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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Pcca (spascer ID:110821)

Gene summary for Pcca

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Pcca
	Gene ID	110821
	Gene name	propionyl-Coenzyme A carboxylase, alpha polypeptide
	Synonyms	C79630
	Cytomap	14 E5\|14 65.99 cM
	Type of gene	protein-coding
	Description	propionyl-CoA carboxylase alpha chain, mitochondrialPCCase subunit alphapropanoyl-CoA:carbon dioxide ligase subunit alphapropionyl CoA-carboxylase alpha
	Modification date	20220424
	UniProtAcc	Q91ZA3

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Pcca	GO:0004658	propionyl-CoA carboxylase activity	21873635	Function
Pcca	GO:0005739	mitochondrion	21873635	Component

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Spatial pattern events for Pcca

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Pcca	Mouse	Brain	S3	34413515	1.14e-14
Pcca	Mouse	Brain	S4	34413515	1.37e-15
Pcca	Mouse	Brain	S6	34413515	4.66e-07
Pcca	Mouse	Brain	S7	34413515	1.87e-12
Pcca	Mouse	Brain	rep_1	35141374	4.32e-09
Pcca	Mouse	Brain	rep_2	35141374	1.69e-15
Pcca	Mouse	Brain	rep_4	35141374	2.84e-15
Pcca	Mouse	Brain	rep_5	35141374	1.47e-15
Pcca	Mouse	Brain	rep_6	35141374	7.02e-11
Pcca	Mouse	Kidney	CLP	34003797	3.77e-15
Pcca	Mouse	Kidney	IRI	34003797	3.92e-15
Pcca	Mouse	Kidney	rep_1	34853151	4.13e-15
Pcca	Mouse	Brain	rep_1	33469025	1.30e-15
Pcca	Mouse	Liver	rep_23	35021063	2.74e-10
Pcca	Mouse	Brain	rep_3	35027729	1.32e-15
Pcca	Mouse	Brain	rep_4	35027729	2.81e-06
Pcca	Mouse	Brain	rep_5	35027729	2.62e-15
Pcca	Mouse	Intestine	rep_3	35149721	2.56e-08
Pcca	Mouse	Lymph	A1	0	9.41e-14
Pcca	Mouse	Lymph	B1	0	2.69e-10
Pcca	Mouse	Brain	rep_1	35210624	1.74e-15
Pcca	Mouse	Brain	rep_2	35210624	1.74e-15
Pcca	Mouse	Brain	rep_3	35210624	4.19e-12

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_CLP_H&E
Kidney_IRI_H&E
Kidney_rep_1_H&E
Brain_rep_1_H&E
Liver_rep_23_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E

