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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Adi1 (spascer ID:104923)

Gene summary for Adi1

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Adi1
	Gene ID	104923
	Gene name	acireductone dioxygenase 1
	Synonyms	AL024210\|Fe-ARD\|MTCBP-1\|Ni-ARD
	Cytomap	12\|12 A2
	Type of gene	protein-coding
	Description	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenaseARDaci-reductone dioxygenaseacireductone dioxygenase (Fe(2+)-requiring)acireductone dioxygenase (Ni(2+)-requiring)fe-ARDmembrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1
	Modification date	20220424
	UniProtAcc	Q99JT9

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Adi1	GO:0006555	methionine metabolic process	21873635	Process
Adi1	GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity	21873635	Function

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Spatial pattern events for Adi1

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Adi1	Mouse	Brain	S1	34413515	3.22e-12
Adi1	Mouse	Brain	S2	34413515	1.56e-15
Adi1	Mouse	Brain	S3	34413515	2.25e-14
Adi1	Mouse	Brain	S4	34413515	1.37e-15
Adi1	Mouse	Brain	S6	34413515	1.46e-15
Adi1	Mouse	Brain	S7	34413515	2.85e-15
Adi1	Mouse	Brain	rep_1	35141374	1.14e-10
Adi1	Mouse	Brain	rep_2	35141374	1.69e-15
Adi1	Mouse	Brain	rep_3	35141374	1.28e-10
Adi1	Mouse	Brain	rep_4	35141374	2.38e-13
Adi1	Mouse	Brain	rep_5	35141374	1.47e-15
Adi1	Mouse	Brain	rep_6	35141374	1.73e-15
Adi1	Mouse	Kidney	IRI	34003797	7.37e-15
Adi1	Mouse	Kidney	rep_4	34853151	3.18e-08
Adi1	Mouse	Brain	rep_1	33469025	1.62e-07
Adi1	Mouse	Liver	rep_14	35021063	1.45e-06
Adi1	Mouse	Liver	rep_17	35021063	4.77e-14
Adi1	Mouse	Liver	rep_18	35021063	1.22e-06
Adi1	Mouse	Liver	rep_19	35021063	9.01e-13
Adi1	Mouse	Liver	rep_20	35021063	1.96e-06
Adi1	Mouse	Liver	rep_21	35021063	1.40e-14
Adi1	Mouse	Liver	rep_22	35021063	1.07e-14
Adi1	Mouse	Brain	rep_1	35027729	1.66e-15
Adi1	Mouse	Brain	rep_2	35027729	1.57e-15
Adi1	Mouse	Brain	rep_3	35027729	1.32e-15
Adi1	Mouse	Brain	rep_4	35027729	3.10e-15
Adi1	Mouse	Brain	rep_5	35027729	1.46e-15
Adi1	Mouse	Lymph	A1	0	4.45e-08
Adi1	Mouse	Lymph	B1	0	6.12e-07
Adi1	Mouse	Brain	rep_1	35210624	1.74e-15
Adi1	Mouse	Brain	rep_2	35210624	1.74e-15
Adi1	Mouse	Brain	rep_3	35210624	1.82e-15
Adi1	Mouse	Brain	rep_4	35210624	2.34e-15
Adi1	Mouse	Brain	rep_5	35210624	2.07e-15
Adi1	Mouse	Brain	rep_6	35210624	2.05e-15
Adi1	Mouse	Brain	rep_7	35210624	1.87e-15

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_IRI_H&E
Kidney_rep_4_H&E
Brain_rep_1_H&E
Liver_rep_14_H&E
Liver_rep_17_H&E
Liver_rep_18_H&E
Liver_rep_19_H&E
Liver_rep_20_H&E
Liver_rep_21_H&E
Liver_rep_22_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E

