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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Hlcs (spascer ID:110948)

Gene summary for Hlcs

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Hlcs
	Gene ID	110948
	Gene name	holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
	Synonyms	410I21.SP6\|D16Jhu34
	Cytomap	16 C4\|16 55.12 cM
	Type of gene	protein-coding
	Description	biotin--protein ligasebiotin apo-protein ligasebiotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase
	Modification date	20220424
	UniProtAcc	Q920N2

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Hlcs	GO:0004077	biotin-[acetyl-CoA-carboxylase] ligase activity	21873635	Function
Hlcs	GO:0005737	cytoplasm	21873635	Component
Hlcs	GO:0009305	protein biotinylation	21873635	Process
Hlcs	GO:0071110	histone biotinylation	21873635	Process

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Spatial pattern events for Hlcs

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Hlcs	Mouse	Kidney	Sham	34003797	1.14e-07
Hlcs	Mouse	Brain	rep_1	33469025	1.93e-09

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_Sham_H&E
Brain_rep_1_H&E

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Spatial pattern pathway has Hlcs envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Hlcs	GOBP_Response_To_Nitrogen_Compound	Mouse	Spinal cord	CN94_E1	5.6e-06
Hlcs	GOBP_Organic_Acid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	7.1e-06
Hlcs	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Hlcs	GOBP_Chromatin_Organization	Mouse	Spinal cord	L7CN45_C1	3.5e-07
Hlcs	GOBP_Chromosome_Organization	Mouse	Spinal cord	L7CN45_C1	3.4e-08
Hlcs	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	6.2e-09
Hlcs	GOBP_Response_To_Extracellular_Stimulus	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Hlcs	GOBP_Response_To_Nutrient	Mouse	Spinal cord	L7CN45_C1	1.2e-06
Hlcs	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Spinal cord	L7CN45_C1	6.3e-07
Hlcs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Hlcs	GOBP_Response_To_Vitamin	Mouse	Spinal cord	L7CN45_C1	8.6e-06
Hlcs	GOBP_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Hlcs	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	4.4e-07
Hlcs	GOBP_Vitamin_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Hlcs	GOBP_Water_Soluble_Vitamin_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.2e-07
Hlcs	GOBP_Vitamin_Metabolic_Process	Mouse	Brain	rep_21	6.6e-05
Hlcs	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Brain	rep_71	8.1e-05
Hlcs	GOBP_Chromosome_Organization	Mouse	Brain	rep_1	3.9e-07
Hlcs	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	rep_3	2.1e-87
Hlcs	GOBP_Chromatin_Organization	Mouse	Brain	rep_3	5.1e-215
Hlcs	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Brain	rep_3	3.2e-119
Hlcs	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	rep_3	1.5e-154
Hlcs	GOBP_Response_To_Extracellular_Stimulus	Mouse	Brain	rep_3	2.2e-117
Hlcs	GOBP_Response_To_Nitrogen_Compound	Mouse	Brain	rep_3	2.5e-82
Hlcs	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Brain	rep_3	3.4e-98
Hlcs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Brain	rep_3	6.3e-92
Hlcs	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	rep_3	2.7e-19
Hlcs	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Brain	rep_3	1.4e-160
Hlcs	GOBP_Vitamin_Metabolic_Process	Mouse	Brain	rep_3	2.6e-174
Hlcs	GOBP_Water_Soluble_Vitamin_Metabolic_Process	Mouse	Brain	rep_3	5.9e-186
Hlcs	GOBP_Vitamin_Metabolic_Process	Mouse	Embryo	rep_6	1.0e-11
Hlcs	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Hlcs	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Embryo	rep_14	7.3e-13
Hlcs	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Embryo	rep_14	5.8e-13
Hlcs	GOBP_Water_Soluble_Vitamin_Metabolic_Process	Mouse	Embryo	rep_14	7.1e-79
Hlcs	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Embryo	rep_1	2.5e-19
Hlcs	GOBP_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_1	1.4e-55
Hlcs	GOBP_Chromatin_Organization	Mouse	Embryo	rep_3	2.9e-87
Hlcs	GOBP_Chromosome_Organization	Mouse	Embryo	rep_3	1.4e-57
Hlcs	GOBP_Organic_Acid_Metabolic_Process	Mouse	Embryo	rep_3	1.4e-07
Hlcs	GOBP_Response_To_Nitrogen_Compound	Mouse	Embryo	rep_3	0.0e+00