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Spatial pattern pathway has Pcca envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Pcca	GOBP_Short_Chain_Fatty_Acid_Metabolic_Process	Mouse	Spinal cord	CN93_D2	8.6e-06
Pcca	GOBP_Organic_Acid_Catabolic_Process	Mouse	Spinal cord	CN94_E1	3.5e-07
Pcca	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	3.7e-06
Pcca	GOBP_Lipid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	8.9e-07
Pcca	GOBP_Organic_Acid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	7.1e-06
Pcca	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.4e-09
Pcca	GOBP_Cellular_Lipid_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	3.0e-07
Pcca	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	2.4e-06
Pcca	GOBP_Fatty_Acid_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	6.6e-10
Pcca	GOBP_Lipid_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Pcca	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Pcca	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	6.2e-09
Pcca	GOBP_Small_Molecule_Catabolic_Process	Mouse	Spinal cord	L7CN45_C1	4.6e-07
Pcca	GOBP_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Pcca	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	4.4e-07
Pcca	GOBP_Vitamin_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.4e-06
Pcca	GOBP_Water_Soluble_Vitamin_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.2e-07
Pcca	GOBP_Short_Chain_Fatty_Acid_Catabolic_Process	Mouse	Spinal cord	L7CN45_E1	4.5e-06
Pcca	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Brain	rep_11	2.7e-06
Pcca	GOBP_Vitamin_Metabolic_Process	Mouse	Brain	rep_21	6.6e-05
Pcca	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Brain	rep_71	8.1e-05
Pcca	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	rep_3	2.1e-87
Pcca	GOBP_Cellular_Lipid_Catabolic_Process	Mouse	Brain	rep_3	3.5e-106
Pcca	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Brain	rep_3	1.3e-180
Pcca	GOBP_Fatty_Acid_Metabolic_Process	Mouse	Brain	rep_3	1.5e-41
Pcca	GOBP_Lipid_Catabolic_Process	Mouse	Brain	rep_3	1.4e-121
Pcca	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Brain	rep_3	2.0e-175
Pcca	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Brain	rep_3	3.2e-119
Pcca	GOBP_Organic_Acid_Catabolic_Process	Mouse	Brain	rep_3	9.6e-181
Pcca	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	rep_3	1.5e-154
Pcca	GOBP_Short_Chain_Fatty_Acid_Catabolic_Process	Mouse	Brain	rep_3	4.2e-105
Pcca	GOBP_Short_Chain_Fatty_Acid_Metabolic_Process	Mouse	Brain	rep_3	5.4e-122
Pcca	GOBP_Small_Molecule_Catabolic_Process	Mouse	Brain	rep_3	9.8e-142
Pcca	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	rep_3	2.7e-19
Pcca	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Brain	rep_3	1.4e-160
Pcca	GOBP_Vitamin_Metabolic_Process	Mouse	Brain	rep_3	2.6e-174
Pcca	GOBP_Water_Soluble_Vitamin_Metabolic_Process	Mouse	Brain	rep_3	5.9e-186
Pcca	GOBP_Short_Chain_Fatty_Acid_Catabolic_Process	Mouse	Embryo	rep_6	6.7e-17
Pcca	GOBP_Vitamin_Metabolic_Process	Mouse	Embryo	rep_6	1.0e-11
Pcca	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Embryo	rep_14	4.7e-16
Pcca	GOBP_Cellular_Lipid_Catabolic_Process	Mouse	Embryo	rep_14	6.6e-12
Pcca	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Embryo	rep_14	1.8e-09
Pcca	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Embryo	rep_14	7.1e-14
Pcca	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Embryo	rep_14	7.3e-13
Pcca	GOBP_Organic_Acid_Catabolic_Process	Mouse	Embryo	rep_14	2.3e-13
Pcca	GOBP_Short_Chain_Fatty_Acid_Metabolic_Process	Mouse	Embryo	rep_14	7.8e-38
Pcca	GOBP_Small_Molecule_Catabolic_Process	Mouse	Embryo	rep_14	7.6e-14
Pcca	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Embryo	rep_14	5.8e-13
Pcca	GOBP_Water_Soluble_Vitamin_Metabolic_Process	Mouse	Embryo	rep_14	7.1e-79
Pcca	GOBP_Lipid_Metabolic_Process	Mouse	Embryo	rep_1	2.1e-39
Pcca	GOBP_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_1	1.4e-55
Pcca	GOBP_Cellular_Lipid_Catabolic_Process	Mouse	Embryo	rep_3	2.1e-07
Pcca	GOBP_Fatty_Acid_Metabolic_Process	Mouse	Embryo	rep_3	1.7e-52
Pcca	GOBP_Lipid_Catabolic_Process	Mouse	Embryo	rep_3	2.1e-07
Pcca	GOBP_Organic_Acid_Metabolic_Process	Mouse	Embryo	rep_3	1.4e-07
Pcca	GOBP_Small_Molecule_Catabolic_Process	Mouse	Embryo	rep_3	2.9e-170
Pcca	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Embryo	rep_4	0.0e+00
Pcca	GOBP_Vitamin_Metabolic_Process	Mouse	Embryo	rep_4	6.0e-12
Pcca	GOBP_Lipid_Metabolic_Process	Mouse	Kidney	Nep	4.2e-26
Pcca	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Kidney	rep_2	2.5e-85
Pcca	GOBP_Cellular_Lipid_Catabolic_Process	Mouse	Kidney	rep_2	2.5e-44