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Spatial pattern pathway has Adi1 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Adi1	GOBP_Methionine_Biosynthetic_Process	Mouse	Spinal cord	CN90_C1	9.7e-07
Adi1	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	7.5e-07
Adi1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Spinal cord	L7bCN02_E1	7.1e-06
Adi1	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7bCN02_E1	1.8e-07
Adi1	GOBP_Aspartate_Family_Amino_Acid_Metabolic_Process	Mouse	Spinal cord	L7CN44_C1	9.7e-08
Adi1	GOBP_Cellular_Metabolic_Compound_Salvage	Mouse	Spinal cord	L7CN45_C1	3.9e-06
Adi1	GOBP_Methionine_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.3e-06
Adi1	GOBP_Organic_Acid_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	5.8e-07
Adi1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	5.6e-08
Adi1	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Spinal cord	L7CN45_C1	4.3e-07
Adi1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	1.7e-07
Adi1	GOBP_Sulfur_Amino_Acid_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	4.7e-07
Adi1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Spinal cord	L7CN45_C1	4.4e-07
Adi1	GOBP_Amino_Acid_Salvage	Mouse	Spinal cord	L7CN47_D1	7.2e-07
Adi1	GOBP_L_Methionine_Salvage_From_Methylthioadenosine	Mouse	Spinal cord	L7CN47_D1	7.2e-07
Adi1	GOBP_Cellular_Metabolic_Compound_Salvage	Mouse	Brain	rep_41	5.6e-06
Adi1	GOBP_Methionine_Biosynthetic_Process	Mouse	Brain	rep_41	8.4e-06
Adi1	GOBP_Methionine_Metabolic_Process	Mouse	Brain	rep_42	2.3e-06
Adi1	GOBP_Organic_Acid_Biosynthetic_Process	Mouse	Brain	rep_71	7.6e-05
Adi1	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Brain	rep_1	8.2e-08
Adi1	GOBP_Alpha_Amino_Acid_Metabolic_Process	Mouse	Brain	rep_3	2.8e-178
Adi1	GOBP_Amino_Acid_Salvage	Mouse	Brain	rep_3	1.4e-42
Adi1	GOBP_Aspartate_Family_Amino_Acid_Biosynthetic_Process	Mouse	Brain	rep_3	3.0e-61
Adi1	GOBP_Aspartate_Family_Amino_Acid_Metabolic_Process	Mouse	Brain	rep_3	4.9e-56
Adi1	GOBP_Cellular_Amino_Acid_Biosynthetic_Process	Mouse	Brain	rep_3	6.3e-192
Adi1	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Brain	rep_3	8.5e-191
Adi1	GOBP_Cellular_Metabolic_Compound_Salvage	Mouse	Brain	rep_3	7.6e-192
Adi1	GOBP_L_Methionine_Salvage_From_Methylthioadenosine	Mouse	Brain	rep_3	1.2e-46
Adi1	GOBP_Methionine_Biosynthetic_Process	Mouse	Brain	rep_3	1.4e-79
Adi1	GOBP_Methionine_Metabolic_Process	Mouse	Brain	rep_3	7.3e-131
Adi1	GOBP_Organic_Acid_Biosynthetic_Process	Mouse	Brain	rep_3	2.0e-17
Adi1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	rep_3	1.5e-154
Adi1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	rep_3	2.9e-144
Adi1	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Brain	rep_3	1.1e-103
Adi1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	rep_3	2.7e-19
Adi1	GOBP_Sulfur_Amino_Acid_Biosynthetic_Process	Mouse	Brain	rep_3	4.4e-110
Adi1	GOBP_Sulfur_Amino_Acid_Metabolic_Process	Mouse	Brain	rep_3	1.5e-208
Adi1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Brain	rep_3	1.4e-160
Adi1	GOBP_Aspartate_Family_Amino_Acid_Biosynthetic_Process	Mouse	Embryo	rep_6	7.5e-17
Adi1	GOBP_Cellular_Amino_Acid_Biosynthetic_Process	Mouse	Embryo	rep_6	4.1e-27
Adi1	GOBP_Methionine_Biosynthetic_Process	Mouse	Embryo	rep_6	2.5e-15
Adi1	GOBP_Methionine_Metabolic_Process	Mouse	Embryo	rep_6	2.4e-07
Adi1	GOBP_Sulfur_Amino_Acid_Biosynthetic_Process	Mouse	Embryo	rep_6	6.1e-30
Adi1	GOBP_Alpha_Amino_Acid_Metabolic_Process	Mouse	Embryo	rep_14	1.5e-20
Adi1	GOBP_Amino_Acid_Salvage	Mouse	Embryo	rep_14	7.8e-14
Adi1	GOBP_Aspartate_Family_Amino_Acid_Metabolic_Process	Mouse	Embryo	rep_14	6.5e-16
Adi1	GOBP_Cellular_Metabolic_Compound_Salvage	Mouse	Embryo	rep_14	6.0e-34
Adi1	GOBP_L_Methionine_Salvage_From_Methylthioadenosine	Mouse	Embryo	rep_14	7.8e-14
Adi1	GOBP_Organic_Acid_Biosynthetic_Process	Mouse	Embryo	rep_14	7.1e-24
Adi1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	2.4e-12
Adi1	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Embryo	rep_14	6.9e-13
Adi1	GOBP_Sulfur_Amino_Acid_Metabolic_Process	Mouse	Embryo	rep_14	4.3e-33
Adi1	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Embryo	rep_14	3.3e-48
Adi1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Embryo	rep_14	5.8e-13
Adi1	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Embryo	rep_1	8.4e-169
Adi1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Embryo	rep_1	1.4e-55
Adi1	GOBP_Alpha_Amino_Acid_Metabolic_Process	Mouse	Embryo	rep_3	9.9e-51
Adi1	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Embryo	rep_3	9.9e-51
Adi1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Embryo	rep_3	1.4e-07
Adi1	GOBP_Organic_Acid_Biosynthetic_Process	Mouse	Embryo	rep_4	1.5e-14
Adi1	GOBP_Alpha_Amino_Acid_Metabolic_Process	Mouse	Kidney	rep_2	7.2e-36
Adi1	GOBP_Amino_Acid_Salvage	Mouse	Kidney	rep_2	5.2e-33
Adi1	GOBP_Aspartate_Family_Amino_Acid_Biosynthetic_Process	Mouse	Kidney	rep_2	1.2e-49
Adi1	GOBP_Cellular_Amino_Acid_Biosynthetic_Process	Mouse	Kidney	rep_2	7.5e-80
Adi1	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Kidney	rep_2	3.8e-34
Adi1	GOBP_Cellular_Metabolic_Compound_Salvage	Mouse	Kidney	rep_2	3.4e-121
Adi1	GOBP_L_Methionine_Salvage_From_Methylthioadenosine	Mouse	Kidney	rep_2	4.1e-18
Adi1	GOBP_Methionine_Biosynthetic_Process	Mouse	Kidney	rep_2	1.1e-84
Adi1	GOBP_Methionine_Metabolic_Process	Mouse	Kidney	rep_2	2.2e-31
Adi1	GOBP_Organic_Acid_Biosynthetic_Process	Mouse	Kidney	rep_2	7.1e-54
Adi1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Kidney	rep_2	3.8e-62
Adi1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Kidney	rep_2	8.9e-78
Adi1	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Kidney	rep_2	1.8e-73
Adi1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Kidney	rep_2	1.8e-43
Adi1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Kidney	rep_2	8.6e-17
Adi1	GOBP_Sulfur_Amino_Acid_Biosynthetic_Process	Mouse	Kidney	rep_3	2.2e-04
Adi1	GOBP_Sulfur_Amino_Acid_Biosynthetic_Process	Mouse	Liver	CN16-D1	7.1e-13
Adi1	GOBP_Amino_Acid_Salvage	Mouse	Liver	CN16-D2	3.6e-09
Adi1	GOBP_L_Methionine_Salvage_From_Methylthioadenosine	Mouse	Liver	CN16-D2	1.1e-07
Adi1	GOBP_Aspartate_Family_Amino_Acid_Biosynthetic_Process	Mouse	Liver	CN65-C1	3.6e-16
Adi1	GOBP_Methionine_Metabolic_Process	Mouse	Liver	CN65-D1	2.7e-08
Adi1	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Liver	CN73-C1	3.0e-08
Adi1	GOBP_L_Methionine_Salvage_From_Methylthioadenosine	Mouse	Liver	rep_16	3.8e-21
Adi1	GOBP_Sulfur_Amino_Acid_Metabolic_Process	Mouse	Intestine	rep_2	2.0e-50
Adi1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Intestine	rep_2	7.1e-07
Adi1	GOBP_Amino_Acid_Salvage	Mouse	Intestine	rep_3	1.0e-25
