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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Slc18a1 (spascer ID:110877)

Gene summary for Slc18a1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Slc18a1
	Gene ID	110877
	Gene name	solute carrier family 18 (vesicular monoamine), member 1
	Synonyms	4832416I10Rik\|Vat1\|Vmat1
	Cytomap	8 B3.3\|8 33.88 cM
	Type of gene	protein-coding
	Description	chromaffin granule amine transportersolute carrier family 18 member 1vesicular amine transporter 1
	Modification date	20220424
	UniProtAcc	Q8R090

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Slc18a1	GO:0005335	serotonin:sodium symporter activity	21873635	Function
Slc18a1	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle	21873635	Process
Slc18a1	GO:0022857	transmembrane transporter activity	21873635	Function
Slc18a1	GO:0030672	synaptic vesicle membrane	21873635	Component
Slc18a1	GO:0043195	terminal bouton	21873635	Component

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Spatial pattern events for Slc18a1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Slc18a1	Mouse	Kidney	CLP	34003797	2.19e-15
Slc18a1	Mouse	Kidney	IRI	34003797	2.29e-15
Slc18a1	Mouse	Kidney	Sham	34003797	2.58e-15
Slc18a1	Mouse	Kidney	rep_1	34853151	2.42e-15
Slc18a1	Mouse	Kidney	rep_3	34853151	2.94e-15
Slc18a1	Mouse	Kidney	rep_4	34853151	4.07e-15
Slc18a1	Mouse	Kidney	rep_5	34853151	3.18e-15
Slc18a1	Mouse	Testicle	rep_4	34731600	4.93e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_Sham_H&E
Kidney_rep_1_H&E
Kidney_rep_3_H&E
Kidney_rep_4_H&E
Kidney_rep_5_H&E

