176	Liver carcinoma	1	CTD_human