Hlcs	GOBP_Response_To_Nutrient	Mouse	Embryo	rep_3	7.7e-11
Hlcs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Embryo	rep_3	0.0e+00
Hlcs	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Embryo	rep_4	0.0e+00
Hlcs	GOBP_Response_To_Extracellular_Stimulus	Mouse	Embryo	rep_4	1.2e-08
Hlcs	GOBP_Vitamin_Metabolic_Process	Mouse	Embryo	rep_4	6.0e-12
Hlcs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Kidney	Nep	6.8e-28
Hlcs	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-85
Hlcs	GOBP_Chromatin_Organization	Mouse	Kidney	rep_2	3.0e-63
Hlcs	GOBP_Chromosome_Organization	Mouse	Kidney	rep_2	1.0e-14
Hlcs	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Kidney	rep_2	4.4e-73
Hlcs	GOBP_Organic_Acid_Metabolic_Process	Mouse	Kidney	rep_2	3.8e-62
Hlcs	GOBP_Response_To_Extracellular_Stimulus	Mouse	Kidney	rep_2	3.8e-52
Hlcs	GOBP_Response_To_Nitrogen_Compound	Mouse	Kidney	rep_2	1.0e-56
Hlcs	GOBP_Response_To_Nutrient	Mouse	Kidney	rep_2	1.4e-72
Hlcs	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Kidney	rep_2	1.3e-60
Hlcs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Kidney	rep_2	6.6e-112
Hlcs	GOBP_Response_To_Vitamin	Mouse	Kidney	rep_2	4.0e-91
Hlcs	GOBP_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	1.8e-43
Hlcs	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Kidney	rep_2	8.6e-17
Hlcs	GOBP_Vitamin_Metabolic_Process	Mouse	Kidney	rep_2	6.7e-44
Hlcs	GOBP_Water_Soluble_Vitamin_Metabolic_Process	Mouse	Kidney	rep_2	6.8e-65
Hlcs	GOBP_Response_To_Nutrient	Mouse	Liver	CN16-E1	2.0e-08
Hlcs	GOBP_Response_To_Extracellular_Stimulus	Mouse	Liver	rep_16	8.0e-26
Hlcs	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Intestine	rep_2	7.1e-07
Hlcs	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Hlcs	GOBP_Chromatin_Organization	Mouse	Lymph	MS-1	9.1e-11
Hlcs	GOBP_Chromosome_Organization	Mouse	Lymph	MS-1	3.5e-09
Hlcs	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-15
Hlcs	GOBP_Organic_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-15
Hlcs	GOBP_Response_To_Extracellular_Stimulus	Mouse	Lymph	MS-1	1.1e-12
Hlcs	GOBP_Response_To_Nitrogen_Compound	Mouse	Lymph	MS-1	1.8e-09
Hlcs	GOBP_Response_To_Nutrient	Mouse	Lymph	MS-1	2.8e-10
Hlcs	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Lymph	MS-1	1.9e-09
Hlcs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Lymph	MS-1	1.8e-09
Hlcs	GOBP_Response_To_Vitamin	Mouse	Lymph	MS-1	1.4e-12
Hlcs	GOBP_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.6e-11
Hlcs	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Lymph	MS-1	7.8e-10
Hlcs	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Lung	rep_1	5.0e-17
Hlcs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Lung	rep_1	1.2e-19
Hlcs	GOBP_Vitamin_Metabolic_Process	Mouse	Brain	HP_ad_rep3	1.3e-07
Hlcs	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.6e-11
Hlcs	GOBP_Chromatin_Organization	Mouse	Brain	HP_ad_rep7	7.6e-11
Hlcs	GOBP_Chromosome_Organization	Mouse	Brain	HP_ad_rep7	2.9e-10
Hlcs	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	HP_ad_rep7	4.1e-08
Hlcs	GOBP_Response_To_Extracellular_Stimulus	Mouse	Brain	HP_ad_rep7	1.4e-09
Hlcs	GOBP_Response_To_Nitrogen_Compound	Mouse	Brain	HP_ad_rep7	3.5e-10
Hlcs	GOBP_Response_To_Organic_Cyclic_Compound	Mouse	Brain	HP_ad_rep7	1.4e-09
Hlcs	GOBP_Response_To_Oxygen_Containing_Compound	Mouse	Brain	HP_ad_rep7	4.2e-09
Hlcs	GOBP_Water_Soluble_Vitamin_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.1e-08
Hlcs	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	1.7e-11
Hlcs	GOBP_Response_To_Nutrient	Mouse	Brain	HP_polb_rep9	2.0e-09
Hlcs	GOBP_Response_To_Vitamin	Mouse	Brain	HP_polb_rep9	6.9e-07
Hlcs	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.0e-09
Hlcs	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.9e-08

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Hlcs function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Hlcs function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Hlcs envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Hlcs

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Hlcs

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Hlcs	C0268581	Holocarboxylase Synthetase Deficiency	14	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT