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	Gene summary
	Spatial pattern genes
	Spatial pattern pathway
	Cell cell interactions using single cell data
	Cell-cell/spot-spot interactions using spatial data
	Transcription factors events
	Related drugs with this gene
	Related diseases with this gene

Spatial pattern gene: Tmed4 (spascer ID:103694)

Gene summary for Tmed4

Gene summary

Gene information
	Species	Mouse
	Gene symbol	Tmed4
	Gene ID	103694
	Gene name	transmembrane p24 trafficking protein 4
	Synonyms	1110014L17Rik\|AI326346
	Cytomap	11\|11 A1
	Type of gene	protein-coding
	Description	transmembrane emp24 domain-containing protein 4ERS25endoplasmic reticulum stress-response protein 25p24 family protein alpha-3p24alpha3p26transmembrane emp24 protein transport domain containing 4
	Modification date	20220424
	UniProtAcc	Q8R1V4

Gene ontology with evidence Inferred from Direct Assay (IDA) and Biological aspect of Ancestor (IBA).

Gene	GO ID	GO term	PubMed ID	Category
Tmed4	GO:0005783	endoplasmic reticulum	21873635	Component
Tmed4	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	21873635	Component
Tmed4	GO:0005794	Golgi apparatus	21873635	Component
Tmed4	GO:0006886	intracellular protein transport	21873635	Process
Tmed4	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	21873635	Process
Tmed4	GO:0007030	Golgi organization	21873635	Process
Tmed4	GO:0030134	COPII-coated ER to Golgi transport vesicle	21873635	Component

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Spatial pattern events for Tmed4

spatial pattern gene list.

Gene symbol	Species	Tissue	Replication	PMID	Adj p-value
Tmed4	Mouse	Brain	S3	34413515	5.72e-15
Tmed4	Mouse	Brain	S4	34413515	4.12e-13
Tmed4	Mouse	Brain	S6	34413515	2.66e-15
Tmed4	Mouse	Brain	S7	34413515	1.55e-15
Tmed4	Mouse	Brain	28B	32637622	1.50e-06
Tmed4	Mouse	Brain	rep_1	35141374	5.96e-14
Tmed4	Mouse	Brain	rep_2	35141374	1.28e-11
Tmed4	Mouse	Brain	rep_3	35141374	1.64e-15
Tmed4	Mouse	Brain	rep_4	35141374	1.57e-15
Tmed4	Mouse	Brain	rep_5	35141374	1.47e-15
Tmed4	Mouse	Brain	rep_6	35141374	1.73e-15
Tmed4	Mouse	Kidney	IRI	34003797	2.29e-15
Tmed4	Mouse	Brain	rep_1	33469025	3.74e-11
Tmed4	Mouse	Brain	rep_1	35027729	4.42e-13
Tmed4	Mouse	Brain	rep_2	35027729	7.07e-14
Tmed4	Mouse	Brain	rep_3	35027729	1.32e-15
Tmed4	Mouse	Brain	rep_4	35027729	2.14e-10
Tmed4	Mouse	Brain	rep_5	35027729	2.52e-10
Tmed4	Mouse	Testicle	rep_4	34731600	6.82e-10
Tmed4	Mouse	Lymph	A1	0	6.87e-14
Tmed4	Mouse	Lymph	B1	0	6.08e-15
Tmed4	Mouse	Brain	rep_1	35210624	3.17e-15
Tmed4	Mouse	Brain	rep_2	35210624	2.54e-08
Tmed4	Mouse	Brain	rep_3	35210624	4.06e-08

spatial pattern gene map.(click to enlarge the image in a new window)

H&E staining (if available)	Singel gene map
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E
Brain_rep_6_H&E
Kidney_IRI_H&E
Brain_rep_1_H&E
Brain_rep_1_H&E
Brain_rep_2_H&E
Brain_rep_3_H&E
Brain_rep_4_H&E
Brain_rep_5_H&E

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Spatial pattern pathway has Tmed4 envolved