Pcca	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Kidney	rep_2	7.4e-43
Pcca	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Kidney	rep_2	7.7e-56
Pcca	GOBP_Fatty_Acid_Metabolic_Process	Mouse	Kidney	rep_2	2.1e-55
Pcca	GOBP_Lipid_Catabolic_Process	Mouse	Kidney	rep_2	1.4e-56
Pcca	GOBP_Lipid_Metabolic_Process	Mouse	Kidney	rep_2	1.4e-78
Pcca	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Kidney	rep_2	2.6e-58
Pcca	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Kidney	rep_2	4.4e-73
Pcca	GOBP_Organic_Acid_Catabolic_Process	Mouse	Kidney	rep_2	1.3e-83
Pcca	GOBP_Organic_Acid_Metabolic_Process	Mouse	Kidney	rep_2	3.8e-62
Pcca	GOBP_Short_Chain_Fatty_Acid_Catabolic_Process	Mouse	Kidney	rep_2	1.4e-177
Pcca	GOBP_Short_Chain_Fatty_Acid_Metabolic_Process	Mouse	Kidney	rep_2	6.5e-105
Pcca	GOBP_Small_Molecule_Catabolic_Process	Mouse	Kidney	rep_2	4.4e-89
Pcca	GOBP_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	1.8e-43
Pcca	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Kidney	rep_2	8.6e-17
Pcca	GOBP_Vitamin_Metabolic_Process	Mouse	Kidney	rep_2	6.7e-44
Pcca	GOBP_Water_Soluble_Vitamin_Metabolic_Process	Mouse	Kidney	rep_2	6.8e-65
Pcca	GOBP_Short_Chain_Fatty_Acid_Catabolic_Process	Mouse	Liver	CN16-D1	1.9e-15
Pcca	GOBP_Short_Chain_Fatty_Acid_Metabolic_Process	Mouse	Liver	CN16-D1	2.4e-11
Pcca	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Liver	CN73-C1	9.9e-09
Pcca	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Intestine	rep_2	3.7e-18
Pcca	GOBP_Fatty_Acid_Metabolic_Process	Mouse	Intestine	rep_2	3.9e-25
Pcca	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Intestine	rep_2	1.5e-14
Pcca	GOBP_Short_Chain_Fatty_Acid_Catabolic_Process	Mouse	Intestine	rep_2	2.7e-91
Pcca	GOBP_Short_Chain_Fatty_Acid_Metabolic_Process	Mouse	Intestine	rep_2	3.1e-38
Pcca	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Intestine	rep_2	7.1e-07
Pcca	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Lymph	MS-1	5.8e-11
Pcca	GOBP_Cellular_Lipid_Catabolic_Process	Mouse	Lymph	MS-1	3.4e-07
Pcca	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Lymph	MS-1	1.1e-14
Pcca	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Lymph	MS-1	6.3e-09
Pcca	GOBP_Fatty_Acid_Metabolic_Process	Mouse	Lymph	MS-1	8.4e-16
Pcca	GOBP_Lipid_Catabolic_Process	Mouse	Lymph	MS-1	2.6e-07
Pcca	GOBP_Lipid_Metabolic_Process	Mouse	Lymph	MS-1	9.7e-11
Pcca	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Lymph	MS-1	4.8e-07
Pcca	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-15
Pcca	GOBP_Organic_Acid_Catabolic_Process	Mouse	Lymph	MS-1	4.1e-10
Pcca	GOBP_Organic_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-15
Pcca	GOBP_Short_Chain_Fatty_Acid_Metabolic_Process	Mouse	Lymph	MS-1	9.3e-13
Pcca	GOBP_Small_Molecule_Catabolic_Process	Mouse	Lymph	MS-1	5.1e-07
Pcca	GOBP_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.6e-11
Pcca	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Lymph	MS-1	7.8e-10
Pcca	GOBP_Short_Chain_Fatty_Acid_Catabolic_Process	Mouse	Brain	HP_ad_rep3	2.4e-07
Pcca	GOBP_Vitamin_Metabolic_Process	Mouse	Brain	HP_ad_rep3	1.3e-07
Pcca	GOBP_Cellular_Amide_Metabolic_Process	Mouse	Brain	HP_ad_rep7	5.6e-11
Pcca	GOBP_Fatty_Acid_Catabolic_Process	Mouse	Brain	HP_ad_rep7	4.7e-07
Pcca	GOBP_Monocarboxylic_Acid_Catabolic_Process	Mouse	Brain	HP_ad_rep7	3.1e-10
Pcca	GOBP_Organic_Acid_Catabolic_Process	Mouse	Brain	HP_ad_rep7	2.2e-13
Pcca	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	HP_ad_rep7	4.1e-08
Pcca	GOBP_Small_Molecule_Catabolic_Process	Mouse	Brain	HP_ad_rep7	2.3e-11
Pcca	GOBP_Water_Soluble_Vitamin_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.1e-08
Pcca	GOBP_Short_Chain_Fatty_Acid_Metabolic_Process	Mouse	Brain	HP_adpolb_rep1	5.5e-08
Pcca	GOBP_Cellular_Lipid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.9e-07
Pcca	GOBP_Lipid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.9e-11
Pcca	GOBP_Monocarboxylic_Acid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	1.7e-11
Pcca	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.0e-09
Pcca	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.9e-08

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Pcca function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Pcca function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Pcca envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Pcca

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Pcca

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Pcca	C0268579	Propionic acidemia	8	CTD_human;GENOMICS_ENGLAND;UNIPROT
Pcca	C1449563	Cardiomyopathy, Familial Idiopathic	1	GENOMICS_ENGLAND
Pcca	C2717876	Propionicaciduria	1	CTD_human;GENOMICS_ENGLAND