Adi1	GOBP_L_Methionine_Salvage_From_Methylthioadenosine	Mouse	Intestine	rep_3	3.6e-18
Adi1	GOBP_Methionine_Metabolic_Process	Mouse	Intestine	rep_3	6.2e-28
Adi1	GOBP_Sulfur_Amino_Acid_Biosynthetic_Process	Mouse	Intestine	rep_3	2.0e-30
Adi1	GOBP_Alpha_Amino_Acid_Metabolic_Process	Mouse	Lymph	MS-1	2.1e-13
Adi1	GOBP_Aspartate_Family_Amino_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.0e-06
Adi1	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-13
Adi1	GOBP_Methionine_Biosynthetic_Process	Mouse	Lymph	MS-1	1.1e-07
Adi1	GOBP_Methionine_Metabolic_Process	Mouse	Lymph	MS-1	1.4e-10
Adi1	GOBP_Organic_Acid_Biosynthetic_Process	Mouse	Lymph	MS-1	6.1e-15
Adi1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Lymph	MS-1	1.3e-15
Adi1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	1.4e-09
Adi1	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Lymph	MS-1	3.0e-17
Adi1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Lymph	MS-1	2.6e-11
Adi1	GOBP_Sulfur_Amino_Acid_Biosynthetic_Process	Mouse	Lymph	MS-1	3.8e-07
Adi1	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Lymph	MS-1	4.5e-10
Adi1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Lymph	MS-1	7.8e-10
Adi1	GOBP_Sulfur_Amino_Acid_Metabolic_Process	Mouse	Lymph	MS-2	2.1e-07
Adi1	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Brain	rep_4	1.9e-21
Adi1	GOBP_Amino_Acid_Salvage	Mouse	Brain	HP_ad_rep3	3.1e-12
Adi1	GOBP_L_Methionine_Salvage_From_Methylthioadenosine	Mouse	Brain	HP_ad_rep3	3.1e-12
Adi1	GOBP_Methionine_Biosynthetic_Process	Mouse	Brain	HP_ad_rep3	3.2e-18
Adi1	GOBP_Methionine_Metabolic_Process	Mouse	Brain	HP_ad_rep3	5.7e-13
Adi1	GOBP_Sulfur_Amino_Acid_Biosynthetic_Process	Mouse	Brain	HP_ad_rep3	1.5e-13
Adi1	GOBP_Alpha_Amino_Acid_Metabolic_Process	Mouse	Brain	HP_ad_rep7	2.5e-12
Adi1	GOBP_Cellular_Amino_Acid_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	2.4e-17
Adi1	GOBP_Cellular_Amino_Acid_Metabolic_Process	Mouse	Brain	HP_ad_rep7	1.0e-14
Adi1	GOBP_Cellular_Metabolic_Compound_Salvage	Mouse	Brain	HP_ad_rep7	1.3e-13
Adi1	GOBP_Organic_Acid_Metabolic_Process	Mouse	Brain	HP_ad_rep7	4.1e-08
Adi1	GOBP_Organonitrogen_Compound_Biosynthetic_Process	Mouse	Brain	HP_ad_rep7	2.8e-08
Adi1	GOBP_Aspartate_Family_Amino_Acid_Metabolic_Process	Mouse	Brain	HP_polb_rep3	3.4e-09
Adi1	GOBP_Aspartate_Family_Amino_Acid_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	3.2e-09
Adi1	GOBP_Organic_Acid_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	3.8e-07
Adi1	GOBP_Small_Molecule_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	2.8e-11
Adi1	GOBP_Small_Molecule_Metabolic_Process	Mouse	Brain	HP_polb_rep9	2.0e-09
Adi1	GOBP_Sulfur_Amino_Acid_Metabolic_Process	Mouse	Brain	HP_polb_rep9	6.2e-07
Adi1	GOBP_Sulfur_Compound_Biosynthetic_Process	Mouse	Brain	HP_polb_rep9	2.2e-10
Adi1	GOBP_Sulfur_Compound_Metabolic_Process	Mouse	Brain	HP_polb_rep9	9.9e-08

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Adi1 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Adi1 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Adi1 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Adi1

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Adi1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	Pubmeds	Source
Adi1	C0033578	Prostatic Neoplasms	1	CTD_human
Adi1	C0376358	Malignant neoplasm of prostate	1	CTD_human