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Spatial pattern pathway has Slc18a1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Slc18a1	GOBP_Xenobiotic_Transport	Mouse	Spinal cord	CN78_C1	3.9e-06
Slc18a1	GOBP_Cation_Transport	Mouse	Spinal cord	CN94_E1	5.8e-06
Slc18a1	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Spinal cord	L7bCN02_E1	3.6e-06
Slc18a1	GOBP_Amine_Transport	Mouse	Spinal cord	L7CN45_C1	2.0e-06
Slc18a1	GOBP_Monoamine_Transport	Mouse	Spinal cord	L7CN45_C1	1.8e-06
Slc18a1	GOBP_Transmembrane_Transport	Mouse	Spinal cord	L7CN45_C1	3.5e-08
Slc18a1	GOBP_Neurotransmitter_Uptake	Mouse	Spinal cord	L7CN60_D1	3.4e-06
Slc18a1	GOBP_Organic_Hydroxy_Compound_Transport	Mouse	Spinal cord	L7CN97_E2	6.7e-06
Slc18a1	GOBP_Cation_Transport	Mouse	Brain	rep_1	1.5e-22
Slc18a1	GOBP_Import_Into_Cell	Mouse	Brain	rep_1	3.8e-20
Slc18a1	GOBP_Neurotransmitter_Reuptake	Mouse	Brain	rep_1	1.7e-52
Slc18a1	GOBP_Neurotransmitter_Transport	Mouse	Brain	rep_1	2.2e-59
Slc18a1	GOBP_Neurotransmitter_Uptake	Mouse	Brain	rep_1	1.5e-82
Slc18a1	GOBP_Regulation_Of_Neurotransmitter_Levels	Mouse	Brain	rep_1	9.8e-46
Slc18a1	GOBP_Serotonin_Transport	Mouse	Brain	rep_1	2.7e-11
Slc18a1	GOBP_Serotonin_Uptake	Mouse	Brain	rep_1	9.9e-14
Slc18a1	GOBP_Transmembrane_Transport	Mouse	Brain	rep_1	3.1e-23
Slc18a1	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Brain	rep_1	6.2e-48
Slc18a1	GOBP_Organic_Hydroxy_Compound_Transport	Mouse	Brain	rep_3	1.0e-11
Slc18a1	GOBP_Xenobiotic_Transport	Mouse	Brain	rep_3	2.0e-175
Slc18a1	GOBP_Amine_Transport	Mouse	Brain	rep_7	2.4e-43
Slc18a1	GOBP_Monoamine_Transport	Mouse	Brain	rep_7	8.2e-81
Slc18a1	GOBP_Amine_Transport	Mouse	Embryo	rep_14	3.7e-40
Slc18a1	GOBP_Import_Into_Cell	Mouse	Embryo	rep_14	8.3e-23
Slc18a1	GOBP_Monoamine_Transport	Mouse	Embryo	rep_14	1.0e-33
Slc18a1	GOBP_Neurotransmitter_Loading_Into_Synaptic_Vesicle	Mouse	Embryo	rep_14	3.9e-21
Slc18a1	GOBP_Neurotransmitter_Reuptake	Mouse	Embryo	rep_14	3.6e-46
Slc18a1	GOBP_Neurotransmitter_Uptake	Mouse	Embryo	rep_14	2.7e-49
Slc18a1	GOBP_Organic_Hydroxy_Compound_Transport	Mouse	Embryo	rep_14	2.5e-24
Slc18a1	GOBP_Xenobiotic_Transport	Mouse	Embryo	rep_14	8.0e-39
Slc18a1	GOBP_Amine_Transport	Mouse	Embryo	rep_3	5.3e-228
Slc18a1	GOBP_Organic_Hydroxy_Compound_Transport	Mouse	Embryo	rep_3	6.0e-46
Slc18a1	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Embryo	rep_3	1.2e-12
Slc18a1	GOBP_Transmembrane_Transport	Mouse	Kidney	Nep	4.2e-26
Slc18a1	GOBP_Amine_Transport	Mouse	Kidney	rep_2	5.4e-132
Slc18a1	GOBP_Cation_Transport	Mouse	Kidney	rep_2	5.9e-23
Slc18a1	GOBP_Import_Into_Cell	Mouse	Kidney	rep_2	2.3e-111
Slc18a1	GOBP_Neurotransmitter_Reuptake	Mouse	Kidney	rep_2	4.6e-128
Slc18a1	GOBP_Neurotransmitter_Transport	Mouse	Kidney	rep_2	5.4e-41
Slc18a1	GOBP_Neurotransmitter_Uptake	Mouse	Kidney	rep_2	3.9e-150
Slc18a1	GOBP_Organic_Hydroxy_Compound_Transport	Mouse	Kidney	rep_2	8.5e-116
Slc18a1	GOBP_Regulation_Of_Neurotransmitter_Levels	Mouse	Kidney	rep_2	7.2e-110
Slc18a1	GOBP_Serotonin_Transport	Mouse	Kidney	rep_2	9.0e-80
Slc18a1	GOBP_Serotonin_Uptake	Mouse	Kidney	rep_2	5.7e-68
Slc18a1	GOBP_Transmembrane_Transport	Mouse	Kidney	rep_2	2.7e-23
Slc18a1	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Kidney	rep_2	1.0e-23
Slc18a1	GOBP_Xenobiotic_Transport	Mouse	Kidney	rep_2	1.1e-35
Slc18a1	GOBP_Neurotransmitter_Loading_Into_Synaptic_Vesicle	Mouse	Kidney	rep_4	8.6e-19
Slc18a1	GOBP_Serotonin_Uptake	Mouse	Liver	CN16-D1	4.3e-07