Symbol	Pathway	Species	Tissue type	Replication	P-value
Tmed4	GOBP_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Spinal cord	L7bCN02_E1	6.8e-06
Tmed4	GOBP_Cellular_Macromolecule_Localization	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Tmed4	GOBP_Endomembrane_System_Organization	Mouse	Spinal cord	L7CN45_C1	1.0e-06
Tmed4	GOBP_Endoplasmic_Reticulum_To_Golgi_Vesicle_Mediated_Transport	Mouse	Spinal cord	L7CN45_C1	7.4e-08
Tmed4	GOBP_Establishment_Of_Protein_Localization	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Tmed4	GOBP_Golgi_Organization	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Tmed4	GOBP_Golgi_Vesicle_Transport	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Tmed4	GOBP_Intracellular_Protein_Transport	Mouse	Spinal cord	L7CN45_C1	3.6e-07
Tmed4	GOBP_Intracellular_Transport	Mouse	Spinal cord	L7CN45_C1	4.4e-06
Tmed4	GOBP_Positive_Regulation_Of_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Spinal cord	L7CN45_C1	9.1e-07
Tmed4	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L7CN45_C1	8.5e-07
Tmed4	GOBP_Positive_Regulation_Of_Signaling	Mouse	Spinal cord	L7CN45_C1	4.2e-07
Tmed4	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Spinal cord	L8CN11_D1	5.6e-09
Tmed4	GOBP_Golgi_Organization	Mouse	Brain	rep_27	5.4e-06
Tmed4	GOBP_Golgi_Vesicle_Transport	Mouse	Brain	rep_27	5.1e-06
Tmed4	GOBP_Endomembrane_System_Organization	Mouse	Brain	rep_1	7.8e-10
Tmed4	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	rep_1	6.6e-07
Tmed4	GOBP_Golgi_Organization	Mouse	Brain	rep_1	5.5e-18
Tmed4	GOBP_Golgi_Vesicle_Transport	Mouse	Brain	rep_1	1.2e-15
Tmed4	GOBP_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Brain	rep_1	1.3e-08
Tmed4	GOBP_Positive_Regulation_Of_Signaling	Mouse	Brain	rep_1	3.1e-07
Tmed4	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	rep_3	1.6e-125
Tmed4	GOBP_Endoplasmic_Reticulum_To_Golgi_Vesicle_Mediated_Transport	Mouse	Brain	rep_3	7.6e-183
Tmed4	GOBP_Intracellular_Protein_Transport	Mouse	Brain	rep_3	2.7e-132
Tmed4	GOBP_Intracellular_Transport	Mouse	Brain	rep_3	1.0e-102
Tmed4	GOBP_Positive_Regulation_Of_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Brain	rep_3	9.2e-94
Tmed4	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	3.3e-214
Tmed4	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	rep_3	1.3e-132
Tmed4	GOBP_Endoplasmic_Reticulum_To_Golgi_Vesicle_Mediated_Transport	Mouse	Embryo	rep_14	4.4e-33
Tmed4	GOBP_Golgi_Vesicle_Transport	Mouse	Embryo	rep_14	5.7e-09
Tmed4	GOBP_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Embryo	rep_14	6.2e-28
Tmed4	GOBP_Positive_Regulation_Of_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Embryo	rep_14	1.9e-23
Tmed4	GOBP_Cellular_Macromolecule_Localization	Mouse	Embryo	rep_2	5.5e-15
Tmed4	GOBP_Positive_Regulation_Of_Signaling	Mouse	Embryo	rep_2	1.4e-07
Tmed4	GOBP_Intracellular_Protein_Transport	Mouse	Embryo	rep_4	1.1e-39
Tmed4	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	Nep	5.3e-07
Tmed4	GOBP_Positive_Regulation_Of_Signaling	Mouse	Kidney	Nep	1.1e-39
Tmed4	GOBP_Cellular_Macromolecule_Localization	Mouse	Kidney	rep_2	3.5e-61
Tmed4	GOBP_Endomembrane_System_Organization	Mouse	Kidney	rep_2	1.0e-161
Tmed4	GOBP_Endoplasmic_Reticulum_To_Golgi_Vesicle_Mediated_Transport	Mouse	Kidney	rep_2	1.8e-93
Tmed4	GOBP_Establishment_Of_Protein_Localization	Mouse	Kidney	rep_2	9.8e-86
Tmed4	GOBP_Golgi_Organization	Mouse	Kidney	rep_2	3.2e-78
Tmed4	GOBP_Golgi_Vesicle_Transport	Mouse	Kidney	rep_2	6.5e-131
Tmed4	GOBP_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Kidney	rep_2	1.5e-43
Tmed4	GOBP_Intracellular_Protein_Transport	Mouse	Kidney	rep_2	7.5e-54
Tmed4	GOBP_Intracellular_Transport	Mouse	Kidney	rep_2	7.9e-80
Tmed4	GOBP_Positive_Regulation_Of_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Kidney	rep_2	2.0e-70
Tmed4	GOBP_Positive_Regulation_Of_Signaling	Mouse	Kidney	rep_2	3.4e-17
Tmed4	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Kidney	rep_2	1.4e-17
Tmed4	GOBP_Positive_Regulation_Of_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Liver	rep_16	5.4e-07
Tmed4	GOBP_Cellular_Macromolecule_Localization	Mouse	Lymph	MS-1	1.1e-11
Tmed4	GOBP_Endomembrane_System_Organization	Mouse	Lymph	MS-1	2.5e-09
Tmed4	GOBP_Endoplasmic_Reticulum_To_Golgi_Vesicle_Mediated_Transport	Mouse	Lymph	MS-1	4.3e-11
Tmed4	GOBP_Establishment_Of_Protein_Localization	Mouse	Lymph	MS-1	2.5e-11
Tmed4	GOBP_Golgi_Organization	Mouse	Lymph	MS-1	9.6e-08
Tmed4	GOBP_Golgi_Vesicle_Transport	Mouse	Lymph	MS-1	5.2e-08
Tmed4	GOBP_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Lymph	MS-1	2.7e-15
Tmed4	GOBP_Intracellular_Protein_Transport	Mouse	Lymph	MS-1	3.0e-17
Tmed4	GOBP_Intracellular_Transport	Mouse	Lymph	MS-1	3.3e-11
Tmed4	GOBP_Positive_Regulation_Of_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Lymph	MS-1	3.7e-16
Tmed4	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	2.3e-12
Tmed4	GOBP_Positive_Regulation_Of_Signaling	Mouse	Lymph	MS-1	2.3e-12
Tmed4	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Lymph	MS-1	1.0e-14
Tmed4	GOBP_Cellular_Macromolecule_Localization	Mouse	Brain	HP_ad_rep7	6.6e-10
Tmed4	GOBP_Endoplasmic_Reticulum_To_Golgi_Vesicle_Mediated_Transport	Mouse	Brain	HP_ad_rep7	6.3e-08
Tmed4	GOBP_Establishment_Of_Protein_Localization	Mouse	Brain	HP_ad_rep7	8.7e-10
Tmed4	GOBP_Golgi_Organization	Mouse	Brain	HP_ad_rep7	2.6e-07
Tmed4	GOBP_Golgi_Vesicle_Transport	Mouse	Brain	HP_ad_rep7	1.1e-09
Tmed4	GOBP_Intracellular_Protein_Transport	Mouse	Brain	HP_ad_rep7	3.6e-08
Tmed4	GOBP_Intracellular_Transport	Mouse	Brain	HP_ad_rep7	3.1e-08
Tmed4	GOBP_Positive_Regulation_Of_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Brain	HP_ad_rep7	1.9e-07
Tmed4	GOBP_Endomembrane_System_Organization	Mouse	Brain	HP_polb_rep9	6.0e-11
Tmed4	GOBP_I_Kappab_Kinase_Nf_Kappab_Signaling	Mouse	Brain	HP_polb_rep9	1.8e-10
Tmed4	GOBP_Positive_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	1.7e-14
Tmed4	GOBP_Positive_Regulation_Of_Signaling	Mouse	Brain	HP_polb_rep9	1.3e-14
Tmed4	GOBP_Regulation_Of_Intracellular_Signal_Transduction	Mouse	Brain	HP_polb_rep9	3.9e-11

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Tmed4 function as liang/receptor in single cell data

Tissue

Source

SourceCell

Target

TargetCell

PMID

Group

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Tmed4 function as liang/receptor across spatial transcriptomics tissue

Interactions using deconvoluted spatial data.

Ligand

Receptor

LR pair

Tissue

Replication

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Transcription factor for Tmed4 envolved

Transcription factor analysis using single cell data.

Tissue

Group

Cell types

Target genes

Rss score

Motif information.

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Related Drugs for Tmed4

Approved drugs targeting this gene.
(DrugBank Version 5.1.9 2022-01-04)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for Tmed4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

Pubmeds

Source