Slc18a1	GOBP_Amine_Transport	Mouse	Liver	CN16-D2	4.4e-07
Slc18a1	GOBP_Monoamine_Transport	Mouse	Liver	CN16-E1	2.4e-09
Slc18a1	GOBP_Neurotransmitter_Loading_Into_Synaptic_Vesicle	Mouse	Liver	CN65-C1	1.9e-09
Slc18a1	GOBP_Serotonin_Transport	Mouse	Liver	CN65-C1	5.7e-07
Slc18a1	GOBP_Neurotransmitter_Reuptake	Mouse	Liver	CN73-C1	2.2e-09
Slc18a1	GOBP_Neurotransmitter_Transport	Mouse	Liver	CN73-C1	1.9e-07
Slc18a1	GOBP_Neurotransmitter_Uptake	Mouse	Liver	CN73-C1	1.4e-10
Slc18a1	GOBP_Neurotransmitter_Loading_Into_Synaptic_Vesicle	Mouse	Liver	rep_15	6.4e-17
Slc18a1	GOBP_Neurotransmitter_Transport	Mouse	Liver	rep_15	5.0e-08
Slc18a1	GOBP_Amine_Transport	Mouse	Liver	rep_16	8.4e-21
Slc18a1	GOBP_Cation_Transport	Mouse	Liver	rep_16	1.2e-18
Slc18a1	GOBP_Monoamine_Transport	Mouse	Liver	rep_16	2.8e-09
Slc18a1	GOBP_Transmembrane_Transport	Mouse	Liver	rep_16	1.4e-13
Slc18a1	GOBP_Serotonin_Transport	Mouse	Liver	rep_23	8.7e-24
Slc18a1	GOBP_Serotonin_Uptake	Mouse	Liver	rep_23	1.0e-19
Slc18a1	GOBP_Xenobiotic_Transport	Mouse	Intestine	rep_2	5.1e-95
Slc18a1	GOBP_Serotonin_Uptake	Mouse	Intestine	rep_3	1.9e-30
Slc18a1	GOBP_Monoamine_Transport	Mouse	Lymph	MS-1	5.7e-07
Slc18a1	GOBP_Neurotransmitter_Transport	Mouse	Lymph	MS-1	9.0e-09
Slc18a1	GOBP_Serotonin_Transport	Mouse	Lymph	MS-1	1.4e-11
Slc18a1	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Lymph	MS-1	1.2e-07
Slc18a1	GOBP_Neurotransmitter_Reuptake	Mouse	Lung	rep_1	1.6e-09
Slc18a1	GOBP_Neurotransmitter_Uptake	Mouse	Lung	rep_1	7.5e-11
Slc18a1	GOBP_Amine_Transport	Mouse	Brain	rep_4	7.8e-73
Slc18a1	GOBP_Monoamine_Transport	Mouse	Brain	rep_4	7.3e-09
Slc18a1	GOBP_Neurotransmitter_Loading_Into_Synaptic_Vesicle	Mouse	Brain	rep_4	1.8e-139
Slc18a1	GOBP_Neurotransmitter_Transport	Mouse	Brain	rep_4	3.0e-17
Slc18a1	GOBP_Regulation_Of_Neurotransmitter_Levels	Mouse	Brain	rep_4	1.0e-22
Slc18a1	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Brain	rep_4	2.9e-13
Slc18a1	GOBP_Xenobiotic_Transport	Mouse	Brain	rep_7	4.0e-13
Slc18a1	GOBP_Amine_Transport	Mouse	Brain	HP_ad_rep7	5.9e-14
Slc18a1	GOBP_Cation_Transport	Mouse	Brain	HP_ad_rep7	7.5e-07
Slc18a1	GOBP_Import_Into_Cell	Mouse	Brain	HP_ad_rep7	7.5e-07
Slc18a1	GOBP_Monoamine_Transport	Mouse	Brain	HP_ad_rep7	3.6e-11
Slc18a1	GOBP_Neurotransmitter_Loading_Into_Synaptic_Vesicle	Mouse	Brain	HP_ad_rep7	4.7e-12
Slc18a1	GOBP_Organic_Hydroxy_Compound_Transport	Mouse	Brain	HP_ad_rep7	4.0e-11
Slc18a1	GOBP_Transmembrane_Transport	Mouse	Brain	HP_ad_rep7	3.4e-07
Slc18a1	GOBP_Xenobiotic_Transport	Mouse	Brain	HP_ad_rep7	1.9e-13
Slc18a1	GOBP_Neurotransmitter_Reuptake	Mouse	Brain	HP_adpolb_rep5	6.1e-12
Slc18a1	GOBP_Neurotransmitter_Uptake	Mouse	Brain	HP_adpolb_rep5	7.8e-08
Slc18a1	GOBP_Neurotransmitter_Transport	Mouse	Brain	HP_polb_rep9	8.4e-10
Slc18a1	GOBP_Regulation_Of_Neurotransmitter_Levels	Mouse	Brain	HP_polb_rep9	4.0e-11
Slc18a1	GOBP_Vesicle_Mediated_Transport_In_Synapse	Mouse	Brain	HP_wt_rep2	1.1e-15

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Slc18a1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Slc18a1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Slc18a1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Slc18a1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Slc18a1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Slc18a1	C0005586	Bipolar Disorder	4	PSYGENET
Slc18a1	C0011570	Mental Depression	1	PSYGENET
Slc18a1	C0011581	Depressive disorder	1	PSYGENET
Slc18a1	C0036341	Schizophrenia	1	PSYGENET